Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A method and system of providing therapy to a patient's uterus is provided, which can include any number of features. The method can include the steps of inserting a uterine device into the uterus and performing a uterine integrity test to determine that the uterus is intact and not perforated. If it is determined that the uterus is not perforated, a patency test can be performed to determine that the uterine device is not clogged or embedded in tissue. If the uterus is intact and the device is not clogged or embedded in tissue, the uterus can be treated with the uterine device, e.g., uterine ablation. Systems for performing these methods are also disclosed.

Abstract: Wastewater is treated though primary treatment of the water by way of a micro-sieve to produce a primary effluent and primary sludge. There is secondary treatment of the primary effluent by way of a membrane bioreactor (MBR) or an integrated fixed film activated sludge (IFAS) reactor to produce a secondary effluent and a waste activated sludge. The micro-sieve may have openings of 250 microns or less, for example about 150 microns. In a process, a gas transfer membrane is immersed in water. Pressurized air flows into the gas transfer membrane. An exhaust gas is withdrawn from the gas transfer membrane and used to produce bubbles from an aerator immersed in the water.

Abstract: A fluid catalytic cracking unit fractionator comprising a fractionator column having a slurry pumparound section and a bottom liquid section. The slurry pumparound section comprises an upper bed and a lower bed each disposed in the fractionator column. The slurry pumparound section further comprises an upper liquid distributor (such as a spray header comprising a plurality of upper nozzles) disposed above the upper bed and configured to distribute liquid from the bottom liquid section onto the upper bed. The slurry pumparound section also comprises a lower liquid distributor (such as a spray header comprising a plurality of lower nozzles) disposed below the upper bed and above the lower bed and configured to distribute liquid from the bottom liquid section onto the lower bed.

Abstract: The present disclosure relates to an aerosol delivery device. The aerosol delivery device may include a control body with a first connector portion and a cartridge with a second connector portion. The first connector portion and the second connector portion may be configured to releasably engage each other. One of the first connector portion and the second connector portion may include an extension and the other of the first connector portion and the second connector portion may include a receptacle configured to receive the extension. The extension may include contact sections positioned along a longitudinal length thereof. The contact sections may be electrically insulated from one another by at least one spacer and may be configured to form an electrical connection with the receptacle. A related assembly method is also provided.

Abstract: The present disclosure relates to a cartridge for an aerosol delivery device such as a smoking article. The cartridge may include a base, a reservoir substrate, and an atomizer. The reservoir substrate may define a cavity therethrough. The atomizer may comprise a liquid transport element and a heating element extending at least partially about the liquid transport element. The atomizer may extend through the cavity through the reservoir substrate such that the heating element is positioned proximate an end of the reservoir substrate. Ends of the liquid transport element may extend to an opposing end of the reservoir substrate. A related method for assembling a cartridge for a smoking article is also provided.

Abstract: Systems and methods for providing stateless management of a virtualization platform are disclosed. In some aspects, the techniques described herein relate to a method including: listening, at an agent executing on a host machine of a plurality of host machines that include a cluster for hosting virtual machines, for an event triggered on a virtual machine manager associated with the agent; determining, by the agent and based on the event, parameters needed for an API call at a central management service that manages a plurality of virtual machines and virtual machine managers; sending a Hypertext Transfer Protocol (HTTP) request to the central management service, wherein the parameters are included in the HTTP request; receiving, by the agent and from the central management service, a response to the HTTP request including return data based on the determined parameters and the API call.

Abstract: A fluid catalytic cracking unit fractionator comprising a fractionator column having a slurry pumparound section and a bottom liquid section. The slurry pumparound section comprises an upper bed and a lower bed each disposed in the fractionator column. The slurry pumparound section further comprises an upper liquid distributor (such as a spray header comprising a plurality of upper nozzles) disposed above the upper bed and configured to distribute liquid from the bottom liquid section onto the upper bed. The slurry pumparound section also comprises a lower liquid distributor (such as a spray header comprising a plurality of lower nozzles) disposed below the upper bed and above the lower bed and configured to distribute liquid from the bottom liquid section onto the lower bed.

Abstract: Provided in some aspects are methods for light-controlled in situ surface patterning of a substrate comprising a step of blocking or ablating oligonucleotide molecules in a boundary region separating a plurality of spot regions, and attaching oligonucleotides to oligonucleotide molecules in a first one or more of the spot regions.

Abstract: A system for use in an aerospace environment includes an array of storage drives each comprising a non-radiation-hardened drive controller, a non-radiation-hardened, non-volatile, storage medium, and a non-radiation-hardened volatile memory. The system includes a radiation-tolerant storage controller coupled to the array. The storage controller provides failure-resistant data redundancy among the storage drives of the array. The system includes a bus host that accesses the array via the storage controller. The storage controller implements security logic and a root-of-trust that provides to the bus host verification of authenticity of the radiation tolerant storage controller and the storage drives.

Abstract: Aspects described herein relate to securely performing cross-boundary backup operations. A service of a computing resource service provider may enable backup operations between a source account and a destination account of an organization based at least in part on a security policy allowing such operations.

Abstract: A data storage system may connect a host to a device and a hardware module that are utilized to satisfy at least one host-generated data access request to the device. A portion of the device is set as dormant by the hardware module prior to identifying an origin of the device with the hardware module during the satisfaction of the at least one host-generated data access request. In response to the identified origin, the previously dormant portion of the device is activated and subsequently utilized to execute a task assigned by the hardware module.

Abstract: The present disclosure relates in some aspects to methods and compositions for manufacturing molecular arrays using a hybrid approach comprising using non-contact printing (e.g., using inkjet printing, slot die coating, and/or blade coating) and photolithography-guided oligonucleotide hybridization and ligation. In particular, the molecular arrays can be used for determining spatial patterns of abundance and/or expression of a biological target in a sample.

Abstract: Apparatus and method for executing controller memory buffer (CMB) based data transfer commands in a distributed data processing environment. In some embodiments, a storage device having a device controller and a main non-volatile memory (NVM) is coupled to a client device via an interface. The client device respectively issues normal data transfer commands and bypass data transfer commands to the storage device. The normal data transfer commands include read and write commands that result in transfer of data between the NVM and the client device using a normal data path through the storage device. The bypass data transfer commands involve an allocated CMB of the storage device directly controlled and accessed by the client device. In this way, write data are directly placed into the CMB for writing to the NVM, and readback data from the NVM are directly recovered from the CMB by the client device.

Abstract: An apparatus includes a flexible fixation member having a body with a longitudinal extent and a width, the body defining a plurality of openings through the body, each of the plurality of openings formed substantially cross wise through the width of the body, and a suture having two terminal ends, the suture being interwoven through each of the plurality of openings in the body of the fixation member such that multiple portions of the fixation member are slidably coupled to the suture and configurable to form a cluster within a surgical site.

Abstract: Apparatus and method for executing hidden computational functions in a distributed data processing environment. In some embodiments, a trust boundary includes a target device such as a storage device, and a source device such as a client device in a computer network. A storage device processor executes a hidden command function (HCF) routine to accumulate HCF output data in a local cache responsive to an HCF command received from the client device over a data interface. The processor further establishes a smaller retention boundary within the trust boundary that includes the storage device and excludes the client device. The HCF output data are stored locally in a non-volatile memory (NVM) of the storage device while not transferring any portion of the HCF output data outside the retention boundary, including to the client device. The HCF routine can update a block-chain ledger or take some other form to provide data security.

Abstract: Apparatus and method for servicing data transfer commands in a computer environment using a selected protocol such as NVMe (Non-Volatile Memory Express). In some embodiments, a secure connection is established between a client device and a bridge device across an interface. A controller of the bridge device presents a unitary namespace as an available memory space to the client device. The controller further communicates with a plurality of downstream target devices to allocate individual namespaces within main memory stores of each of the target devices to form a consolidated namespace to support the unitary namespace presented to the controller. In this way, the bridge device can operate as an NVMe controller with respect to the client device for the unitary namespace, and as a virtual client device to each of the target devices which operate as embedded NVMe controllers for the individual namespaces.

Abstract: A distributed data storage system can be configured with a host connected to a first device and an initialization module that performs a default initialization procedure on the first device in response to detecting the first device has an unknown manufacturing origin. Conducting the default initialization procedure may allow the first device to service data access requests from the host. In response to the connection of a second device to the host and initialization module, a manufacturing origin of the second device is identified with the initialization module before the initialization module customizes the default initialization procedure to a custom procedure that is executed to allow the second device to satisfy a background operation prescribed by the initialization module.

Abstract: A distributed data storage system may connect a host to a device and a dedication module. The dedication module can identify a manufacturing origin of the device before dedicating a type of host-generated data access request to the device. The type of host-generated data access request is chosen by the dedication module in response to an operating capability correlated to the device by the dedication module based on the identified manufacturing origin. At least one host-generated request of the dedicated type is then completed with the device.

Abstract: A distributed data storage system can be configured with a host connected to a device and a distribution module. The distribution module identifies a manufacturing origin of the device and diverts a system operation from an upstream component connected to the distribution module to the device in response to the identified manufacturing origin of the device. The manufacturer installed operating parameters of the device are then used to complete the system operation.