Patents by Inventor Sudhakar Rao

Sudhakar Rao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10370405
    Abstract: The invention relates to C-3 novel triterpenone with C-28 amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases (formula 1).
    Type: Grant
    Filed: March 12, 2016
    Date of Patent: August 6, 2019
    Assignee: HETERO LABS LIMITED
    Inventors: Parthasaradhi Reddy Bandi, Rathnakar Reddy Kura, David Krupadanam Gazula Levi, Panduranga Reddy Adulla, Eswara Rao Bammidi, Bhaskar Reddy Kasireddy, Sudhakar Neela, Carl Thomas Wild, David Eugene Martin, Theodore John Nitz
  • Publication number: 20190050756
    Abstract: A machine learning service implements programmatic interfaces for a variety of operations on several entity types, such as data sources, statistics, feature processing recipes, models, and aliases. A first request to perform an operation on an instance of a particular entity type is received, and a first job corresponding to the requested operation is inserted in a job queue. Prior to the completion of the first job, a second request to perform another operation is received, where the second operation depends on a result of the operation represented by the first job. A second job, indicating a dependency on the first job, is stored in the job queue. The second job is initiated when the first job completes.
    Type: Application
    Filed: October 12, 2018
    Publication date: February 14, 2019
    Applicant: Amazon Technologies, Inc.
    Inventors: Leo Parker Dirac, Nicolle M. Correa, Aleksandr Mikhaylovich Ingerman, Sriram Krishnan, Jin Li, Sudhakar Rao Puvvadi, Saman Zarandioon
  • Patent number: 10102480
    Abstract: A machine learning service implements programmatic interfaces for a variety of operations on several entity types, such as data sources, statistics, feature processing recipes, models, and aliases. A first request to perform an operation on an instance of a particular entity type is received, and a first job corresponding to the requested operation is inserted in a job queue. Prior to the completion of the first job, a second request to perform another operation is received, where the second operation depends on a result of the operation represented by the first job. A second job, indicating a dependency on the first job, is stored in the job queue. The second job is initiated when the first job completes.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: October 16, 2018
    Assignee: Amazon Technologies, Inc.
    Inventors: Leo Parker Dirac, Nicolle M. Correa, Aleksandr Mikhaylovich Ingerman, Sriram Krishnan, Jin Li, Sudhakar Rao Puvvadi, Saman Zarandioon
  • Publication number: 20160348110
    Abstract: The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
    Type: Application
    Filed: August 11, 2016
    Publication date: December 1, 2016
    Inventors: Muthiah MANOHARAN, Kallanthottathil G. RAJEEV, Alexander V. KELIN, Sudhakar Rao TAKKELLAPATI, Shigeo MATSUDA
  • Patent number: 9453043
    Abstract: The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: September 27, 2016
    Assignee: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Alexander V. Kelin, Sudhakar Rao Takkellapati, Shigeo Matsuda
  • Publication number: 20150379424
    Abstract: A machine learning service implements programmatic interfaces for a variety of operations on several entity types, such as data sources, statistics, feature processing recipes, models, and aliases. A first request to perform an operation on an instance of a particular entity type is received, and a first job corresponding to the requested operation is inserted in a job queue. Prior to the completion of the first job, a second request to perform another operation is received, where the second operation depends on a result of the operation represented by the first job. A second job, indicating a dependency on the first job, is stored in the job queue. The second job is initiated when the first job completes.
    Type: Application
    Filed: June 30, 2014
    Publication date: December 31, 2015
    Applicant: AMAZON TECHNOLOGIES, INC.
    Inventors: LEO PARKER DIRAC, NICOLLE M. CORREA, ALEKSANDR MIKHAYLOVICH INGERMAN, SRIRAM KRISHNAN, JIN LI, SUDHAKAR RAO PUVVADI, SAMAN ZARANDIOON
  • Publication number: 20150210733
    Abstract: The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
    Type: Application
    Filed: January 22, 2015
    Publication date: July 30, 2015
    Inventors: Muthiah MANOHARAN, Kallanthottathil G. RAJEEV, Alexander V. KELIN, Sudhakar Rao TAKKELLAPATI, Shigeo MATSUDA
  • Patent number: 8975389
    Abstract: The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: March 10, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Alexander V. Kelin, Sudhakar Rao Takkellapati, Shigeo Matsuda
  • Patent number: 8513222
    Abstract: This invention relates to use of inhibitors of the transforming growth factor-? (TGF-?) type I receptor (ALK5) and/or the activin type I receptor (ALK4) in treating, preventing, or reducing fibrosis, cancer, and vascular injuries.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: August 20, 2013
    Assignee: EWHA University—Industry Collaboration Foundation
    Inventors: Dae-Kee Kim, Yhun Yhong Sheen, Chenghua Jin, Chul-Yong Park, Domalapally Sreenu, Kota Sudhakar Rao, Maddeboina Krishnaiah, Vura Bala Subrahmanyam
  • Patent number: 8377958
    Abstract: Fertility management can include: administering to the subject one or more doses of a compound according to Formula I so as to reduce fertility in the subject. Fertility management can also include administering an effective amount of the compound to: impair Sertoli cell function in a male subject; inhibit spermatogenesis in the subject; reduce testis weight in the subject; reduce ovary weight in a female subject; reduce serum progesterone in the female subject; impair ovarian follicle function in the female subject; causing reversible fertility in the subject. In order to return fertility, the method can include ceasing administration of the compound to the subject so as to return fertility in the subject. The compound can be administered for irreversibly sterilizing the subject.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: February 19, 2013
    Assignee: The University of Kansas
    Inventors: Ingrid Gunda Georg, Joseph S. Tash, Ramappa Chakrasali, Sudhakar Rao Jakkaraj, Katherine Roby
  • Patent number: 8362031
    Abstract: Lonidamine derivatives can be useful in methods of treating, inhibiting, and/or preventing polycystic kidney disease (PKD). Accordingly, lonidamine derivatives can be administered in a therapeutically effective amount for inhibiting, and/or preventing polycystic kidney disease (PKD) in the subject. This can include administering a therapeutically effective amount of the lonidamine derivatives for inhibiting CFTR and/or Hsp90 or biological pathway thereof. Also, the method can include administering the lonidamine derivatives in a therapeutically effective amount for inhibiting ErbB2, Src, Raf-1, B-Raf, MEK, Cdk4, NKCC1, or combinations thereof. For example, the therapeutically effective amount of the lonidamine derivatives can be configured so as to provide a concentration in or adjacent to a kidney cell of about 0.25 uM or more or less.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: January 29, 2013
    Assignee: University of Kansas
    Inventors: Ingrid Gunda Georg, Joseph S. Tash, Ramappa Chakrasali, Sudhakar Rao Jakkaraj, James P. Calvet
  • Patent number: 8332554
    Abstract: In one embodiment of a networking module, a first block receives a serial digital media signal, and provides a parallel digital media signal based on the serial digital media signal. A second block, operative with the first block, stores the parallel digital media signal in a corresponding slot in an outgoing frame, and sends the outgoing frame in response to receiving an incoming frame.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: December 11, 2012
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Baranitharan Subbiah, Sanjay Katabathuni, Shoby A. Cherian, Chi-Lie Wang, Maria Hu, Sudhakar Rao, Kap Soh, Scott W. Mitchell, Raymond Su, Lomberto P. Jimenez
  • Patent number: 8315557
    Abstract: An antenna assembly includes a reflector having a focal plane, a first feed element located along the focal plane that illuminates the reflector to create a first contour beam at a first frequency and a second feed element located further from the reflector than the first feed element that illuminates the reflector to create a first spot beam at a second frequency, the second frequency being different than the first frequency.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: November 20, 2012
    Assignee: Lockheed Martin Corporation
    Inventors: Sudhakar Rao, Jim Wang, Chih-Chien Hsu
  • Patent number: 8311604
    Abstract: A method and apparatus for the collection of physiological data from a patient is disclosed herein. An electrode assembly comprises an external label identifying an anatomical location and an electrode identifying circuitry that produces a signal indicative of the anatomical location to which the electrode assembly is to be attached. The electrode assembly transmits both the collected physiological signal and the identification signal to a data monitor for collection and processing physiological data.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: November 13, 2012
    Assignee: General Electric Company
    Inventors: Gordon Ian Rowlandson, David Thomas Peterson, Donald Eugene Brodnick, Robert Edward Henderson, Chepur Sudhakar Rao
  • Publication number: 20120071641
    Abstract: The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
    Type: Application
    Filed: March 2, 2010
    Publication date: March 22, 2012
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Alexander V. Kelin, Sudhakar Rao Takkellapati, Shigeo Matsuda
  • Publication number: 20110319406
    Abstract: This invention relates to 2-pyridyl substituted imidazoles which are inhibitors of the transforming growth factor-? (TGF-?) type I receptor (ALK5) and/or the activin type I receptor (ALK4), methods for their preparation, and their use in medicine, specifically in the treatment and prevention of a disease state mediated by these receptors.
    Type: Application
    Filed: June 29, 2010
    Publication date: December 29, 2011
    Applicant: EWHA University-Industry Collaboration Foundation
    Inventors: Dae-Kee Kim, Yhun Yhong Sheen, Chenghua Jin, Chul-Yong Park, Domalapally Sreenu, Kota Sudhakar Rao, Maddeboina Krishnaiah, Vura Bala Subrahmanyam
  • Publication number: 20110319408
    Abstract: This invention relates to use of inhibitors of the transforming growth factor-? (TGF-?) type I receptor (ALK5) and/or the activin type I receptor (ALK4) in treating, preventing, or reducing fibrosis, cancer, and vascular injuries.
    Type: Application
    Filed: June 24, 2011
    Publication date: December 29, 2011
    Applicant: EWHA University-Industry Collaboration Foundation
    Inventors: Dae-Kee Kim, Yhun Yhong Sheen, Chenghua Jin, Chul-Yong Park, Domalapally Sreenu, Kota Sudhakar Rao, Maddeboina Krishnaiah, Vura Bala Subrahmanyam
  • Publication number: 20110320648
    Abstract: In one embodiment of a networking module, a first block receives a serial digital media signal, and provides a parallel digital media signal based on the serial digital media signal. A second block, operative with the first block, stores the parallel digital media signal in a corresponding slot in an outgoing frame, and sends the outgoing frame in response to receiving an incoming frame.
    Type: Application
    Filed: June 29, 2011
    Publication date: December 29, 2011
    Inventors: Baranitharan Subbiah, Sanjay Katabathuni, Shoby A. Cherian, Chi-Lie Wang, Maria Hu, Sudhakar Rao, Kap Soh, Scott W. Mitchell, Raymond Su, Lomberto P. Jimenez
  • Patent number: RE47122
    Abstract: This invention relates to 2-pyridyl substituted imidazoles which are inhibitors of the transforming growth factor-? (TGF-?) type I receptor (ALK5) and/or the activin type I receptor (ALK4), methods for their preparation, and their use in medicine, specifically in the treatment and prevention of a disease state mediated by these receptors.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: November 13, 2018
    Assignee: EWHA UNIVERSITY—INDUSTRY COLLABORATION FOUNDATION
    Inventors: Dae-Kee Kim, Yhun Yhong Sheen, Chenghua Jin, Chul-Yong Park, Sreenu Domalapally, Sudhakar Rao Kota, Krishnaiah Maddeboina, Subrahmanyam Vura Bala
  • Patent number: RE47141
    Abstract: This invention relates to use of inhibitors of the transforming growth factor-? (TGF-?) type I receptor (ALK5) and/or the activin type I receptor (ALK4) in treating, preventing, or reducing fibrosis, cancer, and vascular injuries.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: November 27, 2018
    Assignee: EWHA UNIVERSITY—INDUSTRY COLLABORATION FOUNDATION
    Inventors: Dae-Kee Kim, Yhun Yhong Sheen, Chenghua Jin, Chul-Yong Park, Sreenu Domalapally, Sudhakar Rao Kota, Krishnaiah Maddeboina, Subrahmanyam Vura Bala