Patents by Inventor Steven O'Toole

Steven O'Toole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220380459
    Abstract: Multi-specific binding proteins that bind to and kill human cancer cells expressing CD33 (Siglec-3) are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of CD33 expressing cancer. The invention relates to multi-specific binding proteins that bind to human cancer cells expressing CD33, and exhibit high potency and maximum lysis of target cells compared to anti-CD33 monoclonal antibodies.
    Type: Application
    Filed: May 3, 2022
    Publication date: December 1, 2022
    Inventors: Gregory P. Chang, Ann F. Cheung, Asya Grinberg, Dhruv Kam Sethi, William Haney, Bianka Prinz, Bradley M. Lunde, Ronnie Wei, Daniel Fallon, Steven O'Neil
  • Publication number: 20220215140
    Abstract: A risk/reliability assessment tool for ultra-deepwater well control equipment used for offshore drilling operations is disclosed. Embodiments take into consideration all of the processes required for competent risk/reliability assessment for loss mitigation. In an illustrative embodiment, the system provides a simulation tool which evaluates equipment components and simulates the various failure modes for each component and the effect on the other components in the equipment being evaluated. An automated reporting tool quickly identifies components, failure modes for components, and troubleshooting information.
    Type: Application
    Filed: March 22, 2022
    Publication date: July 7, 2022
    Inventors: Garry Edward Davis, Steven O'Leary
  • Publication number: 20220195065
    Abstract: This disclosure relates to pharmaceutical formulations for multi-specific binding proteins having an epidermal growth factor receptor 2 (ErbB2 or HER2)-binding scFv, an NKG2D-binding Fab, and an antibody Fc domain. Also provided are dosage regimens for such multi-specific binding proteins and pharmaceutical formulations for use in treating cancer, such as locally advanced or metastatic solid tumor.
    Type: Application
    Filed: February 28, 2022
    Publication date: June 23, 2022
    Inventors: Gregory P. Chang, Ann F. Cheung, Jean-Marie Cuillerot, Daniel Fallon, Asya Grinberg, William Haney, Christopher Ryan Morgan, Michael C. Naill, Steven O'Neil, Nicolai Wagtmann, Ronnie Wei
  • Publication number: 20220175156
    Abstract: A refrigerated display case chassis includes a first insulated panel and a second insulated panel. The first insulated panel has a first foam layer bounded by a first pair of thermally conductive sheets. The first insulated panel forms a first wall of the refrigerated display case chassis. The second insulated panel has a second foam layer bounded by a second pair of thermally conductive sheets. The second insulated panel forms a second wall of the refrigerated display case chassis. The second insulated panel mates with the first insulated panel to form a thermally insulated joint where, in cross-section, one sheet of the first pair of thermally conductive sheets terminates at a surface of the second foam layer. The thermally conductive sheets have a greater thermal conductivity than the first or second foam layers.
    Type: Application
    Filed: December 6, 2021
    Publication date: June 9, 2022
    Inventors: Lawrence William Eget, Steven O. Stubblefield, Nicholas Jeffers, Daniela Guadalupe Medina
  • Publication number: 20220153848
    Abstract: Multi-specific binding proteins that bind NKG2D receptor, CD 16, and a tumor-associated antigen selected from c-MET, KIT, F3, IGF1R, Lewis Y, MUC13, MUC4, MCAM, LRRC32, sialyl-Tn, gpA33, GD3, GM2, EPHA3, TNFRSF10A, TNFSF11, CD74, and PMEL are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.
    Type: Application
    Filed: August 8, 2019
    Publication date: May 19, 2022
    Inventors: Gregory P. CHANG, Ann F. CHEUNG, Jinyan DU, Daniel FALLON, Asya GRINBERG, William HANEY, Bradley M. LUNDE, Steven O'NEIL, Bianka PRINZ, Ronnie WEI
  • Patent number: 11329023
    Abstract: A method for interconnecting a first conductor and a second conductor includes forming a layer of substantially pure copper on the first conductor, applying a copper sintering material to the first conductor, the second conductor, or both, and interconnecting the first conductor and the second conductor by sintering the copper sintering material so as to form a copper-copper interface that includes the layer of substantially pure copper, the second conductor, and the copper sintering material.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: May 10, 2022
    Assignee: Schlumberger Technology Corporation
    Inventors: Mark Alex Kostinovsky, Steven O. Dunford, Lweness Mazari
  • Publication number: 20220089760
    Abstract: Multi-specific binding proteins that bind to and kill human cancer cells are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer. The cancer can be B-cell maturation antigen (BCMA)-expressing cancer. The multi-specific binding proteins provided herein exhibit high potency and maximum lysis of target cells compared to anti-BCMA monoclonal antibodies.
    Type: Application
    Filed: December 6, 2021
    Publication date: March 24, 2022
    Inventors: Mitchell Bigelow, Gregory P. Chang, Ann F. Cheung, Asya Grinberg, William Haney, Nicolai Wagtmann, Bradley M. Lunde, Bianka Prinz, Ronnie Wei, Daniel Fallon, Steven O'Neil
  • Publication number: 20220059489
    Abstract: A method for interconnecting two conductors includes creating a first nickel layer on a first conductor of an electrical component, producing a first non-gold protective layer on the first nickel layer, the first non-gold protective layer being configured to prevent the first nickel layer from oxidizing, creating a second nickel layer on a second conductor, producing a second non-gold protective layer on the second nickel layer, the second non-gold protective layer being configured to prevent the second nickel layer from oxidizing, and interconnecting the first and second nickel layers using a solder layer that interfaces with the first and second nickel layers between the first and second conductors.
    Type: Application
    Filed: August 24, 2020
    Publication date: February 24, 2022
    Inventors: Mark Alex Kostinovsky, Steven O. Dunford, Lweness Mazari
  • Publication number: 20220025037
    Abstract: Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting DLL3 (Delta-like 3) on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer.
    Type: Application
    Filed: April 3, 2019
    Publication date: January 27, 2022
    Inventors: Hemanta Baruah, Ann F. Cheung, Daniel Fallon, Asya Grinberg, William Haney, Steven O'Neil
  • Publication number: 20210320082
    Abstract: A method for interconnecting a first conductor and a second conductor includes forming a layer of substantially pure copper on the first conductor, applying a copper sintering material to the first conductor, the second conductor, or both, and interconnecting the first conductor and the second conductor by sintering the copper sintering material so as to form a copper-copper interface that includes the layer of substantially pure copper, the second conductor, and the copper sintering material.
    Type: Application
    Filed: August 24, 2020
    Publication date: October 14, 2021
    Inventors: Mark Alex Kostinovsky, Steven O. Dunford, Lweness Mazari
  • Publication number: 20210221894
    Abstract: Multi-specific binding proteins that bind the NKG2D receptor, CD 16, and a tumor-associated antigen on tumor cells, or an antigen on myeloid-derived suppressor cells or tumor-associated macrophages are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.
    Type: Application
    Filed: April 3, 2019
    Publication date: July 22, 2021
    Inventors: Mitchell Bigelow, Gregory P. Chang, Ann F. Cheung, Jean-Marie Cuillerot, Jinyan Du, Asya Grinberg, William Haney, Steven O'Neil, Nicolai Wagtmann, Bradley M. Lunde, Bianka Prinz
  • Publication number: 20210214436
    Abstract: The invention provides improvements on single-chain variable fragment (scFv) antibodies, multi-specific binding proteins, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer.
    Type: Application
    Filed: May 28, 2019
    Publication date: July 15, 2021
    Inventors: Gregory P. Chang, Ann F. Cheung, Jinyan Du, Daniel Fallon, Asya Grinberg, William Haney, Steven O'Neil, Ronnie Wei, Bradley M. Lunde, Bianka Prinz
  • Patent number: 10959873
    Abstract: Reusable cups for collecting catamenia having a base, outer and inner walls, apertures, ribs, and ridges. In some examples, the reusable cups include a trimmable stem. In some further examples, the reusable cups include a circumferential band as a double seal for leak protection and to aid the reusable cups in fully expanding upon insertion and while in situ. In further examples, the reusable cups include indentations and indicia at the base of the reusable cups to work in tandem with the ribs and the apertures such that when the reusable cup is pinched at the base, the suction seal at the aperture and the lip is broken.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: March 30, 2021
    Inventors: Amanda Wilson, Steven O'toole Dodson
  • Patent number: 10925976
    Abstract: The present invention provides for the incorporation of target sequences of microRNAs into the 3?UTR region of a gene of interest in nucleic acid vectors. The invention also provides for an expression system comprising such vectors, a pharmaceutical composition comprising such vectors, as well as methods of treating or preventing cardiovascular disease by using such vectors.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: February 23, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Hana Totary-Jain, Andrew Robert Marks, Steven O. Marx
  • Publication number: 20200345463
    Abstract: An orthodontic appliance is disclosed and which cooperates with both the upper and lower dental arches of a patient and which includes an archwire coupler which is attached to individual archwires that are releasably attached to individual orthodontic brackets on the anterior facing surface of a patient's teeth requiring orthodontic treatment; and a multiple section elongated telescoping assembly which is rotatably and releasably coupled to the archwires attached to the upper and lower dental arches of a patient undergoing treatment, and wherein the multiple section elongated telescoping assembly effects movement of the upper dental arch in a rearward direction, and the lower dental arch in a forward direction when the multiple section elongated telescoping assembly is in a given position along a predetermined course of travel.
    Type: Application
    Filed: July 17, 2020
    Publication date: November 5, 2020
    Inventors: Terry G. Dischinger, William M. Dischinger, Steven O. Luse
  • Patent number: 10769280
    Abstract: A system and method for minimizing the likelihood that the secret key used by a bootloader is compromised is disclosed. A bootloader is installed on the device. The bootloader is a software program that performs many functions. These functions may include checking the checksum of the incoming software image for integrity, decrypting the incoming software image using a secret key, deleting data in the FLASH memory, installing the new software image in the FLASH memory and other functions. The bootloader utilizes various techniques to track the versions of the software image being installed. The method counts the number of incomplete attempts that are made when trying to update the software image. By monitoring these parameters, the bootloader can determine when a malicious actor is attempting a side channel attack. In response, the bootloader may not allow a new software image to be loaded or the secret key to be accessed.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: September 8, 2020
    Assignee: Silicon Laboratories, Inc.
    Inventors: Joshua Jay Norem, Daniel Riedler, Chad Steven O'Neill
  • Patent number: 10716646
    Abstract: An orthodontic appliance is disclosed and which cooperates with both the upper and lower dental arches of a patient and which includes an archwire coupler which is attached to individual archwires that are releasably attached to the anterior facing surface of a patient's teeth requiring orthodontic treatment; and a multiple section elongated telescoping assembly which is rotatably and releasably coupled to the archwires attached to the upper and lower dental arches of a patient undergoing treatment, and wherein the multiple section elongated telescoping assembly effects movement of the upper dental arch in a rearward direction, and the lower dental arch in a forward direction when the multiple section elongated telescoping assembly is in a given position along a predetermined course of travel.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: July 21, 2020
    Inventors: Terry G. Dischinger, William M. Dischinger, Steven O. Luse
  • Publication number: 20200193028
    Abstract: A system and method for minimizing the likelihood that the secret key used by a bootloader is compromised is disclosed. A bootloader is installed on the device. The bootloader is a software program that performs many functions. These functions may include checking the checksum of the incoming software image for integrity, decrypting the incoming software image using a secret key, deleting data in the FLASH memory, installing the new software image in the FLASH memory and other functions. The bootloader utilizes various techniques to track the versions of the software image being installed. The method also counts the number of incomplete attempts that are made when trying to update the software image. By monitoring these parameters, the bootloader can determine when a malicious actor is attempting a side channel attack. In response, the bootloader may not allow a new software image to be loaded or the secret key to be accessed.
    Type: Application
    Filed: December 13, 2018
    Publication date: June 18, 2020
    Inventors: Joshua Jay Norem, Daniel Riedler, Chad Steven O'Neill
  • Publication number: 20200120813
    Abstract: A method of forming electronic substrates and assemblies is provided. The method includes depositing a material. The material is deposited as a powder or slurry. The method includes sintering the material, and retrieving an article, including a solid electronic substrate. Also provided are electronic substrates formed by additive manufacturing, and methods of deploying the same.
    Type: Application
    Filed: October 10, 2018
    Publication date: April 16, 2020
    Inventors: Steven O. Dunford, Mark Kostinovsky, Suriyakan Kleitz, Man To, Lweness Mazari
  • Patent number: D906476
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: December 29, 2020
    Assignee: SORD FISHING PRODUCTS LLC
    Inventor: Steven O Vanden Heuvel