Patents by Inventor Stuart Thomas

Stuart Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel 5,6-Dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives
    Publication number: 20170355718
    Abstract: There are provided inter alia compounds which are intended to treat or prevent respiratory syncytial virus infections and associated disease particularly infections caused by the A and B strains thereof.
    Type: Application
    Filed: December 18, 2015
    Publication date: December 14, 2017
    Applicant: PULMOCIDE LIMITED
    Inventors: Euan Alexander Fraser FORDYCE, Simon Fraser HUNT, Stuart Thomas ONIONS, Vladimir SHERBUKHIN, Matthew Stephen COATES, Daniel William BROOKES, Kazuhiro ITO, Peter STRONG, John KING-UNDERWOOD
  • NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVES
    Publication number: 20170355717
    Abstract: There are provided 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives which are useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection.
    Type: Application
    Filed: October 8, 2015
    Publication date: December 14, 2017
    Inventors: Simon Fraser HUNT, Stuart Thomas ONIONS, Vladimir SHERBUKHIN, Euan Alexander Fraser FORDYCE, Peter John MURRAY, Matthew Stephen COATES, Daniel William BROOKES, Kazuhiro ITO, Peter STRONG
  • 2-((4-AMINO-3-(3-FLUORO-5-HYDROXYPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1 -YL)METHYL)-3-(2-(TRIFLUORO-MET HYL)BENZYL)QUINAZOLIN-4(3H)-ONE DERIVATIVES AND THEIR USE AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS
    Publication number: 20170334919
    Abstract: The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.
    Type: Application
    Filed: July 27, 2017
    Publication date: November 23, 2017
    Applicant: RESPIVERT LTD.
    Inventors: Rudy Laurent Maria Broeckx, Alex Herman Copmans, Alun John Smith, David Michel Adrien Taddei, Stuart Thomas Onions
  • COMPOUND
    Publication number: 20170320858
    Abstract: This invention relates to compounds, as defined in the specification, useful in the treatment of mycoses, compositions containing them and their use in therapy.
    Type: Application
    Filed: December 4, 2015
    Publication date: November 9, 2017
    Inventors: Thomas Christopher COLLEY, Kazuhiro ITO, Garth RAPEPORT, Peter STRONG, Peter John MURRAY, Stuart Thomas ONIONS, Mihiro SUNOSE
  • 1-PYRAZOLYL-3-(4-((2-ANILINOPYRIMIDIN-4 -YL) OXY) NAPTHTHALEN-1 - YL) UREAS AS P38 MAP KNASE INHIBITORS
    Publication number: 20170312279
    Abstract: There are provided compounds of formula (I) which are inhibitors of the family of p38 mitogen-activated protein kinase enzymes, and to their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.
    Type: Application
    Filed: June 29, 2017
    Publication date: November 2, 2017
    Applicant: Respivert Ltd.
    Inventors: Kazuhiro Ito, Catherine Elisabeth Charron, John King-Underwood, Stuart Thomas Onions, Alistair Ian Lonshaw
  • Novel 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative
    Publication number: 20170305935
    Abstract: There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. (Formula (1)).
    Type: Application
    Filed: July 6, 2017
    Publication date: October 26, 2017
    Inventors: Simon Fraser HUNT, Stuart Thomas ONIONS, Vladimir SHERBUKHIN, Euan Alexander Fraser FORDYCE, Peter John MURRAY, Daniel William BROOKES, Kazuhiro ITO, Peter STRONG
  • Pyrazole p38 map kinase inhibitors
    Patent number: 9771354
    Abstract: There are provided inter alia compounds of formula (I) wherein R1, R2a, R2b, R3, R4, L, X, R5 and R6 are as defined in the description for use in the treatment of inflammatory diseases.
    Type: Grant
    Filed: January 18, 2016
    Date of Patent: September 26, 2017
    Assignee: Respivert Ltd.
    Inventors: John King-Underwood, George Hardy, Peter John Murray, Jonathan Gareth Williams, Stuart Thomas Onions
  • 2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl)methyl)-3-(2-(trifluoromethyl)benzyl) quinazolin-4(3H)-one derivatives and their use as phosphoinositide 3-kinase inhibitors
    Patent number: 9745306
    Abstract: The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 29, 2017
    Assignee: Respivert Limited
    Inventors: Rudy Laurent Maria Broeckx, Alex Herman Copmans, Alun John Smith, David Michel Adrien Taddei, Stuart Thomas Onions
  • 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative
    Patent number: 9732098
    Abstract: There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. (Formula (1)).
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: August 15, 2017
    Assignee: PULMOCIDE LIMITED
    Inventors: Simon Fraser Hunt, Stuart Thomas Onions, Vladimir Sherbukhin, Euan Alexander Fordyce, Peter John Murray, Daniel William Brookes, Kazuhiro Ito, Peter Strong
  • 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as P38 MAP knase inhibitors
    Patent number: 9724347
    Abstract: There are provided compounds of formula (I) which are inhibitors of the family of p38 mitogen-activated protein kinase enzymes, and to their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: August 8, 2017
    Assignee: Respivert, Ltd.
    Inventors: Kazuhiro Ito, Catherine Elisabeth Charron, John King-Underwood, Stuart Thomas Onions, Alistair Ian Longshaw
  • Pyrazolyl-ureas as kinase inhibitors
    Patent number: 9701670
    Abstract: There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: July 11, 2017
    Assignees: RESPIVERT LIMITED, TOPIVERT PHARMA LIMITED
    Inventors: Claire Anne Marie Cariou, Catherine Elisabeth Charron, Euan Alexander Fraser Fordyce, Daniel Hamza, Matthew Colin Thor Fyfe, Kazuhiro Ito, John King-Underwood, Peter John Murray, Stuart Thomas Onions, Stephen Malcolm Thom, Hayley Tegan Angela Watson, Jonathan Gareth Williams
  • NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVE
    Publication number: 20170190718
    Abstract: There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. (Formula (1)).
    Type: Application
    Filed: October 8, 2015
    Publication date: July 6, 2017
    Applicant: Akliebolaget SKF
    Inventors: Simon Fraser HUNT, Stuart Thomas ONIONS, Vladimir SHERBUKHIN, Euan Alexander FORDYCE, Peter John MURRAY, Daniel William BROOKES, Kazuhiro ITO, Peter STRONG
  • INHIBITOR OF p38 MAP KINASE
    Publication number: 20170182039
    Abstract: A dry powder pharmaceutical formulation for inhalation including a compound of formula (I): that is 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((6-ethylpyrazin-2-yl)amino)pyridin-4-yl)methoxy)naphthalen-1-yl)urea or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and isotopic derivatives thereof; and lactose as a topically acceptable diluent. An inhaler device containing the dry powder pharmaceutical formulation is also described.
    Type: Application
    Filed: March 13, 2017
    Publication date: June 29, 2017
    Inventors: ALISTAIR IAN LONGSHAW, EUAN ALEXANDER FRASER FORDYCE, STUART THOMAS ONIONS, JOHN KING-UNDERWOOD, JENNIFER VENABLE
  • Inhibitor of p38 MAP kinase
    Patent number: 9624196
    Abstract: A compound of formula (XV): wherein R1 represents an amino group, a protected amino group or nitro group; or a salt thereof. The compound is a p38 MAP kinase inhibitor. The compound and its pharmaceutically acceptable salts can be used for treatment of conditions, such as inflammatory diseases.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: April 18, 2017
    Assignees: RESPIVERT LTD., TOPIVERT PHARMA LTD.
    Inventors: Alistair Ian Longshaw, Euan Alexander Fraser Fordyce, Stuart Thomas Onions, John King-Underwood, Jennifer Venable
  • AQUEOUS SUSPENSION OF INORGANIC PARTICULATE MATERIAL
    Publication number: 20170088713
    Abstract: An aqueous suspension comprising an inorganic particulate material and dimethylethanolamine, use of dimethylethanolamine to prevent pH decrease or reduce the rate of pH decrease of an aqueous suspension comprising an inorganic particulate material over time, use of dimethylethanolamine as an anti-microbial additive in an aqueous suspension comprising an inorganic particulate material, and a method of preparing an aqueous suspension comprising inorganic particulate material.
    Type: Application
    Filed: December 19, 2014
    Publication date: March 30, 2017
    Inventors: Desmond Charles PAYTON, Stuart THOMAS
  • NOVEL COMPOUNDS
    Publication number: 20170057945
    Abstract: There are provided compounds of formula (I) as defined in the specification which are p38 MAP kinase inhibitors for use as medicaments for the treatment inter alia of inflammatory diseases.
    Type: Application
    Filed: February 13, 2015
    Publication date: March 2, 2017
    Inventors: Alistair Ian LONGSHAW, Euan Alexander Fraser FORDYCE, Stuart Thomas ONIONS, John KING-UNDERWOOD, Jennifer Diane VENABLE, Iain WALTERS
  • Phosphoinositide 3-kinase inhibitors
    Patent number: 9556184
    Abstract: The present invention relates inter alia to a compound of formula (I) and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compounds.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: January 31, 2017
    Assignee: Respivert, Ltd.
    Inventors: David Michel Adrien Taddei, Stuart Thomas Onions, Alun John Smith, Alex Herman Copmans, Rudy Laurent Maria Broeckx
  • Profiling tool for determining material thickness for inspection sites having complex topography
    Patent number: 9551690
    Abstract: A phased array ultrasonic probe may be mounted to a component to be inspected for wall thickness on an apparatus that includes a split ring adapted to be magnetically held in place on the component. In particular, the probe may be mounted to a carriage connected to the split ring in a manner that allows the carriage to rotate around the split ring while the probe is in operation. Between the probe and the component, a transducer shoe defining, by a flexible membrane, a cavity and an aperture. Conveniently, the construction of the flexible membrane allows wall thickness measurements to be acquired in portions of the component that have complex topography, such as welds. The apparatus is installed on an adaptor assembly for inspection of straight section of pipes. This adaptor assembly is not used in absence of straight section.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: January 24, 2017
    Assignee: Atomic Energy Of Canada Limited
    Inventors: Michel Joseph Gilles Gaudet, Robert Hayden Lumsden, Glenn Curtis Longhurst, Kristopher Kyle Jones, Stuart Thomas Craig, David Walter Dunford, Paul Gregory Adams, Kenneth Robert Chaplin, Helene Marie Hebert
  • 1-PYRAZOLYL-3-(4-((2-ANILINOPYRIMIDIN-4 -YL) OXY) NAPTHTHALEN-1 - YL) UREAS AS P38 MAP KNASE INHIBITORS
    Publication number: 20170007604
    Abstract: There are provided compounds of formula (I) which are inhibitors of the family of p38 mitogen-activated protein kinase enzymes, and to their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.
    Type: Application
    Filed: September 8, 2016
    Publication date: January 12, 2017
    Applicant: Respivert Ltd.
    Inventors: Kazuhiro Ito, Catherine Elisabeth Charron, John King-Underwood, Stuart Thomas Onions, Alistair Ian Longshaw
  • INHIBITOR OF p38 MAP KINASE
    Publication number: 20160368896
    Abstract: A compound of formula (XV): wherein R1 represents an amino group, a protected amino group or nitro group; or a salt thereof. The compound is a p38 MAP kinase inhibitor. The compound and its pharmaceutically acceptable salts can be used for treatment of conditions, such as inflammatory diseases.
    Type: Application
    Filed: August 31, 2016
    Publication date: December 22, 2016
    Inventors: ALISTAIR IAN LONGSHAW, EUAN ALEXANDER FRASER FORDYCE, STUART THOMAS ONIONS, JOHN KING-UNDERWOOD, JENNIFER VENABLE