Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

Abstract: An example valve includes: a seat member; a spool configured to be seated on the seat member to block fluid flow from a first port to a second port when the valve is in a closed state, wherein fluid at the first port applies a fluid force on the spool; a spring applying a biasing force on the spool toward the seat member, wherein as the fluid force overcomes the biasing force, the spool moves in the proximal direction off the seat member, thereby allowing fluid flow from the first port to the second port through a flow area formed between the spool and the seat member; a turbine configured to rotate as fluid flowing through the flow area flows downstream across the turbine; and an electric generator coupled to the turbine, such that rotation of the turbine causes the electric generator to generate electric power.

Abstract: The present disclosure provides compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, or tautomer thereof, and uses of the same in treating a disease or disorder (e.g., cancer or fibrosis).

Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

Abstract: A hose assembly includes an inner hose component, a first braid of reinforcement fiber material that extends around the inner hose component, and a second braid of reinforcement fiber material that extends around the first braid. The first braid and the second braid each has a 3 over 3 braid design, and the first braid has a first modulus and the second braid has a second modulus different from the first modulus. The first braid may be a high strength braid having a strength greater than a strength of the second braid, and the second braid may be a high modulus braid having a modulus greater than a modulus of the first braid. The hose assembly optionally may have a third braid with a high angle configuration of the braid segments. The hose assembly may be combined with an enhanced fitting for securing the hose assembly to fluid system equipment.

Abstract: Suture buttons are disclosed for fixing two bones together. The suture buttons may enable surgeons to more easily and effectively implement a suture button technique, such as to repair syndesmosis injuries in ankles. A first suture button includes a pulley peg extending from a button head. The pulley peg may be positioned with a bone hole upon installation of the first suture button, which may help protect suture and help reduce potential patient discomfort. The second suture button helps facilitate the second suture button flipping into place upon deployment from a button inserter. Each of the first and second provided suture buttons may help reduce friction between the respective buttons and suture during an installation procedure. The first and second provided suture buttons may be used together in a surgical procedure or individually with other suitable buttons or anchors.

Abstract: Suture buttons are disclosed for fixing two bones together. The suture buttons may enable surgeons to more easily and effectively implement the suture button technique, such as to repair syndesmosis injuries in ankles. A first suture button includes a pulley peg extending from a button head. The pulley peg may be positioned with a bone hole upon installation of the first suture button, which may help protect suture and help reduce potential patient discomfort. The second suture button helps facilitate the second suture button flipping into place upon deployment from a button inserter. Each of the first and second provided suture buttons may help reduce friction between the respective buttons and suture during an installation procedure. The first and second provided suture buttons may be used together in a surgical procedure or individually with other suitable buttons or anchors.

Abstract: Suture buttons are disclosed for fixing two bones together. The suture buttons may enable surgeons to more easily and effectively implement the suture button technique, such as to repair syndesmosis injuries in ankles. A first suture button includes a pulley peg extending from a button head. The pulley peg may be positioned with a bone hole upon installation of the first suture button, which may help protect suture and help reduce potential patient discomfort. The second suture button helps facilitate the second suture button flipping into place upon deployment from a button inserter. Each of the first and second provided suture buttons may help reduce friction between the respective buttons and suture during an installation procedure. The first and second provided suture buttons may be used together in a surgical procedure or individually with other suitable buttons or anchors.

Abstract: A company may implement automated workflows for convenience of users or to reduce support costs. For example, allowing a user to change an address using an automated workflow may be faster or less expensive than with a human agent. Companies may provide support over different types of communications channels with different capabilities, such as voice channels and text channels. Instead of implementing different workflows for different channels, a company may separate aspects of the workflow that are common to different channels from aspects of the workflow that are different for different channels. For example, a workflow may be implemented to determine an action in response to a received communication where the action may be used with multiple channels. The action may then be used to select an action implementation that is specific to a channel.

Abstract: Using geo-mapping data and only at least one inertial sensor, a Bayesian estimator uses at least one element of an uncorrected inertial navigation vector, of a moveable object on a surface, to estimate inertial navigation error information including corresponding statistical information. The estimated inertial navigation error information is used to error correct the uncorrected inertial navigation vector. The Bayesian filter also predicts inertial navigation error information, including corresponding statistical information, for a future time instance when a next uncorrected inertial navigation vector will be obtained.

Abstract: Suture buttons are disclosed for fixing two bones together. The suture buttons may enable surgeons to more easily and effectively implement the suture button technique, such as to repair syndesmosis injuries in ankles. A first suture button includes a pulley peg extending from a button head. The pulley peg may be positioned with a bone hole upon installation of the first suture button, which may help protect suture and help reduce potential patient discomfort. The second suture button helps facilitate the second suture button flipping into place upon deployment from a button inserter. Each of the first and second provided suture buttons may help reduce friction between the respective buttons and suture during an installation procedure. The first and second provided suture buttons may be used together in a surgical procedure or individually with other suitable buttons or anchors.

Abstract: Suture buttons are disclosed for fixing two bones together. The suture buttons may enable surgeons to more easily and effectively implement a suture button technique, such as to repair syndesmosis injuries in ankles. A first suture button includes a pulley peg extending from a button head. The pulley peg may be positioned with a bone hole upon installation of the first suture button, which may help protect suture and help reduce potential patient discomfort. The second suture button helps facilitate the second suture button flipping into place upon deployment from a button inserter. Each of the first and second provided suture buttons may help reduce friction between the respective buttons and suture during an installation procedure. The first and second provided suture buttons may be used together in a surgical procedure or individually with other suitable buttons or anchors.

Abstract: Using geo-mapping data and only at least one inertial sensor, a Bayesian estimator uses at least one element of an uncorrected inertial navigation vector, of a moveable object on a surface, to estimate inertial navigation error information including corresponding statistical information. The estimated inertial navigation error information is used to error correct the uncorrected inertial navigation vector. The Bayesian filter also predicts inertial navigation error information, including corresponding statistical information, for a future time instance when a next uncorrected inertial navigation vector will be obtained.

Abstract: A company may implement automated workflows for convenience of users or to reduce support costs. For example, allowing a user to change an address using an automated workflow may be faster or less expensive than with a human agent. Companies may provide support over different types of communications channels with different capabilities, such as voice channels and text channels. Instead of implementing different workflows for different channels, a company may separate aspects of the workflow that are common to different channels from aspects of the workflow that are different for different channels. For example, a workflow may be implemented to determine an action in response to a received communication where the action may be used with multiple channels. The action may then be used to select an action implementation that is specific to a channel.

Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL) domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.

Abstract: An attitude estimator system is provided. The attitude estimator system includes a navigation system, a Kalman filter, and a form observations module. The navigation system receives input from a first accelerometer and gyroscope, a second accelerometer and gyroscope, and a third accelerometer and gyroscope. The form observations module receives input from at least one high performance accelerometer and/or gyroscope; forms and outputs at least one of velocity-derived observations and attitude-derived observations.

Abstract: A hose assembly includes an inner hose component, a first braid of reinforcement fiber material that extends around the inner hose component, and a second braid of reinforcement fiber material that extends around the first braid. The first braid and the second braid each has a 3 over 3 braid design, and the first braid has a first modulus and the second braid has a second modulus different from the first modulus. The first braid may be a high strength braid having a strength greater than a strength of the second braid, and the second braid may be a high modulus braid having a modulus greater than a modulus of the first braid. The hose assembly optionally may have a third braid with a high angle configuration of the braid segments. The hose assembly may be combined with an enhanced fitting for securing the hose assembly to fluid system equipment.

Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH/CL) domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.

Abstract: A rolling mill for producing rolling mill product is provided. The rolling mill includes a rolling mill line that moves the rolling mill product. A plurality of rolling mill stands are coupled to the rolling mill line that receives the rolling mill product and rolls the rolling mill product. A plurality of speed measuring devices that are positioned in close proximity to each rolling mill stand, where each speed measuring device measures the speed of the rolling mill product as it passes the speed measuring devices. A control device receives information associated with the speed measuring devices and adjusts the speed of the rolling mill product for any speed differential that might exist between any of the rolling mill stands.