Abstract: RNA interference (RNAi) agents and RNAi agent conjugates for inhibiting the expression of the LPA (apo(a)) gene are described. Pharmaceutical compositions comprising one or more LPA RNAi agents optionally with one or more additional therapeutics are also described. Delivery of the described LPA RNAi agents to liver cells in vivo provides for inhibition of LPA gene expression and treatment of cardiovascular and cardiovascular-related diseases.

Abstract: The present invention relates to Ras inhibitors, intermediates in the synthesis thereto, and methods for preparing the Ras inhibitors and the intermediates.

Abstract: A hardware accelerator device is provided with accelerator hardware to perform dictionary compressions in hardware based on a request from an application executed by a processor device coupled to the hardware accelerator device to compress data for the application.

Abstract: Pesticidal compositions for improving physical characteristics of pesticide formulations which comprise natural pesticidal oil active ingredients are disclosed. One such composition comprises a pesticidal natural oil active ingredient, a surfactant to disperse the active ingredient in a water emulsion and a polymeric pour point depressant effective to reduce a pour point temperature of the pesticidal natural oil active ingredient. Methods for providing pesticidal compositions and application to control one or more pests are also disclosed.

Abstract: The present disclosure relates to rheology modified, low foaming aqueous antimicrobial compositions. The compositions are phase stable under acidic conditions, and do not need to be rinsed from the surface to which they are applied. The present disclosure further relates to methods of use thereof.

Abstract: Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.

Abstract: The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments. The present disclosure provides compounds of Formula (I).

Abstract: In an illustrative embodiment, an automated system determines similarities between properties at a location using customized features sets. The system can generate feature sets for properties from property attribute data received from external and internal sources. The system can transform one or more elements of attribute data of combined internal and external data into customized property attributes that enhance property attribute comparisons. The combined attribute data can be applied to a machine learning algorithm that identifies a portion of the combined attribute data for using in property similarity calculations. Using the identified features, the system can calculate similarity scores identifying an amount of similarity between properties at the location and a property identified in a comparable property query, which can be output to an external device.

Abstract: Some implementations relate to generating a training and/or evaluation dataset with LLM prompts (e.g., derived from user queries) based on a prompt complexity. An input prompt, for example derived from a user query, is received. The input prompt is decomposed into a prompt tree comprising a plurality of nodes. The plurality of nodes comprise: a plurality of leaf nodes corresponding to simple sub-prompts of the input query; a plurality of branch nodes of sub-prompts each corresponding to multiple simple sub-prompts; and a root node corresponding to the input prompt. A prompt complexity is determined based on a path length of the prompt tree. The prompt complexity is compared to a threshold complexity. If the prompt complexity is above the threshold complexity, the input prompt is included in a set of training prompts and/or a set of evaluation prompts.

Abstract: The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: A multi-element filtration vessel included spaced beams for supporting and/or aligning filtration elements from below. The filtration elements have bottom ends adapted to rest upon adjacent support beams and also to extend between them to form a cavity that can capture feed fluid and an aeration gas and conduct it into the filtration element. In another aspect, a multi-element filtration vessel has removable aerators mounted on a projection on the wall of the filtration vessel.

Abstract: In one embodiment, a method includes initializing latent codes respectively associated with times associated with frames in a training video of a scene captured by a camera. For each of the frames, a system (1) generates rendered pixel values for a set of pixels in the frame by querying NeRF using the latent code associated with the frame, a camera viewpoint associated with the frame, and ray directions associated with the set of pixels, and (2) updates the latent code associated with the frame and the NeRF based on comparisons between the rendered pixel values and original pixel values for the set of pixels. Once trained, the system renders output frames for an output video of the scene, wherein each output frame is rendered by querying the updated NeRF using one of the updated latent codes corresponding to a desired time associated with the output frame.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Abstract: The present disclosure provides a communication method and apparatus. The method may include: A terminal device receives a first timer from a network device that indicates a first duration after which the terminal device initiates periodic connection establishment to the network device. The first duration is greater than or equal to a duration of the terminal device in a non-coverage area of a satellite. The terminal device activates the first timer when the terminal device determines that the terminal device leaves a coverage area of the satellite.

Abstract: Systems and methods for detecting roadway lane boundaries are disclosed herein. One embodiment receives image data of a portion of a roadway; receives historical vehicle trajectory data for the portion of the roadway; generates, from the historical vehicle trajectory data, a heatmap indicating, for a given pixel in the heatmap, an extent to which the given pixel coincides spatially with vehicle trajectories in the historical vehicle trajectory data; and projects the heatmap onto the image data to generate a composite image that is used in training a neural network to detect roadway lane boundaries, the projected heatmap acting as supervisory data. The trained neural network is deployed in a vehicle to generate and save map data including detected roadway lane boundaries for use by other vehicles or to control operation of the vehicle itself based, at least in part, on roadway lane boundaries detected by the trained neural network.

Abstract: The provided interactive map user interface is through a server connected to multiple computer devices via the internet, equipped with a processor and memory to store and execute program code for various controllers. These controllers manage polygonal data for creating polygonal icons on the map, alongside user profile and classification data. The interface allows for dynamic navigation and displays maps enriched with geographic data, where polygonal icons—generated through polygon recognition techniques like edge detection—are overlaid. These icons can be color-coded based on classifications, such as sale history, to visually represent properties. Additionally, the system may include geocoding capabilities to convert street addresses into precise geographic locations, facilitating spatial analysis and enhancing user interaction with property data.

Abstract: Disclosed are various approaches for using drag-and-drop to open local files remotely. In one approach, a client device renders a user interface including a first indicium corresponding to a local file of the client device and a second indicium corresponding to a remotely executed application. A drag-and-drop action of the first indicium relative to the second indicium is detected. Responsive to the drag-and-drop action, the remotely executed application opens a copy of the local file.

Abstract: A system includes at least one hardware processor and at least one memory storing instructions that cause the at least one hardware processor to perform operations. The operations include configuring a processing stack in an execution node process. The processing stack includes a telemetry application programming interface (API). At least one configuration of a trace event is retrieved using an API call received by the execution node process. Telemetry information of the trace even is collected using the telemetry API based on the at least one configuration. An event table is updated based on the telemetry information.

Abstract: Implementations relate to a method implemented by one or more processors, the method including: receiving natural language (NL) based input associated with a client device; generating, using a large language model (LLM) and based on processing the NL based input, LLM output; determining, based on the LLM output, a sequence of LLM responses, the sequence of LLM responses including at least one intermediate LLM response and a final LLM response. In some implementations, the method may further include causing the final LLM response to be rendered at the client device. In additional or alternative implementations, the method may further include storing, as an instance of training data for fine-tuning the LLM or an additional LLM, the NL based input along with the final LLM response.

Abstract: Provided herein are scalable methods of processing wet-spun fiber comprising recombinant spider silk polypeptides to generate a three-dimensional crystalline lattice of beta-sheet structures in the fiber.