Abstract: A method of treatment for the prevention or therapy of a protein aggregation disease includes the administration in combination of a first active medicament and a second active medicament, wherein the first active medicament is active to impede aggregation of amyloid protein and the second active medicament is active to disaggregate previously formed aggregates of amyloid protein.

Abstract: A linear sensor (101, 201) comprising electrically conductive textile fibers (103, 105, 205, 207) and electrically insulating textile fibers (106, 208). The sensor comprises at least two conductive elements (102, 104, 204, 206) having electrically conductive textile fibers (103,105, 205, 207). The sensor also has electrically insulating textile fibers (106, 208) spaced to separate the two electrically conductive elements when no pressure is applied to said sensor, and to allow electrical conduction between the two conductive elements under the application of pressure.

Abstract: A sensor having a three layer construction comprising a first knitted conductive textile plane, a second conductive textile plane and an intermediate separating plane penetrable by the first knitted conductive textile plane to allow the first conductive textile plane and the second conductive textile plane to make electrical contact under a mechanical interaction. The intermediate separating plane defines structural endpoints from which the first knitted conductive textile plane deforms towards the second conductive textile plane under a mechanical interaction. The first knitted conductive textile plane has conductive yarn knitted to form a repeating pattern of stitches each comprising a stitch looping portion SLP having a looping portion footprint LPF. Within the sensor, there is at least one of a plurality of described dimensional relationships between stitches of the first knitted conductive textile plane and structural endpoints of the intermediate separating plane.

Abstract: A linear sensor (101, 201) comprising electrically conductive textile fibers (103, 105, 205, 207) and electrically insulating textile fibers (106, 208). The sensor comprises at least two conductive elements (102, 104, 204, 206) having electricall conductive textile fibers (103,105, 205, 207). The sensor also has electrically insulating textile fibers (106, 208) spaced to sepa the two electrically conductive elements when no pressure is applied to said sensor, and to allow electrical conduction between the two conductive elements under the application of pressure.

Abstract: A computer system comprising a first and second computer entity having program-accessible information; wherein the second computer entity is arranged to modify the second computer entity's program-accessible information in accordance with a received change to the first computer entity's program-accessible information if the second computer entity determines that the received change to the first computer entities program-accessible information complies with a first predetermined criteria and irrefutably establishes that the received change is associated with the first computer entity.

Abstract: A method for use in a computer system is provided that links a patient with patient-related data that is displayed on a graphical user interface. The method includes first determining if a digital watermark is required. If a digital watermark is required, the current background color for the display of patient-related data is obtained, along with an intensity value. The subject matter for the watermark is also obtained. The color of the digital watermark is calculated, based upon the obtained background color and intensity value. The digital watermark is then rendered on the display.

Abstract: The present invention relates to a manually operable input apparatus (202) for a portable electronic processing device (102), such as a mobile phone or hand-held processor. The apparatus defines a plurality of regions (303, 304) each representing a respective data item and comprises a plurality of sheets configured to produce a response to a mechanical interaction. Furthermore, the sheets are configured to be wrapped around the device to provide a protective cover.

Abstract: A method for use in a computer system is provided that links a patient with patient-related data that is displayed on a graphical user interface. The method includes first determining if a digital watermark is required. If a digital watermark is required, the current background color for the display of patient-related data is obtained, along with an intensity value. The subject matter for the watermark is also obtained. The color of the digital watermark is calculated, based upon the obtained background color and intensity value. The digital watermark is then rendered on the display.

Abstract: A computer system comprising a first and second computer entity having program-accessible information; wherein the second computer entity is arranged to modify the second computer entity's program-accessible information in accordance with a received change to the first computer entity's program-accessible information if the second computer entity determines that the received change to the first computer entities program-accessible information complies with a first predetermined criteria and irrefutably establishes that the received change is associated with the first computer entity.

Abstract: A method for detecting aggregation or polymerization of molecules in a sample, which method comprises the steps of: a) exposing a sample containing the molecules to at least two labelling moieties which will bind to only a single mutually exclusive site on each of the said molecules; and b) determining whether multiply-bound labelling moieties are present. The method is particularly of use in differentiating pathogenic aggregated protein molecules from non-pathogenic, non-aggregated protein molecules.

Abstract: A tactile feedback simulating fabrication for use with an input device provides flexible mouldings (801) locatable above detection positions. Flexible mouldings (801) provide tactile feedback simulating a key-press. Each of the mouldings (801) defines a top portion (802) and a flexible side wall (803). A flexible fabric layer (804) is attached to the flexible mouldings thereby significantly enhancing the durability of these mouldings.

Abstract: The present invention relates to a manually operable input apparatus (202) for a portable electronic processing device (102), such as a mobile phone or hand-held processor. The apparatus defines a plurality of regions (303, 304) each representing a respective data item and comprises a plurality of sheets configured to produce a response to a mechanical interaction. Furthermore, the sheets are configured to be wrapped around the device to provide a protective cover.

Abstract: The present invention relates to a data input device suitable for inputting data to electronic processing means. The data input device is configured to produce an output in response to a mechanical interaction and may be reconfigured into two operational configurations. In a first flexible configuration the device may be bent or flexed about a first axis, and in a second rigid configuration the data input device is substantially rigid such that bending or flexing of the device about the first axis is inhibited.

Abstract: The present invention relates to a method for detecting a target material in a sample, which method comprises the steps of: a) exposing a sample, expected to contain that target material, to at least two viruses which are capable of binding directly or indirectly with that target material so as to form a virally bound target material and to endow the virally bound target material with a distinctive property; and b) cultivating the product from stage a in the presence of an indicator material to which the viruses carried by the virally bound target material attach so as to cause the indicator material to adopt the distinctive property of the virally bound target material; and c) monitoring the presence or otherwise of virally attached indicator material. The invention also provides a kit for use in the method of the invention.

Abstract: A tactile feedback simulating fabrication for use with an input device provides flexible mouldings (801) locatable above detection positions. Flexible mouldings (801) provide tactile feedback simulating a key-press. Each of the mouldings (801) defines a top portion (802) and a flexible side wall (803). A flexible fabric layer (804) is attached to the flexible mouldings thereby significantly enhancing the durability of these mouldings.

Abstract: The present invention relates to a method for enhancing the time of response of an assay for a first bacterium, wherein: a) the first bacterium is exposed to infection by phage particles to which the first bacterium is permissive; b) the infected bacterium is treated to inactivate exogenous phage particles; c) the treated bacterium is cultivated in the presence of a second bacterium which is permissive to infection by the phage or its replicand and which has a doubling rate greater than the effective doubling rate of the first bacterium; and d) assessing the extent of plaque formation and/or of second bacterium growth in the cultivated second bacterium cells.

Abstract: The present invention relates to a data input device suitable for inputting data to electronic processing means. The data input device is configured to produce an output in response to a mechanical interaction and may be reconfigured into two operational configurations. In a first flexible configuration the device may be bent or flexed about a first axis, and in a second rigid configuration the data input device is substantially rigid such that bending or flexing of the device about the first axis is inhibited.