Abstract: A hand-held fluid substance applicator for applying a fluid substance to a skin surface is provided. The hand-held fluid substance applicator includes a first body having a middle portion extending continuously between a front side and rear side. The first body forms a first chamber that can hold a fluid substance, wherein the first chamber is in fluid communication with a first pad. A first valve dispenses the fluid substance to the first pad upon increased pressure in the first chamber. A second body is removably secured to the first body and includes a second chamber in fluid communication with a second pad, wherein the second chamber can hold the fluid substance. The first pad is used to apply the fluid substance to a first part of a user's body and the second pad is used to apply the fluid substance, or a second fluid substance, to a second part of a user's body.

Abstract: An aero damping measurement system is provided. The system includes a shroud defining a tunnel, a hub disposed within the tunnel, and a plurality of blades coupled to the hub. The blades may rotate about the hub. A gas pressure probe may have a tip extending to the tunnel to deliver a pressurized burst into the tunnel. An aeromechanical identification system may include a pressurized gas source, a valve in fluid communication with the pressurized gas source, and the gas pressure probe may be in fluid communication with the valve. The valve may control a flow of a pressurized gas from the pressurized gas source into the gas pressure probe. A pressure sensor may be coupled to the gas pressure probe and configured to measure a pressure within the gas pressure probe.

Abstract: Disclosed are methods, systems, and devices for the endovascular repair of cardiac valves, particularly the atrioventricular valves which inhibit back flow of blood from a heart ventricle during contraction. The procedures described herein can be performed with interventional tools, guides and supporting catheters and other equipment introduced to the heart chambers from the patient's arterial or venous vasculature remote from the heart. The interventional tools and other equipment may be introduced percutaneously or may be introduced via a surgical cut down, and then advanced from the remote access site through the vasculature until they reach the heart.

Abstract: The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

Abstract: Systems for autonomous management of hyperconverged distributed computing and storage systems. A method embodiment commences upon receiving a set of system measurements that correspond to system metrics associated with the computing system. A user interface is presented to users to capture a set of user sentiment indications. Over a period of time, a time series of system measurements and a time series of user sentiment indications are captured and used to form a learning model that comprises dynamically-changing user sentiment correlations between the system measurements and the user sentiment. At some moment in time, a system metric threshold breach event occurs. The learning model is consulted to determine a tracking value between the set of user sentiment indications and the system metric pertaining to the system metric threshold. Based on the tracking value, the respective system metric threshold is adjusted to more closely track with the historical user sentiment indications.

Abstract: An aero damping measurement system is provided. The system includes a shroud defining a tunnel, a hub disposed within the tunnel, and a plurality of blades coupled to the hub. The blades may rotate about the hub. A gas pressure probe may have a tip extending to the tunnel to deliver a pressurized burst into the tunnel. An aeromechanical identification system may include a pressurized gas source, a valve in fluid communication with the pressurized gas source, and the gas pressure probe may be in fluid communication with the valve. The valve may control a flow of a pressurized gas from the pressurized gas source into the gas pressure probe. A pressure sensor may be coupled to the gas pressure probe and configured to measure a pressure within the gas pressure probe.

Abstract: The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

Abstract: Systems for autonomous management of hyperconverged distributed computing and storage systems. A method embodiment commences upon receiving a set of system measurements that correspond to system metrics associated with the computing system. A user interface is presented to users to capture a set of user sentiment indications. Over a period of time, a time series of system measurements and a time series of user sentiment indications are captured and used to form a learning model that comprises dynamically-changing user sentiment correlations between the system measurements and the user sentiment. At some moment in time, a system metric threshold breach event occurs. The learning model is consulted to determine a tracking value between the set of user sentiment indications and the system metric pertaining to the system metric threshold. Based on the tracking value, the respective system metric threshold is adjusted to more closely track with the historical user sentiment indications.

Abstract: A delivery catheter comprises an inner shaft and an outer sheath. A stent-graft is held on a region of the inner shaft. An enlarged diameter distal region of the outer sheath constrains the stent-graft. Its retraction allows the stent-graft to deploy. A finger wheel on a handle is used to retract the outer sheath and is coupled to a sliding block with cable(s). The sliding block is coupled to the outer sheath and is held within a sliding track. The wheel can be actuated to tension the cable(s) and deform latch(es) coupled to sliding block, freeing them from slot(s) in the sliding track and allowing retraction of the sliding block and the outer sheath. A reinforcement sleeve is coupled to a smaller diameter proximal region of the outer sheath. A gap between the outer sheath distal region and the reinforcement sleeve allows the distal outer shaft region to be retracted.

Abstract: The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

Abstract: Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.

Abstract: Disclosed are methods, systems, and devices for the endovascular repair of cardiac valves, particularly the atrioventricular valves which inhibit back flow of blood from a heart ventricle during contraction. The procedures described herein can be performed with interventional tools, guides and supporting catheters and other equipment introduced to the heart chambers from the patient's arterial or venous vasculature remote from the heart. The interventional tools and other equipment may be introduced percutaneously or may be introduced via a surgical cut down, and then advanced from the remote access site through the vasculature until they reach the heart.

Abstract: A delivery catheter comprises an inner shaft and an outer sheath. A stent-graft is held on a region of the inner shaft. An enlarged diameter distal region of the outer sheath constrains the stent-graft. Its retraction allows the stent-graft to deploy. A finger wheel on a handle is used to retract the outer sheath and is coupled to a sliding block with cable(s). The sliding block is coupled to the outer sheath and is held within a sliding track. The wheel can be actuated to tension the cable(s) and deform latch(es) coupled to sliding block, freeing them from slot(s) in the sliding track and allowing retraction of the sliding block and the outer sheath. A reinforcement sleeve is coupled to a smaller diameter proximal region of the outer sheath. A gap between the outer sheath distal region and the reinforcement sleeve allows the distal outer shaft region to be retracted.

Abstract: Disclosed are methods, systems, and devices for the endovascular repair of cardiac valves, particularly the atrioventricular valves which inhibit back flow of blood from a heart ventricle during contraction. The procedures described herein can be performed with interventional tools, guides and supporting catheters and other equipment introduced to the heart chambers from the patient's arterial or venous vasculature remote from the heart. The interventional tools and other equipment may be introduced percutaneously or may be introduced via a surgical cut down, and then advanced from the remote access site through the vasculature until they reach the heart.

Abstract: A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.

Abstract: An aero damping measurement system is provided. The system includes a shroud defining a tunnel, a hub disposed within the tunnel, and a plurality of blades coupled to the hub. The blades may rotate about the hub. A gas pressure probe may have a tip extending to the tunnel to deliver a pressurized burst into the tunnel. An aeromechanical identification system may include a pressurized gas source, a valve in fluid communication with the pressurized gas source, and the gas pressure probe may be in fluid communication with the valve. The valve may control a flow of a pressurized gas from the pressurized gas source into the gas pressure probe. A pressure sensor may be coupled to the gas pressure probe and configured to measure a pressure within the gas pressure probe.

Abstract: A hand-held applicator for applying a fluid substance to a skin surface is disclosed. The applicator may be wedge-shaped to facilitate the application of the fluid substance to both broad and constricted portions of the user's skin by way of a broad base portion and a narrow end tip portion, respectively. The applicator may also comprise a means for limiting the flow of the fluid substance to the broad base portion of the wedge to facilitate application primarily from the narrow tip portion. The applicator may comprise a means for discharging the fluid substance from the applicator in the form of a user-actuated ratchet member or turning wheel mechanism interconnected to a press plate. The applicator may comprise a handle configured to store in a closed position and to rotate to an open position to enable the application of the fluid substance to hard to reach areas of a skin surface.

Abstract: A delivery catheter comprises an inner shaft and an outer sheath. A stent-graft is held on a region of the inner shaft. An enlarged diameter distal region of the outer sheath constrains the stent-graft. Its retraction allows the stent-graft to deploy. A finger wheel on a handle is used to retract the outer sheath and is coupled to a sliding block with cable(s). The sliding block is coupled to the outer sheath and is held within a sliding track. The wheel can be actuated to tension the cable(s) and deform latch(es) coupled to sliding block, freeing them from slot(s) in the sliding track and allowing retraction of the sliding block and the outer sheath. A reinforcement sleeve is coupled to a smaller diameter proximal region of the outer sheath. A gap between the outer sheath distal region and the reinforcement sleeve allows the distal outer shaft region to be retracted.

Abstract: Described is a mobile point-of sale cart for use in a retail store. The cart has four legs and three platforms coupled to the legs. Each of the three platforms is at a different height above the ground. The legs have wheels for easy movement from one place to another, and the legs are telescoping so the cart can be easily stored. The cart holds the equipment needed for a retail store employee to checkout customers and perform other common tasks. The cart has multiple bins to hold a handheld scanner, a debit card reader, and a portable printer. The cart has a bagging station coupled to the top platform, and a shopping bag support surface coupled to the second platform. The cart can be moved about the store to easily ring up purchases, and can be stored when not in use.