Patents by Inventor Steven M. Menchen

Steven M. Menchen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230407391
    Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
    Type: Application
    Filed: June 14, 2023
    Publication date: December 21, 2023
    Inventors: Steven M. MENCHEN, Alan BLANCHARD, Luisa ANDRUZZI, Shaheer KHAN, Dmitriy GREMYACHINSKIY, Alfred LUI, Craig STOLARCZYK, Tanya SOKOLSKY, Prasanna Krishnan THWAR
  • Patent number: 11702696
    Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: July 18, 2023
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Steven M. Menchen, Alan Blanchard, Luisa Andruzzi, Shaheer Khan, Dmitriy Gremyachinskiy, Alfred Lui, Craig Stolarczyk, Tanya Sokolsky, Prasanna Krishnan Thwar
  • Publication number: 20230167210
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Application
    Filed: January 26, 2023
    Publication date: June 1, 2023
    Inventors: Geir FONNUM, Grete Irene MODAHL, Nini Hofsloekken KJUS, Astrid Evenroed MOLTEBERG, Diem Thuy Thi TRAN, Jo AASERUD, M. Talha GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
  • Patent number: 11572427
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Grant
    Filed: February 2, 2021
    Date of Patent: February 7, 2023
    Assignees: LIFE TECHNOLOGIES CORPORATION, LIFE TECHNOLOGIES AS
    Inventors: Geir Fonnum, Grete Irene Modahl, Nini Hofsloekken Kjus, Astrid Evenroed Molteberg, Diem Thuy Thi Tran, Jo Aaserud, M. Talha Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
  • Publication number: 20210155726
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Application
    Filed: February 2, 2021
    Publication date: May 27, 2021
    Inventors: Geir FONNUM, Grete Irene MODAHL, Nini Hofsloekken KJUS, Astrid Evenroed MOLTEBERG, Diem Thuy Thi TRAN, Jo AASERUD, M. Tahla GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
  • Patent number: 10947333
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: March 16, 2021
    Assignees: LIFE TECHNOLOGIES CORPORATION, LIFE TECHNOLOGIES AS
    Inventors: Geir Fonnum, Grete Irene Modahl, Nini Hofsloekken Kjus, Astrid Evenroed Molteberg, Diem Thuy Thi Tran, Jo Aaserud, Muhammed Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
  • Patent number: 10941439
    Abstract: A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling site, and a functional moiety coupled between the terminal end of the oligonucleotide and the coupling site. Such a hydrogel network can be formed by a method including activating a coupling site of a substrate and binding a linker moiety coupled to a terminal end of an oligonucleotide to the activated coupling site, a functional moiety coupled between the terminal end of the oligonucleotide and the linker moiety.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: March 9, 2021
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Steven M. Menchen, Guobing Xiang, Prasanna Thwar, Jeffrey Frediani, Allen Wong, Alfred Lui, Lily Lu
  • Patent number: 10888831
    Abstract: A method of preparing a discrete polymer network array include mixing a plurality of nucleic acid polymer networks with a plurality of color-activated polymer networks to form a dispersion, applying the dispersion to an array of wells, the nucleic acid polymer networks selectively depositing into wells of the array of wells, and rinsing the array of wells to selectively remove the plurality of color-activated polymer networks.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: January 12, 2021
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Alexander Mastroianni, Scott C. Benson, Steven M. Menchen, John Scott
  • Publication number: 20200354789
    Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
    Type: Application
    Filed: July 24, 2020
    Publication date: November 12, 2020
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Steven M. MENCHEN, Alan BLANCHARD, Luisa ANDRUZZI, Shaheer KHAN, Dmitriy GREMYACHINSKIY, Alfred LUI, Craig STOLARCZYK, Tanya SOKOLSKY, Prasanna Krishnan THWAR
  • Patent number: 10724094
    Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: July 28, 2020
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Steven M. Menchen, Alan Blanchard, Luisa Andruzzi, Shaheer H. Khan, Dmitriy Gremyachinskiy, Alfred Lui, Craig Stolarczyk, Tanya Sokolsky, Prasanna Krishnan Thwar
  • Patent number: 10676790
    Abstract: A polymer substrate, such as a polymer coating or a polymer hydrogel network, includes carboxyl moieties that can be used as conjugation sites to which receptor or analyte molecules can be attached. In an example, the polymer substrate includes a polyacrylamide polymer network having alkanoic acid moieties or derivatives thereof, which can react with carboxyl activating compounds to provide an activated alkanoate moieties on the polyacrylamide network. Amine-terminated nucleic acids can react with the activated alkanoate moieties to capture the nucleic acid to the polymer network through an alkylamide moiety.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: June 9, 2020
    Assignees: LIFE TECHNOLOGIES CORPORATION, LIFE TECHNOLOGIES AS
    Inventors: Geir Fonnum, Steven M. Menchen, Alfred Lui, Guobing Xiang, Synne Larsen
  • Publication number: 20190390018
    Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
    Type: Application
    Filed: January 21, 2019
    Publication date: December 26, 2019
    Inventors: Geir FONNUM, Steven M. MENCHEN, M. Talha GOKMEN, Pontus LUNDBERG, Prasanna Krishnan THWAR, Alfred LUI, Lily LU, Wolfgang HINZ, Lene HUSABOE, Elisabeth BREIVOLD, Astrid Evenroed MOLTEBERG, Synne LARSEN
  • Publication number: 20190233558
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Application
    Filed: January 28, 2019
    Publication date: August 1, 2019
    Applicant: LIFE TECHNOLOGIES AS
    Inventors: Geir FONNUM, Grete Irene MODAHL, Nini KJUS, Astrid Evenroed MOLTEBERG, Diem Thuy Thi TRAN, Jo AASERUD, Muhammed GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
  • Publication number: 20190177787
    Abstract: A polymer substrate, such as a polymer coating or a polymer hydrogel network, includes carboxyl moieties that can be used as conjugation sites to which receptor or analyte molecules can be attached. In an example, the polymer substrate includes a polyacrylamide polymer network having alkanoic acid moieties or derivatives thereof, which can react with carboxyl activating compounds to provide an activated alkanoate moieties on the polyacrylamide network Amine-terminated nucleic acids can react with the activated alkanoate moieties to capture the nucleic acid to the polymer network through an alkylamide moiety.
    Type: Application
    Filed: November 30, 2018
    Publication date: June 13, 2019
    Inventors: Geir FONNUM, Steven M. MENCHEN, Alfred LUI, Guobing XIANG, Synne LARSEN
  • Patent number: 10246533
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of monomer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: April 2, 2019
    Assignees: LIFE TECHNOLOGIES AS, LIFE TECHNOLOGIES Corporation
    Inventors: Geir Fonnum, Grete Irene Modahl, Nini Hofslokken Kjus, Astrid Evenroed Molteberg, Diem Tran, Jo Aaserud, M. Talha Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
  • Publication number: 20190091648
    Abstract: A method of preparing a discrete polymer network array include mixing a plurality of nucleic acid polymer networks with a plurality of color-activated polymer networks to form a dispersion, applying the dispersion to an array of wells, the nucleic acid polymer networks selectively depositing into wells of the array of wells, and rinsing the array of wells to selectively remove the plurality of color-activated polymer networks.
    Type: Application
    Filed: November 30, 2018
    Publication date: March 28, 2019
    Inventors: Alexander MASTROIANNI, Scott C. BENSON, Steven M. MENCHEN, John SCOTT
  • Publication number: 20190062807
    Abstract: A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling site, and a functional moiety coupled between the terminal end of the oligonucleotide and the coupling site. Such a hydrogel network can be formed by a method including activating a coupling site of a substrate and binding a linker moiety coupled to a terminal end of an oligonucleotide to the activated coupling site, a functional moiety coupled between the terminal end of the oligonucleotide and the linker moiety.
    Type: Application
    Filed: October 31, 2018
    Publication date: February 28, 2019
    Inventors: Steven M. Menchen, Guobing Xiang, Prasanna Thwar, Jeffrey Frediani, Allen Wong, Alfred Lui, Lily Lu
  • Patent number: 10202473
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: February 12, 2019
    Assignees: LIFE TECHNOLOGIES AS, LIFE TECHNOLOGIES CORPORATION
    Inventors: Geir Fonnum, Grete Irene Modahl, Nini Hofsloekken Kjus, Astrid Evenroed Molteberg, Diem Thuy Thi Tran, Jo Aaserud, M. Talha Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
  • Patent number: 10189956
    Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: January 29, 2019
    Assignees: LIFE TECHNOLOGIES AS, LIFE TECHNOLOGIES CORPORATION
    Inventors: Geir Fonnum, Steven M. Menchen, M. Talha Gokmen, Pontus Lundberg, Prasanna Krishnan Thwar, Alfred Lui, Lily Lu, Wolfgang Hinz, Lene Husaboe, Elisabeth Breivold, Astrid Evenroed Molteberg, Synne Larsen
  • Patent number: 10150992
    Abstract: A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling site, and a functional moiety coupled between the terminal end of the oligonucleotide and the coupling site. Such a hydrogel network can be formed by a method including activating a coupling site of a substrate and binding a linker moiety coupled to a terminal end of an oligonucleotide to the activated coupling site, a functional moiety coupled between the terminal end of the oligonucleotide and the linker moiety.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: December 11, 2018
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Steven M. Menchen, Guobing Xiang, Prasanna Krishnan Thwar, Jeffrey Frediani, Allen Wong, Alfred Lui, Lily Lu