Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula

Abstract: A coal uncovering construction method for blasting large cross-section gas tunnels includes: analyzing stress distribution characteristics in front of a tunnel boring working face, and then determining a thickness calculation model of a reserved rock wall based on a limit equilibrium theory; establishing a tunnel model, simulating a construction condition and analyzing a construction result, and determining a thickness of the reserved rock wall; and fixing a detonator through a fixed sand ring, fitting the detonator with a construction hole by adjusting an adjustable protective plate, then embedding the detonator into a blast hole, and blasting the detonator for tunnel construction. Furthermore, an extension ring is fixed between the fixed sand ring and the adjustable protective plate.

Abstract: An LED string light includes a first conducting wire, a second conducting wire, and a third conducting wire which are arranged in parallel. The first, second, and third conducting wires all comprise a conducting wire core and an insulation layer coating a surface of the conducting wire core, and the first conducting wire and the second conducting wire define a plurality of lamp welding regions. The LED string light also includes a plurality of SMD LEDs respectively disposed at the plurality of lamp welding regions. The first conducting wire is selectively cut off at a plurality of first positions and the second conducting wire is selectively cut off at a plurality of second positions based on whether the plurality of the SMD LEDs are connected in series or in hybrid of series and parallel.

Abstract: A coater is provided for depositing a coating onto a sequence of samples to be analyzed in a microscope. The coater includes a process chamber to maintain a low-pressure vacuum or controlled gaseous environment at a deposition region inside the process chamber, a sample conveyor to support and convey samples through the deposition region, an evaporant supply to vaporize material from an evaporant source onto the samples at the deposition region, and a controller to control one or more operations of the coater.

Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula (I)

Abstract: An LED string light includes a first conducting wire, a second conducting wire, and a third conducting wire which are arranged in parallel. The first conducting wire, the second conducting wire and the third conducting wire all comprise a conducting wire core and an insulation layer coating a surface of the conducting wire core, and the first conducting wire and the second conducting wire defines a plurality of lamp welding regions. The LED string light also includes a plurality of SMD LEDs respectively disposed at the plurality of lamp welding regions. Each SMD LED has a first welding leg and a second welding leg, which are respectively welded onto the first welding spot and the second welding spot at one corresponding lamp welding region, and the plurality of the SMD LEDs are connected in parallel. A plurality of encapsulation colloids respectively coat the plurality of the SMD LEDs.

Abstract: A recommendation method includes obtaining a candidate item to be recommended to a social network user, the social network user belonging to a group of users in an online social network, and determining attention of the group to the candidate item in the online social network. The determined attention of the group to the candidate item is based on an importance weight of each user in the group and based on attention of each user in the group to the candidate item. The method further includes determining, according to the determined attention of the group, whether to recommend the candidate item to the social network user through the online social network.

Abstract: A mobile liquid nitrogen fire extinguishing system for a utility tunnel is provided, including a liquid nitrogen production assembly, a fire extinguishing assembly, a monitoring device, and a liquid nitrogen conveying tubing. The mobile fire extinguishing assembly includes a liquid nitrogen storage tank and a liquid nitrogen booster pump. The liquid nitrogen storage tank is connected to the liquid nitrogen booster pump. The liquid nitrogen booster pump conveys liquid nitrogen to branch pipes in the utility tunnel through the liquid nitrogen conveying tubing. Liquid nitrogen injection ports are formed in each of the branch pipes. The liquid nitrogen production assembly is mobile and conveys the prepared liquid nitrogen to the liquid nitrogen storage tank. The monitoring device includes a first monitoring assembly and a second monitoring assembly.

Abstract: A recommendation method is provided. In the method, a candidate item to be recommended to a social network user is obtained. The social network user has at least two different types of social relationships. For at least one target social object in each of the at least two different types of social relationships of the social network user, attention of each of the at least one target social object in the respective type of social relationship to the candidate item is determined. According to the attention of each of the at least one target social object in the at least two different types of social relationships to the candidate item, a comprehensive attention of the target social objects of the at least two different types of social relationships to the candidate item is determined. According to the comprehensive attention, whether to recommend the candidate item to the social network user is determined.

Abstract: An LED string light includes a first conducting wire, a second conducting wire, and a third conducting wire which are arranged in parallel. The first, second, and third conducting wires all comprise a conducting wire core and an insulation layer coating a surface of the conducting wire core, and the first conducting wire and the second conducting wire define a plurality of lamp welding regions. The LED string light also includes a plurality of SMD LEDs respectively disposed at the plurality of lamp welding regions. The first conducting wire is selectively cut off at a plurality of first positions and the second conducting wire is selectively cut off at a plurality of second positions based on whether the plurality of the SMD LEDs are connected in series or in hybrid of series and parallel.

Abstract: The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.

Abstract: The present disclosure discloses an LED light string ornament and a method for producing the same. The LED light string ornament includes an LED light string and a plurality of decorative pieces. The LED light string includes three wires, a plurality of SMD LEDs, and a plurality of adhesive bodies. A part or a whole of the decorative piece are transparent or semi-transparent. The decorative piece includes a first housing and a second housing. The first housing and the second housing are buckled to form an accommodating cavity, and a plurality of LED beads of the LED light string are respectively accommodated in the accommodating cavities of the plurality of decorative pieces.

Abstract: An LED string light includes: a first conducting wire, a second conducting wire, a third conducting wire arranged in parallel, insulation layers of the first and second conducting wires are removed at intervals of the predetermined length along axial direction of the conducting wire to form a plurality of first and second welding spots; a plurality of SMD LEDs respectively disposed at the plurality of lamp welding regions, two welding legs of each SMD LED being respectively welded onto a first welding spot and a second welding spot at one corresponding lamp welding region, the plurality of the SMD LEDs being connected in series, in parallel or in hybrid; and a plurality of encapsulation colloids respectively coating the plurality of the SMD LEDs and surfaces of portions of the third conducting wire corresponding to positions of the plurality of the SMD LEDs, to form a plurality of lamp beads.

Abstract: Disclosed are C16 amide derivatives of C2?-epi-amphotericin B (C2?epiAmB) and amphotericin B (AmB), characterized by improved clinical efficacy with reduced toxicity compared to AmB. Also disclosed are pharmaceutical compositions comprising either type of the C16 amide derivatives, and therapeutic methods of using either type of the C16 amide derivatives; and methods of making the C16 amide derivatives of C2?-epi-amphotericin B.

Abstract: A method for obtaining a user portrait includes: obtaining a user feature vector of a target user and tag feature vectors of content tags of multimedia content in a target application, and determining an alternative tag of the target user according to similarities between the user feature vector and the tag feature vectors, to further determine a user portrait of the target user according to the alternative tag.

Abstract: A charged-particle-beam microscope for imaging a sample, the microscope having a stage to hold a sample and an automated sample feeder to repeatedly and automatically exchange the sample from among a plurality of samples. A charged-particle-beam column is provided to direct a charged-particle-beam onto the sample, the charged-particle-beam column. The column includes a charged-particle-beam source to generate an electron beam and charged-particle-beam optics to converge the charged-particle beam onto the sample. A detector is provided to detect charged particles emanating from the sample to generate image data. A controller executes an artificial intelligence algorithm to analyze the image data.

Abstract: The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

Abstract: The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

Abstract: An LED light string with single wire. The LED light string includes one wire including a composite wire core, and a plurality of light bodies. The composite wire core is composed of at least one first conductor layer extending in an axial direction of the wire, at least one second conductor layer extending in the axial direction of the wire, and an insulation layer therebetween. The plurality of light bodies arranged spaced away at set intervals along the axial direction of the wire. Each of the light bodies includes at least one patch LED light-emitting part and an encapsulation colloid coated on a surface of the at least one patch LED light-emitting part. A positive electrode and a negative electrode of the at least one patch LED light-emitting part being electrically connected to the at least one first conductor layer and the at least one second conductor layer, respectively.

Abstract: A charged-particle beam microscope is provided for imaging a sample. The microscope has a vacuum chamber to maintain a low-pressure environment. A motorized stage is provided to hold and move a sample in the vacuum chamber. A charged-particle beam source generates a charged-particle beam. Charged-particle beam optics converge the charged-particle beam onto the sample. A detector is provided to detect charged-particle radiation emanating from the sample. A controller analyzes the detected charged-particle radiation to generate an image of the sample. A power supply powers at least the charged-particle beam optics and the controller. The charged-particle beam microscope weighs less than about 50 kg.