Patents by Inventor Steven P. Adams

Steven P. Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell adhesion inhibitors
    Patent number: 6306840
    Abstract: The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
    Type: Grant
    Filed: January 23, 1995
    Date of Patent: October 23, 2001
    Assignee: Biogen, Inc.
    Inventors: Steven P. Adams, Ko-Chung Lin, Wen-Cherng Lee, Alfredo C. Castro, Craig N. Zimmerman, Charles E. Hammond, Yu-Sheng Liao
  • Cell adhesion inhibitors
    Patent number: 6248713
    Abstract: The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
    Type: Grant
    Filed: July 11, 1995
    Date of Patent: June 19, 2001
    Assignee: Biogen, Inc.
    Inventors: Ko-Chung Lin, Steven P. Adams, Alfredo C. Castro, Craig N. Zimmerman, Julio Hernan Cuervo, Wen-Cherng Lee, Charles E. Hammond, Mary Beth Carter, Ronald G. Almquist
  • Cell adhesion inhibitors
    Patent number: 6239108
    Abstract: The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
    Type: Grant
    Filed: August 10, 1998
    Date of Patent: May 29, 2001
    Assignee: Biogen, Inc.
    Inventors: Ko-Chung Lin, Steven P. Adams, Alfredo C. Castro, Craig N. Zimmerman, Julio Hernan Cuervo, Wen-Cherng Lee, Charles E. Hammond, Mary Beth Carter, Ronald G. Almquist
  • Fatty acid analog enzyme substrates
    Patent number: 5959145
    Abstract: Novel oxy- and thio-substituted fatty acid analog substrates of myristoylating enzymes are provided which contain an oxygen or sulfur in place of a methylene group in a carbon position from 4 to 13 in the fatty acid chain of a C.sub.13 -C.sub.14 fatty acid or alkyl ester thereof.
    Type: Grant
    Filed: July 15, 1993
    Date of Patent: September 28, 1999
    Assignee: Washington University
    Inventors: Robert O. Heuckeroth, Steven P. Adams, Jeffrey I. Gordon
  • Fatty acid analog enzyme substrates
    Patent number: 5871954
    Abstract: Novel oxy- and thio-substituted fatty acid analog substrates of myristoylating enzymes are provided which contain an oxygen or sulfur in place of a methylene group in a carbon position from 4 to 13 in the fatty acid chain of a C.sub.13 -C.sub.14 fatty acid or alkyl ester thereof.
    Type: Grant
    Filed: July 15, 1993
    Date of Patent: February 16, 1999
    Assignee: Washington University
    Inventors: Robert O. Heuckeroth, Steven P. Adams, Jeffrey I. Gordon
  • Pyrimidinylamidino .beta.-amino acid derivatives useful as inhibitors of platelet aggregation
    Patent number: 5872122
    Abstract: This invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions of such compounds and a method of treatment to inhibit aggregation of platelets.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: February 16, 1999
    Assignee: Monsanto Company
    Inventors: Philippe R. Bovy, Henry E. Dayringer, Steven P. Adams
  • Urea derivatives useful as platelet aggregation inhibitors
    Patent number: 5624956
    Abstract: Novel urea derivatives and pharmaceutical compositions thereof are provided which inhibit platelet aggregation.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: April 29, 1997
    Assignee: The Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth, Dudley E. McMackins, Steven P. Adams
  • Urea compounds which are useful as platelet aggregation inhibitors
    Patent number: 5614539
    Abstract: Novel urea derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 25, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Steven P. Adams, Foe S. Tjoeng, Mark E. Zupec
  • Method of N-acylating peptide and proteins with diheteroatom substituted analogs of myristic acid
    Patent number: 5571689
    Abstract: A method for acylating peptides and proteins with the CoA-ester of diheteroatom substituted C.sub.13 to C.sub.14 myristic acid analogs catalyzed by N-myristoyltransferase is presented. In the analogs, two non-adjacent methylene groups, which are normally at positions 3-13, are replaced with oxygen or sulfur atoms.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: November 5, 1996
    Assignee: Washington University
    Inventors: Robert O. Heuckeroth, Steven P. Adams, Jeffrey I. Gordon, George W. Gokel
  • Method of inhibiting platelet aggregation using phenyl amidine thio derivatives
    Patent number: 5543425
    Abstract: This invention relates to a method of inhibiting platelet aggregation comprising administering compounds having the following formula ##STR1##
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: August 6, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Steven P. Adams, Richard J. Lindmark, Masateru Miyano, Joseph G. Rico
  • Urea derivatives useful as platelet aggregation inhibitors
    Patent number: 5475025
    Abstract: Novel urea compounds are provided which inhibit platelet aggregation as well as pharmaceutical compositions and methods of using said compounds.
    Type: Grant
    Filed: February 23, 1994
    Date of Patent: December 12, 1995
    Assignee: The Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth, Dudley E. McMackins, Steven P. Adams
  • Phenyl amidine thio derivatives useful as platelet aggregation inhibitors
    Patent number: 5409939
    Abstract: This invention relates to compounds having the following formula ##STR1## which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine thio derivatives.
    Type: Grant
    Filed: February 12, 1993
    Date of Patent: April 25, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Steven P. Adams, Richard J. Lindmark, Masateru Miyano, Joseph G. Rico
  • Azido-substituted fatty acid analog enzyme substrates
    Patent number: 5397701
    Abstract: Azido-substituted fatty acid analogs which are useful in the fatty acid acylation of peptides and proteins and as antiviral agents are disclosed having the following chemical structure:Z--(CH.sub.2).sub.x COORwhereinZ=azido, tetrazolyl or triazolylR=H or C.sub.1 -C.sub.8 alkyl, andx=8-12.
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: March 14, 1995
    Assignee: Washington University
    Inventors: Balekudru Devadas, Jeffrey I. Gordon, Steven P. Adams
  • Modified deazapyrimidines
    Patent number: 5359053
    Abstract: The probes of the invention are able to withstand higher temperatures, thereby allowing unmatched probes and mismatched probes to be washed off at higher hybridization stringency, thereby eliminating background readings and improving ease and accuracy of probe use.
    Type: Grant
    Filed: May 6, 1992
    Date of Patent: October 25, 1994
    Assignee: G. D. Searle & Co.
    Inventors: Thomas E. Rogers, Steven H. Gray, Balekudru Devadas, Steven P. Adams
  • Triazolyl, tetrazolyl and azido-substituted fatty acid analog enzyme substrates
    Patent number: 5338858
    Abstract: Azido-substituted fatty acid analogs which are useful in the fatty acid acylation of peptides and proteins and as antiviral agents are disclosed having the following chemical structure:Z--(CH.sub.2).sub.x COORwhereinZ=azido, tetrazolyl or triazolylR=H or C.sub.1 -C.sub.8 alkyl, andx=8-12.
    Type: Grant
    Filed: October 20, 1992
    Date of Patent: August 16, 1994
    Assignee: Washington University
    Inventors: Balekudru Devadas, Jeffrey I. Gordon, Steven P. Adams
  • Urea derivatives useful as platelet aggregation inhibitors
    Patent number: 5314902
    Abstract: Novel urea derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
    Type: Grant
    Filed: January 27, 1993
    Date of Patent: May 24, 1994
    Assignee: Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth, Dudley E. McMackins, Steven P. Adams
  • Phenyl amidines sulfonamides useful as platelet aggregation inhibitors
    Patent number: 5264457
    Abstract: This invention relates to compounds having the following formula ##STR1## which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine sulfones derivatives.
    Type: Grant
    Filed: February 14, 1992
    Date of Patent: November 23, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Steven P. Adams, Joseph G. Rico, Masateru Miyano
  • Hexapeptide Lys Gly Ala Gly Asp Val
    Patent number: 5225531
    Abstract: A novel hexapeptide is disclosed which has ligand binding specificity of the leukocyte response integrin expressed by human neutrophils and that has the following amino acid sequence ##STR1##
    Type: Grant
    Filed: April 9, 1992
    Date of Patent: July 6, 1993
    Assignee: Washington University
    Inventors: Hattie D. Gresham, Steven P. Adams, Eric J. Brown
  • Binding peptides
    Patent number: 5175253
    Abstract: Novel short peptides of up to about 20 amino acid residues are disclosed that bind to the SEC receptor. These novel peptides preferably are pentapeptides which are synthetic analogs of a pentapeptide domain in the carboxy-terminal fragment of .alpha..sub.1 -antitrypsin (amino acids 370-374, Phe-Val-Phe-Leu-Met [SEQ ID NO:2]). A preferred binding peptide is Phe-Val-Ala-Leu-Met [SEQ ID NO;6].
    Type: Grant
    Filed: April 24, 1991
    Date of Patent: December 29, 1992
    Assignee: Washington University
    Inventors: Robert J. Fallon, Joseph W. Bulock, Steven P. Adams, David H. Perlmutter
  • Method of inhibiting parasitic activity
    Patent number: 5151445
    Abstract: A method of inhibiting parasitic activity is disclosed in which the biosynthesis of the glycosyl phosphatidylinositol (GPI) anchor of said parasite is inhibited by incorporating into said GPI anchor an oxy-substituted fatty acid analog in place of myristate. The inhibitory compounds ar C.sub.13 and C.sub.14 fatty acids or alkyl esters thereof in which a methylene group normally in carbon position 4 to 13 of said fatty acid is replaced with oxygen.
    Type: Grant
    Filed: January 8, 1991
    Date of Patent: September 29, 1992
    Assignee: Washington University
    Inventors: Joseph K. Welply, Steven P. Adams, Jeffrey I. Gordon