Abstract: Systems, apparatuses, and methods for treating a patent foramen ovale (PFO) of a patient. A system may include a catheter configured to extend within at least a portion of the patients heart. One or more stabilizer balloons may be coupled to the catheter and configured to be positioned within a tunnel of the patent foramen ovale and inflated to apply a force to at least one of a septum primum or a septum secundum of the patients heart. An injection device may be configured to inject material into at least one of the septum primum or the septum secundum to cause swelling of the injected septum primum or the injected septum secundum in a direction towards the opposing septum primum or the opposing septum secundum.

Abstract: The disclosure presents methods and systems for applying a suction force to a surface of a left atrial appendage (LAA) with a tube attached to an exterior surface of an inflatable balloon. The disclosure also presents methods and systems for inflating a first inflatable balloon within a cavity of a left atrial appendage (LAA). A method may include applying a suction force with at least one tube coupled to the first inflatable balloon to attract the first inflatable balloon to an interior surface of the LAA or to a second inflatable balloon. A method may include puncturing, using a tissue-penetrating tip, a target surface of the LAA.

Abstract: The disclosure presents methods and systems for applying a suction force to a surface of a left atrial appendage (LAA) with a tube attached to an exterior surface of an inflatable balloon. The disclosure also presents methods and systems for inflating a first inflatable balloon within a cavity of a left atrial appendage (LAA). A method may include applying a suction force with at least one tube coupled to the first inflatable balloon to attract the first inflatable balloon to an interior surface of the LAA or to a second inflatable balloon. A method may include puncturing, using a tissue-penetrating tip, a target surface of the LAA.

Abstract: The disclosure presents methods and systems for applying a suction force to a surface of a left atrial appendage (LAA) with a plurality of tubes. A method may include puncturing the surface of the LAA using a tissue-penetrating tip while the suction force is applied to the surface. The disclosure also presents methods and systems for inflating a first inflatable balloon within a cavity of a left atrial appendage (LAA). A method may include applying a suction force with at least one tube coupled to the first inflatable balloon to attract the first inflatable balloon to an interior surface of the LAA or to a second inflatable balloon.

Abstract: A lead for in vivo procedures for stimulation of a tissue is provided that has stimulating electrodes and a fixation mechanism disposed at a distal end of the lead. The fixation mechanism includes a fixation component disposed on an opposite side with respect to an active surface of the stimulation electrodes. The lead fixation mechanism when deployed disposes the active surface of stimulation electrodes onto a tissue region opposite to the fixation component. A system and a method for optimally positioning the lead for stimulation of the tissue are also provided.

Abstract: The invention presents methods and systems for accessing a pericardial space and preventing strokes arising from a left atrial appendage (“LAA”) by achieving a complete occlusion of the LAA using an epicardial approach without creating a puckering of the LAA ostium. A complete occlusion of the LAA is desired because blood clots arising from the LAA often leads to embolic strokes. Due to the peculiar anatomy of the LAA ostium, traditional LAA ligation techniques using sutures can lead to puckering, thus compromising the occlusion of the LAA. The invention achieves a complete occlusion and a more effective hemostatic seal with the use of inflatable balloons having electromagnetic coils internally, as well as hydrogels, sponges, and caliber tubes attached to the respective balloon's exterior, anchoring balloons, a closure device having a suture looped through two semi-rigid hollow tube that can be coated with hydrogel or silicone, and locking mechanisms.

Abstract: Bleeding arising from the left atrial appendage (LAA) can have fatal consequences because it can result in cardiac tamponade. The present invention provides apparatuses and methods for treating and preventing bleeding arising from the LAA, at the pre-hemorrhage and post-hemorrhage stages. In particular, catheters having inflatable catheter balloons are advanced into the LAA and the inflatable catheter balloons are inflated in and around the LAA in a manner that occludes the LAA ostium and the LAA cavity. Additionally, electromagnetic coils are present within the inflatable catheter balloons to create electromagnetic forces that help to further occlude the LAA ostium firmly. When the catheter balloons are inflated, these electromagnetic coils also expand.

Abstract: Bleeding arising from the left atrial appendage (LAA) can have fatal consequences because it can result in cardiac tamponade. The present invention provides apparatuses and methods for treating and preventing bleeding arising from the LAA, at the pre-hemorrhage and post-hemorrhage stages. In particular, catheters having inflatable catheter balloons are advanced into the LAA and the inflatable catheter balloons are inflated in and around the LAA in a manner that occludes the LAA ostium and the LAA cavity. Additionally, electromagnetic coils are present within the inflatable catheter balloons to create electromagnetic forces that help to further occlude the LAA ostium firmly. When the catheter balloons are inflated, these electromagnetic coils also expand.

Abstract: The disclosure presents methods and systems for applying a suction force to a surface of a left atrial appendage (LAA) with a plurality of tubes. A method may include puncturing the surface of the LAA using a tissue-penetrating tip while the suction force is applied to the surface. The disclosure also presents methods and systems for inflating a first inflatable balloon within a cavity of a left atrial appendage (LAA). A method may include applying a suction force with at least one tube coupled to the first inflatable balloon to attract the first inflatable balloon to an interior surface of the LAA or to a second inflatable balloon.

Abstract: Bleeding arising from the left atrial appendage (LAA) can have fatal consequences because it can result in cardiac tamponade. The present invention provides apparatuses and methods for treating and preventing bleeding arising from the LAA, at the pre-hemorrhage and post-hemorrhage stages. In particular, catheters having inflatable catheter balloons are advanced into the LAA and the inflatable catheter balloons are inflated in and around the LAA in a manner that occludes the LAA ostium and the LAA cavity. Additionally, electromagnetic coils are present within the inflatable catheter balloons to create electromagnetic forces that help to further occlude the LAA ostium firmly. When the catheter balloons are inflated, these electromagnetic coils also expand.

Abstract: The invention presents methods and systems for accessing a pericardial space and preventing strokes arising from a left atrial appendage (“LAA”) by achieving a complete occlusion of the LAA using an epicardial approach without creating a puckering of the LAA ostium. A complete occlusion of the LAA is desired because bleeding arising from the LAA often leads to embolic strokes. Due to the peculiar anatomy of the LAA ostium, traditional LAA ligation techniques using sutures can lead to puckering, thus compromising the occlusion of the LAA. The invention achieves a complete occlusion and a more effective hemostatic seal with the use of inflatable balloons having electromagnetic coils internally, as well as hydrogels, sponges, and caliber tubes attached to the respective balloon's exterior, anchoring balloons, a closure device having a suture looped through two semi-rigid hollow tube that can be coated with hydrogel or silicone, and locking mechanisms.

Abstract: The invention presents methods and systems for accessing a pericardial space and preventing strokes arising from a left atrial appendage (“LAA”) by achieving a complete occlusion of the LAA using an epicardial approach without creating a puckering of the LAA ostium. A complete occlusion of the LAA is desired because bleeding arising from the LAA often leads to embolic strokes. Due to the peculiar anatomy of the LAA ostium, traditional LAA ligation techniques using sutures can lead to puckering, thus compromising the occlusion of the LAA. The invention achieves a complete occlusion and a more effective hemostatic seal with the use of inflatable balloons having electromagnetic coils internally, as well as hydrogels, sponges, and caliber tubes attached to the respective balloon's exterior, anchoring balloons, a closure device having a suture looped through two semi-rigid hollow tube that can be coated with hydrogel or silicone, and locking mechanisms.

Abstract: Bleeding arising from the left atrial appendage (LAA) can have fatal consequences because it can result in cardiac tamponade. The present invention provides apparatuses and methods for treating and preventing bleeding arising from the LAA, at the pre-hemorrhage and post-hemorrhage stages. In particular, catheters having inflatable catheter balloons are advanced into the LAA and the inflatable catheter balloons are inflated in and around the LAA in a manner that occludes the LAA ostium and the LAA cavity. Additionally, electromagnetic coils are present within the inflatable catheter balloons to create electromagnetic forces that help to further occlude the LAA ostium firmly. When the catheter balloons are inflated, these electromagnetic coils also expand.

Abstract: A lead for in vivo procedures for stimulation of a tissue is provided that has stimulating electrodes and a fixation mechanism disposed at a distal end of the lead. The fixation mechanism includes a fixation component disposed on an opposite side with respect to an active surface of the stimulation electrodes. The lead fixation mechanism when deployed disposes the active surface of stimulation electrodes onto a tissue region opposite to the fixation component. A system and a method for optimally positioning the lead for stimulation of the tissue are also provided.

Abstract: Bleeding arising from the left atrial appendage (LAA) can have fatal consequences because it can result in cardiac tamponade. The present invention provides apparatuses and methods for treating and preventing bleeding arising from the LAA, at the pre-hemorrhage and post-hemorrhage stages. In particular, catheters having inflatable catheter balloons are advanced into the LAA and the inflatable catheter balloons are inflated in and around the LAA in a manner that occludes the LAA ostium and the LAA cavity. Additionally, electromagnetic coils are present within the inflatable catheter balloons to create electromagnetic forces that help to further occlude the LAA ostium firmly. When the catheter balloons are inflated, these electromagnetic coils also expand.

Abstract: The invention presents methods and systems for accessing a pericardial space and preventing strokes arising from a left atrial appendage (“LAA”) by achieving a complete occlusion of the LAA using an epicardial approach without creating a puckering of the LAA ostium. A complete occlusion of the LAA is desired because bleeding arising from the LAA often leads to embolic strokes. Due to the peculiar anatomy of the LAA ostium, traditional LAA ligation techniques using sutures can lead to puckering, thus compromising the occlusion of the LAA. The invention achieves a complete occlusion and a more effective hemostatic seal with the use of inflatable balloons having electromagnetic coils internally, as well as hydrogels, sponges, and caliber tubes attached to the respective balloon's exterior, anchoring balloons, a closure device having a suture looped through two semi-rigid hollow tube that can be coated with hydrogel or silicone, and locking mechanisms.