Abstract: A system and method of storing and reading digital data, including providing a nanopore polymer memory (NPM) device having at least one memory cell comprising at least two addition chambers each arranged to add a unique chemical construct (or codes) to a polymer (or DNA) string when the polymer enters the respective addition chamber, the data comprising a series of codes; successively steering the polymer from deblock chambers through the nanopore into the addition chambers to add codes to the polymer to create the digital data pattern on the polymer; and accurately controlling the bit rate of the polymer using a servo controller. The device may have loading chamber(s) to load (or remove) the polymer into/from the deblock chambers through at least one “micro-hole”. The cell may be part of a memory system that stores and retrieves “raw” data and allows for remote retrieval and conversion. The cell may store multi-bit data having a plurality of states for the codes.

Abstract: Systems and methods are disclosed that facilitate the reduction of both radio frequency (RF) noise and photoacoustic artefacts in differential photoacoustic radar imaging through a multi-step electrical and optical domain calibration method. An example two-step calibration method involves reducing RF image noise via an initial calibration step that involves the control of the relative amplitudes and phases of electrical driving modulation waveforms, while a second calibration step involves the differential suppression of photoacoustic artefact signals via tuning, in the optical domain, of the relative intensity the optical beams that are delivered to the sample. Another example embodiment involves the use of the standard deviation of the unwrapped phase that is obtained, after performing frequency-domain cross-correlation and an inverse transform to the time domain, to improve the amplitude signal that is employed to generate a differential photoacoustic radar image.

Abstract: A system and method of storing and reading digital data, including providing a nanopore polymer memory (NPM) device having at least one memory cell comprising at least two addition chambers each arranged to add a unique chemical construct (or codes) to a polymer (or DNA) string when the polymer enters the respective addition chamber, the data comprising a series of codes; successively steering the polymer from deblock chambers through the nanopore into the addition chambers to add codes to the polymer to create the digital data pattern on the polymer; and accurately controlling the bit rate of the polymer using a servo controller. The device may have loading chamber(s) to load (or remove) the polymer into/from the deblock chambers through at least one “micro-hole”. The cell may be part of a memory system that stores and retrieves “raw” data and allows for remote retrieval and conversion. The cell may store multi-bit data having a plurality of states for the codes.

Abstract: A system and method of storing and reading digital data, including providing a nanopore polymer memory (NPM) device having at least one memory cell comprising at least two addition chambers each arranged to add a unique chemical construct (or codes) to a polymer (or DNA) string when the polymer enters the respective addition chamber, the data comprising a series of codes; successively steering the polymer from deblock chambers through the nanopore into the addition chambers to add codes to the polymer to create the digital data pattern on the polymer; and accurately controlling the bit rate of the polymer using a servo controller. The device may have loading chamber(s) to load (or remove) the polymer into/from the deblock chambers through at least one “micro-hole”. The cell may be part of a memory system that stores and retrieves “raw” data and allows for remote retrieval and conversion. The cell may store multi-bit data having a plurality of states for the codes.

Abstract: A dual frequency transducer array includes one or more low frequency transducer arrays and a high frequency transducer array. Unfocused ultrasound such as plane waves are transmitted by the one or more low frequency transducer arrays in a number of different directions into an imaging region of the high frequency transducer array. High frequency echo signals produced by excited contrast agent in the imaging region are received by the high frequency transducer array to produce a contrast agent image. In another embodiment, the high frequency transducer produces unfocused ultrasound to excite the contrast agent in the imaging region and the low frequency transducer(s) receives low frequency echo signals from the excited contrast agent. A tissue image is created from echo signals received by the high or low frequency transducer. Echo data from the tissue image and the contrast agent image are combined to produce a combined tissue/contrast agent image.

Abstract: The present invention provides scanning mechanisms for imaging probes using for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and/or optical coherence tomography. The imaging probes include adjustable rotational drive mechanism for imparting rotational motion to an imaging assembly containing either optical or ultrasound transducers which emit energy into the surrounding area. The imaging assembly includes a scanning mechanism having including a movable member configured to deliver the energy beam along a path out of said elongate hollow shaft at a variable angle with respect to said longitudinal axis to give forward and side viewing capability of the imaging assembly. The movable member is mounted in such a way that the variable angle is a function of the angular velocity of the imaging assembly.

Abstract: A method is disclosed. In various examples, the method may include receiving an instruction for generating a signal that comprises a ranging signal and a data signal, and transmitting the signal at least partially responsive to the instruction. In various examples the signal may be transmitted via a terrestrial transmitter for transmitting radio waves having encoded messaging information and timing information for one or more of positioning, navigation and timing. In various examples, the signal may include a pulse group comprising a first pulse having a first start time; and a second pulse having a second start time. The second start time may be an integer number of inter-pulse intervals plus an encoding delay after the first start time. The encoding delay may encode data.

Abstract: A method is disclosed. In various examples, the method may include receiving an instruction for generating a signal comprising a ranging signal and a data signal. The method may also include transmitting, via a terrestrial transmitter for transmitting radio waves having encoded messaging information and timing information for one or more of positioning, navigation and timing, the signal at least partially responsive to the instruction. The signal may include a pulse group comprising a number of ranging pulses and a number of data pulses subsequent to the number of ranging pulses. Respective ones of the number of data pulses may have a phase of either a positive-going phase or a negative-going phase. Information may be encoded using the either positive-going phases or negative-going phases of the data pulses.

Abstract: A device is disclosed. In one or more examples, the device may include an antenna to receive a signal encoding timing information for one or more of positioning, navigation, and timing. The signal may include a pulse group comprising a number of ranging pulses and a number of data pulses subsequent to the number of ranging pulses. Respective ones of the number of data pulses may have a phase of either a positive-going phase or a negative-going phase. Data may be encoded using the either positive-going phases or negative-going phases of the data pulses. The device may include a processor to decode the data at least partially responsive to the phases of the respective ones of the number of data pulses.

Abstract: A device is disclosed. The device may include an antenna, which antenna may receive a ranging signal encoding timing information for one or more of positioning, navigation, and timing. The ranging signal may include a first pulse of a pulse group, a second pulse of the pulse group, and an inter-pulse interval between a start of the first pulse and a start of the second pulse. The device may include a processor, which processor may identify a transmitter of the ranging signal at least partially responsive to the inter-pulse interval.

Abstract: A device is disclosed. In one or more examples, the device may include an antenna to receive a signal comprising a ranging signal and a data signal. The signal may encode timing information for one or more of positioning, navigation, and timing. The signal may include a first pulse having a first start time and a second pulse having a second start time. The second start time may be an integer number of inter-pulse intervals plus an encoding delay after the first start time. The encoding delay may encode data. The device may include a processor to obtain the data responsive to the encoding delay.

Abstract: A method is disclosed. In various examples, the method may include receiving an instruction for generating a ranging signal, and transmitting the ranging signal at least partially responsive to the instruction. In various examples the ranging signal may be transmitted via a terrestrial transmitter for transmitting radio waves having encoded messaging information and timing information for one or more of positioning, navigation and timing. In various examples, the ranging signal may exhibit a first ranging pulse and a second ranging pulse of a pulse group and an encoded transmitter identifier, the transmitter identifier encoded by modulating an inter-pulse interval defined between a start of the first ranging pulse and a start of the second ranging pulse.

Abstract: Systems and methods are disclosed that facilitate the reduction of both radio frequency (RF) noise and photoacoustic artefacts in differential photoacoustic radar imaging through a multi-step electrical and optical domain calibration method. An example two-step calibration method involves reducing RF image noise via an initial calibration step that involves the control of the relative amplitudes and phases of electrical driving modulation waveforms, while a second calibration step involves the differential suppression of photoacoustic artefact signals via tuning, in the optical domain, of the relative intensity the optical beams that are delivered to the sample. Another example embodiment involves the use of the standard deviation of the unwrapped phase that is obtained, after performing frequency-domain cross-correlation and an inverse transform to the time domain, to improve the amplitude signal that is employed to generate a differential photoacoustic radar image.

Abstract: A system and method of storing and reading digital data, including providing a nanopore polymer memory (NPM) device having at least one memory cell comprising at least two addition chambers each arranged to add a unique chemical construct (or codes) to a polymer (or DNA) string when the polymer enters the respective addition chamber, the data comprising a series of codes; successively steering the polymer from deblock chambers through the nanopore into the addition chambers to add codes to the polymer to create the digital data pattern on the polymer; and accurately controlling the bit rate of the polymer using a servo controller. The device may have loading chamber(s) to load (or remove) the polymer into/from the deblock chambers through at least one “micro-hole”. The cell may be part of a memory system that stores and retrieves “raw” data and allows for remote retrieval and conversion. The cell may store multi-bit data having a plurality of states for the codes.

Abstract: The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (IVUS) and optical imaging methods such as optical coherence tomography (OCT) and to accurate co-registering of images obtained from ultrasound image signals and optical image signals during scanning a region of interest.

Abstract: A system and method of storing and reading digital data, including providing a nanopore polymer memory (NPM) device having at least one memory cell comprising at least two addition chambers each arranged to add a unique chemical construct (or codes) to a polymer (or DNA) string when the polymer enters the respective addition chamber, the data comprising a series of codes; successively steering the polymer from deblock chambers through the nanopore into the addition chambers to add codes to the polymer to create the digital data pattern on the polymer; and accurately controlling the bit rate of the polymer using a servo controller. The device may have loading chamber(s) to load (or remove) the polymer into/from the deblock chambers through at least one “micro-hole”. The cell may be part of a memory system that stores and retrieves “raw” data and allows for remote retrieval and conversion. The cell may store multi-bit data having a plurality of states for the codes.

Abstract: The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (IVUS) and optical imaging methods such as optical coherence tomography (OCT) and to accurate co-registering of images obtained from ultrasound image signals and optical image signals during scanning a region of interest.

Abstract: The present invention provides scanning mechanisms for imaging probes using for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and/or optical coherence tomography. The imaging probes include adjustable rotational drive mechanism for imparting rotational motion to an imaging assembly containing either optical or ultrasound transducers which emit energy into the surrounding area. The imaging assembly includes a scanning mechanism having including a movable member configured to deliver the energy beam along a path out of said elongate hollow shaft at a variable angle with respect to said longitudinal axis to give forward and side viewing capability of the imaging assembly. The movable member is mounted in such a way that the variable angle is a function of the angular velocity of the imaging assembly.

Abstract: A system and method of storing and reading digital data, including providing a nanopore polymer memory (NPM) device having at least one memory cell comprising at least two addition chambers each arranged to add a unique chemical construct (or codes) to a polymer (or DNA) string when the polymer enters the respective addition chamber, the data comprising a series of codes; successively steering the polymer from deblock chambers through the nanopore into the addition chambers to add codes to the polymer to create the digital data pattern on the polymer; and accurately controlling the bit rate of the polymer using a servo controller. The device may have loading chamber(s) to load (or remove) the polymer into/from the deblock chambers through at least one “micro-hole”. The cell may be part of a memory system that stores and retrieves “raw” data and allows for remote retrieval and conversion. The cell may store multi-bit data having a plurality of states for the codes.

Abstract: The present invention provides scanning mechanisms for imaging probes using for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and/or optical coherence tomography. The imaging probes include adjustable rotational drive mechanism for imparting rotational motion to an imaging assembly containing either optical or ultrasound transducers which emit energy into the surrounding area. The imaging assembly includes a scanning mechanism having including a movable member configured to deliver the energy beam along a path out of said elongate hollow shaft at a variable angle with respect to said longitudinal axis to give forward and side viewing capability of the imaging assembly. The movable member is mounted in such a way that the variable angle is a function of the angular velocity of the imaging assembly.