Patents by Inventor Steven M. Ruben

Steven M. Ruben has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies to cytokine receptor common gamma chain like
    Patent number: 6861227
    Abstract: The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: March 1, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Paul A. Moore
  • PGRP-L polynucleotides, polypeptides, and antibodies
    Patent number: 6849413
    Abstract: The present invention relates to novel human and murine proteins called PGRP-L, and isolated polynucleotides encoding these proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: February 1, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Paul E. Young, Steven M. Ruben
  • Antibody to an IL-17 receptor like protein
    Patent number: 6849719
    Abstract: The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: February 1, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Yanggu Shi, Steven M. Ruben
  • Cytokine receptor common gamma chain like
    Patent number: 6844170
    Abstract: The present invention relates to a novel human protein called Cytokine Receptor Common Gamma Chain Like, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: January 18, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Paul A. Moore, Craig A. Rosen, Steven M. Ruben
  • Synferon
    Patent number: 6843988
    Abstract: The present invention relates to a novel Synferon protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a synthetic interferon polypeptide, called “Synferon”. Synferon polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Synferon activity. Also provided are therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: January 18, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Henrik S. Olsen, Reiner L. Gentz, Steven M. Ruben
  • Cytokine receptor common gamma chain like
    Publication number: 20040266693
    Abstract: The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.
    Type: Application
    Filed: July 27, 2004
    Publication date: December 30, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Paul A. Moore
  • Human G-protein receptor HGBER32
    Publication number: 20040265894
    Abstract: Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
    Type: Application
    Filed: July 20, 2004
    Publication date: December 30, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Daniel R. Soppet, Yi Li, Craig A. Rosen, Steven M. Ruben
  • Tissue plasminogen activator-like protease
    Publication number: 20040265968
    Abstract: The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.
    Type: Application
    Filed: July 20, 2004
    Publication date: December 30, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul A. Moore, Steven M. Ruben, Reinhard Ebner
  • 47 human secreted proteins
    Publication number: 20040253684
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: July 7, 2004
    Publication date: December 16, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Reinhard Ebner, Craig A. Rosen, Gregory A. Endress, Daniel R. Soppet, Jian Ni, Roxanne D. Duan, Paul A. Moore, Yanggu Shi, David W. LaFleur, Henrik S. Olsen, Kimberly A. Florence
  • 20 human secreted proteins
    Publication number: 20040253672
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: December 4, 2003
    Publication date: December 16, 2004
    Inventors: Steven M. Ruben, Adam Bell, Charles E. Birse, George A. Komatsoulis, Gil H. Choi, Henrik S. Olsen, Jian Ni, Kevin P. Baker
  • Antibodies that bind human prostate specific G-protein receptor HPRAJ70
    Patent number: 6824993
    Abstract: The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer.
    Type: Grant
    Filed: October 2, 2001
    Date of Patent: November 30, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Daniel R. Soppet, Yi Li, Craig A. Rosen, Steven M. Ruben
  • 18 human secreted proteins
    Publication number: 20040235113
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: June 24, 2004
    Publication date: November 25, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Yanggu Shi, Paul E. Young, Reinhard Ebner, Daniel R. Soppet, Steven M. Ruben
  • Keratinocyte derived interferon
    Publication number: 20040225113
    Abstract: The present invention relates to a novel KDI protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a human interferon polypeptide, called “KDI”. KDI polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of KDI activity. Also provided are therapeutic methods for treating immune system-related disorders.
    Type: Application
    Filed: September 12, 2002
    Publication date: November 11, 2004
    Inventors: David W. LaFleur, Paul A. Moore, Steven M. Ruben
  • Keratinocyte growth factor-2
    Publication number: 20040224387
    Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
    Type: Application
    Filed: December 12, 2003
    Publication date: November 11, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Pablo Jimenez, D. Roxanne Duan, Mark A. Rampy, Donna Mendrick, Jun Zhang, Jian Ni, Paul A. Moore, Timothy A. Coleman, Joachim R. Gruber, Patrick J. Dillon, Reiner L. Gentz
  • Human parotid secretory protein
    Publication number: 20040224357
    Abstract: The present invention relates to a novel human parotid secretory protein (hPSP) protein which is a member of the PSP family. In particular, isolated nucleic acid molecules are provided encoding the human hPSP protein. hPSP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of hPSP activity. Also provided are diagnostic methods for detecting digestive, nonimmune defense, endocrine or immune system-related disorders and therapeutic methods for treating such disorders.
    Type: Application
    Filed: June 18, 2004
    Publication date: November 11, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Roxanne Duan, Steven M. Ruben
  • 31 human secreted proteins
    Publication number: 20040225118
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: July 7, 2003
    Publication date: November 11, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steven M. Ruben, Craig A. Rosen, Reinhard Ebner, Kimberly A. Florence, Paul E. Young, Charles E. Birse, Kenneth C. Carter, George Komatsoulis
  • Methods of using chemokine beta-6
    Patent number: 6815420
    Abstract: Human chemokine &bgr;-6 agonist and antagonist polypeptides and DNA encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. The chemokine &bgr;-6 antagonists of the present invention may be employed to treat rheumatoid arthritis, lung inflammation, allergy, asmtha, infectious diseases and to prevent inflammation and atherosclerosis. The chemokine &bgr;-6 agonists may be employed to myeloprotect patients undergoing chemotherapy.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: November 9, 2004
    Assignee: Human Genome Sciences, INC
    Inventors: Brent L. Kreider, Steven M. Ruben, Henrik S Olsen
  • Tissue plasminogen activator-like protease
    Patent number: 6815534
    Abstract: The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: November 9, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Paul A. Moore, Steven M. Ruben, Reinhard Ebner
  • Human monocyte colony inhibitory factor (M-CIF) polypeptides
    Patent number: 6811773
    Abstract: There are disclosed therapeutic compositions and methods using a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-&ggr; chemokine &bgr;1(CK&bgr;1 or ckb-1)), as well as ioslated nucleic acid molecules encoding M-CIF, and vectors, host cells and recombinant methods for producing the same.
    Type: Grant
    Filed: May 15, 2000
    Date of Patent: November 2, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Brent L. Kreider, Jun Zhang, Michael Antonaccio, Donna Mendrick, Pablo Jimenez, Vikram Patel, Craig A. Rosen, Mark D. Adams, Haodong Li, Steven M. Ruben
  • Human tumor necrosis factor receptor TR16
    Publication number: 20040209328
    Abstract: The present invention relates to a novel protein, TR16, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR16 protein. TR16 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR16 activity.
    Type: Application
    Filed: May 10, 2004
    Publication date: October 21, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Kevin P. Baker, Paul E. Young, Steven M. Ruben