Patents by Inventor Sumith A. Kularatne

Sumith A. Kularatne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20200188523
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: December 17, 2019
    Publication date: June 18, 2020
    Inventors: Philip S. Low, Sumith A. Kularatne
  • Synthesis and composition of photodynamic therapeutic agents for the targeted treatment of cancer
    Patent number: 10676487
    Abstract: The present invention describes new compounds that are useful for image-guided surgery and photodynamic therapy. In particular the compounds may be targeted to the nucleus or the mitochondria after compounds were delivered to diseased tissues such as cancer using a ligand that target receptor that express on the diseased tissue and followed by receptor mediated endocytosis and provide effective activity against cancer cells as well as other disorders. Methods and compositions for use of the same are described.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: June 9, 2020
    Assignee: On Target Laboratories, LLC
    Inventors: Sumith A. Kularatne, Pravin Gagare, Carrie H. Myers
  • CA IX - NIR DYES AND THEIR USES
    Publication number: 20200174009
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Application
    Filed: December 20, 2019
    Publication date: June 4, 2020
    Inventors: Sumith A. Kularatne, Pravin Gagare, Ananda Kumar Kanduluru
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20200155695
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: July 10, 2019
    Publication date: May 21, 2020
    Inventors: Philip S. Low, Sumith A. Kularatne
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20200155696
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: January 22, 2020
    Publication date: May 21, 2020
    Inventors: Philip S. Low, Sumith A. Kularatne
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 10646581
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: May 12, 2020
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A. Kularatne
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 10624970
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: April 21, 2020
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A Kularatne
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 10624969
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: April 21, 2020
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A. Kularatne
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 10624971
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: April 21, 2020
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A. Kularatne
  • CA IX—NIR dyes and their uses
    Patent number: 10557854
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: February 11, 2020
    Assignee: On Target Laboratories, LLC
    Inventors: Sumith A Kularatne, Pravin Gagare, Ananda Kumar Kanduluru
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 10557128
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: March 24, 2018
    Date of Patent: February 11, 2020
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Venkatesh Chelvam, Youngsoon Kim, Sumith A. Kularatne
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 10517957
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: December 31, 2019
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A. Kularatne
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 10517956
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: December 31, 2019
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A. Kularatne
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 10485878
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: November 26, 2019
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A. Kularatne
  • PSMA—targeted NIR dyes and their uses
    Patent number: 10456482
    Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: October 29, 2019
    Assignee: On Target Laboratories, LLC
    Inventors: Sumith A. Kularatne, Pravin Gagare
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 10406240
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: September 10, 2019
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A. Kularatne
  • PSMA-targeted NIR dyes and their uses
    Patent number: 10308606
    Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for a method for synthesizing a compound of the formula:
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: June 4, 2019
    Assignee: On Target Laboratories, LLC
    Inventors: Sumith A. Kularatne, Pravin Gagare
  • PSMA-TARGETED NIR DYES AND THEIR USES
    Publication number: 20190151480
    Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Application
    Filed: September 10, 2018
    Publication date: May 23, 2019
    Inventors: Sumith A Kularatne, Mini Thomas
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20190002861
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: March 24, 2018
    Publication date: January 3, 2019
    Inventors: Philip Stewart Low, Venkatesh Chelvam, Youngsoon Kim, Sumith A. Kularatne
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20180303950
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: June 4, 2018
    Publication date: October 25, 2018
    Inventors: Philip S. Low, Sumith A. Kularatne