Abstract: Naturally occurring miRNAs that regulate human oncogenes and methods of use therof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The compositions containing nucleic acids are administered to a patient in need of treatment or prophylaxis of at least one symptom or manifestation of cancer. In one embodiment, the compositions are administered in an effective amount to inhibit gene expression of one or more oncogenes. Methods for treatment or prevention of at least one symptom or manifestation of cancer are also described.

Abstract: Naturally occurring miRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA ,or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The compositions are administered to a subject prior to administration of a cytotoxic therapy in an amount effective to sensitize cells or tissues to be treated to the effects of the cytotoxic therapy.

Abstract: A cooling system includes a console and a tissue cooling device such as a head-cooling device. An operator applies the head-cooling device to the head of a patient at risk for ischemic injury. The console provides a cooling fluid to a fluid circulation space located between the cooling device and the patient's head under a positive gage pressure. Direct contact between the cooling fluid and the patient's head provides a relatively rapid induction of systemic hypothermia in the patient, thereby minimizing or preventing ischemic injury in the patient. The console also removes air from a channel disposed about an inner rim of the cooling device, using a negative gage pressure. Such removal of the air from the channel seals the rim of the cooling device to the head of the patient, including portions of the channel in contact with hair of the patient's head, and minimizes leaking of the cooling fluid beyond the rim of the cooling device.

Abstract: The invention described herein provides for a simple, economical system and method for reducing environmental release of dental amalgamous mercury from teeth caused by cremation of corpses. The invention controls and reduces the amount of mercury released using a pre-crematorial and non-disfiguring system and method. The system of the invention can include a dental containment and applicator delivery system to apply a curable thermal protectant composition onto the teeth. The composition coating significantly inhibits the extent of thermal destruction of the tooth per se including its amalgam filling content.

Abstract: A cooling system includes a console and a tissue cooling device such as a head-cooling device. An operator applies the head-cooling device to the head of a patient at risk for ischemic injury. The console provides a cooling fluid to a fluid circulation space located between the cooling device and the patient's head under a positive gage pressure. Direct contact between the cooling fluid and the patient's head provides a relatively rapid induction of systemic hypothermia in the patient, thereby minimizing or preventing ischemic injury in the patient. The console also removes air from a channel disposed about an inner rim of the cooling device, using a negative gage pressure. Such removal of the air from the channel seals the rim of the cooling device to the head of the patient, including portions of the channel in contact with hair of the patient's head, and minimizes leaking of the cooling fluid beyond the rim of the cooling device.

Abstract: An electronic handheld device with remote cable release mechanism, a handle portion and method for performing the same. The device includes a housing defining an internal cavity and has an elastically deformable flexible portion. An electrical connector block is disposed in the cavity and includes a female receptacle configured for receiving a male electrical cable connector having a movable locking clip configured to releasably engage the connector block. An actuating protrusion is preferably disposed on the flexible portion of the housing for releasing the cable connector. The protrusion is movable towards the connector block in response to the application of an inward pressing force on the flexible portion. The protrusion operates to depress the locking clip on the cable connector, thereby releasing the cable connector. In another embodiment, a resealable dimple may be provided in the flexible portion which can be punctured via a probe to access the locking clip.

Abstract: Bisaryloxime ethers and bisarylhydroazones are shown to be effective for inhibiting formation of amyloid fibrils of transthyretin.

Abstract: An umbrella retaining device may be incorporated into or integrally attached to a vehicle seat from the vehicle factory and may employ a compartment or holder that defines a ventilation and drain hole to drain water from a wet umbrella. An umbrella compartment may further comprise a flap pivoting along a bottom edge of the compartment, a gusset on each side of the flap, and a snap or magnetic closure device proximate to the flap's upper edge. Alternatively, an umbrella retaining compartment may angularly lie within a bottom portion of the seat or seat supporting portion, such as a front seat side shield. The compartment may have a cover, such as a pivoting cover. Alternatively, the umbrella retaining member may be a vertical tubular restraining member with a top, angled opening and a bottom opening. A support loop may lie below the tubular member to provide vertical support.

Abstract: Naturally occurring miRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The compositions are administered to a subject prior to administration of a cytotoxic therapy in an amount effective to sensitize cells or tissues to be treated to the effects of the cytotoxic therapy.

Abstract: Bisaryloxime ethers and bisarylhydroazones are shown to be effective for inhibiting formation of amyloid fibrils of transthyretin.

Abstract: A polymeric container for holding a fluid and a gas includes a specially designed base. The base includes an annular outer ridge connected to a convex dome by a flexible annular joint. During a hot fill operation, the structure of the base resists outward deformation. The top is then sealed. During the subsequent cooling of the container, the interior volume decreases forcing the dome upward toward the top of the container thereby reducing the tendency of the sidewall to inwardly collapse. In an embodiment of the invention, the sidewall of the container has a plurality of internally protruding diagonal ridges.

Abstract: A communications system incorporating a plurality of vehicle mounted web cams that collect video information and transmit the video information together with other local information via a wireless network to a server. The video streams from the web cams and associated information are available to users on a internet web page. Each camera has a specific identifier to permit users to access the video of specific individual cameras. Optimization software permits users to take virtual trips along predetermined routes. The system also permits sequential access to multiple video feeds from desired locations. Multiple alternative one way and two way video communication methods taking advantage of the network of mobile web cams are described.

Abstract: A cooling system includes a console and a tissue cooling device such as a head-cooling device. An operator applies the head-cooling device to the head of a patient at risk for ischemic injury. The console provides a cooling fluid to a fluid circulation space located between the cooling device and the patient's head under a positive gage pressure. Direct contact between the cooling fluid and the patient's head provides a relatively rapid induction of systemic hypothermia in the patient, thereby minimizing or preventing ischemic injury in the patient. The console also removes air from a channel disposed about an inner rim of the cooling device, using a negative gage pressure. Such removal of the air from the channel seals the rim of the cooling device to the head of the patient, including portions of the channel in contact with hair of the patient's head, and minimizes leaking of the cooling fluid beyond the rim of the cooling device.

Abstract: Apparatuses, methods, systems, and arrangements facilitate the upkeep of an electronic device. In certain described implementations, one or more analyses and/or determinations may be completed with regard to one or more replaceable issues. If the replaceable issue(s) are determined to be deficient (including potentially deficient), then the electronic device may produce one or more upkeep-related items to facilitate an operator's upkeep thereof. Exemplary replaceable issues may be related to consumable item(s), maintenance items(s), ability items(s), etc. Exemplary upkeep-related items may include order-related items, reports, etc. Exemplary order-related items may include order forms, discount coupons and codes, network address and information combinations, etc.

Abstract: A cooling system includes a console and a tissue cooling device such as a head-cooling device. An operator applies the head-cooling device to the head of a patient at risk for ischemic injury. The console provides a cooling fluid to a fluid circulation space located between the cooling device and the patient's head under a positive gage pressure. Direct contact between the cooling fluid and the patient's head provides a relatively rapid induction of systemic hypothermia in the patient, thereby minimizing or preventing ischemic injury in the patient. The console also removes air from a channel disposed about an inner rim of the cooling device, using a negative gage pressure. Such removal of the air from the channel seals the rim of the cooling device to the head of the patient, including portions of the channel in contact with hair of the patient's head, and minimizes leaking of the cooling fluid beyond the rim of the cooling device.

Abstract: This invention relates to the printing of transparent media often used for later projection, commonly referred to as Over Head Transparencies, or OHT's. These OHTs are used in several ways: They can be printed in advance and projected in sequence, created in the course of the presentation using marking pens, or a combination of he two, where a pre-printed OHT is edited or modified after printing or in the course of presentation using pens or other marking means. This third use is often compromised by incompatibilities between the marking technology used to create the pre-printed image and the marking pens used to edit the image later. This invention describes a technique for separating the two images, placing each on opposite sides of the transparent film, avoiding this conflict and producing a better solution for the user.

Abstract: Apparatuses, methods, systems, and arrangements facilitate the upkeep of an electronic device. In certain described implementations, one or more analyses and/or determinations may be completed with regard to one or more replaceable issues. If the replaceable issue(s) are determined to be deficient (including potentially deficient), then the electronic device may produce one or more upkeep-related items to facilitate an operator's upkeep thereof. Exemplary replaceable issues may be related to consumable item(s), maintenance items(s), ability items(s), etc. Exemplary upkeep-related items may include order-related items, reports, etc. Exemplary order-related items may include order forms, discount coupons and codes, network address and information combinations, etc.

Abstract: A multi-function printer device is configured for use with job control sheets having machine readable indicia thereon, the multi-function printer device including a housing; an imaging area supported by the housing; a scanner supported by the housing to selectively scan at the imaging area; a print engine supported by the same housing; a control keypad supported by the housing; computer network interface hardware supported by the housing and adapted to be coupled to a computer network; and a controller coupled to the scanner, print engine, control keypad and computer network interface hardware and configured to control the print engine, and the scanner to provide a plurality of predefined printing, scanning, and copying functions, the functions including a function to receive a digital document from the computer network via the network interface hardware and to print one or more copies, a number of the functions being selectable from the computer network, but only a subset of the number of functions being sel

Abstract: This invention relates to a method for printing out release notes/advertisements after the firmware in the printer or other such firmware-containing devices have been upgraded. Such methods of this type, generally, provide the printer user with release notes which detail how the printer was upgraded and/or provide the user with advertisements, such as, but not limited to, promotions, coupons, rebates, product releases or the like.

Abstract: A communications system incorporating a plurality of vehicle mounted web cams that collect video information and transmit the video information together with other local information via a wireless network to a server. The video streams from the web cams and associated information are available to users on a internet web page. Each camera has a specific identifier to permit users to access the video of specific individual cameras. Optimization software permits users to take virtual trips along predetermined routes. The system also permits sequential access to multiple video feeds from desired locations. Multiple alternative one way and two way video communication methods taking advantage of the network of mobile web cams are described.