Patents by Inventor Steven M. Ruben

Steven M. Ruben has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antimicrobial peptide
    Patent number: 7223840
    Abstract: The present invention relates to a novel human antimicrobial peptide which is a member of the defensin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human antimicrobial peptide. Antimicrobial peptide are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system and therapeutic methods for such disorders.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: May 29, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Henrik S. Olsen, Steven M. Ruben
  • Antibodies that immunospecifically bind to B lymphocyte stimulator protein
    Patent number: 7220840
    Abstract: The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: May 22, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Gil H. Choi, Tristan Vaughan, David Hilbert
  • Antibodies to chemokine Alpha-6
    Patent number: 7217529
    Abstract: The present invention relates to a novel CK?-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-6 protein. CK?-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK?-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: May 15, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Steven M. Ruben, Craig A. Rosen
  • Antibodies to HFXJW48 polypeptide
    Patent number: 7217528
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: May 15, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Charles Florence
  • Method of treating reproductive system cancer by administering follistatin-3
    Patent number: 7208470
    Abstract: The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: April 24, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: D. Roxanne Duan, Steven M. Ruben
  • Vascular endothelial growth factor 2
    Patent number: 7208582
    Abstract: Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: April 24, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Craig A. Rosen, Vivian R. Albert, Steven M. Ruben, Ruth E. Wager
  • Tissue plasminogen activator-like protease
    Patent number: 7205139
    Abstract: The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.
    Type: Grant
    Filed: July 20, 2004
    Date of Patent: April 17, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Paul A. Moore, Steven M. Ruben, Reinhard Ebner
  • Secreted protein HHTLF25
    Patent number: 7196164
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: March 27, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Craig A. Rosen, Steven M. Ruben, David W. LaFleur
  • Antibodies against tumor necrosis factor delta (APRIL)
    Patent number: 7189820
    Abstract: The present invention relates to antibodies and related molecules that immunospecifically bind to Tumor Necrosis Factor Delta (TNF-delta; APRIL). The present invention also relates to methods and compositions for detecting, diagnosing, prognosing, treating, preventing, or ameliorating a disease or disorder associated with aberrant APRIL or APRIL receptor expression or aberrant function of APRIL or APRIL receptor, comprising antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to APRIL.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: March 13, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventor: Steven M. Ruben
  • Tumor necrosis factor 6? and 6?
    Patent number: 7186800
    Abstract: The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6? & -6? proteins. TNFR-6? & -6? polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6? & -6? activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: March 6, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Reinhard Ebner, Guo-Liang Yu, Steven M. Ruben, Jian Ni, Ping Feng
  • Human G-protein Chemokine Receptor (CCR5) HDGNR10
    Patent number: 7175988
    Abstract: The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: February 13, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Viktor Roschke, Craig A. Rosen, Steven M. Ruben
  • Antibodies to HASAV70 polypeptide
    Patent number: 7169565
    Abstract: The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: January 30, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Reinhard Ebner, Yanggu Shi
  • Metalloproteinases
    Patent number: 7169566
    Abstract: The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
    Type: Grant
    Filed: November 2, 2004
    Date of Patent: January 30, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steven M. Ruben, Laurie A. Brewer, Reiner L. Gentz, Craig A. Rosen
  • Human tumor necrosis factor TR20 and methods based thereon
    Patent number: 7164004
    Abstract: The present invention relates to TR20 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR20 protein. TR20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR20 activity.
    Type: Grant
    Filed: July 15, 2003
    Date of Patent: January 16, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Kevin P. Baker, Jian Ni
  • 50 human secreted proteins
    Patent number: 7163797
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: January 16, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Reinhard Ebner
  • Human G-protein chemokine receptor (CCR5) HDGNR10
    Patent number: 7160546
    Abstract: Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
    Type: Grant
    Filed: September 3, 2002
    Date of Patent: January 9, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Yi Li, Steven M Ruben
  • Albumin fusion proteins comprising GLP-1 polypeptides
    Patent number: 7141547
    Abstract: The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disordrs or conditions using albumin fusion proteins of the invention.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: November 28, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Craig A. Rosen, William A. Haseltine, David J. Ballance, Andrew J. Turner, Steven M. Ruben
  • Antibodies that immunospecifically bind BLyS
    Patent number: 7138501
    Abstract: The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: November 21, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Gil H. Choi, Tristan Vaughan, David Hilbert
  • T1 receptor-like ligand II and uses thereof
    Patent number: 7128906
    Abstract: The present invention relates to a novel T1 Receptor (T1R)-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same. This invention further relates to pharmaceutical compositions and formulations comprising T1R-like ligand II. Also provided are methods of using T1R-like ligand II polynucleotides, polypeptides, antibodies or agonists/antagonists for therapeutic and diagnostic purposes. Diagnostic kits are further provided.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: October 31, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner L. Gentz, Steven M. Ruben
  • Interleukin-1? converting enzyme like apoptotic protease-6
    Patent number: 7115260
    Abstract: Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: October 3, 2006
    Assignees: Human Genome Sciences, Inc., SmithKline Beecham Corporation, The Regents of the University of Michigan
    Inventors: Vishva M. Dixit, Wei-Wu He, Kristine K. Kikly, Steven M. Ruben