Abstract: Provided herein are methods of treating, managing and/or preventing viral infections. A particular method comprises administering to a subject in need thereof an effective amount of an adaptor associated kinase 1 inhibitor of the formula wherein R1, R2 and R3 are defined herein.

Abstract: A wireless charging device includes a driver unit configured to generate one of a first AC voltage signal having a first frequency and a second AC voltage signal having a second frequency. Also, the wireless charging device includes a transmitting unit having a first coil and a first capacitor and configured to transmit the first AC voltage signal. Further, the transmitting unit includes a second coil and a second capacitor and configured to transmit the second AC voltage signal. Additionally, the wireless charging device includes a control unit configured to detect a first receiver device operating at the first frequency based on a change in a first voltage in the transmitting unit, and detect a second receiver device operating at the second frequency based on a change in a second voltage in the transmitting unit.

Abstract: A charging pad for charging one or more receiver devices is disclosed. The charging pad includes a power drive unit configured to generate a first AC voltage signal having a first frequency and a second AC voltage signal having a second frequency Further, the charging pad includes a transmitting unit including a single power exchange coil coupled to the power drive unit, wherein the single power exchange coil includes a first coil segment configured to transmit the first AC voltage signal having the first frequency when the first AC voltage signal is received from the power drive unit. Also, the single power exchange coil includes a second coil segment configured to transmit the second AC voltage signal having the second frequency when the second AC voltage signal is received from the power drive unit.

Abstract: This disclosure provides systems, devices, apparatus and methods, including computer programs encoded on storage media, for wireless power transmission. A wireless power transmission apparatus (such as a charging pad) may provide multiple wireless power signals to a wireless power receiving apparatus. The wireless power receiving apparatus may combine wireless power received from multiple secondary coils to provide a combined wireless power signal to a load, such as a battery charger or electronic device. In some implementations, each set of primary coil and secondary coil may utilize low power wireless power signals (such as 15 Watts or less) in accordance with a wireless charging standard. By combining wireless energy from multiple low power wireless power signals, the wireless power receiving apparatus may support higher power requirements of an electronic device. The disclosed designs may minimize electromagnetic interference (EMI) and provide greater efficiency of wireless power transfer.

Abstract: A spark plug assembly includes a spark plug, where the spark plug includes a high voltage connector, an insulator body, a metallic shell, and an electrical conductor at least partly disposed in the insulator body and the metallic shell. The spark plug assembly includes a detection unit having a transmitter device and a receiver device. The transmitter device is coupled to the spark plug and is electrically disposed between the high voltage connector and the electrical conductor. Further, the transmitter device is configured to draw an excitation current from the electrical conductor. The transmitter device includes an optical signal generator that is configured to generate an optical signal in response to the drawn excitation current. The receiver device is disposed in optical communication with the transmitter device and configured to receive the optical signal from the transmitter device.

Abstract: Provided herein are methods of treating, managing and/or preventing viral infections.

Abstract: Implementations of the present disclosure include generating, by a design generation assistant, a design image representing a design subject, the design subject having one or more regulations applicable thereto, querying, by a regulation assistant, an answer extractor to provide a query result based on a query, the answer extractor including at least one deep learning model that processes the query to provide the query result, the query being descriptive of at least a portion of the design subject, the query result being representative of at least one regulation applicable to the design subject, and displaying, within a graphical user interface (GUI), the query result.

Abstract: An analog switch includes a first field effect transistor (FET) which has a first terminal coupled to an input voltage terminal, a second terminal coupled to a common source, and a control terminal coupled to a common gate. The switch includes a second FET which has a first terminal coupled to an output voltage terminal, a second terminal coupled to the common source, and a control terminal coupled to the common gate. The switch includes a switched current source which has an input coupled to a high voltage supply terminal and an output coupled to the common gate. The switch includes a clamp circuit which has a first terminal coupled to the common gate, a second terminal coupled to the common source, and a third terminal coupled to the low voltage supply terminal.

Abstract: A charging pad for charging one or more receiver devices is disclosed. The charging pad includes a power drive unit configured to generate a first AC voltage signal having a first frequency and a second AC voltage signal having a second frequency. Further, the charging pad includes a transmitting unit including a single power exchange coil coupled to the power drive unit, wherein the single power exchange coil includes a first coil segment configured to transmit the first AC voltage signal having the first frequency when the first AC voltage signal is received from the power drive unit. Also, the single power exchange coil includes a second coil segment configured to transmit the second AC voltage signal having the second frequency when the second AC voltage signal is received from the power drive unit.

Abstract: A spiking retina microscope comprising microscope optics and a neuromorphic imaging sensor. The microscope optics are configured to direct a magnified image of a specimen onto the neuromorphic imaging sensor. The neuromorphic imaging sensor comprises a plurality of sensor elements that are configured to generate spike signals in response to integrated light from the magnified image reaching a threshold. The spike signals may be processed by a processor unit to generate a result, such as tracking biological particles in a specimen comprising biological material.

Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a laminin polypeptide (e.g., a human laminin polypeptide) and/or a filaggrin polypeptide (e g , a human filaggrin polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of Junctional Epidermolysis Bullosa); and articles of manufacture or kits thereof.

Abstract: Exemplary battery pack designs for use in electrified vehicles may include an enclosure assembly that houses one or more battery internal components. One or more brackets may be used to mount each of the battery internal components within the enclosure assembly. Each bracket may include at least one attachment point for securing the bracket to the enclosure assembly and at least two attachment points for securing the bracket to a support structure of the battery internal component. Fasteners may be received through the brackets and then into either the enclosure assembly or the support structure in order to mount the battery internal component inside the battery packs.

Abstract: A non-transitory, tangible, computer-readable storage medium may contain a program of instructions that cause a computer system running the program of instructions to automatically generate a 3D avatar of a living being, including automatically: causing one or more sensors to generate 3D data indicative of the three dimensional shape and appearance of at least a portion of the living being; and generating a virtual character based on the 3D data that can be animated and controlled.

Abstract: In one embodiment, a first computer networking device executes an election algorithm to determine whether at least the first computer networking device or a second computer networking device is responsible for forwarding, to at least one receiving device, communications addressed to a specified group of computing devices. The first computer networking device may further store first data indicating that the first computer networking device is responsible for forwarding the communications. However, in response to the first computer networking device determining that it is no longer receiving the communications, it may store second data indicating that the first computer networking device is no longer responsible for forwarding the communications and may send, to the second computer networking device, third data indicating that the first computer networking device is not receiving the communications.

Abstract: The present disclosure relates, in part, to pharmaceutical compositions comprising one or more polynucleotides suitable for enhancing, increasing, augmenting, and/or supplementing the levels of Collagen alpha-1 (VII) chain polypeptide and/or Lysyl hydroxylase 3 polypeptide and/or Keratin type I cytoskeletal 17 polypeptide in a subject. The present disclosure also relates, in part, to pharmaceutical compositions and methods of use for providing prophylactic, palliative, or therapeutic relief of a wound, disorder, or disease of the skin in a subject, including a subject having, or at risk of developing, one or more symptoms of epidermolysis bullosa.

Abstract: Provided herein are methods of treating cancer with a TPH1 inhibitor. In certain embodiments, methods are provided which display remarkable efficacy and bioavailability for the treatment of certain tumors, for example, a neuroendocrine tumor in a human patient. In certain embodiments, the methods comprising treating the patient with telotristat, a telotristat prodrug, or a pharmaceutically acceptable salt thereof, which can be administered either alone or in combination with other anticancer or antidiarrheal agents.

Abstract: Integrated mounting systems for mounting electric drive components within electrified vehicles may include a cross brace assembly that mounts or supports one or more electric drive components relative to a vehicle frame. A cross brace assembly of the mounting system may include a cross brace, a first bridging side bracket, and a second bridging side bracket. The cross brace may be mounted to lower surfaces of vehicle frame rails and the bridging side brackets may be mounted to upper surfaces of the vehicle frame rails to provide a robust and serviceable mounting solution that evenly distributes vehicle loads.

Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide (e.g., a human CFTR polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of a chronic lung disease, such as cystic fibrosis); and articles of manufacture or kits thereof.

Abstract: A computer-implemented method is provided for transferring a target text style using Reinforcement Learning (RL). The method includes pre-determining, by a Long Short-Term Memory (LSTM) Neural Network (NN), the target text style of a target-style natural language sentence. The method further includes transforming, by a hardware processor using the LSTM NN, a source-style natural language sentence into the target-style natural language sentence that maintains the target text style of the target-style natural language sentence. The method also includes calculating an accuracy rating of a transformation of the source-style natural language sentence into the target-style natural language sentence based upon rewards relating to at least the target text style of the source-style natural language sentence.

Abstract: This disclosure generally relates to repeaters, and, in particular, repeaters for open-drain systems. In one embodiment, an apparatus comprises a first port, a second port, a current detector, a transistor, and a control logic circuit. A current detector input of the current detector is coupled to the first port. A transistor channel electrode of the transistor is coupled to the second port. A control logic circuit input of the control logic circuit is coupled to the current detector output, and a control logic circuit output of the control logic circuit is coupled to a transistor control electrode of the transistor.