Abstract: The present invention provides fusion proteins for targeted delivery of plasminogen activators to platelet-VWF complexes, or alternatively to the site where these are located, in a fibrin-independent manner. The fusion protein of the invention are for use in methods for the prevention or treatment of diseases or conditions associated with such platelet-VWF complexes, which may cause microvascular thrombosis in diseases such as e.g. thrombotic thrombocytopenia purpura. Preferred targeting agents for incorporation into the fusion proteins are e.g. nanobodies against VWF or platelets. Preferred plasminogen activators for use in the fusion proteins comprise the protease domains of uPA or tPA. The invention further pertains to nucleic acid molecule encoding the fusion proteins of the invention, e.g. a gene therapy vector, and to pharmaceutical compositions comprising the fusion proteins of the invention or such gene therapy vectors.

Abstract: A method is provided for synthesizing bio-based LPG from renewable sources via a bio-based synthetic gas feedstock, using a solvent absorption process and a solid adsorption process for recovering LPG in high yield while providing for high recovery and reuse, with low pressure drop, of unreacted synthesis gas components.

Abstract: A high strength J-bolt for a saddle-mount is provided for use in attaching the saddle-mount to an axle of a vehicle. The high strength J-bolt can include a round distal end, a tapered and/or round mid-section, and a hook end with a specified inside bend radius and cross-sectional shape configured to accommodate an increased range of axle sizes. A D-shaped cross-sectional shape can be formed for the hook end to provide for increased contact area with the axle, a larger cross-sectional area, and a higher section modulus along a critical bending axis as compared to a non-critical bending axis to maximize a clamping force that can be applied to the axle and militate against mechanical failure of the high strength J-bolt. A hot forging process can be used to form the shape of the high strength J-bolt.

Abstract: An intercomponent seal arrangement includes a plurality of wall segments extending circumferentially. Adjacent wall segments from the plurality of wall segments include opposing first and second end wall portions defining a gap therebetween. The gap includes a saddle portion facing radially outwards and including a first sealing face on the first end wall portion and a second sealing face on the second end wall portion. The intercomponent seal arrangement further includes an intercomponent seal located within the saddle portion and including at least a first contact point contacting the first sealing face, a second contact point contacting the second sealing face, and a third contact point radially inwards from the first and second contact points and contacting one of the first and second sealing faces.

Abstract: Systems, methods, and apparatuses for providing a customer a central location to manage permissions provided to third-parties and devices to access and use customer information maintained by a financial institution are described. The central location serves as a central portal where a customer of the financial institution can manage all access to account information and personal information stored at the financial institution. Accordingly, the customer does not need to log into each individual third-party system or customer device to manage previously provided access to the customer information or to provision new access to the customer information. A user additionally is able to have user data and third-party accounts of the user deleted from devices, applications, and third-party systems via a central portal. Restrictions on how user data is used by devices, applications, and third-party systems can be imposed via a central portal.

Abstract: An example electronic device includes a front display, e.g., on a front side of the electronic device, and a side display, e.g., on a lateral side of the electronic device. While displaying a control user interface on the side display, the electronic device detects an input at the side display. In response to detecting the input, the electronic device displays a portion of the control user interface on the front display.

Abstract: A system for processing medical claims, comprising a processor configured to receive device-generated information from a medical device. The device-generated information includes performance information. The processor generates a first biometric signature, and using the device-generated information, generates a second biometric signature, wherein the second biometric signature uses the performance information. Using the first and second biometric signatures, the processor generates a signature comparison. Using the signature comparison, the processor generates a signature indicator and transmits the signature indicator.

Abstract: Techniques for improved efficiency of sintering in additive fabrication are described. According to some aspects, mechanisms for depositing and leveling source material are combined with a mechanism for heating the material. In some embodiments, one or more heating elements may be arranged to lead and/or follow a material deposition mechanism such that heat may be applied to the build region in concert with deposition of material. As a result of this technique, the heating and depositing steps may be performed closer together in time and/or heat may be applied more directly to the material than in conventional systems. As a result, greater control over material temperature may be achieved, thereby avoiding excess temperature exposure and subsequent undesirable changes to the material.

Abstract: A control system for a military vehicle includes processing circuitry configured to obtain a weight, an incline, a brake air supply pressure, a current gear, and a transaxle range of the military vehicle. The processing circuitry is also configured to determine a minimum brake air supply pressure for the military vehicle based on the weight, the incline, the current gear, and the transaxle range of the military vehicle. The processing circuitry is also configured to compare the brake air supply pressure to the minimum brake air supply pressure, and, in response to the brake air supply pressure being less than the minimum brake air supply pressure, operate a display of the military vehicle to provide an alarm to an operator of the military vehicle to notify the operator that the brake air supply pressure is less than the minimum brake air supply pressure.

Abstract: Some embodiments provide a three-dimensional (3D) circuit structure that has two or more vertically stacked bonded layers with a machine-trained network on at least one bonded layer. As described above, each bonded layer can be an IC die or an IC wafer in some embodiments with different embodiments encompassing different combinations of wafers and dies for the different bonded layers. The machine-trained network in some embodiments includes several stages of machine-trained processing nodes with routing fabric that supplies the outputs of earlier stage nodes to drive the inputs of later stage nodes. In some embodiments, the machine-trained network is a neural network and the processing nodes are neurons of the neural network. In some embodiments, one or more parameters associated with each processing node (e.g., each neuron) is defined through machine-trained processes that define the values of these parameters in order to allow the machine-trained network (e.g.

Abstract: The disclosure relates to microspheres comprising a core and a shell. More particularly the disclosure relates to microspheres for extended, controlled release of a poorly water-soluble therapeutic agent having a solubility in water of 50 ?g/mL or less, the microsphere having a core comprising the therapeutic agent, and a substantially impermeable shell surrounding the core. Methods of making and using the microspheres are also provided.

Abstract: The present disclosure pertains to the use of fospropofol, pharmaceutically acceptable salts of fospropofol, or mixtures thereof. Pharmaceutical compositions comprising fospropofol, pharmaceutically acceptable salts of fospropofol, or mixtures thereof, and methods of treating diseases or disorders, including migraine are also disclosed.

Abstract: The present disclosure provides a candle that includes a jar having an interior surface, a fuel within the jar, a wick positioned within the fuel, and a material layer at least partially extending between the fuel and the interior surface of the jar, wherein the material layer includes a hydrophobic molecule. Further provided herein is a method for producing a candle, which includes a step of providing a jar having an interior surface, a step of pre-coating the interior surface with a hydrophobic molecule, a step of pouring a fuel composition into the jar, and a step of allowing the fuel composition to solidify.

Abstract: Articles, such as sanitary tissue products, including fibrous structures, and more particularly articles including fibrous structures having a plurality of fibrous elements wherein the article exhibits differential cellulose content throughout the thickness of the article and methods for making same are provided.

Abstract: A method and system for integrated surface water and groundwater modelling using a dynamic mesh evolution. The system includes a dynamic mesh evolution that enables elevation changes in a landscape to be better represented in a simulation model. By moving, adding or removing computation nodes within the model over a predetermined range and updating the metadata, elevation changes may be better represented.

Abstract: The present inventive subject matter provides systems, methods, software, and data structures for patent mapping, storage, and searching. Some such embodiments include mapping patent documents, claims, and claim limitations. Some further embodiments provide for searching a universe of patent documents by patent document, claim, limitation, class, element, or concept.

Abstract: A method, system, and computer-readable media for modeling cyberspace operations and the effects thereof. Network and connectivity data for an operational environment model may be retrieved from a network scan. Likelihood data that a network element takes a plurality of possible configurations may be mapped. Determination of a probability of effect of a capability acting on the network element may be based on the likelihood data and uncertainties associated with the capability. Multiple attacks within the operational environment model may be modeled to determine an attack path therethrough. Functional modeling techniques to model functional impacts of attacks on an operational environment model are also disclosed.

Abstract: A computer-implemented method for adapting connections between nodes of a layered network. The layered network comprises a plurality of nodes arranged in an ordered set of layers. The ordered set of layers comprises, in order, a core layer comprising a set of core nodes, a second layer comprising a set of second nodes, and one or more outer layers each comprising a respective set of outer nodes. Each core node is connected to at least one other core node. The method is performed by an adapting node, the adapting node being a node of the layered network that is connected to one or more second nodes and multiple core nodes. The method comprises, based on one or more network properties of the layered network, disabling a respective connection between the adapting node and at least one but not all of the multiple core nodes.

Abstract: The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.