Abstract: A terminated hollow-core optical fiber includes a capillary, a hollow-core optical fiber including a structured cladding, and an endcap. A first end of the hollow-core optical fiber terminates inside the capillary a non-zero distance away from a first end face of the capillary. The hollow-core optical fiber is adhered to the capillary at a second end face of the capillary where the hollow-core optical fiber extends out of the capillary. The endcap is fused to the first end face of the capillary. The endcap has a larger diameter than the first end of the hollow-core optical fiber. This termination scheme does not require fusing the hollow-core fiber itself to the endcap or any other part. Therefore, this termination scheme is applicable to hollow-core fibers with a structured cladding that cannot tolerate the temperatures associated with fusing the hollow-core fiber to another part.

Abstract: Described herein is a method of treating, ameliorating and/or preventing heart failure in a subject in need thereof. The method includes administering to the subject an effective amount of a myotrope using a dosing scheme having an administration-withdrawal cycle. Also described herein are a method of promoting growth of a heart muscle, the method including intermittently contacting the heart muscle with a myotrope. Also described herein are kits for performing the methods described herein.

Abstract: A terminated hollow-core optical fiber includes a capillary, a hollow-core optical fiber including a structured cladding, and an endcap. A first end of the hollow-core optical fiber terminates inside the capillary a non-zero distance away from a first end face of the capillary. The hollow-core optical fiber is adhered to the capillary at a second end face of the capillary where the hollow-core optical fiber extends out of the capillary. The endcap is fused to the first end face of the capillary. The endcap has a larger diameter than the first end of the hollow-core optical fiber. This termination scheme does not require fusing the hollow-core fiber itself to the endcap or any other part. Therefore, this termination scheme is applicable to hollow-core fibers with a structured cladding that cannot tolerate the temperatures associated with fusing the hollow-core fiber to another part.

Abstract: A terminated hollow-core optical fiber includes a capillary, a hollow-core optical fiber including a structured cladding, and an endcap. A first end of the hollow-core optical fiber terminates inside the capillary a non-zero distance away from a first end face of the capillary. The hollow-core optical fiber is adhered to the capillary at a second end face of the capillary where the hollow-core optical fiber extends out of the capillary. The endcap is fused to the first end face of the capillary. The endcap has a larger diameter than the first end of the hollow-core optical fiber. This termination scheme does not require fusing the hollow-core fiber itself to the endcap or any other part. Therefore, this termination scheme is applicable to hollow-core fibers with a structured cladding that cannot tolerate the temperatures associated with fusing the hollow-core fiber to another part.

Abstract: A system and method for predicting stats for different destinations is provided. The system and method can include receiving a dataset of stats in a spatial format and a request for stats in a geographical area. The system and method can include determining a grid of cells based on the geographical area, determining an origin point in each cell in the grid of cell, determining a graph based on the grid of cells, determining a proportion of the stat to assign to each node, edge or both in the graph in the geographical area based on an overlap between the dataset of stats and the graph, and determining a total for the stat for the geographical area.

Abstract: A terminated hollow-core optical fiber includes a capillary, a hollow-core optical fiber including a structured cladding, and an endcap. A first end of the hollow-core optical fiber terminates inside the capillary a non-zero distance away from a first end face of the capillary. The hollow-core optical fiber is adhered to the capillary at a second end face of the capillary where the hollow-core optical fiber extends out of the capillary. The endcap is fused to the first end face of the capillary. The endcap has a larger diameter than the first end of the hollow-core optical fiber. This termination scheme does not require fusing the hollow-core fiber itself to the endcap or any other part. Therefore, this termination scheme is applicable to hollow-core fibers with a structured cladding that cannot tolerate the temperatures associated with fusing the hollow-core fiber to another part.

Abstract: The present invention relates in part to devices, systems, and methods for the production and characterization of engineered tissue constructs. The devices and methods generate decellularized tissue constructs that can be recellularized using donor cells for high-throughput studies of organ physiology, and/or organ pathology. The devices and methods can be used with the systems to mechanically and electrically stimulate the engineered tissue constructs under culture or physiological conditions to detect and assess the presence and degree of any organ pathologies.

Abstract: The invention relates to a method of automatic dishwashing in a dishwasher having a wash tank, comprising: in a first step, delivering a first composition to dishware in the tank in the form of a mist; and afterwards, in a second step, delivering a second composition to the dishware in the tank in the form of a jet; wherein the first and second compositions are different, the first composition comprises a bleach, and the second composition is alkaline and comprises a builder. The invention also provides a dishwasher adapted to carry out the inventive method.

Abstract: The invention relates to a method of automatic dishwashing of dishware using wash water, in which, in a first step, a first composition, which comprises an oxygen bleach but substantially no enzyme, is supplied to the wash water, and the dishware is washed in a washing zone with the oxygen bleach-containing wash water; and, in a second step which occurs after the first step, a second composition, which comprises an enzyme but substantially no bleach, is supplied to the wash water, and the dishware is washed in said washing zone with the enzyme-containing wash water. The invention also relates to an automatic dishwasher and a cartridge suitable for use in this method.

Abstract: The invention relates to an optical assembly (100) comprising a first optical fiber (101) propagating coherent light in a predetermined direction (P) into an input end (110) of the optical assembly (100), said optical fiber having a core and a cladding; a heat sink (111) surrounding the optical fiber (101) at the input end (110); and a lens (120) arranged after the heat sink (111) in the propagating direction (P). The optical assembly (100) further comprises a filter (130) arranged after the lens (120), wherein the filter (130) has a reflective surface (131) arranged to transmit light having one or more desired wavelengths and to reflect one or more undesired wavelengths back through the lens (120). The invention further relates to a method for separating desired and undesired wavelengths.

Abstract: The invention relates to an optical assembly (100) comprising a first optical fiber (101) propagating coherent light in a predetermined direction (P) into an input end (110) of the optical assembly (100), said optical fiber having a core and a cladding; a heat sink (111) surrounding the optical fiber (101) at the input end (110); and a lens (120) arranged after the heat sink (111) in the propagating direction (P). The optical assembly (100) further comprises a filter (130) arranged after the lens (120), wherein the filter (130) has a reflective surface (131) arranged to transmit light having one or more desired wavelengths and to reflect one or more undesired wavelengths back through the lens (120). The invention further relates to a method for separating desired and undesired wavelengths.

Abstract: The invention relates to detergent compositions comprising granular non-phosphate builder. The granules comprise an amino acid based builder, preferably MGDA, and s silicate. The composition is housed in a rigid PVOH capsule.

Abstract: The present invention relates in part to devices, systems, and methods for the production and characterization of engineered tissue constructs. The devices and methods generate decellularized tissue constructs that can be recellularized using donor cells for high-throughput studies of organ physiology, and/or organ pathology. The devices and methods can be used with the systems to mechanically and electrically stimulate the engineered tissue constructs under culture or physiological conditions to detect and assess the presence and degree of any organ pathologies.

Abstract: The invention relates to a method of automatic dishwashing in a dishwasher having a wash tank, comprising: in a first step, delivering a first composition to dishware in the tank in the form of a mist; and afterwards, in a second step, delivering a second composition to the dishware in the tank in the form of a jet; wherein the first and second compositions are different, the first composition comprises a bleach, and the second composition is alkaline and comprises a builder. The invention also provides a dishwasher adapted to carry out the inventive method.

Abstract: The invention relates to a method of automatic dishwashing of dishware using wash water, in which, in a first step, a first composition, which comprises an oxygen bleach but substantially no enzyme, is supplied to the wash water, and the dishware is washed in a washing zone with the oxygen bleach-containing wash water; and, in a second step which occurs after the first step, a second composition, which comprises an enzyme but substantially no bleach, is supplied to the wash water, and the dishware is washed in said washing zone with the enzyme-containing wash water. The invention also relates to an automatic dishwasher and a cartridge suitable for use in this method.

Abstract: The present invention provides a non-aqueous liquid, gel or paste composition, comprising a colourant and methylglycine diacetic acid (MGDA) or a salt thereof. The compositions afford enhanced stability of the colourant in the presence of MGDA. The invention also provides a unit dose detergent product comprising the inventive composition, a washing or cleaning process that utilizes this composition or product, and the use of this composition or product for washing or cleaning.

Abstract: The invention relates to detergent compositions comprising granular non-phosphate builder. The granules comprise an amino acid based builder, preferably MGDA, and s silicate. The composition is housed in a rigid PVOH capsule.