Patents by Inventor Steven M. Ruben

Steven M. Ruben has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human Ependymin
    Publication number: 20040122215
    Abstract: The present invention relates to a novel human Ependymin protein which is a member of the ependymin family. In particular, isolated nucleic acid molecules are provided encoding the human Ependymin protein. Ependymin polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Ependymin activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.
    Type: Application
    Filed: December 12, 2003
    Publication date: June 24, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Reinhard Ebner, Steven M. Ruben
  • Nucleic acids encoding human serpin polypeptide HMCIS41
    Patent number: 6753164
    Abstract: The present invention relates to novel human Serpin polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human Serpin polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human Serpin polypeptides.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: June 22, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steven M. Ruben, Yanggu Shi
  • Interleukin 17 receptor-like protein
    Publication number: 20040115698
    Abstract: The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.
    Type: Application
    Filed: August 22, 2003
    Publication date: June 17, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Yanggu Shi, Steven M. Ruben
  • Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
    Patent number: 6743594
    Abstract: Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: June 1, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Yi Li, Steven M. Ruben
  • Lysyl-oxidase HOHEC84 polynucleotides
    Patent number: 6743613
    Abstract: The present invention relates to novel human BMP polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human BMP polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human BMP polypeptides.
    Type: Grant
    Filed: February 7, 2002
    Date of Patent: June 1, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steven M. Ruben, Yanggu Shi
  • Nucleic acids, proteins, and antibodies
    Publication number: 20040101927
    Abstract: The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
    Type: Application
    Filed: January 17, 2001
    Publication date: May 27, 2004
    Inventors: Craig A. Rosen, Steven M. Ruben, Steven C. Barash
  • ANTIBODIES AGAINST INTERLEUKIN-17 RECEPTOR LIKE PROTEIN
    Publication number: 20040096935
    Abstract: The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.
    Type: Application
    Filed: March 2, 2001
    Publication date: May 20, 2004
    Inventors: Yanggu Shi, Steven M. Ruben
  • Pancreas-derived plasminogen activator inhibitor
    Publication number: 20040086978
    Abstract: The present invention relates to a novel member of the plasminogen activator inhibitor protein family. In particular, isolated nucleic acid molecules are provided encoding the pancreas-derived plasminogen activator inhibitor protein. Pancreas-derived plasminogen activator inhibitor polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to methods for treating physiologic and pathologic disease conditions and diagnostic methods for detecting pathologic disorders.
    Type: Application
    Filed: July 29, 2003
    Publication date: May 6, 2004
    Inventors: Jian Ni, Reiner L. Gentz, Steven M. Ruben, Y. Eric Shi
  • Heregulin-like factor
    Patent number: 6727077
    Abstract: The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of HLF activity. Also provided are diagnostic methods for detecting disorders of the regulation of cell growth and therapeutic methods for treating disorders of the regulation of cell growth.
    Type: Grant
    Filed: June 16, 1998
    Date of Patent: April 27, 2004
    Assignees: Human Genome Sciences, Inc., Georgetown University Medical Center
    Inventors: Paul E. Young, C. Richter King, Mai Hijazi, Steven M. Ruben
  • 36 human secreted proteins
    Publication number: 20040067518
    Abstract: The present invention relates to 36 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: August 4, 2003
    Publication date: April 8, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Henrik S. Olsen, Steven M. Ruben, Craig A. Rosen, Laurie A. Brewer, Reinhard Ebner, Roxanne Duan, Kimberly Florence
  • Hematopoietic signaling factor
    Publication number: 20040063127
    Abstract: The present invention relates to a novel hematopoietic signaling factor (HSF) protein which is a member of the cytokine superfamily. In particular, isolated nucleic acid molecules are provided encoding the human HSF protein. HSF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same.
    Type: Application
    Filed: August 18, 2003
    Publication date: April 1, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Daniel R. Soppet, Steven M. Ruben
  • 20 Human secreted proteins
    Publication number: 20040063128
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: August 28, 2003
    Publication date: April 1, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Craig A. Rosen, Steven M. Ruben, Guo-Liang Yu, Jian Ni, Ping Feng
  • Apoptosis inducing molecule I
    Publication number: 20040047864
    Abstract: The invention relates to antibodies specific to AIM-I polypeptides useful in biological, diagnostic, clinical or therapeutic arts.
    Type: Application
    Filed: September 16, 2003
    Publication date: March 11, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventor: Steven M. Ruben
  • 95 human secreted proteins
    Publication number: 20040048304
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: September 3, 2003
    Publication date: March 11, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Jian Ni, Craig A. Rosen, Guo-Liang Yu, Paul Young, Ping Feng, Daniel R. Soppet, Ying-Fei Wei, Gregory A. Endress, Roxanne Duan, Hla Kyaw, Reinhard Ebner, David W. LaFleur, Henrik Olsen, Yanggu Shi, Paul A. Moore
  • Heregulin-like factor
    Publication number: 20040048295
    Abstract: The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of HLF activity. Also provided are diagnostic methods for detecting disorders of the regulation of cell growth and therapeutic methods for treating disorders of the regulation of cell growth.
    Type: Application
    Filed: July 1, 2003
    Publication date: March 11, 2004
    Applicants: Human Genome Sciences, Inc., Georgetown University Medical Center
    Inventors: Paul E. Young, C. Richter King, Mia Hijazi, Steven M. Ruben
  • Apoptosis inducing molecule I
    Publication number: 20040048340
    Abstract: The invention relates to Apoptosis Inducing Molecule-1 (AIM-I) polypeptides useful in biological, diagnostic, clinical or therapeutic arts.
    Type: Application
    Filed: September 16, 2003
    Publication date: March 11, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventor: Steven M. Ruben
  • Human tumor necrosis factor TR20 and methods based thereon
    Publication number: 20040048296
    Abstract: The present invention relates to TR20 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR20 protein. TR20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR20 activity.
    Type: Application
    Filed: July 15, 2003
    Publication date: March 11, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Kevin P. Baker, Jian Ni
  • 31 human secreted proteins
    Publication number: 20040048294
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: June 27, 2003
    Publication date: March 11, 2004
    Applicant: Human Genome Sciences,Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Roxanne D. Duan, Yanggu Shi, David W. LaFleur, Paul E. Young, Jian Ni, George Komatsoulis, Gregory A. Endress, Daniel R. Soppet
  • 123 human secreted proteins
    Publication number: 20040044191
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: October 10, 2001
    Publication date: March 4, 2004
    Inventors: Carrie L. Fischer, Craig A. Rosen, Daniel R. Soppet, Steven M. Ruben, Hla Kyaw, Yi Li, Zhizhen Zeng, David W. LaFleur, Paul A. Moore, Yanggu Shi, Henrik Olsen, Reinhard Ebner, Charles E. Birse
  • 125 human secreted proteins
    Publication number: 20040038277
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: July 18, 2003
    Publication date: February 26, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Craig A. Rosen, Ping Feng, Steven M. Ruben, Reinhard Ebner, Henrik Olsen, Jian Ni, Ying-Fei Wei, Daniel R. Soppet, Paul A. Moore, Hla Kyaw, David W. LaFleur, Yanggu Shi, Fouad Janat, Gregory A. Endress, Kenneth C. Carter, Charles E. Birse