Abstract: A terminated hollow-core optical fiber includes a capillary, a hollow-core optical fiber including a structured cladding, and an endcap. A first end of the hollow-core optical fiber terminates inside the capillary a non-zero distance away from a first end face of the capillary. The hollow-core optical fiber is adhered to the capillary at a second end face of the capillary where the hollow-core optical fiber extends out of the capillary. The endcap is fused to the first end face of the capillary. The endcap has a larger diameter than the first end of the hollow-core optical fiber. This termination scheme does not require fusing the hollow-core fiber itself to the endcap or any other part. Therefore, this termination scheme is applicable to hollow-core fibers with a structured cladding that cannot tolerate the temperatures associated with fusing the hollow-core fiber to another part.

Abstract: A preservation system comprising: i. itaconic acid or salt thereof and ii. an aromatic alcohol selected from the group consisting of ethylvanillin, eugenol, thymol, P-hydroxybenzaldehyde, 4n butyl phenol, P-hydroxyacetophenone, vanillin, salicylic acid or salt thereof, o-cymen-5-ol, carvacrol and mixtures thereof.

Abstract: An antimicrobial preservation system comprising: i. itaconic acid or salt thereof and ii. benzoic acid or salt thereof.

Abstract: An antimicrobial preservation system comprising: i. itaconic acid or salt thereof and ii. benzoic acid or salt thereof.

Abstract: A preservation system comprising: i) itaconic acid or salt thereof and ii) a secondary preservation chemical selected from the list consisting of terpineol, geraniol, perillyl alcohol, menthol, terpinene, linalool, citronellol and mixtures thereof.

Abstract: The present invention relates in part to devices, systems, and methods for the production and characterization of engineered tissue constructs. The devices and methods generate decellularized tissue constructs that can be recellularized using donor cells for high-throughput studies of organ physiology, and/or organ pathology. The devices and methods can be used with the systems to mechanically and electrically stimulate the engineered tissue constructs under culture or physiological conditions to detect and assess the presence and degree of any organ pathologies.

Abstract: A personal care composition comprising a cleansing phase comprising one or more cleansing surfactants comprising: i. a piroctone compound; ii. sodium benzoate; iii. a fragrance comprising a fragrance component selected from benzyl acetate, hexyl acetate, phenethyl alcohol, ethyl butyrate, eucalyptol, limonene, undecalactone, eugenol and mixtures thereof, in which the ratio of piroctone to sodium benzoate to the defined fragrance components iii) is from 1:1:1 to 1:130:130.

Abstract: The invention relates to a method of automatic dishwashing in a dishwasher having a wash tank, comprising: in a first step, delivering a first composition to dishware in the tank in the form of a mist; and afterwards, in a second step, delivering a second composition to the dishware in the tank in the form of a jet; wherein the first and second compositions are different, the first composition comprises a bleach, and the second composition is alkaline and comprises a builder. The invention also provides a dishwasher adapted to carry out the inventive method.

Abstract: The invention relates to a method of automatic dishwashing of dishware using wash water, in which, in a first step, a first composition, which comprises an oxygen bleach but substantially no enzyme, is supplied to the wash water, and the dishware is washed in a washing zone with the oxygen bleach-containing wash water; and, in a second step which occurs after the first step, a second composition, which comprises an enzyme but substantially no bleach, is supplied to the wash water, and the dishware is washed in said washing zone with the enzyme-containing wash water. The invention also relates to an automatic dishwasher and a cartridge suitable for use in this method.

Abstract: A biofilm targeting microcapsule, suitable for deposition onto a biofilm from an aqueous dispersion, comprising a solid microparticle with average diameter from 1 to 100 micron, the microparticle carrying a non-volatile functional material to be delivered to the biofilm after the microparticle has been deposited onto the biofilm, characterised in that the microparticle has attached to its outer surface from 0.5 to 5 wt %, based on the microparticle weight, of nonionic polysaccharide polymer.

Abstract: The invention relates to an optical assembly (100) comprising a first optical fiber (101) propagating coherent light in a predetermined direction (P) into an input end (110) of the optical assembly (100), said optical fiber having a core and a cladding; a heat sink (111) surrounding the optical fiber (101) at the input end (110); and a lens (120) arranged after the heat sink (111) in the propagating direction (P). The optical assembly (100) further comprises a filter (130) arranged after the lens (120), wherein the filter (130) has a reflective surface (131) arranged to transmit light having one or more desired wavelengths and to reflect one or more undesired wavelengths back through the lens (120). The invention further relates to a method for separating desired and undesired wavelengths.

Abstract: The invention relates to detergent compositions comprising granular non-phosphate builder. The granules comprise an amino acid based builder, preferably MGDA, and s silicate. The composition is housed in a rigid PVOH capsule.

Abstract: A mouthpiece (10) for an inhaler or inhalation device (100) includes an elongated body (12) having a substantially oval opening (14) at a first end and a substantially round opening (18) at a second end opposite from the first end, a plurality of depending arms (24), extending from the elongated body forming at least one air passageway (26) between two depending arms (24), and at least one flexible gripping finger (32) coupled to an inner surface of each depending arm (24), extending inwardly into the medicament delivery passageway of the mouthpiece at or near the substantially round opening (18) at the opposite end. Once coupled with an inhaler or inhalation device, the mouthpiece functions as a “pass through” mouthpiece to improve the consistency of inhaled medicament/drug delivery.

Abstract: Synthetic representative HCV subtypes, including a 1a and 1b genome, dubbed Bole1a and Bole1b, are provided using an inventive method of Bayesian phylogenetic tree analysis, ancestral sequence reconstruction and covariance analysis. Bole1a branches centrally among 390 full-genome sequences used in its design, a carefully curated 143 sequence full-genome dataset, and separate genomic regions including an independent set of 214 E1E2 sequences from a Baltimore cohort. Bole1a is phylogenetically representative of widely circulating strains. Full genome non-synonymous diversity comparison and 9-mer peptide coverage analysis showed that Bole1a is able to provide more coverage (94% and 78% respectively) than any other sequence in the dataset including H77, a traditional reference sequence. Bole1a also provides unsurpassed epitope coverage when compared to all known T cell epitopes.

Abstract: The present invention relates in part to devices, systems, and methods for the production and characterization of engineered tissue constructs. The devices and methods generate decellularized tissue constructs that can be recellularized using donor cells for high-throughput studies of organ physiology, and/or organ pathology. The devices and methods can be used with the systems to mechanically and electrically stimulate the engineered tissue constructs under culture or physiological conditions to detect and assess the presence and degree of any organ pathologies.

Abstract: The invention relates to a method of automatic dishwashing in a dishwasher having a wash tank, comprising: in a first step, delivering a first composition to dishware in the tank in the form of a mist; and afterwards, in a second step, delivering a second composition to the dishware in the tank in the form of a jet; wherein the first and second compositions are different, the first composition comprises a bleach, and the second composition is alkaline and comprises a builder. The invention also provides a dishwasher adapted to carry out the inventive method.

Abstract: The invention relates to a method of automatic dishwashing of dishware using wash water, in which, in a first step, a first composition, which comprises an oxygen bleach but substantially no enzyme, is supplied to the wash water, and the dishware is washed in a washing zone with the oxygen bleach-containing wash water; and, in a second step which occurs after the first step, a second composition, which comprises an enzyme but substantially no bleach, is supplied to the wash water, and the dishware is washed in said washing zone with the enzyme-containing wash water. The invention also relates to an automatic dishwasher and a cartridge suitable for use in this method.

Abstract: Synthetic representative HCV subtypes, including a 1a and 1b genome, dubbed Bole1a and Bole1b, are provided using an inventive method of Bayesian phylogenetic tree analysis, ancestral sequence reconstruction and covariance analysis. Bole1a branches centrally among 390 full-genome sequences used in its design, a carefully curated 143 sequence full-genome dataset, and separate genomic regions including an independent set of 214 E1E2 sequences from a Baltimore cohort. Bole1a is phylogenetically representative of widely circulating strains. Full genome non-synonymous diversity comparison and 9-mer peptide coverage analysis showed that Bole1a is able to provide more coverage (94% and 78% respectively) than any other sequence in the dataset including H77, a traditional reference sequence. Bole1a also provides unsurpassed epitope coverage when compared to all known T cell epitopes.

Abstract: Synthetic representative HCV subtypes, including a 1a and 1b genome, dubbed Bole1a and Bole1b, are provided using an inventive method of Bayesian phylogenetic tree analysis, ancestral sequence reconstruction and covariance analysis. Bole1a branches centrally among 390 full-genome sequences used in its design, a carefully curated 143 sequence full-genome dataset, and separate genomic regions including an independent set of 214 E1E2 sequences from a Baltimore cohort. Bole1a is phylogenetically representative of widely circulating strains. Full genome non-synonymous diversity comparison and 9-mer peptide coverage analysis showed that Bole1a is able to provide more coverage (94% and 78% respectively) than any other sequence in the dataset including H77, a traditional reference sequence. Bole1a also provides unsurpassed epitope coverage when compared to all known T cell epitopes.