Abstract: A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA.

Abstract: This document describes tools useful in relaying a data stream from a data device to a network tunnel. These tools may utilize an encapsulation scheme to convert data packets from a user format to a tunnel format required by a network tunnel. Similarly, the tools may utilize a de-encapsulation scheme to convert data packets from the tunnel format to the user format required by the user. The tools may also forward the data packets from a user network to the network tunnel and vice versa, through a conventional switch module. In some embodiments, the tools do so by modifying the data packets to add a provisional identifier recognized by the switch module to map a particular data stream into a particular network tunnel.

Abstract: A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a filamentous bacteriophage particle containing DNA encoding the sbp member, wherein the sbp member has a binding domain that consists of a dAb fragment. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected filamentous bacteriophage particles for expression of the selected sbp members.

Abstract: Provided are a method, system, and article of manufacture for receiving an initial request from a first device to a second device. A response to the initial request is received from the second device to the first device. Each response and request received from the first device to the second device is processed by accessing the response or request from a packet encoded using a first communication protocol; generating a packet including the accessed response or request into a packet encoded using a second communication protocol; and transmitting the generated packet to the second device. Each response and request received from the second device to the first device is processed by accessing the response or request from a packet encoded using the second communication protocol; generating a packet including the accessed response or request into a packet encoded using the first communication protocol; and transmitting the generated packet to the second device.

Abstract: A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA.

Abstract: A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA.

Abstract: This document describes tools useful in relaying a data stream from a data device to a network tunnel, such as by enabling virtual switching using a provisional identifier to conceal a user identifier. These tools, for example, may use an inexpensive switch module to create virtual switch instances. To do so, the tools may assign data packets to a virtual switch instance by mapping the data packets to a particular provisional identifier and then modifying the data packets to include the provisional identifier. The switch module may then forward the data packets based on the provisional identifier rather than on the user identifier. The tools may remove the provisional identifier before forwarding the data packets to a destination.

Abstract: A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA.

Abstract: This document describes tools useful in relaying a data stream from a data device to a network tunnel, such as by enabling virtual switching using a provisional identifier to conceal a user identifier. These tools, for example, may use an inexpensive switch module to create virtual switch instances. To do so, the tools may assign data packets to a virtual switch instance by mapping the data packets to a particular provisional identifier and then modifying the data packets to include the provisional identifier. The switch module may then forward the data packets based on the provisional identifier rather than on the user identifier. The tools may remove the provisional identifier before forwarding the data packets to a destination.

Abstract: A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA.

Abstract: A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA.

Abstract: Provided are a method, system, and article of manufacture to process communications between a host and storage drive having a storage media. An Input/Output (I/O) request is received from the host directed to the storage media that requires requested information be sent to the storage drive to use to execute the I/O request against the storage media. A message is sent to the host to cause the host to modify I/O timeout operations in response to determining that the requested information is required.

Abstract: Thiophenepyrimidinone compounds and their use in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring inhibition of 17?-hydroxysteroid dehydrogenase enzymes.

Abstract: An apparatus, system, and storage medium are disclosed for utilizing data protection by a storage device to minimize loss of sensitive data on a storage medium. The apparatus includes a monitor module, a verification module, and a process module. The monitor module recognizes a write-type command from a host connected to an electronic data storage device. The verification module determines a presence of a passkey associated with the write-type command. The process module processes the write-type command according to the determination of the presence of the passkey. The apparatus, system, and storage medium provide protection of sensitive data at the device level so that a designated protected area on the electronic data storage device is protected against an inadvertent data overlay.

Abstract: A fast dispersing solid pharmaceutical composition having a monoamine oxidase B inhibitor as the only active ingredient is disclosed for the treatment of Parkinson's disease. The composition is formulated to promote absorption through the buccal, sublingual, pharyngeal and/or esophageal mucous membranes, such that at least 5% of the active ingredient is absorbed in one minute, as determined by a buccal absorption test.

Abstract: Provided are a method, system, and article of manufacture to process communications between a host and storage drive having a storage media. An Input/Output (I/O) request is received from the host directed to the storage media that requires requested information be sent to the storage drive to use to execute the I/O request against the storage media. A message is sent to the host to cause the host to modify I/O timeout operations in response to determining that the requested information is required.

Abstract: Provided are a method, system, and article of manufacture for receiving an initial request from a first device to a second device. A response to the initial request is received from the second device to the first device. Each response and request received from the first device to the second device is processed by accessing the response or request from a packet encoded using a first communication protocol; generating a packet including the accessed response or request into a packet encoded using a second communication protocol; and transmitting the generated packet to the second device. Each response and request received from the second device to the first device is processed by accessing the response or request from a packet encoded using the second communication protocol; generating a packet including the accessed response or request into a packet encoded using the first communication protocol; and transmitting the generated packet to the second device.

Abstract: Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGF?) bind specifically isoforms TGF?2 and TGF?1 or both, preferentially compared with TGF?3. Specific binding members may be isolated and utilized in the treatment of disease, particularly fibrotic disease and also immune/inflammatory diseases. Therapeutic utility is demonstrated using in vitro and in vivo models. Full sequence and binding information is provided, including epitope sequence information for particularly advantageous specific binding member which binds the active form of TGF?2, neutralizing its activity, but does not bind the latent member.

Abstract: A connection manager receives connection status indicators from a remote access service and invokes status threshold based responses. A received status indicator is received in response to a connection request. In another example, the status indicator is pushed to the connection manager. Status indicators are recorded in a status data structure. Status threshold based responses are identified in a status threshold response data structure. When a status indication count corresponds with a threshold value in a status threshold response data structure, a corresponding status threshold based response is invoked. A status data structure is sent to a remote server, and a new status data structure is received. In another example, a new status threshold response data structure is received. In another example, one or more new or updated status responses are received.

Abstract: A data traffic shaping system, comprises a plurality of burst groups, each burst group having a burst group credit allocation mechanism configured to earn credit over time; a shaping engine configured to manage incoming entries of traffic and to assign each incoming entry of traffic to a selected queue of the burst group depending on the characteristics of the entry; a plurality of queues, respective queues belonging to respective burst groups; and a bandwidth allocation table including locations identifying a queue and an amount of bandwidth credit to allocate to that queue, the shaping engine being configured to traverse the locations, to determine the bandwidth earned by the queues, such credit only being made available to the queue if its assigned burst group has at least that much credit available at that instant in time, and to process an entry in that queue only if the queue has earned a predetermined minimum amount of credit, relative to the current entry on the queue in question.