Abstract: A method, apparatus and system for transforming genomic data into a computer database environment comprising a forward lookup table and a plurality of reverse lookup tables which relate consecutive overlapping reference sequence segments to reference sequences stored in the forward lookup table enables rapid and precise matching of undefined biological sequences with reference sequences.

Abstract: A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.

Abstract: The present invention relates generally to medical apparatuses and methods and more particularly to devices and methods for positioning and anchoring a lining to a hollow body organ, such as a stomach, intestine or gastrointestinal tract.

Abstract: A portable imaging system for imaging a region of interest (ROI) includes a housing (12), a radiation detector(16)mounted to the housing (12), the detector generating radiation data indicating a location of gamma photon strikes on the detector, a motion sensor (20) which senses motion of the detector and outputs motion data indicative of the location and orientation of the detector at the time of each gamma photon strike, and at least one processor (22, 26) programmed to receive the radiation data from the radiation detectors (16) and the motion data from the motion sensor (20) and reconstruct a 3D volume image of the ROI from the received radiation and motion data.

Abstract: A process for producing a pharmaceutical suspension that comprises an active pharmaceutical ingredient (“API”) having low solubility, the process comprises: (a) preparing a first solution comprising a carboxy-containing vinyl polymer and a solvent; and (b) adding a compound of the API to said first solution under conditions of high-shear mixing for a time from about 5 minutes to about 5 hours, said compound being soluble in said solvent, thereby producing a suspension of particles of said API in a composition comprising said carboxy-containing vinyl polymer; wherein a concentration of said API in said suspension is higher than a solubility of said API in said solvent. The present invention also provides a suspension produced by such process.

Abstract: Systems and methods for delivering multiple ocular implants to reduce intraocular pressure are disclosed. The ocular implants can be implanted at multiple sites within a single human eye without requiring removal of the delivery apparatus from the eye. A system for delivering multiple ocular implants can include at least two implants preloaded within a delivery device and configured to be implanted within the eye, a metering device configured to transfer energy to the implants for delivery at selected locations within the eye, wherein the metering device is configured to meter a variable amount of energy for each implant delivery event in the eye. The system can further include an injector mechanism configured to serially engage and drive each of the implants.

Abstract: Some embodiments provide a method of designing an integrated circuit (IC). The design is expressed as a graph that includes several nodes that represent several IC components. The nodes include a first set of nodes that represent a set of clocked elements. The method creates a second set of nodes by removing all nodes in the first set from the nodes that represent the IC components. The method identifies a set of edges that connect two nodes in the second set without encompassing a third node in the second set. The method assigns an event time to each node in the second set. The method assigns a cost function based on the event times of the nodes connected by each edge and the number of nodes in the first set encompassed by each edge. The method optimizes the cost function and places the components based on the cost function optimization.

Abstract: A floor treatment apparatus is provided that includes a chassis that supports at least one cleaning element. The chassis is supported by a plurality of wheels, one which is steerable via a steering wheel interconnected to a housing also associated with the chassis. The chassis provided includes a plurality of movable housing members, one of which is associated with the steering wheel. To access the internal components of the floor treatment apparatus, the front housing is rotated or moved away from the other housings wherein the steering wheel does not require disconnection to allow this movement.

Abstract: The invention relates to an imaging system for imaging a periodically moving object. An assigning unit (18) assigns ultrasound signals like A-lines to motion phases based on a provided phase signal, wherein an ultrasound images generation unit (19) generates several ultrasound images like gated M-mode images for the different motion phases based on the ultrasound signals assigned to the respective motion phase. A selecting unit (20) is used to select an ultrasound image from the generated ultrasound images, wherein a display unit (21) displays the selected ultrasound image. The selected ultrasound image corresponds therefore to a single motion phase only such that motion artifacts in the displayed ultrasound image are reduced. The imaging system is particularly useful for, for instance, monitoring cardiac ablation procedures.

Abstract: Systems and methods for training users to more proficiently make wildlife calls, whether for hunting or other purposes, are described herein. For instance, an embodiment of an interactive learning system can train an enthusiast to more consistently and proficiently make calls that are efficacious with attracting wildlife. The system may implement advanced signal processing techniques that can compare a user-generated signal (attempting to mimic a wildlife call) with a prerecorded wildlife call. The system may provide feedback to the user to enable the user to assess his or her performance in reproducing the wildlife call. The user can use the feedback to improve reproduction of the wildlife call.

Abstract: A flexible membrane for use in a carrier head has a generally circular main portion with a lower surface, an annular outer portion for connection to a base assembly, and an annular flap extending from the main portion on a side opposite the lower surface for connection to the base assembly. At least one surface of the flap has a surface texture to prevent adhesion.

Abstract: In a first aspect, a system for playing a video game is provided that includes (1) one or more sensors adapted to monitor one or more biometric parameters of a user and communicate the one or more monitored biometric parameters (MBPs); (2) a computing device adapted to communicate with the one or more sensors and to receive the one or more communicated MBPs; and (3) a video game having an avatar adapted to move an object on an incline, the video game adapted to execute on the computing device. The video game is adapted to control the avatar to perform an action in the video game based in part on the received one or more communicated MBPs. Numerous other aspects are provided.

Abstract: Embodiments described herein generally relate to an electrostatic chuck (ESC). The ESC may contain a first plurality of electrodes adapted to electrostatically couple a substrate to the ESC and a second plurality of electrodes adapted to electrostatically couple the ESC to a substrate support. Instead of being integrally disposed within the substrate support, the ESC may be easily removed from the substrate support and removed from a chamber for maintenance or replacement purposes.

Abstract: A method for managing an electronic document (ED) using an electronic content management (ECM) system, including: receiving a submission comprising the ED; generating a unique identifier (UID), a first version number, and a first mapping linking the UID and the first version number to the ED; inserting a first symbol corresponding to the UID and the first version number into the ED; generating a first archived document corresponding to the ED and comprising the first symbol; distributing the first archived document; receiving a submission comprising a revised version of the ED from a user; generating a second version number and a second mapping linking the UID and the second version number to the revised version; inserting a second symbol corresponding to the UID and the second version number into the revised version; and generating a second archived document corresponding to the revised version and comprising the second symbol.

Abstract: A method of performing a dynamic built-in self-test (BIST). The method includes performing a first test of a circuit on a semiconductor chip. The first test includes a first switch factor. The circuit during the first test is monitored with one or more sensors. A first sensor value of one or more sensors monitoring the circuit is determined. It is also determined whether the first sensor value is within a range of a programmable constant. A second switch factor is determined in response to determining that the first sensor value outside the range of the programmable constant.

Abstract: A vehicle instrument panel assembly configured to determine an orientation angle of a stepper motor actuated pointer of the assembly. The assembly includes a pointer, a stepper motor, a magnet, and a sensor. The pointer is movable about an axis to point to indicia on a display surface of the assembly. The stepper motor is coupled to the pointer via a reduction gear arrangement. The magnet is fixedly coupled to the pointer such that a magnetic field direction generated by the magnet corresponds to an angle of the pointer. The sensor is configured to determine the magnetic field direction of the magnet and output a signal indicative of the angle of the pointer.

Abstract: An electrical machine includes a stator having a stator winding and a secondary transformer coil. A rotor is operatively connected to rotate relative to the stator, wherein the rotor includes a plurality of embedded permanent magnets. A primary transformer coil is wound on the rotor and is operatively connected to form a rotating transformer with the secondary transformer coil. An inverter/active rectifier component is operatively connected to the stator winding and the secondary transformer coil to control the stator winding based on a sense in the secondary transformer coil received from the primary transformer coil.

Abstract: A docking stand for an electronic device. The docking stand can include a bottom support surface configured to support a bottom side of the electronic device. The docking stand also can include a back support surface configured to support a side of the electronic device. The back support surface can be substantially upright when a base of the docking stand is placed on a substantially horizontal surface. The docking stand further can include a docking connector configured to removably attach to a docking port of the electronic device. The docking port can be proximate to the bottom side of the electronic device. The docking stand also can include an adjustment mechanism configured to adjust a height of the docking connector relative to the bottom support surface. Other embodiments are provided.

Abstract: The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II ? and ? polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.

Abstract: A fiber optic connector including a connector body including a distal end and a proximal end. The distal end forming a plug end of the connector body and an optical fiber routed through the connector body. The optical fiber having an end face accessible at the plug end of the connector body and a strain relief boot that mounts at the proximal end of the connector body. The strain relief boot defines a longitudinal axis that extends through the strain relief boot between distal and proximal ends of the strain relief boot. The strain relief boot includes an interior surface that defines a fiber passage through which the optical fiber is routed; the fiber passage extends along the longitudinal axis of the boot. The strain relief boot includes an exterior surface that defines a tapered exterior shape that tapers inwardly toward the longitudinal axis as the tapered exterior shape extends in a proximal direction along the longitudinal axis.