Abstract: The present invention relates to a device (10) for detecting a misuse of a medical imaging system (20), comprising a data interface (12) for acquiring medical image data (24) and audit log data (26) from the medical imaging system (20); a processing unit (14) which is configured to configured to analyse the medical image data (24) to determine whether or not a part of a fetus is imaged in the medical image data (24), to compare the medical image data (24) and the audit log data (26) with each other, and to determine based on said comparison whether there is a mismatch between the medical image data (24) and the audit log data (26); and a feedback unit (16) which is configured to generate a misuse alert signal if a mismatch is detected by the processing unit (14).

Abstract: A computer-implemented method for visualization of an elongated anatomical structure (20), for example of a fetal spine using ultrasound is provided.

Abstract: The invention relates to a computer-implemented method for automatically detecting anatomical structures (3) in a medical image (1) of a subject, the method comprising applying an object detector function (4) to the medical image, wherein the object detector function performs the steps of: (A) applying a first neural network (40) to the medical image, wherein the first neural network is trained to detect a first plurality of classes of larger-sized anatomical structures (3a), thereby generating as output the coordinates of at least one first bounding box (51) and the confidence score of it containing a larger-sized anatomical structure; (B) cropping (42) the medical image to the first bounding box, thereby generating a cropped image (11) containing the image content within the first bounding box (51); and (C) applying a second neural network (44) to the cropped medical image, wherein the second neural network is trained to detect at least one second class of smaller-sized anatomical structures (3b), thereby g

Abstract: The present invention relates to a device (2) and a method (100) for determining at least one final two-dimensional image or slice for visualizing an object of interest in a three-dimensional ultrasound volume.

Abstract: Disclosed in the present disclosure is a method, system and apparatus for prediction, estimation and prevention of occurrence of agitation episode in a subject predisposed to agitation. The method comprises receiving, from a first monitoring device attached to a subject, physiological data of sympathetic nervous system activity in the subject and activity data of the subject; receiving, from a computing device, a plurality of indications associated with a plurality of agitation episodes of the subject; analyzing, using at least one machine learning model, the physiological data, the activity data, and the plurality of indications to determine a probability of an occurrence of an agitation episode of the subject; and sending a signal to a second monitoring device to notify the second monitoring device of the probability of the occurrence of the agitation episode of the subject such that treatment can be provided to the subject to decrease sympathetic nervous system activity in the subject.

Abstract: In some embodiments, a method includes receiving first physiological data of sympathetic nervous system activity and establishing a baseline value of at least one physiological parameter by training at least one machine learning model using the first physiological data. The method further includes receiving, from a first monitoring device attached to a subject, second physiological data of sympathetic nervous system activity in the subject. Using the at least one machine learning model and based on the baseline value of at least one physiological parameter, the method includes analyzing the second physiological data to predict an agitation episode of the subject and sending a signal to a second monitoring device to notify of the prediction of the agitation episode of the subject such that treatment can be provided to the subject to decrease sympathetic nervous system activity in the subject.

Abstract: The invention provides for a method of obtaining a composite 3D ultrasound image of a region of interest. The method includes obtaining preliminary ultrasound data from a region of interest of a subject and identifying an anatomical feature within the region of interest based on the preliminary ultrasound data. A first imaging position and one or more additional imaging positions are then determined based on the anatomical feature. A first 3D ultrasound image is obtained from the first imaging position and one or more additional 3D ultrasound images are obtained from the one or more additional imaging positions, wherein a portion of the first 3D ultrasound image overlaps a portion of the one or more additional 3D ultrasound images, thereby forming an overlapping portion comprising the anatomical feature.

Abstract: The present invention relates to a device (2) and a method (100) for determining at least one final two-dimensional image or slice for visualizing an object of interest in a three-dimensional ultrasound volume.

Abstract: The present invention relates to a device (10) for detecting a misuse of a medical imaging system (20), comprising a data interface (12) for acquiring medical image data (24) and audit log data (26) from the medical imaging system (20); a processing unit (14) which is configured to configured to analyse the medical image data (24) to determine whether or not a part of a fetus is imaged in the medical image data (24), to compare the medical image data (24) and the audit log data (26) with each other, and to determine based on said comparison whether there is a mismatch between the medical image data (24) and the audit log data (26); and a feedback unit (16) which is configured to generate a misuse alert signal if a mismatch is detected by the processing unit (14).

Abstract: The invention relates to a method and an apparatus for cervical image analysis, wherein a transformation zone is identified in an acetic acid image by registering with its Lugol's iodine counterpart. Then, regions in the transformation zone which show significant changes in whiteness are identified as aceto-white regions and registered with the corresponding Lugol's iodine image, and it is determined if the identified regions in the Lugol's iodine image are iodine negative or positive. Based thereon, the aceto-white region can be categorized as one of metaplasia, inflammation or premalignant lesion region.

Abstract: The invention relates to a brachytherapy system for supporting application of radiation to a patient body. The system cooperates with an applicator (1) configured for fixating at least one radiation source in a body region and comprises an ultrasound device (3) configured for generating a three-dimensional image of the body region including the applicator (1). Further, an image generation unit (9) comprises a pre-stored three-dimensional model of the applicator (1) and is configured to obtain position information relating the applicator (1) on the basis of the three-dimensional image of the body region and to align the three-dimensional image of the body region and the pre-stored three-dimensional model of the applicator (1) on the basis of the position information.

Abstract: The invention provides a system (100) for acquiring cervical images which comprises an image acquisition subsystem (120) for acquiring cervical images (122) of a cervical region of a patient during a colposcopy procedure, and a display subsystem (160) for displaying the cervical images on a display (060) by providing image data (162) of the cervical images to the display. According to the invention, the image acquisition subsystem (120) is arranged for, when operating in an interval mode, acquiring the cervical images (122) at predetermined time intervals to obtain a time-series of cervical images showing changes in the cervical region over time, and reporting a progress of said acquiring to the display subsystem. Moreover, the display subsystem (160) is arranged for establishing a progress indicator (400-416) on the display by generating indicator data (164) and providing the indicator data to the display (060), the progress indicator providing visual feedback on the progress of said acquiring to a user.

Abstract: The present invention relates to a colposcopy apparatus (10) for performing a colposcopy procedure. The colposcopy apparatus (10) comprises an imaging unit (11) comprising an optics unit (12) having an optical axis (22) and an image acquiring unit (13) for acquiring an image (21) of a cervix (23) through the optics unit, and at least three light beam emitting units (14, 15, 16, 17) spaced apart from the optical axis, wherein the at least three light beam emitting units are adapted to emit light beams that are coplanar with the optical axis and that intersect on the optical axis at a predefined distance (d10) in front of the colposcopy apparatus, wherein not all of the emitted light beams lie in a same plane. The colposcopy apparatus allows better supporting a user, for instance, a gynecologist, in positioning and/or configuring the colposcopy apparatus for performing the colposcopy procedure.

Abstract: A method or system detects abnormalities in a biological sample cells. The method or system performs at least the following steps, or is capable to carry out at least the following steps, respectively: a) acquiring an image of the sample by digital image acquisition, b) optionally, carrying out digital image processing, c) selecting a field of view, d) determining, by digital image processing, whether or not, in the field of view, cell aggregates exist, and e1) selecting a new field of view and carrying on with step c) if, in step d), it turns out that, in the field of view, the determination of cell aggregates is negative, or e2) carrying out further process steps if in step d), it turns out that, in the field of view, the determination of cell aggregates is affirmative.

Abstract: The invention relates to a method and an apparatus for cervical image analysis, wherein a transformation zone is identified in an acetic acid image by registering with its Lugol's iodine counterpart. Then, regions in the transformation zone which show significant changes in whiteness are identified as aceto-white regions and registered with the corresponding Lugol's iodine image, and it is determined if the identified regions in the Lugol's iodine image are iodine negative or positive. Based thereon, the aceto-white region can be categorized as one of metaplasia, inflammation or premalignant lesion region.

Abstract: A method and system to detect the microcalcifications (MC) in different type of images viz. X-ray images/mammograms/computer tomography with varied densities using nonlinear energy operator (NEO) is disclosed to favor precise detection of early breast cancer. Such Microcalcifications are associated with both high intensity and high frequency content. The same NEO output is useful to detect and remove the irrelevant curvilinear structures (CLS) thereby helps in reducing the false alarms in micro calcification detection technique. This is effective on different dataset (scanned film, mammograms with large spatial resolution such as CR and DR) of varied breast composition (viz. dense, fatty glandular, fatty), demonstrated quantitatively by Free-response receiver operating characteristic (FROC). Importantly, the method and apparatus of the invention can be used in conjunction with machine learning techniques viz.

Abstract: The invention provides a system (100) for acquiring cervical images which comprises an image acquisition subsystem (120) for acquiring cervical images (122) of a cervical region of a patient during a colposcopy procedure, and a display subsystem (160) for displaying the cervical images on a display (060) by providing image data (162) of the cervical images to the display. According to the invention, the image acquisition subsystem (120) is arranged for, when operating in an interval mode, acquiring the cervical images (122) at predetermined time intervals to obtain a time-series of cervical images showing changes in the cervical region over time, and reporting a progress of said acquiring to the display subsystem. Moreover, the display subsystem (160) is arranged for establishing a progress indicator (400-416) on the display by generating indicator data (164) and providing the indicator data to the display (060), the progress indicator providing visual feedback on the progress of said acquiring to a user.

Abstract: The present invention is related to a method or system for the detection of abnormalities in a biological sample comprising cells. Said method or system comprises at least the following steps, or is capable to carry out, and/or comprises means capable to carry out, at least the following steps, respectively: a) acquiring an image of said sample by digital image acquisition, b) optionally, carrying out digital image processing, c) selecting a field of view, d) determining, by digital image processing, whether or not, in said field of view, cell aggregates exist, and e1) selecting a new field of view and carrying on with step c) if, in step d), it turns out that, in said field of view, the determination of cell aggregates is negative, or e2) carrying out further process steps if in step d), it turns out that, in said field of view, the determination of cell aggregates is affirmative.

Abstract: A method and system to detect the microcalcifications (MC) in different type of images viz. X-ray images/mammograms/computer tomography with varied densities using nonlinear energy operator (NEO) is disclosed to favor precise detection of early breast cancer. Such Microcalcifications are associated with both high intensity and high frequency content. The same NEO output is useful to detect and remove the irrelevant curvilinear structures (CLS) thereby helps in reducing the false alarms in micro calcification detection technique. This is effective on different dataset (scanned film, mammograms with large spatial resolution such as CR and DR) of varied breast composition (viz. dense, fatty glandular, fatty), demonstrated quantitatively by Free-response receiver operating characteristic (FROC). Importantly, the method and apparatus of the invention can be used in conjunction with machine learning techniques viz.

Abstract: The present invention relates to triazine derivatives as cell adhesion inhibitors. The compounds of this invention can be useful inter alia, for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis. The compounds can be used to formulate pharmacological compositions, and the methods of treating bronchial asthma, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or autoimmune disorders, using the compounds are also provided herein.