Abstract: Provided herein are certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. He conjugates are useful to treat certain diseases, such as acromegaly.

Abstract: An aero damping measurement system is provided. The system includes a shroud defining a tunnel, a hub disposed within the tunnel, and a plurality of blades coupled to the hub. The blades may rotate about the hub. A gas pressure probe may have a tip extending to the tunnel to deliver a pressurized burst into the tunnel. An aeromechanical identification system may include a pressurized gas source, a valve in fluid communication with the pressurized gas source, and the gas pressure probe may be in fluid communication with the valve. The valve may control a flow of a pressurized gas from the pressurized gas source into the gas pressure probe. A pressure sensor may be coupled to the gas pressure probe and configured to measure a pressure within the gas pressure probe.

Abstract: A delivery catheter comprises an inner shaft and an outer sheath. A stent-graft is held on a region of the inner shaft. An enlarged diameter distal region of the outer sheath constrains the stent-graft. Its retraction allows the stent-graft to deploy. A finger wheel on a handle is used to retract the outer sheath and is coupled to a sliding block with cable(s). The sliding block is coupled to the outer sheath and is held within a sliding track. The wheel can be actuated to tension the cable(s) and deform latch(es) coupled to sliding block, freeing them from slot(s) in the sliding track and allowing retraction of the sliding block and the outer sheath. A reinforcement sleeve is coupled to a smaller diameter proximal region of the outer sheath. A gap between the outer sheath distal region and the reinforcement sleeve allows the distal outer shaft region to be retracted.

Abstract: A computer-implemented method to generate a graphical user interface for a lead management system includes calculating, by a lead management system, lead management data based on determined type and format of the data and raw lead management data, generating first machine-readable instructions to render a graphical user interface including a first lead management data graphical representation, the first lead management data graphical representation including one or more graphical representations of electronic cards each configurable between: (i) a first orientation in which the electronic card displays a portion of the calculated lead management data; and (ii) a second orientation in which the electronic card displays first and second data relating to the type and format of the portion of the calculated lead management data, and transmitting, to a user electronic device, the first machine-readable instructions so as to cause the user electronic device to render the graphical user interface on a display associ

Abstract: A novel maize variety designated X18R892 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X18R892 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X18R892 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X18R892, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X18R892 are provided. Methods for producing maize varieties derived from maize variety X18R892 and methods of using maize variety X18R892 are disclosed.

Abstract: A novel maize variety designated X18R893 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X18R893 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X18R893 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X18R893, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X18R893 are provided. Methods for producing maize varieties derived from maize variety X18R893 and methods of using maize variety X18R893 are disclosed.

Abstract: Disclosed are methods, systems, and devices for the endovascular repair of cardiac valves, particularly the atrioventricular valves which inhibit back flow of blood from a heart ventricle during contraction. The procedures described herein can be performed with interventional tools, guides and supporting catheters and other equipment introduced to the heart chambers from the patient's arterial or venous vasculature remote from the heart. The interventional tools and other equipment may be introduced percutaneously or may be introduced via a surgical cut down, and then advanced from the remote access site through the vasculature until they reach the heart.

Abstract: A novel maize variety designated PH4C1K and seed, plants and plant parts thereof are provided. Methods for producing a maize plant comprise crossing maize variety PH4C1K with another maize plant are provided. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH4C1K through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby are provided. Hybrid maize seed, plants or plant parts are produced by crossing the variety PH4C1K or a locus conversion of PH4C1K with another maize variety.

Abstract: A delivery catheter comprises an inner shaft and an outer sheath. A stent-graft is held on a region of the inner shaft. An enlarged diameter distal region of the outer sheath constrains the stent-graft. Its retraction allows the stent-graft to deploy. A finger wheel on a handle is used to retract the outer sheath and is coupled to a sliding block with cable(s). The sliding block is coupled to the outer sheath and is held within a sliding track. The wheel can be actuated to tension the cable(s) and deform latch(es) coupled to sliding block, freeing them from slot(s) in the sliding track and allowing retraction of the sliding block and the outer sheath. A reinforcement sleeve is coupled to a smaller diameter proximal region of the outer sheath. A gap between the outer sheath distal region and the reinforcement sleeve allows the distal outer shaft region to be retracted.

Abstract: An apparatus and methods for tissue restoration are provided. The apparatus may include a catheter shaft extending from a proximal end to a distal tip, the catheter shaft defining lumens including an inflation lumen and a light fiber lumen, a coated balloon positioned on a translucent distal segment of the catheter shaft proximal to the distal tip in fluid communication with the inflation lumen, the coated distal balloon comprising a translucent material and a coated material on an outer surface of the coated balloon, and a light fiber positioned in the catheter shaft in the light fiber lumen and extending through the translucent distal segment.

Abstract: A novel maize variety designated X18N892 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X18N892 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X18N892 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X18N892, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X18N892 are provided. Methods for producing maize varieties derived from maize variety X18N892 and methods of using maize variety X18N892 are disclosed.

Abstract: A novel maize variety designated X18N907 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X18N907 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X18N907 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X18N907, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X18N907 are provided. Methods for producing maize varieties derived from maize variety X18N907 and methods of using maize variety X18N907 are disclosed.

Abstract: A novel maize variety designated PH4C1K and seed, plants and plant parts thereof are provided. Methods for producing a maize plant comprise crossing maize variety PH4C1K with another maize plant are provided. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH4C1K through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby are provided. Hybrid maize seed, plants or plant parts are produced by crossing the variety PH4C1K or a locus conversion of PH4C1K with another maize variety.

Abstract: The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

Abstract: The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

Abstract: Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.

Abstract: The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

Abstract: A method disclosed assists users to schedule an appointment at a desired time and venue, given a number of open possibilities at one or more venues. This method is explained through its application aimed at assisting golf players to reserve a tee time by using possible event times at venues within the users' defined search for a particular tee time of a given time of day at each golf course. This algorithm allows a user to determine how quickly or slowly golf play may occur based on the number of golfers playing during a particular time period and consecutive and non-consecutive tee time availability. Through the user interface, nearby golf courses can be compared for the user to select a preferred tee time based on crowdedness and tee time availability. The method can be effective for bowling alleys, doctors' visits and other similar applications.

Abstract: A hand-held fluid substance applicator for applying a fluid substance to a skin surface is provided. The hand-held fluid substance applicator includes a first body having a middle portion extending continuously between a front side and rear side. The first body forms a first chamber that can hold a fluid substance, wherein the first chamber is in fluid communication with a first pad. A first valve dispenses the fluid substance to the first pad upon increased pressure in the first chamber. A second body is removably secured to the first body and includes a second chamber in fluid communication with a second pad, wherein the second chamber can hold the fluid substance. The first pad is used to apply the fluid substance to a first part of a user's body and the second pad is used to apply the fluid substance, or a second fluid substance, to a second part of a user's body.