Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: A fastener driver includes a housing, a cylinder disposed within the housing, a piston positioned and moveable within the cylinder, and a driver blade. The driver blade includes a body defining a first end having an aperture defined therein, a second end opposite the first end, and a plurality of teeth between the first and second ends. The aperture is sized to receive a fastener to attach the driver blade to the piston. The driver blade is moveable with the piston from a first position toward a second position along a longitudinal axis during a fastener driving operation. A nosepiece at least partially defining a fastener driving track through which fasteners are driven. A total length of the fastener driver as measured between a distal end of the nosepiece and a distal end of the cylinder is less than 11.4 inches (289.6 mm).

Abstract: Provided herein are methods for preparing an SHP2 inhibitor and intermediates useful therein.

Abstract: Active end-effectors for guiding an instrument during a robot-assisted surgery. The surgical robot system may include a robot having a robot base, a robot arm coupled to the robot base, and the active end-effector coupled to the robot arm. The active end-effector may have a slide mechanism, which may provide for a greater range of motion of a surgical instrument along a vertical axis.

Abstract: Techniques are provided for implementing and using a travelling wave resonator, comprising planar optical waveguide including at least two stacked cores, to diminish Kerr effect in the travelling wave resonator. The travelling wave resonator may be used in a resonator optical gyroscope.

Abstract: A shoulder implant system comprising a glenoid implant; a baseplate comprising an implant facing surface to face the glenoid implant; wherein the glenoid implant comprises at least one fixation element configured to engage with at least one fixation element of the baseplate; wherein the at least one fixation element of the glenoid implant comprises a center post having a distal end; wherein the at least one fixation element of the baseplate comprises a center post receptacle; wherein the baseplate comprises an outer periphery; wherein the implant facing surface of the baseplate comprises a channel which extends from the outer periphery of the baseplate to the center post receptacle of the baseplate; and wherein the channel is configured such that, during an assembly of the glenoid implant and the baseplate, the distal end of the post is movable in the channel from the outer periphery of the baseplate to the center post receptacle of the baseplate.

Abstract: Systems and methods to extend a life of a component of a cylinder deactivation system are provided. A method includes initiating, by a controller, a CDA mode for an engine; determining, by the controller, a first cycle count for a first oil control solenoid of the CDA system; determining, by the controller, a second cycle count for a second oil control solenoid of the CDA system; comparing, by the controller, the first cycle count and the second cycle count; and modifying, by the controller, operation of the CDA mode for the engine based on the comparison.

Abstract: Devices, systems, and methods for treating pulmonary disease are disclosed herein. According to some embodiments, the present technology includes identifying diseased tissue on a lobe of the patient's lung, collapsing the lobe, and percutaneously inserting a device into the patient and a therapeutic element carried by the device. The present technology further includes thoracoscopically delivering the therapeutic element into the patient's chest cavity, administering the therapeutic element on and around at least the diseased tissue, and applying an atraumatic compressive load to and/or restricting expansion of at least a portion of the diseased tissue.

Abstract: The present disclosure is directed to compositions, methods and kits for amplifying target nucleic acids while reducing non-specific amplification and undesired amplification products using a dual hot start reaction mixture that comprise at least two different hot start mechanisms.

Abstract: A system and method for a procedure that can be performed on any appropriate subject. Procedures can include assembling any appropriate work piece or installing members into a work piece, such as an airframe, autoframe, etc. Regardless of the subject, tracking a substantially small tracking device in a plurality of degrees of freedom is provided. The tracking device can be positioned on or be formed in an instrument to be tracked.

Abstract: A lubricant supply system is for a compressor that compresses a first working fluid in a heat transfer circuit. The lubricant supply system includes a lubricant tank, a lubricant pathway for supplying lubricant from the lubricant tank to one or more bearings of the compressor, and a lubricant refrigeration system with a lubricant heater and a lubricant cooler. The lubricant heater configured to heat the lubricant discharged from the one or more bearings and the lubricant cooler configured to cool the lubricant flowing through the lubricant pathway. A method of lubricating a compressor includes heating the lubricant, directing the lubricant from a lubricant tank through a lubricant pathway to one or more bearings of the compressor, and cooling the lubricant passing through the lubricant pathway.

Abstract: A device for providing sets of cards having repurposed cards includes at least a first card handling means comprising a card supply means and a plurality of card storage means. The card handling means includes at least one card grouping means adapted to merge cards from different series of the plurality of series of randomly ordered cards, into a group of cards. A control means is adapted to identify each card of the plurality of series of randomly ordered cards; assign each identified card to one of the plurality of card storage means; and control the card supply means and/or the card grouping means to merge one or more identified cards assigned to the same card storage means, into the group of cards. A group delivering means is adapted to deliver the group of cards in the card grouping means into the card storage means.

Abstract: An anti-buckling device for an interventional device assembly includes a telescoping tube having a plurality of concentric telescopically axially extendable and collapsible tube segments each having a proximal end and a distal end, the plurality of tube segments having an innermost tube segment and one or more outer tube segments, the innermost tube segment being configured to couple to a hub of an interventional device assembly, the telescoping tube being configured to extend distally from the hub. Each of the one or more outer tube segments is coupled to a cap at its proximal end, the cap having a through hole configured to receive an interventional device of the interventional device assembly therethrough and an outer diameter greater than an outer diameter of the outer tube segment to which the cap is coupled.

Abstract: Embodiments of the present invention provide for methods of treating cancer and methods of delivering toll-like receptor (TLR) agonists to solid tumors in the liver using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating primary liver cancers such as hepatocellular carcinoma (HCC) and intra-hepatic cholangiocarcinoma (ICC) comprising administering TLR9 agonists to the liver.

Abstract: A clamp assembly is provided with a band having a length sized to wrap about a joint. A plurality of retainer segments is attached to the band to engage a peripheral flange of a pair of tube ends at the joint. A first threaded fastener is connected to the band at a first location. A second threaded fastener is sized to engage the band at a second location to extend to the first threaded fastener to fasten to the first threaded fastener upon rotation of the second threaded fastener to tighten the band and the plurality of retainer segments to clamp the joint.

Abstract: System, apparatus, and methods are disclosed for identifying passing opportunities for a vehicle and controlling the vehicle in response to the passing opportunities. For example, operation of one or more components of the vehicle can be changed in advance of attempting the pass to better prepare the vehicle for acceleration to initiate and complete the pass attempt. Operation of one or more components of the vehicle can be changed during passing to assist the vehicle in completing the pass.

Abstract: An engine can utilize a combustor to combust fuel to drive the engine. A fuel nozzle assembly can supply fuel to the combustor for combustion or ignition of the fuel. The fuel nozzle assembly can include a swirler and a fuel nozzle to supply a mixture of fuel and air for combustion. The fuel nozzle can include both a primary and secondary fuel passage, and an additional air passage to provide for greater flame control, fuel provision, or local fuel and air mixing prior to combustion.

Abstract: Various embodiments of systems, devices, components, and methods for providing external therapeutic vibration stimulation to a patient are disclosed and described. Therapeutic vibration stimulation is provided to at least one location on or adjacent to a patient's skin (such as through clothing or a layer disposed next to the patient's skin), and is configured to trigger or induce resonance or high amplitude oscillations in a cardiovascular system of the patient. Inducing such resonance can aid in training autonomic reflexes and improve their functioning.

Abstract: The invention includes systems and methods for fabrication and use of an assembly for a component of a robot. The assembly includes a first member including a set of electrically conductive annular surfaces, and a second member including a set of electrically conductive components configured to contact the set of electrically conductive annular surfaces. The first member and the second member are included within the component of the robot. Each component in the set of electrically conductive components includes a first convex curvilinear portion configured to contact a corresponding annular surface in the set of electrically conductive annular surfaces.

Abstract: Described herein are compounds that are EP2 antagonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of diseases or conditions associated with EP2 activity.