Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: A vaporizer device includes various modular components. The vaporizer device includes a first subassembly. The first subassembly includes a cartridge connector that secures a vaporizer cartridge to the vaporizer device and includes at least two receptacle contacts that electrically communicate with the vaporizer cartridge. The vaporizer device includes a second subassembly. The second subassembly includes a skeleton defining a rigid tray that retains at least a power source. The vaporizer device also includes a third subassembly. The third subassembly includes a plurality of charging contacts that supply power to the power source, and an end cap that encloses an end of the vaporizer device.

Abstract: An example medical device for occluding the left atrial appendage includes an expandable member having a first end region, a second end region and an inflation cavity. The medical device also includes a plurality of spine members coupled to the expandable member, the plurality of spine members spaced circumferentially around an outer surface of the expandable member. Additionally, the medical device includes a valve member extending at least partially into the inflation cavity, wherein the plurality of spine members are configured to position the medical device within an opening of the left atrial appendage and wherein the expandable member is configured to expand and seal the opening of the left atrial appendage.

Abstract: A detector system is described that includes a detector that is sensitive to wavelengths in a detection wavelength range. The detector system further includes a light control film that is disposed on the detector and includes a plurality of alternating first and second regions. Each first region has a width W and a height H, where H/W?1. Each first region has a substantially low transmission in a first portion of the detection wavelength range and a substantially high transmission in the remaining portion of the detection wavelength range. Each second region has a substantially high transmission in the detection wavelength range.

Abstract: A retroreflective system is disclosed that includes a retroreflective sheet for retroreflecting light, and a light control film disposed on the retroreflective sheet. For a first wavelength, light incident on the light control film at each of a first and second angles of incidence is retroreflected. For a second wavelength, light incident on the light control film at the first, but not the second, angle of incidence is retroreflected.

Abstract: A light control film is disclosed that includes a plurality of spaced apart first regions. Each first region has a substantially low transmission in one or two of a first wavelength range from about 300 nm to about 400 nm, a second wavelength range from about 400 nm to about 700 nm, and a third wavelength range from about 700 nm to about 1200 nm, and a substantially high transmission in the remaining wavelength ranges. The light control film has a viewing angle of less than about 70 degrees along a predetermined first direction.

Abstract: A light control film is disclosed that includes a plurality of spaced apart first regions. Each first region has a substantially low transmission in one or two of a first wavelength range from about 300 nm to about 400 nm, a second wavelength range from about 400 nm to about 700 nm, and a third wavelength range from about 700 nm to about 1200 nm, and a substantially high transmission in the remaining wavelength ranges. The light control film has a viewing angle of less than about 70 degrees along a predetermined first direction.

Abstract: A light control film is disclosed that includes a plurality of spaced apart first regions. Each first region has a substantially low transmission in one or two of a first wavelength range from about 300 nm to about 400 nm, a second wavelength range from about 400 nm to about 700 nm, and a third wavelength range from about 700 nm to about 1200 nm, and a substantially high transmission in the remaining wavelength ranges.

Abstract: A detector system is disclosed that includes a detector that is sensitive to wavelengths in a detection wavelength range. The detector system further includes a light control film that is disposed on the detector and includes a plurality of alternating first and second regions. Each first region has a width W and a height H, where H/W?1. Each first region has a substantially low transmission in a first portion of the detection wavelength range and a substantially high transmission in the remaining portion of the detection wavelength range. Each second region has a substantially high transmission in the detection wavelength range.

Abstract: A retroreflective system is disclosed that includes a retroreflective sheet for retroreflecting light, and a light control film disposed on the retroreflective sheet. For a first wavelength, light incident on the light control film at each of a first and second angles of incidence is retroreflected. For a second wavelength, light incident on the light control film at the first, but not the second, angle of incidence is retroreflected.

Abstract: Compositions and methods useful in identifying and selecting maize plants with increased ear weight and yield are provided herein. The methods use molecular genetic markers to identify and/or select maize plants with increased ear weight and increased yield or to identify and counter-select maize plants with decreased ear weight and decreased yield.

Abstract: Compositions and methods useful in identifying and selecting maize plants with increased ear weight and yield are provided herein. The methods use molecular genetic markers to identify and/or select maize plants with increased ear weight and increased yield or to identify and counter-select maize plants with decreased ear weight and decreased yield.

Abstract: A protective cap having finger grips, a window, and port. The protective cap may also have one or more clips (or snaps), one or more relief slots, and/or one or more guides. Protective cap 200 may also have a fill indicator and/or a material relief. An insertion system having a handpiece, a pushrod assembly, a cartridge, and a cap with a window and a port. The cap is configured and dimensioned to couple with the distal end of the cartridge. The insertion system may also have a pushrod with a plunger having a marker configured and dimensioned to indicate axially translation of the pushrod assembly within the handpiece.

Abstract: A cap configured and dimensioned to sweep or fold one or more haptics when removed from an insertion device. The cap may further have a pin, one or more snaps and/or one or more locks. The cap may also have one or more ports and/or one or more windows. An insertion system having a handpiece, a cartridge, and a cap configured and dimensioned to sweep or fold one or more haptics when the cap is removed from the insertion system. The cap is configured and dimensioned to couple with the distal end of the cartridge.

Abstract: A lens case for storing an intraocular lens contains a housing for storing an intraocular lens and a support member configured to support the intraocular lens. The support member includes a plurality of jaws, the jaws having a closed configuration for holding the intraocular lens and an open configuration for releasing the intraocular lens. The lens case further comprises a passage formed when the jaws are in the open configuration, the passage including an opening in the lens case for transfer of the intraocular lens into an intraocular lens inserter. The lens case may further comprise an intraocular lens that is disposed between the jaws, the intraocular lens comprising an optic and a haptic coupled to the optic. The lens case may be configured to maintain the haptic in either a first position in which a distal portion of the haptic is disposed farther from the optic or a second position in which the distal portion of the haptic is disposed closer to optic.

Abstract: A cap configured and dimensioned to sweep or fold one or more haptics when removed from an insertion device. The cap may further have a pin, one or more snaps and/or one or more locks. The cap may also have one or more ports and/or one or more windows. An insertion system having a handpiece, a cartridge, and a cap configured and dimensioned to sweep or fold one or more haptics when the cap is removed from the insertion system. The cap is configured and dimensioned to couple with the distal end of the cartridge.

Abstract: A lens case for storing an intraocular lens contains a housing for storing an intraocular lens and a support member configured to support the intraocular lens. The support member includes a plurality of jaws, the jaws having a closed configuration for holding the intraocular lens and an open configuration for releasing the intraocular lens. The lens case further comprises a passage formed when the jaws are in the open configuration, the passage including an opening in the lens case for transfer of the intraocular lens into an intraocular lens inserter. The lens case may further comprise an intraocular lens that is disposed between the jaws, the intraocular lens comprising an optic and a haptic coupled to the optic. The lens case may be configured to maintain the haptic in either a first position in which a distal portion of the haptic is disposed farther from the optic or a second position in which the distal portion of the haptic is disposed closer to optic.

Abstract: A surgical clip applier includes a train of clips disposed in a plane with a single clip removed from the train of clips and disposed in a staging position. A pair of jaws are adapted to receive the single clip from the staging position by operation of a jaw loader moveable outside the plane of the train of clips. In an associate method, a handle assembly is provided which is moveable in an open stroke and a closed stroke. A source of surgical clips are provided along with a pair of jaws which are adapted to receive one of the clips as the handle assembly is moved in an open stroke, the jaws are open to receive the clip. Following the opening of the jaws, a jaw loader is extended to a position between the jaws to move the clip into the jaws. The handle assembly is moveable in a closed stroke during which the jaws are closed to crimp the clip. Prior to this closing of the jaws, the jaw loader is retracted from the position between the jaws leaving the clip in the jaws.

Abstract: A pushrod tip having a top and bottom jaw, wherein the top and bottom jaws are coupled together to form an opening, wherein the top jaw is capable of flexing towards the bottom jaw when the pushrod tip is passed through a lumen. A pushrod having a top and bottom jaw, each with a first and second side along a longitudinal axis of the pushrod; the top and bottom jaw are coupled together; and the top jaw comprises a notch on the first side of the pushrod. An insertion system having a handpiece with a channel(s); and a pushrod assembly having a pushrod and a plunger; the pushrod having a rail(s) that is configured to couple with the channel(s) of the handpiece. An insertion system having a handpiece with a detent(s) and a key(s); and a pushrod assembly having a pushrod, a plunger, and a nut lock that has a series of radial keyways and a groove. The groove of the nut lock is configured to mate with the detent(s), and the series of radial keyways are configured to mate with the key(s).

Abstract: A system for easily transferring an intraocular lens (IOL) from an inserter into a patient's eye. The system includes an inserter handpiece with a holding station for receiving or storing an IOL. The IOL may be pre-loaded within the holding station during manufacture, and the inserter handpiece coupled to a delivery tube so that the entire system is ready for use by a surgeon to implant an IOL. The IOL may have an optic and leading and trailing haptics coupled to the optic, and the holding station may be capable of manipulating the haptics as desired to facilitate transfer of the IOL through the delivery tube into the eye. For instance, the holding station may fold one or both of the haptics over the optic. Preferably, the holding station maintains the haptics in their folded positions during transfer of the IOL into the delivery tube. The holding station desirably maintains the IOL in a relaxed configuration during storage.