Abstract: A dry powder pharmaceutical formulation for inhalation including a compound of formula (I): that is 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((6-ethylpyrazin-2-yl)amino)pyridin-4-yl)methoxy)naphthalen-1-yl)urea or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and isotopic derivatives thereof; and lactose as a topically acceptable diluent. An inhaler device containing the dry powder pharmaceutical formulation is also described.

Abstract: There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. (Formula (1)).

Abstract: There are provided compounds of formula (I) which are inhibitors of the family of p38 mitogen-activated protein kinase enzymes, and to their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.

Abstract: The present invention relates to respiratory formulations comprising a compound of formula (I): and use of said compounds and compositions in treatment, for example in the treatment of an inflammatory disease or a respiratory disorder, in particular an inflammatory mediated and/or virally mediated respiratory disorder such as asthma and COPD or the treatment or prevention of viral infection, for example infection by influenza virus, rhinovirus or RSV. The invention also extends to certain novel compounds of formula (I).

Abstract: There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. (Formula (1)).

Abstract: There are provided inter alia compounds of formula (I) wherein R1, R2a, R2b, R3, R4, L, X, R5 and R6 are as defined in the description for use in the treatment of inflammatory diseases.

Abstract: There are provided compounds of formula (I) which are inhibitors of the family of p38 mitogen-activated protein kinase enzymes, and to their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.

Abstract: There is provided a compound of formula (I) which is an inhibitor of the family of p38 mitogen-activated protein kinase enzymes, and to its use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.

Abstract: A compound which is a benzimidazolyl isoxazole of formula (I): wherein: R0 and R, which are the same or different, are each H or C1-6 alkyl; R9, R9 and R9, which are the same or different, are each H or F; X is -(alkn-, -alk-C(?O)—NR—, -alk-NR—C(?O)— or -alk-C(?O)—; R1 is selected from —S(?O)2R?; a 4- to 6-membered, C-linked heterocyclic group which is unsubstituted or substituted; and an N-linked spiro group of the following formula: R2 and R2?, which are the same or different, are each H or C1-6 alkyl, or R2 and R2? form, together with the C atom to which they are attached, a C3-6 cycloalkyl group; R3 and R3, which are the same or different, are each H, C1-6 alkyl, OH or F; R4 is phenyl or a 5- to 12-membered, N-containing heteroaryl group and is unsubstituted or substituted; alk is C1-6 alkylene; R? is C1-6 alkyl; and n is 0 or 1; or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.

Abstract: There are provided compounds of formula (I) as defined in the specification which are p38 MAP kinase inhibitors for use as medicaments for the treatment inter alia of inflammatory diseases.

Abstract: The present invention is a method or system of analyzing items to create a data structure using lexicon analysis and filtering process. The present invention drives the analysis without a user being required to provide search terms and Boolean queries. Further, the present invention merges the use of unstructured data and structured data using a lexicon as a focus. Structured data is mapped to lexicon terms through one analysis process, while unstructured data is mapped to lexicon terms through a separate analysis process. In some disclosed embodiments, the mapping process uses a tuple structure of the source data to match with lexicon terms. The result is an analysis that merges the two different sets of data, which enables a user to navigate through the items using lexicons. Analysis results are displayed simultaneously in a tabular view, geospatial view, and lexicon histogram.

Abstract: The present invention is a method or system of generating statistical distributions using lexicon analysis and filtering process. The present invention drives the analysis without a user being required to provide search terms and Boolean queries. Further, the present invention merges the use of unstructured data and structured data using a lexicon as a focus. Structured data is mapped to lexicon terms through one analysis process, while unstructured data is mapped to lexicon terms through a separate analysis process. The result is an analysis that merges the two different sets of data, which enables a user to navigate through the items using lexicons. Analysis results are displayed simultaneously in a tabular view, geospatial view, and lexicon histogram.

Abstract: There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. (Formula (1)).

Abstract: A downhole actuator typically for a downhole tool such as a valve, and typically for incorporation in a string of tubulars in an oil or gas well has a central axis with radially movable counterweights on opposite sides of the axis, which move radially outward to change the activation state of the actuator. The counterweights are supported by link arms which control the movement of the counterweights in response to centrifugal force created by rotation of the body, for example, during rotary drilling operations of the string. Radial outward movement of the counterweights typically transmits axial forces between sleeves at the upper and lower ends of the counterweights, so when the counterweights move radially outward, the upper and lower sleeves approach one another, which typically triggers the actuator.

Abstract: There are provided compounds of formula (I) as defined in the specification, which are p38 MAP kinase inhibitors for use as medicaments for the treatment inter alia of inflammatory diseases.

Abstract: The invention is directed to compounds of general formula (I), and pharmaceutical compositions containing such compounds. The compounds and compositions have valuable pharmaceutical properties. In particular, they may be used for the treatment of cancer. Novel intermediates and novel methods of preparation are also disclosed.

Abstract: The present invention is a method or system of analyzing items using lexicon analysis and filtering process. The present invention drives the analysis without a user being required to provide search terms and Boolean queries. Further, the present invention merges the use of unstructured data and structured data using a lexicon as a focus. Structured data is mapped to lexicon terms through one analysis process, while unstructured data is mapped to lexicon terms through a separate analysis process. The result is an analysis that merges the two different sets of data, which enables a user to navigate through the items using lexicons. Analysis results are displayed simultaneously in a tabular view, geospatial view, and lexicon histogram.

Abstract: There is provided a compound of formula (I) which is an inhibitor of the family of p38 mitogen-activated protein kinase enzymes, and to its use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.

Abstract: There are provided inter alia compounds of formula (I) wherein R1, R2a, R2b, R3, R4, L, X, R5 and R6 are as defined in the description for use in the treatment of inflammatory diseases.

Abstract: A downhole actuator typically for a downhole tool such as a valve, and typically for incorporation in a string of tubulars in an oil or gas well has a central axis with radially movable counterweights on opposite sides of the axis, which move radially outward to change the activation state of the actuator. The counterweights are supported by link arms which control the movement of the counterweights in response to centrifugal force created by rotation of the body, for example, during rotary drilling operations of the string. Radial outward movement of the counterweights typically transmits axial forces between sleeves at the upper and lower ends of the counterweights, so when the counterweights move radially outward, the upper and lower sleeves approach one another, which typically triggers the actuator.