Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: This present disclosure provides devices, systems, and methods relating to modulating the temperature of a target tissue in a subject for various therapeutic purposes. In particular, the present disclosure provides devices, systems, and methods for the focal delivery of cytostatic hypothermia to a target tissue to treat a disease or condition in a subject (e.g., cancerous tumors).

Abstract: This invention is directed to a filter removal tool comprising: a cup configured to engage with a filter so that rotating the cup rotates the filter; an opening in a shaft or cup and extending through the cup so that when a puncture cap that can be received into the cup punctures the filter, fluid flows from the filter out of the cup. The shaft can transition from a first position to a second position wherein the puncture cap can puncture the filter in the second position. A wrench or other tool can be used to remove the filter using the cup. The cup can be secured to the filter with a magnet or collet assembly. A tube can be connected to the cup to direct fluid that exits the filter. An impact member can be used to force the puncture cap into the filter.

Abstract: Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy.

Abstract: This invention is directed to a filter removal tool comprising: a cup configured to engage with a filter so that rotating the cup rotates the filter; a shaft having a bore and extending through the cup at a proximal end of the cup; a puncture cap removably attached to the shaft and configured to be received in the cup and to puncture the filter when the shaft transitions from a first position to a second position; a lateral puncture cap opening defined in the puncture cap in fluid communication with the bore; and, a removal tool portion carried by the cup configured to receive a tool for rotating the cup.

Abstract: An engine system includes a gearbox assembly that includes a housing having plural interconnected gears disposed between an engine side of the housing and an alternator side of the housing, a rotatable engine coupler connected with the engine side of the housing, the engine coupler configured to engage a rotatable shaft of an engine, and a rotatable alternator coupler connected with the alternator side of the housing, the alternator coupler configured to engage a rotor of a first alternator. The housing is configured to be positioned between the engine and the first alternator. The engine coupler is configured to engage the engine that is resiliently mounted in the powered system and the alternator coupler is configured to engage the first alternator that is rigidly mounted in the powered system to transfer rotation of the shaft of the engine to rotation of the rotor of the first alternator.

Abstract: An electrode assembly (1) for an active implantable medical device comprising: an elongated, biocompatible, electrically non-conductive body (3) having a first portion (7) and a second portion (9); one or more biocompatible, electrically conductive filaments (5) inside the elongated non-conductive body (3) between the first portion (7) and the second portion (9); and one or more fluid passages (11) along the elongated electrically non-conductive body (3) between the first portion (7) and second portion (9), wherein the one or more fluid passages (11) allow a surrounding fluid (13) of a patient to be in electrical contact with the one or more conductive filaments (5). There is also disclosed a method of manufacturing an electrode assembly.

Abstract: Embodiments of the present disclosure relate generally to fishing lures that employ channeled water technology. Embodiments further relate to fishing lures with a vented head configured to allow removal and replacement of a swim body. In specific embodiments, the vented head is provided as a two-piece configuration having locational alignment features and lateral securement features for maintaining the swim body in a secured position.

Abstract: In one aspect the invention provides an implant conductor lead assembly which includes an electrode lead, and at least one field target conductor. The field target conductor(s) is located adjacent to the electrode lead to mutually couple the field target conductor to the electrode lead. The electrode lead acts to concentrate electromagnetic fields in the vicinity of the implant conductor assembly towards the field target conductor or conductors.

Abstract: An electrode assembly (1) for an active implantable medical device comprising: an elongated, biocompatible, electrically non-conductive body (3) having a first portion (7) and a second portion (9); one or more biocompatible, electrically conductive filaments (5) inside the elongated non-conductive body (3) between the first portion (7) and the second portion (9); and one or more fluid passages (11) along the elongated electrically non-conductive body (3) between the first portion (7) and second portion (9), wherein the one or more fluid passages (11) allow a surrounding fluid (13) of a patient to be in electrical contact with the one or more conductive filaments (5). There is also disclosed a method of manufacturing an electrode assembly.

Abstract: This invention is directed to a filter removal tool comprising: a cup configured to engage with a filter so that rotating the cup rotates the filter; a shaft having a bore and extending through the cup at a proximal end of the cup; a puncture cap removably attached to the shaft and configured to be received in the cup and to puncture the filter when the shaft transitions from a first position to a second position; a lateral puncture cap opening defined in the puncture cap in fluid communication with the bore; and, a removal tool portion carried by the cup configured to receive a tool for rotating the cup.

Abstract: An engine system includes a gearbox assembly that includes a housing having plural interconnected gears disposed between an engine side of the housing and an alternator side of the housing, a rotatable engine coupler connected with the engine side of the housing, the engine coupler configured to engage a rotatable shaft of an engine, and a rotatable alternator coupler connected with the alternator side of the housing, the alternator coupler configured to engage a rotor of a first alternator. The housing is configured to be positioned between the engine and the first alternator. The engine coupler is configured to engage the engine that is resiliently mounted in the powered system and the alternator coupler is configured to engage the first alternator that is rigidly mounted in the powered system to transfer rotation of the shaft of the engine to rotation of the rotor of the first alternator.

Abstract: A computer-implemented method and system for seeding video programs with episodic interactive items improve computer performance by averting tracking loss. The system includes a scene map table that maintains a scene record for every scene in the video. The scene record contains boundary information for the scene and linking information to companion scenes that are visually similar. When a developer tags an episodic item in the video for interactivity, the scene record for the scene where the item is tagged is accessed in the scene map table. The boundary information from this scene record is used to track the item across the scene without tracking loss and the linking information from this scene record is used to access scene records for companion scenes, allowing the item to be tracked across the companion scenes without tracking loss.

Abstract: In one aspect the invention provides an implant conductor lead assembly which includes an electrode lead, and at least one field target conductor. The field target conductor(s) is located adjacent to the electrode lead to mutually couple the field target conductor to the electrode lead. The electrode lead acts to concentrate electromagnetic fields in the vicinity of the implant conductor assembly towards the field target conductor or conductors.

Abstract: What is disclosed is a system and method for determining whether all processes performed by various secondary devices on a print/copy/scan job in a document reproduction environment completed. In one embodiment, a user/customer selects an application services represented by selectable icons displayed on a user interface of a multi-function device. In response to an application service having been selected, a list of process steps is retrieved. The various process steps are to be performed by one or more secondary devices for the selected application service. Then, for each secondary device in the retrieved list, a processor communicates to each secondary device to begin performing its associated process steps and waits until a notification is received from each secondary device that it has completed its various process steps. Upon complete of all process steps by all secondary devices, a notification is communicated to the user/customer that the job completed.

Abstract: A computer-implemented method and system for seeding video programs with episodic interactive items improve computer performance by averting tracking loss. The system includes a scene map table that maintains a scene record for every scene in the video. The scene record contains boundary information for the scene and linking information to companion scenes that are visually similar. When a developer tags an episodic item in the video for interactivity, the scene record for the scene where the item is tagged is accessed in the scene map table. The boundary information from this scene record is used to track the item across the scene without tracking loss and the linking information from this scene record is used to access scene records for companion scenes, allowing the item to be tracked across the companion scenes without tracking loss.

Abstract: A deodorizing storage container includes a substantially hollow body, a rack, a lid, a plurality of air intake holes and an air-purification system. The substantially hollow body is defined by an inner chamber, an interior wall and an exterior wall. The rack may be removably positioned within the inner chamber of the substantially hollow body. The lid may be removably attached to the substantially hollow body and the plurality of air intake holes may be located at a bottom portion of the substantially hollow body. The deodorizing storage container provides users with a deodorizing storage container capable of containing and effectively eradicating undesirable odors due to smelly shoes, socks, clothes, jerseys, uniforms, pads, sporting equipment and much more. It allows athletes, parents, college students, outdoorsmen and others to be in close quarters with their stored smelly equipment that would otherwise contaminate the air quality of the inhabited space.

Abstract: In one aspect the invention provides a surgical implant conductor formed from a length of conductive material which exhibits increased radio frequency alternating current resistance. This conductive material defines an exterior surface where at least a portion of the exterior surface of the conductor defines a region with a roughened surface. Preferably the roughening of the exterior surface increases the area of the exterior surface when compared to a non-roughened surface, resulting in a reduction in the effective cross-section area of the conductor used to transport alternating currents.

Abstract: A fastener includes a head, a shank extending from the head, a first threaded portion having a plurality of first threads formed on the shank adjacent to the head, and a second threaded portion having a plurality of second threads formed on the shank distal from the head. The plurality of first threads have a handedness that is different from a handedness of the plurality of second threads.