Abstract: Provided herein are compositions, methods, and uses involving anti-Mucin-16 (MUC16) agents that immunospecifically bind an epitope of Mucin-16 (MUC16). Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer and diseases associated with positive MUC16 expression.

Abstract: The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

Abstract: A mobile liquid nitrogen fire extinguishing system for a utility tunnel is provided, including a liquid nitrogen production assembly, a fire extinguishing assembly, a monitoring device, and a liquid nitrogen conveying tubing. The mobile fire extinguishing assembly includes a liquid nitrogen storage tank and a liquid nitrogen booster pump. The liquid nitrogen storage tank is connected to the liquid nitrogen booster pump. The liquid nitrogen booster pump conveys liquid nitrogen to branch pipes in the utility tunnel through the liquid nitrogen conveying tubing. Liquid nitrogen injection ports are formed in each of the branch pipes. The liquid nitrogen production assembly is mobile and conveys the prepared liquid nitrogen to the liquid nitrogen storage tank. The monitoring device includes a first monitoring assembly and a second monitoring assembly.

Abstract: This application discloses a content recommendation method performed at a computer device and belongs to the field of artificial intelligence. The method includes: acquiring a target user vector of a target user; determining n groups of seed user vectors according to the target user vector, each group of seed user vectors corresponding to a respective piece of candidate recommendation content; invoking a look-alike model to calculate a similarity between the target user vector and each group of seed user vectors, the look-alike model being used for calculating a similarity between user vectors based on an attention mechanism; and determining, among the n pieces of candidate recommendation content, target content to be recommended to the target user according to the respective similarities of the corresponding n groups of seed user vectors. This application can resolve a problem of relatively low accuracy of a recommendation method in the related art.

Abstract: A method is provided for determining a social rank of a node in a social network, the social network including a plurality of nodes connected by relationship chains. The method includes determining a user corresponding to at least one of the plurality of nodes in the social network, determining a connection structure of the relationship chains between the plurality of nodes, and determining, according to the connection structure of the relationship chains between the plurality of nodes, a social rank of the user corresponding to the at least one of the plurality of nodes.

Abstract: This application relates to a user tag generation method performed by a computer device, relating to the field of neural networks. The method includes: obtaining discrete user data corresponding to a target user identifier in multiple feature fields respectively; for each feature field, obtaining an intra-field feature corresponding to the target user identifier according to the discrete user data in the feature field; merging the intra-field features to obtain an inter-field feature corresponding to the target user identifier; performing feature crossing on sub-features in the inter-field feature to obtain a cross feature corresponding to the target user identifier; and selecting, from candidate user tags, a target user tag corresponding to the target user identifier according to the inter-field feature and the cross feature. The solutions provided by this application can improve the accuracy of generating user tags.

Abstract: A coal uncovering construction method for blasting large cross-section gas tunnels includes: analyzing stress distribution characteristics in front of a tunnel boring working face, and then determining a thickness calculation model of a reserved rock wall based on a limit equilibrium theory; establishing a tunnel model, simulating a construction condition and analyzing a construction result, and determining a thickness of the reserved rock wall; and fixing a detonator through a fixed sand ring, fitting the detonator with a construction hole by adjusting an adjustable protective plate, then embedding the detonator into a blast hole, and blasting the detonator for tunnel construction. Furthermore, an extension ring is fixed between the fixed sand ring and the adjustable protective plate.

Abstract: An LED string light includes a first conducting wire, a second conducting wire, and a third conducting wire which are arranged in parallel. The first conducting wire, the second conducting wire and the third conducting wire all comprise a conducting wire core and an insulation layer coating a surface of the conducting wire core, and the first conducting wire and the second conducting wire defines a plurality of lamp welding regions. The LED string light also includes a plurality of SMD LEDs respectively disposed at the plurality of lamp welding regions. Each SMD LED has a first welding leg and a second welding leg, which are respectively welded onto the first welding spot and the second welding spot at one corresponding lamp welding region, and the plurality of the SMD LEDs are connected in parallel. A plurality of encapsulation colloids respectively coat the plurality of the SMD LEDs.

Abstract: The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula

Abstract: A coal uncovering construction method for blasting large cross-section gas tunnels includes: analyzing stress distribution characteristics in front of a tunnel boring working face, and then determining a thickness calculation model of a reserved rock wall based on a limit equilibrium theory; establishing a tunnel model, simulating a construction condition and analyzing a construction result, and determining a thickness of the reserved rock wall; and fixing a detonator through a fixed sand ring, fitting the detonator with a construction hole by adjusting an adjustable protective plate, then embedding the detonator into a blast hole, and blasting the detonator for tunnel construction. Furthermore, an extension ring is fixed between the fixed sand ring and the adjustable protective plate.

Abstract: An LED string light includes a first conducting wire, a second conducting wire, and a third conducting wire which are arranged in parallel. The first, second, and third conducting wires all comprise a conducting wire core and an insulation layer coating a surface of the conducting wire core, and the first conducting wire and the second conducting wire define a plurality of lamp welding regions. The LED string light also includes a plurality of SMD LEDs respectively disposed at the plurality of lamp welding regions. The first conducting wire is selectively cut off at a plurality of first positions and the second conducting wire is selectively cut off at a plurality of second positions based on whether the plurality of the SMD LEDs are connected in series or in hybrid of series and parallel.

Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula (I)

Abstract: An LED string light includes a first conducting wire, a second conducting wire, and a third conducting wire which are arranged in parallel. The first conducting wire, the second conducting wire and the third conducting wire all comprise a conducting wire core and an insulation layer coating a surface of the conducting wire core, and the first conducting wire and the second conducting wire defines a plurality of lamp welding regions. The LED string light also includes a plurality of SMD LEDs respectively disposed at the plurality of lamp welding regions. Each SMD LED has a first welding leg and a second welding leg, which are respectively welded onto the first welding spot and the second welding spot at one corresponding lamp welding region, and the plurality of the SMD LEDs are connected in parallel. A plurality of encapsulation colloids respectively coat the plurality of the SMD LEDs.

Abstract: A recommendation method includes obtaining a candidate item to be recommended to a social network user, the social network user belonging to a group of users in an online social network, and determining attention of the group to the candidate item in the online social network. The determined attention of the group to the candidate item is based on an importance weight of each user in the group and based on attention of each user in the group to the candidate item. The method further includes determining, according to the determined attention of the group, whether to recommend the candidate item to the social network user through the online social network.

Abstract: A mobile liquid nitrogen fire extinguishing system for a utility tunnel is provided, including a liquid nitrogen production assembly, a fire extinguishing assembly, a monitoring device, and a liquid nitrogen conveying tubing. The mobile fire extinguishing assembly includes a liquid nitrogen storage tank and a liquid nitrogen booster pump. The liquid nitrogen storage tank is connected to the liquid nitrogen booster pump. The liquid nitrogen booster pump conveys liquid nitrogen to branch pipes in the utility tunnel through the liquid nitrogen conveying tubing. Liquid nitrogen injection ports are formed in each of the branch pipes. The liquid nitrogen production assembly is mobile and conveys the prepared liquid nitrogen to the liquid nitrogen storage tank. The monitoring device includes a first monitoring assembly and a second monitoring assembly.

Abstract: A recommendation method is provided. In the method, a candidate item to be recommended to a social network user is obtained. The social network user has at least two different types of social relationships. For at least one target social object in each of the at least two different types of social relationships of the social network user, attention of each of the at least one target social object in the respective type of social relationship to the candidate item is determined. According to the attention of each of the at least one target social object in the at least two different types of social relationships to the candidate item, a comprehensive attention of the target social objects of the at least two different types of social relationships to the candidate item is determined. According to the comprehensive attention, whether to recommend the candidate item to the social network user is determined.

Abstract: An LED string light includes a first conducting wire, a second conducting wire, and a third conducting wire which are arranged in parallel. The first, second, and third conducting wires all comprise a conducting wire core and an insulation layer coating a surface of the conducting wire core, and the first conducting wire and the second conducting wire define a plurality of lamp welding regions. The LED string light also includes a plurality of SMD LEDs respectively disposed at the plurality of lamp welding regions. The first conducting wire is selectively cut off at a plurality of first positions and the second conducting wire is selectively cut off at a plurality of second positions based on whether the plurality of the SMD LEDs are connected in series or in hybrid of series and parallel.

Abstract: The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.

Abstract: The present disclosure discloses an LED light string ornament and a method for producing the same. The LED light string ornament includes an LED light string and a plurality of decorative pieces. The LED light string includes three wires, a plurality of SMD LEDs, and a plurality of adhesive bodies. A part or a whole of the decorative piece are transparent or semi-transparent. The decorative piece includes a first housing and a second housing. The first housing and the second housing are buckled to form an accommodating cavity, and a plurality of LED beads of the LED light string are respectively accommodated in the accommodating cavities of the plurality of decorative pieces.