Abstract: Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system may assist a clinician in identifying one or more electrode combinations for sensing a brain signal. In another example, a user interface may display brain signal information and values of a stimulation parameter at least partially defining electrical stimulation delivered to a patient when the brain signal information was sensed.

Abstract: A three-stream engine is provided. The three-stream engine includes a fan section, a core engine disposed downstream of the fan section, and a core cowl annularly encasing the core engine and at least partially defining a core duct. A fan cowl is disposed radially outward from the core cowl and annularly encasing at least a portion of the core cowl. The fan cowl at least partially defining an inlet duct and a fan duct. The fan duct and the core duct at least partially co-extending axially on opposite sides of the core cowl. A heat exchanger disposed within the fan duct. The heat exchanger provides for thermal communication between a fluid flowing through fan duct and a motive fluid flowing through the heat exchanger.

Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: Devices and methods for automating the process of making flatbread, such as roti. In some embodiments, an apparatus includes a housing, an ingredient metering assembly, a mixing bowl assembly, a mixing actuator assembly, a cooking assembly, and an electronic assembly. The housing defines an interior volume and has several access openings with corresponding lids and/or covers. The ingredient metering assembly includes a flour container assembly, a flour delivery system, a water reservoir, and an oil reservoir. The mixing bowl assembly includes two bowls and a measurement system. The mixing actuator assembly includes a mixing mount, a mixing motor, a mixing paddle assembly, and a lower motor. The cooking assembly includes two platens and an actuator assembly. The electronic assembly includes a power source, a control module, and a LCD input/output screen. All components are integrated within the housing such that the apparatus is a consumer grade countertop appliance.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Combine harvesters are provided for use in harvesting seed corn from corn plants in fields. In connection therewith, a method for producing such seed corn from the corn plants, for use in growing subsequent corn plants, includes measuring a moisture content of corn kernels on ears of the corn plants in the field and removing, by one of the combine harvesters, the ears of corn from the corn plants when the moisture content satisfies a threshold moisture content. The method then includes separating the corn kernels from cobs of the ears of corn onboard the combine harvester and collecting the separated corn kernels for use as seed corn, whereby one or more subsequent corn plants can be grown from the collected corn kernels.

Abstract: A smart monitoring system comprising a plurality of sensor devices coupled to appliances and fixtures within a dwelling environment, where at least one of the plurality of sensor devices comprises sensor elements including an accelerometer. The system further comprising a computing device operative to receive event signals from the plurality of sensor devices, identify a possible fall event from one or more of the plurality of sensor devices based on the event signals, sample sensor data from one or more of the plurality of sensor devices wherein the sensor data includes measurements of movement. The computer device is further operative to determine a fall has occurred based on the sampled sensor data, sample additional sensor data from the one or more of the plurality of sensor devices for additional motion at a period of time subsequent to the possible fall event, and determine a recovery from the fall based on the additional sensor data.

Abstract: A heat exchanger is provided. The heat exchanger includes a first wall manifold. The heat exchanger further includes a second wall manifold spaced apart from the first wall manifold. The heat exchanger further includes a plurality of vanes that extend generally circumferentially between the first wall manifold and the second wall manifold. The heat exchanger further includes a plurality of fluid circuits defined within the heat exchanger. Each fluid circuit in the plurality of fluid circuits includes an inlet channel portion and an outlet channel portion defined within the first wall manifold. A return channel portion defined within the second wall manifold. At least one passage portion of a plurality of passage portions defined within each vane of the plurality of vanes. The at least one passage portion extends between the return channel portion and one of the inlet channel portion and the outlet channel portion.

Abstract: An autonomous floor cleaner can include a housing, a drive system for autonomously moving the housing over the surface to be cleaned, and a controller for controlling the operation of the autonomous floor cleaner. The drive system can include at least one drive wheel for driving the housing across a surface to be cleaned. The drive wheel can be selectively moved from an engaged or in-use position to a disengaged or maintenance position. In the disengaged or maintenance position, the wheel is disengaged from the autonomously moveable housing such that it can be pivoted, extended, removed, or otherwise moved farther away from the autonomously moveable housing.

Abstract: A surface cleaning apparatus is provided with a base assembly, an upright assembly, and a fluid recovery system. The base assembly includes a base housing, a brush chamber, at least one brushroll in the brush chamber; and a removable brush housing. A portion of the brush chamber is removable with the brush housing.

Abstract: A surface cleaning apparatus is provided with a base assembly, an upright assembly, and a fluid recovery system. The base assembly includes a base housing, a brush chamber, at least one brushroll in the brush chamber; and a removable brush housing. A portion of the brush chamber is removable with the brush housing.

Abstract: An autonomous floor cleaner can include a housing, a drive system for autonomously moving the housing over the surface to be cleaned, and a controller for controlling the operation of the autonomous floor cleaner. The drive system can include at least one drive wheel for driving the housing across a surface to be cleaned. The drive wheel can be selectively moved from an engaged or in-use position to a disengaged or maintenance position. In the disengaged or maintenance position, the wheel is disengaged from the autonomously moveable housing such that it can be pivoted, extended, removed, or otherwise moved farther away from the autonomously moveable housing.

Abstract: An autonomous floor cleaner can include a housing, a drive system for autonomously moving the housing over the surface to be cleaned, and a controller for controlling the operation of the autonomous floor cleaner. The drive system can include at least one drive wheel for driving the housing across a surface to be cleaned. The drive wheel can be selectively moved from an engaged or in-use position to a disengaged or maintenance position. In the disengaged or maintenance position, the wheel is disengaged from the autonomously moveable housing such that it can be pivoted, extended, removed, or otherwise moved farther away from the autonomously moveable housing.

Abstract: A surface cleaning apparatus is provided with a primary fluid distributor and an auxiliary fluid distributor. Each distributor can have a separate and independent flow control actuator. The flow control actuator for the auxiliary fluid distributor is operably coupled with a push-push flow control mechanism, where push-push flow control mechanism has a push on/push off configuration such that pushing the auxiliary flow control actuator once starts fluid flow from the auxiliary fluid distributor and subsequently pushing the auxiliary flow control actuator again stops fluid flow from the auxiliary fluid distributor.

Abstract: The present disclosure provides a surface cleaning apparatus that mechanically removes liquid and debris from a brushroll and stores the mechanically-removed liquid and debris onboard the apparatus in a first collection area. The surface cleaning apparatus also collects further liquid and debris from the brushroll by a source of suction including a vacuum motor or a pump and stores the collected liquid and debris onboard the apparatus in a second collection area.

Abstract: Devices and methods for automating the process of making flatbread, such as roti. In some embodiments, an apparatus includes a housing, an ingredient metering assembly, a mixing bowl assembly, a mixing actuator assembly, a cooking assembly, and an electronic assembly. The housing defines an interior volume and has several access openings with corresponding lids and/or covers. The ingredient metering assembly includes a flour container assembly, a flour delivery system, a water reservoir, and an oil reservoir. The mixing bowl assembly includes two bowls and a measurement system. The mixing actuator assembly includes a mixing mount, a mixing motor, a mixing paddle assembly, and a lower motor. The cooking assembly includes two platens and an actuator assembly. The electronic assembly includes a power source, a control module, and a LCD input/output screen. All components are integrated within the housing such that the apparatus is a consumer grade countertop appliance.

Abstract: Devices and methods for automating the process of making flatbread, such as roti. In some embodiments, an apparatus includes a housing, an ingredient metering assembly, a mixing bowl assembly, a mixing actuator assembly, a cooking assembly, and an electronic assembly. The housing defines an interior volume and has several access openings with corresponding lids and/or covers. The ingredient metering assembly includes a flour container assembly, a flour delivery system, a water reservoir, and an oil reservoir. The mixing bowl assembly includes two bowls and a measurement system. The mixing actuator assembly includes a mixing mount, a mixing motor, a mixing paddle assembly, and a lower motor. The cooking assembly includes two platens and an actuator assembly. The electronic assembly includes a power source, a control module, and a LCD input/output screen. All components are integrated within the housing such that the apparatus is a consumer grade countertop appliance.