Patents by Inventor Steven P. Adams

Steven P. Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Improved probes using nucleosides containing 3-dezauracil analogs
    Patent number: 5134066
    Abstract: The deazauracil containing probes of the invention are able to withstand higher temperatures, thereby allowing unmatched probes and mismatched probes to be washed off at higher hybridization stringency, thereby eliminating background readings and improving ease and accuracy of probe use.
    Type: Grant
    Filed: August 29, 1989
    Date of Patent: July 28, 1992
    Assignee: Monsanto Company
    Inventors: Thomas E. Rogers, Steven H. Gray, Balekudru Devadas, Steven P. Adams
  • Antiviral peptides
    Patent number: 5104854
    Abstract: Novel antiviral peptides are disclosed which have a sequence of about 6 to 30 amino acids and which are substantially identical to a small portion of a glycoprotein in a virus that contains a lipid-bilayer in its structure. A preferred peptide having antiviral activity against influenza virus is the decapeptide amide N-G-S-L-Q-C-R-I-C-I-NH.sub.2 [SEQ ID NO:3].
    Type: Grant
    Filed: May 21, 1991
    Date of Patent: April 14, 1992
    Assignee: Washington University
    Inventors: Milton J. Schlesinger, Nancy C. Collier, Steven P. Adams
  • Pyridyl peptide mimetic compounds which are useful platelet-aggregation inhibitors
    Patent number: 5091396
    Abstract: Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=4 to 8,y=0 to 4,W=CH.sub.2 --CH.sub.2 or C.dbd.CH,Z=H, COOH, CONH.sub.2, CH.sub.2 OH, CO.sub.2 R, CH.sub.2 OR or C.sub.1-6 alkyl,R=C.sub.1-6 alkyl,Ar=a nitrogen-containing heterocyclic group, andAsp=aspartic acid residue.
    Type: Grant
    Filed: January 7, 1991
    Date of Patent: February 25, 1992
    Assignees: Monsanto Co., G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Steven P. Adams, Robert B. Garland, Masateru Miyano
  • Novel fatty acid analog enzyme substrates
    Patent number: 5082967
    Abstract: Novel diheteroatom-substituted fatty acid analog substrates of myristoylating enzymes are provided which contain oxyen and/or sulfur in place of two methylene groups in carbon positions from 3 to 13 in the fatty acid chain of a C.sub.13 -C.sub.14 fatty acid analog or alkyl ester thereof in which said oxygen or sulfur atoms are separated by at least one methylene group.
    Type: Grant
    Filed: February 9, 1990
    Date of Patent: January 21, 1992
    Assignee: Washington University
    Inventors: Robert O. Heuckeroth, Steven P. Adams, Jeffrey I. Gordon, George W. Gokel
  • Method of inhibiting virus
    Patent number: 5073571
    Abstract: A method of inhibiting viruses by treatment with oxy- and thio-substituted fatty acid analog substrates of myristoylating enzymes is disclosed. These fatty acid analogs contain an oxygen or sulfur in place of a methylene group in a carbon position from 4 to 13 in the fatty acid chain of a C.sub.13 -C.sub.14 fatty acid or alkyl ester thereof.
    Type: Grant
    Filed: September 1, 1989
    Date of Patent: December 17, 1991
    Assignee: Washington University
    Inventors: Robert O. Heuckeroth, Steven P. Adams, Jeffrey I. Gordon
  • Novel platelet-aggregation inhibitor
    Patent number: 5053393
    Abstract: N-[8-[(Aminoiminomethyl)amino]-1-oxooctyl]-N-L-.alpha.-aspartyl-L-phenylani ne is disclosed as a highly potent inhibitor of platelet aggregation.
    Type: Grant
    Filed: June 20, 1990
    Date of Patent: October 1, 1991
    Assignees: Monsanto Company, G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Larry P. Feigen, Steven P. Adams
  • Bioactive fragment of interleukin-1-B that has antagonistic activity
    Patent number: 5039790
    Abstract: The present invention discloses a peptide capable of blocking activity of Interleukin-1. The peptide corresponds to the 157-186 amino acid residue of the IL-1.beta. molecules.
    Type: Grant
    Filed: January 11, 1989
    Date of Patent: August 13, 1991
    Assignee: Monsanto Company
    Inventors: Steven P. Adams, Joseph W. Bulock, Kam F. Fok
  • Indolyl platelet-aggregation inhibitors
    Patent number: 5037808
    Abstract: Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=4 to 8,y=0 to 4,W=CH.sub.2 --CH.sub.2 or CH.dbd.CH,Z=H, COOH, CONH.sub.2, CH.sub.2 OH, CO.sub.2 R, CH.sub.2 OR or C.sub.1-6 alkyl,R=C.sub.1-6 alkyl,Ar=a nitrogen-containing heterocyclic group, andAsp=aspartic acid residue.
    Type: Grant
    Filed: April 23, 1990
    Date of Patent: August 6, 1991
    Assignees: Monsanto Co., G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Steven P. Adams, Robert B. Garland, Masateru Miyano
  • Antibodies to VPF
    Patent number: 5036003
    Abstract: A method of producing antibodies against vascular permeability factor (VPF) is disclosed which comprises immunizing a host animal with a peptide having an amino acid sequence as follows: ##STR1## or a fragment of said peptide containing an antigenic determinant of VPF.
    Type: Grant
    Filed: September 2, 1988
    Date of Patent: July 30, 1991
    Assignee: Monsanto Company
    Inventors: Jitka V. Olander, Daniel T. Connolly, Steven P. Adams, Joseph Feder
  • Antiviral peptides
    Patent number: 5026686
    Abstract: Novel antiviral peptides are disclosed which have a sequence of about 4 to 10 amino acids and which are substantially identical to a small portion of the cytoplasmic domain of a glycoprotein in a virus that contains a lipid-bilayer in its structure.
    Type: Grant
    Filed: February 1, 1989
    Date of Patent: June 25, 1991
    Assignee: Washington University
    Inventors: Milton J. Schlesinger, Steven P. Adams
  • Peptide inhibitors of motor neuron attachment to s-laminin
    Patent number: 5003044
    Abstract: Novel peptides having inhibitor activity toward the binding of motor neurons to s-laminin are disclosed which are selected from the group consisting ofAEKQLREQVGDQYQTVRALAEand fragments thereof containing the essential sequence LRE.
    Type: Grant
    Filed: July 19, 1989
    Date of Patent: March 26, 1991
    Assignee: Washington University
    Inventors: Dale D. Hunter, Joshua R. Sanes, John P. Merlie, Steven P. Adams
  • Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation
    Patent number: 4992463
    Abstract: Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=6 to 10,y=0 to 4,Z=H, COOH, CONH.sub.2 or C.sub.1-6 alkyl,Ar=phenyl, biphenyl or napthyl, each substituted with 1 to 3 methoxy groups, or an unsubstituted phenyl, biphenyl, napthyl, pyridyl or thienyl group, andAsp=aspartic acid residue.
    Type: Grant
    Filed: August 18, 1989
    Date of Patent: February 12, 1991
    Assignee: Monsanto Company
    Inventors: Foe S. Tjoeng, Steven P. Adams
  • Novel platelet-aggregation inhibitors
    Patent number: 4879313
    Abstract: Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=6 to 10,y=0 to 4,Z=H, COOH, CONH.sub.2 or C.sub.1-6 alkyl,Ar=phenyl, biphenyl or napthyl, each substituted with 1 to 3 methoxy groups, or an unsubstituted phenyl, biphenyl, napthyl, pyridyl or thienyl group, andAsp=aspartic acid residue.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: November 7, 1989
    Assignee: Mosanto Company
    Inventors: Foe S. Tjoeng, Steven P. Adams
  • Novel platelet-aggregation inhibitor peptide derivatives
    Patent number: 4857508
    Abstract: Novel tetrapeptide derivatives are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the sequence X-Gly-Asp-Y wherein X is illustrated by arginine and Y is illustrated by O-methyltyrosine amide.
    Type: Grant
    Filed: December 3, 1987
    Date of Patent: August 15, 1989
    Assignees: Monsanto Company, G. D. Searle & Co.
    Inventors: Steven P. Adams, Larry P. Feigen, Masateru Miyano
  • Novel inhibitor peptides I
    Patent number: 4778878
    Abstract: An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence as follows or a physiologically acceptable amide or salt derivative thereof: ##STR1##
    Type: Grant
    Filed: September 30, 1987
    Date of Patent: October 18, 1988
    Assignee: Washington University
    Inventors: Steven P. Adams, Dwight A. Towler, Jeffrey I. Gordon
  • Novel inhibitor peptides II
    Patent number: 4778877
    Abstract: An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence as follows or a physiologically acceptable amide or salt derivative thereof: ##STR1##
    Type: Grant
    Filed: September 30, 1987
    Date of Patent: October 18, 1988
    Assignee: Washington University
    Inventors: Steven P. Adams, Dwight A. Towler, Jeffrey I. Gordon
  • Novel substrate peptides
    Patent number: 4740588
    Abstract: A peptide substrate for myristoylating enzymes is disclosed having an amino acid sequence selected from the group consisting of the following sequences or a physiologically acceptable amide or salt derivative thereof: ##STR1## wherein R=Ala, Asn, Gln or Ser;S=Ala, Arg, Gln, Glu, Phe or Ser;T=Ala or Lys;W=Ala or Ser;X=Ala, Tyr, or Lys;Y=Arg or Pro; andZ=Arg, Leu or Lys.
    Type: Grant
    Filed: October 29, 1986
    Date of Patent: April 26, 1988
    Assignee: Washington University
    Inventors: Steven P. Adams, Dwight A. Towler, Luis Glaser
  • Synthetic airial peptides
    Patent number: 4716147
    Abstract: Novel synthetic atrial peptides are provided with enhanced natriuretic properties by substituting one or two arginine residues for the N-terminal ser-ser in atriopeptins I, II and III and their physiologically acceptable salts, esters and amides.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: December 29, 1987
    Assignee: Monsanto Company
    Inventors: Foe S. Tjoeng, Kam F. Fok, Steven P. Adams
  • Novel inhibitor peptides
    Patent number: 4709012
    Abstract: An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence selected from the group consisting of the following sequences or a physiologically acceptable amide or salt derivative thereof: ##STR1## wherein R=Leu, Phe, Tyr or Val.
    Type: Grant
    Filed: August 7, 1986
    Date of Patent: November 24, 1987
    Assignee: Washington University
    Inventors: Steven P. Adams, Dwight A. Towler, Luis Glaser