Abstract: The present invention provides membrane lytic poly(amido amine) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.

Abstract: Some embodiments provide irrigation valve control apparatuses comprising: multiple terminals coupled with a multi-wire path; a first charge storage circuitry electrically coupled with at least one of the multiple terminals, wherein the first charge storage circuitry is configured to be charged by a voltage on the multi-wire path; a control circuitry configured to determine the voltage on the multi-wire path; and a boost circuitry controlled by the control circuitry, wherein the control circuitry in response to determining that the voltage on the multi-wire path is below a threshold activates the boost circuitry to increase a voltage stored by the first charge storage circuitry.

Abstract: The disclosure pertains to amphiphilic block copolymers comprising an aliphatic polycarbonate chain coupled to a hydrophilic polymer. Such amphiphilic polymers may have the formula A-L-B, where A- is a polycarbonate or polyethercarbonate chain having from about 3 to about 500 repeating units, L is a linker moiety and —B is a hydrophilic oligomer having from about 4 to about 200 repeating units. Provided copolymers are useful as surfactants capable of emulsifying aqueous solutions and supercritical carbon dioxide. Provided copolymers also have utility as additives for use in enhanced oil recovery methods.

Abstract: A fire resistant shutter is provided including a first panel including wood and a second panel including a cementitious material located adjacent to the first panel. The fire resistant shutter further includes a hasp attached to the second panel and configured to be attached to a building structure with a detachable connector, and a pin including wax disposed in an aperture defined by the hasp. The pin prevents the hasp from opening. When the fire resistant shutter is attached to a building structure, heat from an approaching fire at least partially melts the pin, which opens the hasp, detaches the connector, and allows the shutter to drop. The deployed shutter provides fire resistance to the building structure, such as at a window.

Abstract: A first oligomerization stream is oligomerized over a first catalyst in a first oligomerization reactor zone to make oligomerate. An oligomerate stream is separated to provide a heavy oligomerate boiling in the diesel range and a second oligomerization feed stream. The latter is fed to a second oligomerization reactor zone with a second different catalyst to produce the heavy oligomerate.

Abstract: Wellbore fluid compositions containing a base fluid; at least one synthetic fiber; and a particulate solid; where one or more of the at least one synthetic fiber and the particulate solid are completely or substantially acid soluble are provided. In another aspect, methods of reducing loss of wellbore fluid in a wellbore to a formation are provided, including: introducing into the wellbore a fluid composition comprising one or more synthetic fibers and one or more particulate solids.

Abstract: In an example embodiment, a patent portfolio management tool automatically tracks changes in ownership information of a patent matter listed in a database at a patent registry. The method comprises receiving input from a user identifying the patent matter, with the input further including data associated with a plurality of fields of enquiry relating to a change in ownership information of the patent matter.

Abstract: In one aspect, an elastic averaging strap system for securing an object to a component having an aperture is provided. The system includes a strap having a first end and a second end. The strap second end couples to the strap first end such that the strap forms a loop around the object to retain the object therein. An alignment member extends from the first end, and the alignment member is an elastically deformable material such that when the alignment member is inserted into the component aperture, the alignment member elastically deforms to an elastically averaged final configuration to facilitate positioning the object in a desired orientation relative to the component.

Abstract: Techniques are described for spreading the data into statistically meaningful visualizations and generating reports. A method comprising providing a graphical user interface displaying a data chart and a plurality of available options for data spreading models, receiving a first user input via the graphical user interface selecting one or more data elements of the data chart, receiving a second user input via the graphical user interface selecting a data spreading model from among the plurality of available options for data spreading models, generating a revised data chart based on the one or more data elements of the data chart in accordance with the data spreading model, wherein the revised data chart renders the one or more data elements of the data chart in a modified representation within the chart in accordance with the data spreading model, and outputting for display the revised data chart.

Abstract: The present invention is a photodiode or photodiode array having improved ruggedness for a shallow junction photodiode which is typically used in the detection of short wavelengths of light. In one embodiment, the photodiode has a relatively deep, lightly-doped P zone underneath a P+ layer. By moving the shallow junction to a deeper junction in a range of 2-5 ?m below the photodiode surface, the improved device has improved ruggedness, is less prone to degradation, and has an improved linear current.

Abstract: Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.

Abstract: Methods of treating disorders in which TNF? activity is detrimental via biweekly, subcutaneous administration of human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor ? (hTNF?) are disclosed. The antibody may be administered with or without methotrexate. These antibodies have high affinity for hTNF? (e.g., Kd=10?8 M or less), a slow off rate for hTNF? dissociation (e.g., Koff=10?3 sec?1 or less) and neutralize hTNF? activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Kits containing a pharmaceutical composition and instructions for dosing, and preloaded syringes containing pharmaceutical compositions are also encompassed by the invention.

Abstract: One embodiment of the present invention may take the form of a method and a system for performance enhancing proxy (PEP). A PEP system may include a configuration of software components and hardware devices to increase the performance of a two-way satellite broadband service. The PEP system may include one or more embodiments to reduce the time necessary for users to transmit and receive data provided through a communication network.

Abstract: A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule.

Abstract: This invention is directed to methods for recovery of C3-C6 alcohols. The recovery process advantageously utilizes the immiscible properties of a first phase liquid and a second phase liquid to separate the liquids prior to processing C3-C6 alcohols to recovery. The invention is also directed to C3-C6 alcohol-containing compositions.

Abstract: A power tool includes a housing, a motor enclosed within the housing, and a work element configured to be driven by the motor. A trigger is movably secured to the housing for controlling power to the motor. A locking assembly is provided that includes a lock-OFF mechanism configured to lock the trigger in the OFF position and a lock-ON mechanism configured to lock the trigger in the ON position.

Abstract: A data processing system comprising a host computer system and a network interface device for connection to a network, the host computer system and network interface device being coupled together by means of a data bus, and: the network interface device comprising: a controller unit having a first data port for connection to a network, a second data port, and a data bus interface connected to said data bus, the controller unit being operable to perform, in dependence on the network endpoints to which data packets received at the network interface device are directed, switching of data packets between the first and second data ports and the data bus interface; and an accelerator module having a first medium access controller coupled to said second data port of the controller unit and a processor operable to perform one or more functions in hardware on data packets received at the accelerator module, the said first medium access controller being operable to support one or more first network endpoints; the host

Abstract: An electric motor assembly including a stator having a stator core and windings around the stator core is disclosed. The stator core has opposing ends and an outer surface extending between the opposing ends. The electric motor assembly also includes a housing having an inner surface enclosing at least a portion of the stator, and at least one fluid passage between the outer surface of the stator core and the inner surface of the housing. The fluid passage permits a coolant in the fluid passage to contact one or more portions of the outer surface of the stator core to remove heat from the stator core during operation of the electric motor assembly. Additional motor assemblies including stator and/or rotor cooling features are disclosed.

Abstract: The present disclosure relates to an oral, extended release, abuse deterrent pill containing at least one active pharmaceutical ingredient susceptible to abuse which is homogenously spread throughout a matrix used to deter abuse. The pill can be prepared using a hot melt extrusion process and a forming unit. The formed pill meets regulatory guidelines for extended release formulations and is abuse deterrent to parenteral administration due at least to particle size, viscosity, or purity limitations.

Abstract: Some embodiments provide irrigation valve control apparatuses comprising: a solenoid configured to cooperate with a plunger; an input stimulus source coupled with the solenoid and configured to apply an input stimulus while a plunger drive signal is not being applied and that is sufficiently small to not cause the plunger to move; sampling circuitry configured to measure one or more voltage measurements corresponding to one or more voltages across the solenoid, wherein the one or more voltage measurements are dependent upon the current position of the plunger relative to the solenoid; and control circuitry cooperated with the sampling circuitry to receive the one or more voltage measurements from the sampling circuitry, wherein the control circuitry is configured to determine whether the plunger is in one of the open and closed positions based on the one or more voltage measurements.