Abstract: The invention provides a compound which is (a) an amino acid derivative of formula (I) or a tautomer thereof, or (b) a pharmaceutically acceptable salt, N-oxide, hydrate or solvate thereof: wherein R1, R2, L1, Het, A, x, y and W are as defined herein. The compounds are useful in the treatment of diseases mediated by HSP90.

Abstract: A beverage dispensing system includes serving spouts in fluid connection with inlet pipes locatable within beverage receptacles. The serving spouts have receptacle identifiers and are associated with prices/price groups or points/points groups. Product data sets in computer memory include a product identifier and have associated receptacle identifiers and prices or points. A reading device calculates value from a stored value device. Stored value device data sets in computer memory include stored value device identifiers and stored values. A user selection component obtains a serving spout selection, and dispenses a volume of beverage from the selected serving spout by comparing the prices or points associated with the selected serving spout and the stored value. User data sets and transaction data sets in computer memory include user identifiers, stored value device identifiers, stored value device identifiers, and receptacle identifiers.

Abstract: Novel flavonoid compounds having anti-oxidant activity are described. Formula 1. The compounds have been shown to exhibit anti-oxidative properties in biological systems and their utility in a sunscreen or skincare composition or to treat conditions involving oxidative damage, especially curative or prophylactic treatment of Alzheimer's disease or ischaemia-reperfusion injury, is described.

Abstract: An ETF pricing mechanism for use in managed Exchange Traded Fund (ETF) or other collective investment vehicle (CIV) that retains the confidentiality of the vehicle's assets. The method of pricing may comprise: selecting a security price for each portfolio security, wherein each selected security price is associated with a time offset within a pricing interval, and wherein the time offsets are not identical for all of the selected security prices; generating a plurality of partial price components based on the selected security prices; determining a intra-day indicative value (IIV) of a CIV share in response to the plurality of partial price components; and, publishing the determined IIV.

Abstract: A microwave antenna suitable for cardiac ablation, in particular for catheter ablation, and a method for making such an antenna. The antenna comprises a transmission line having an inner conductor, an outer conductor, and a dielectric insulator to provide insulation between the inner and outer conductors. An energy emitting antenna element is located at the distal end of the transmission line. The antenna element has an inner conductor which is electrically coupled to the inner conductor of the transmission line, and, around the inner conductor, a sheath of dielectric insulator continuous with the insulator of the transmission line. At its distal end, a hollow metallic cap is electrically connected to the inner conductor, surrounding a length of the insulator.

Abstract: A hydraulic turbine has a distributor located between the scroll of the turbine and its runner. The distributor has upper and lower stay ring portions with stay vanes extending therebetween. A plurality of movable wicket gates control flow of liquid through the distributor. The lower and upper stay ring portions have built up fish friendly projections adjacent sweep areas defined where the wicket gates sweep across the lower and upper stay ring portions. The projections also extend outwardly of the upper and lower stay ring portions adjacent the sweep areas and act as barriers preventing fish from being trapped between the wicket gates and the stay ring. Each projection has a sill portion projecting outwardly at least coextensive with, and adjacent to, one sweep area and a first apron portion extending from the sill portion to an appropriate one of the upper and lower stay ring portions.

Abstract: An elongate, malleable ablation probe including an elongate malleable body and a plurality of longitudinally spaced apart electrodes disposed at a distal end thereof. The electrodes are separated one from another by insulative material. In one embodiment, a malleable insert is provided for insertion into a flexible longitudinal sleeve, the flexible longitudinal sleeve conforming to the shape of the malleable insert upon such insertion. In other embodiments, a malleable core is surrounded by a flexible body, the electrodes being mounted to the body.

Abstract: An elongate, malleable ablation probe including an elongate malleable body (38) and a plurality of longitudinally spaced apart electrodes (40) disposed at a distal end thereof. The electrodes (40) are separated one from another by insulative material. In one embodiment, a malleable insert is provided for insertion into a flexible longitudinal sleeve, the flexible longitudinal sleeve conforming to the shape of the malleable insert upon such insertion. In other embodiments, a malleable core is surrounded by a flexible body, the electrodes (40) being mounted to the body.

Abstract: The present invention provides a process using a zeolite or molecular sieve for recovering isoflavones from aqueous mixtures, such as soy whey and other biological waste products. A zeolite, such as a large pore, hydrophobic zeolite, has a significantly higher affinity for isoflavones than conventional polymeric adsorbents, and has essentially no affinity for the undesired oligosaccharides raffinose and stachyose.

Abstract: The present invention provides a process using zeolites for recovering isoflavones and removing undesired oligosaccharides from aqueous mixtures, such as soy whey and other plant processing waste products. The aqueous mixture is treated with a large pore hydrophobic zeolite, such as zeolite Beta, to remove isoflavones, followed by treatment with an ultrastabilized, hydrophobic zeolite Y, such as CBV-901 or HiSiv™ 4000, to remove the undesired oligosaccharides raffinose and stachyose. The recovered isoflavones and digestible sugars, glucose, sucrose, and fructose, are useful in food products.

Abstract: The present invention relates to a process for selectively removing undesired oligosaccharides from aqueous mixtures such as plant processing waste products, including soy whey and other vegetable wheys, using an ultrastabilized large pore, hydrophobic zeolite Y. The resulting solution, which contains isoflavones and digestible sugars such as glucose, fructose and sucrose, can serve as the basis for a nutritious new product.

Abstract: This invention relates to a process for producing a mixture of levulinic acid esters and formic acid esters from biomass and olefins, and the composition prepared therefrom. This invention also relates to usage of the mixture of these esters as fuel additives for gasoline fuel, diesel fuel, and biofuel.

Abstract: A method and system for analyzing hydraulic turbine noise vibrations involves recording the noise of a hydraulic turbine either during operation or intentionally produced for testing from a remote site. A standard laptop computer is utilized by personnel at the turbine site to record the sound at different power outputs as specified by turbine experts with a standard Windows sound recording program that produce sound files. The sound files are compressed at the site and sent to the expert office location via Email. Once received at the expert location, the sound files are uncompressed and analyzed immediately by the turbine experts without the experts having had to travel to the remote site. The analysis is done with a software sound analyzer. The analyzed signals are used to diagnose the machine and address any unusual recorded noise.

Abstract: Method and apparatus for mounting an axially slidable brake disc (12) in a spot-type automotive disc brake provides a technique for refining the brake performance by largely eliminating vibration and/or judder in use by the adoption of a brake disc friction face (18) inner edge which is radially outwardly displaced with respect to normal practice and is likewise (radially) relatively close to the teeth of keys of the disc drive system. In this way the more slender braking surface of the brake disc together with its relatively closely adjacent axially slidable drive, leads to improved dynamic performance while maintaining thermal capacity requirements.

Abstract: Reaction hydraulic turbine that includes a draft tube having side wails arranged to define an inlet and an outlet and an elbow arranged to position the outlet substantially perpendicular to the inlet. A turbine runner is positioned adjacent the inlet and the outlet is arranged to define a flow exit, and a splitter vane is mounted within the draft tube to partially extend across a width of the draft tube. In this manner, flow is redirected about the elbow of the draft tube. The splitter vane includes opposing side edge surfaces that are spaced from the side walls, such that swirl flow is permitted around the splitter vane within the draft tube.

Abstract: An elongate, malleable ablation probe including an elongate malleable body (38) and a plurality of longitudinally spaced apart electrodes (40) disposed at a distal end thereof. The electrodes (40) are separated one from another by insulative material. In one embodiment, a malleable insert is provided for insertion into a flexible longitudinal sleeve, the flexible longitudinal sleeve conforming to the shape of the malleable insert upon such insertion. In other embodiments, a malleable core is surrounded by a flexible body, the electrodes (40) being mounted to the body.

Abstract: A foot actuated computer mouse adaptor for operating a conventional computer mouse with a computer user's foot, used individually or in conjunction with one or more modular electronic adaptors that allow simultaneous use of additional conventional computer mice to drive a single cursor or multiple cursors. The foot actuated computer mouse adaptor allows a computer user to move and actuate the buttons of a conventional computer mouse via movement of one of the user's feet on any substantially flat surface. Simultaneous actuation of two or more conventional computer mice is achieved with an electronic modular adaptor that accepts input from each individual mouse and combines the two inputs to produce a single output. This single output can then be plugged directly into a computer, or into another modular adaptor, thereby allowing the simultaneous use of an unlimited number of conventional computer mice.

Abstract: An elongate, malleable ablation probe including an elongate malleable body (38) and a plurality of longitudinally spaced apart electrodes (40) disposed at a distal end thereof. The electrodes (40) are separated one from another by insulative material. In one embodiment, a malleable insert is provided for insertion into a flexible longitudinal sleeve, the flexible longitudinal sleeve conforming to the shape of the malleable insert upon such insertion. In other embodiments, a malleable core is surrounded by a flexible body, the electrodes (40) being mounted to the body.

Abstract: A lithographic process for device fabrication in which a pattern is transferred from a mask into an energy sensitive material by projecting charged particle (e.g. electron beam) radiation onto the mask is disclosed. The pattern on the mask is divided into segments. The radiation transmitted through the mask and incident on the layer of energy sensitive material transfers a continuous image of the segmented mask pattern into the energy sensitive material. The images of each segment are joined together to form the continuous image by seam blending techniques. The seam blending techniques employ duplicate pattern information on segments for which the images are joined together. The image of the duplicate pattern information from a first segment is overlapped with the image of the duplicate pattern information from the second segment to blend the seams together.

Abstract: The locking member of a ZIF socket, which is movable between a locked position, in which high contact forces are present between contact springs within the socket and pins extending from an electronic module into the socket, and an unlocked position, in which the pins are released from the contact springs, is held in the locked position by means of a portion of a clamping spring inserted into a gap between the locking member and a portion of the housing of the ZIF socket. The clamping spring also holds a heat sink in place on the electronic module.