Abstract: A charged-particle beam microscope is provided for imaging a sample. The microscope has a vacuum chamber to maintain a low-pressure environment. A motorized stage is provided to hold and move a sample in the vacuum chamber. A charged-particle beam source generates a charged-particle beam. Charged-particle beam optics converge the charged-particle beam onto the sample. A detector is provided to detect charged-particle radiation emanating from the sample. A controller analyzes the detected charged-particle radiation to generate an image of the sample. A power supply powers at least the charged-particle beam optics and the controller. The charged-particle beam microscope weighs less than about 50 kg.

Abstract: Provided herein are compositions, methods, and uses involving anti-Mucin-16 (MUC16) agents that immunospecifically bind an epitope of Mucin-16 (MUC16). Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer and diseases associated with positive MUC16 expression.

Abstract: An apparatus is provided for microscopy, inspection, or analysis of a sample. The apparatus has a vacuum chamber and a charged-particle beam column in the vacuum chamber to direct a charged-particle beam onto a sample. The charged-particle beam column includes a charged-particle beam source to generate a charged-particle beam and charged-particle beam optics to direct the charged-particle beam onto the sample. The apparatus has a detector to detect radiation emanating from the sample to generate an image. A cartridge is provided to support the sample in the path of the charged-particle beam in the vacuum chamber. The cartridge is mechanically decoupled from the environment external to the vacuum chamber. A controller is provided to analyze the detected radiation to generate an image of the sample.

Abstract: The presently disclosed subject matter provides antigen-binding proteins that specifically bind to Preferentially expressed antigen of melanoma (PRAME), including humanized, chimeric and fully human antibodies against PRAME, antibody fragments (e.g., scFv, Fab and F(ab)2), chimeric antigen receptors (CARs), fusion proteins, and conjugates thereof. The antigen-binding proteins and antibodies bind to a PRAME peptide/HLA class I molecule complex. Such antibodies, fragments, fusion proteins and conjugates thereof are useful for the treatment of PRAME associated diseases, including for example, breast cancer, ovarian cancer, melanoma, lung cancer, gastrointestinal cancer, brain tumor, head and neck cancer, renal cancer, myeloma, neuroblastoma, mantle cell lymphoma, chronic myelocytic leukemia, multiple myeloma, acute lymphoblastic leukemia (ALL), acute myeloid/myelogenous leukemia (AML), Non-Hodgkin lymphoma (NHL), and Chronic lymphocytic leukemia (CLL).

Abstract: An LED string light includes: a first conducting wire, a second conducting wire, a third conducting wire arranged in parallel, insulation layers of the first and second conducting wires are removed at intervals of the predetermined length along axial direction of the conducting wire to form a plurality of first and second welding spots; a plurality of SMD LEDs respectively disposed at the plurality of lamp welding regions, two welding legs of each SMD LED being respectively welded onto a first welding spot and a second welding spot at one corresponding lamp welding region, the plurality of the SMD LEDs being connected in series, in parallel or in hybrid; and a plurality of encapsulation colloids respectively coating the plurality of the SMD LEDs and surfaces of portions of the third conducting wire corresponding to positions of the plurality of the SMD LEDs, to form a plurality of lamp beads.

Abstract: An LED hose lamp includes: an LED string light including a first conducting wire, a second conducting wire, a third conducting wire, a plurality of SMD LEDs and a plurality of encapsulation colloids, wherein a plurality of first and second welding spots are formed by removing insulation layers of the first and second conducting wire at intervals of a predetermined distance along axial directions of the first and second conducting wires respectively, two welding legs of each SMD LED are respectively welded onto a first welding spot and a second welding spot, the plurality of encapsulation colloids respectively coat the plurality of SMD LEDs and surfaces of portions of the third conducting wire corresponding to positions of the plurality of the SMD LEDs; and a soft tube coating outside the first conducting wire, the second conducting wire, the third conducting wire and the encapsulation colloid through an injection molding.

Abstract: This application discloses an information recommendation method and apparatus, a device, and a storage medium, and belongs to the field of information recommendation. The method includes starting an application program according to a start operation, a first account being logged in in the application program; obtaining a recommended information flow for the first account, recommended information in the recommended information flow including at least one piece of interactive recommended information, the interactive recommended information being information for which a second account generates an interactive message, the first account and the second account having a social relationship; and displaying an information presentation interface, the information presentation interface comprising the recommended information displayed in an information flow form.

Abstract: An LED string light includes: a first conducting wire, a second conducting wire, a third conducting wire arranged in parallel, insulation layers of the first and second conducting wires are removed at intervals of the predetermined length along axial direction of the conducting wire to form a plurality of first and second welding spots; a plurality of SMD LEDs respectively disposed at the plurality of lamp welding regions, two welding legs of each SMD LED being respectively welded onto a first welding spot and a second welding spot at one corresponding lamp welding region, the plurality of the SMD LEDs being connected in series, in parallel or in hybrid; and a plurality of encapsulation colloids respectively coating the plurality of the SMD LEDs and surfaces of portions of the third conducting wire corresponding to positions of the plurality of the SMD LEDs, to form a plurality of lamp beads.

Abstract: An electrodeless side-mounted LED string light, a method and an apparatus for manufacturing the same are provided by the disclosure. The electrodeless side-mounted LED string light includes: a first wire and a second wire, a plurality of LED units and a plurality of encapsulants. Each LED unit includes a first surface-mounted LED and a second surface-mounted LED. Luminous surfaces of the first and second surface-mounted LEDs are opposite to each other. The luminous surfaces of the first and second surface-mounted LEDs are perpendicular to an axial direction of the first and second wires. The plurality of encapsulants respectively encapsulants the first and second surface-mounted LEDs therein. With the electrodeless side-mounted LED string light of the disclosure, the utilization rate of the lighting wire of the string light is improved, the utilization rates of raw materials and apparatus are improved, the product quality and manufacturing efficiency are improved.

Abstract: Described herein are antibodies, fragments thereof and multi-specific binding agents that bind an Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) peptide presented by HLA class I molecules, in particular, HLA-A02. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by expression of an EBV-LMP2 peptide presented by HLA-A02, in particular, Burkit's lymphoma, Hodgkin's lymphoma and nasopharyngeal carcinoma.

Abstract: The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.

Abstract: This application discloses a content recommendation method performed at a computer device and belongs to the field of artificial intelligence. The method includes: acquiring a target user vector of a target user; determining n groups of seed user vectors according to the target user vector, each group of seed user vectors corresponding to a respective piece of candidate recommendation content; invoking a look-alike model to calculate a similarity between the target user vector and each group of seed user vectors, the look-alike model being used for calculating a similarity between user vectors based on an attention mechanism; and determining, among the n pieces of candidate recommendation content, target content to be recommended to the target user according to the respective similarities of the corresponding n groups of seed user vectors. This application can resolve a problem of relatively low accuracy of a recommendation method in the related art.

Abstract: A method is provided for determining a social rank of a node in a social network, the social network including a plurality of nodes connected by relationship chains. The method includes determining a user corresponding to at least one of the plurality of nodes in the social network, determining a connection structure of the relationship chains between the plurality of nodes, and determining, according to the connection structure of the relationship chains between the plurality of nodes, a social rank of the user corresponding to the at least one of the plurality of nodes.

Abstract: An electrodeless surface-mounted LED string light, a method and an apparatus for manufacturing the same are disclosed. The electrodeless surface-mounted LED string light includes: a first wire and a second wire; a plurality of LED units, wherein each LED units includes two surface-mounted LEDs, and luminous surfaces of the two surface-mounted LEDs are opposite to each other, and the luminous surfaces of the two surface-mounted LEDs are parallel to an axial direction of the first and second wires; and a plurality of encapsulants respectively encapsulating the two surface-mounted LEDs of the plurality of LED units therein.

Abstract: The disclosure provides antibody agents that bind to inhibitory human killer immunoglobulin-like receptors (KIRs). Particular antibody agents of the disclosure include antibody agents that bind to KIR3DL1 (also known as CD158e). Also provided are related nucleic acids, vectors, compositions and methods of using KIR-binding antibody agents of the present technology.

Abstract: This application relates to a user tag generation method performed by a computer device, relating to the field of neural networks. The method includes: obtaining discrete user data corresponding to a target user identifier in multiple feature fields respectively; for each feature field, obtaining an intra-field feature corresponding to the target user identifier according to the discrete user data in the feature field; merging the intra-field features to obtain an inter-field feature corresponding to the target user identifier; performing feature crossing on sub-features in the inter-field feature to obtain a cross feature corresponding to the target user identifier; and selecting, from candidate user tags, a target user tag corresponding to the target user identifier according to the inter-field feature and the cross feature. The solutions provided by this application can improve the accuracy of generating user tags.

Abstract: A multi-station concurrent testing method, comprising: a step A in which the control station controls the handler to send SOT signal(s) of corresponding testing station(s) based on previous testing results at adjacent testing stations of the testing stations; a step B in which the control station constructs an SOT signal sequence based on the received SOT signal(s) and in correspondence to orders of the testing stations; and a step C in which the control station compares the SOT signal sequence and an SOT signal prediction value sequence generated by the control station, wherein if the SOT signal sequence and the SOT signal prediction value sequence match, the corresponding testing station(s) executes the test of device(s) under test, and otherwise, the handler is controlled to purge the devices under test at the testing stations, the SOT signal prediction value sequence is generated based on previous testing results at the testing stations.

Abstract: The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

Abstract: A set of documents is parsed. Members of the set of documents include a set of text elements and a set of visual elements. A text content stream based on the set of text elements and a visual content stream based on the set of visual elements are produced. For respective documents, a set of respective visual element summarizations is built from the visual content stream. Each visual summarization includes a textual description of a respective visual element in the respective document. A holistic index is created by indexing the text content from the text content stream and the text descriptions of the visual elements for each document in a single search index. The indexing uses a set of semantic relationships between the text content from the text content stream and the textual descriptions of the visual elements. A user interface allows a user to selectively search text content and visual content.

Abstract: A multi-station concurrent testing method, comprising: a step A in which the control station controls the handler to send SOT signal(s) of corresponding testing station(s) based on previous testing results at adjacent testing stations of the testing stations; a step B in which the control station constructs an SOT signal sequence based on the received SOT signal(s) and in correspondence to orders of the testing stations; and a step C in which the control station compares the SOT signal sequence and an SOT signal prediction value sequence generated by the control station, wherein if the SOT signal sequence and the SOT signal prediction value sequence match, the corresponding testing station(s) executes the test of device(s) under test, and otherwise, the handler is controlled to purge the devices under test at the testing stations, the SOT signal prediction value sequence is generated based on previous testing results at the testing stations.