Patents by Inventor Sumith A. Kularatne

Sumith A. Kularatne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20180289827
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: May 25, 2018
    Publication date: October 11, 2018
    Inventors: Philip S. LOW, Sumith A. KULARATNE
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20180289829
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: May 25, 2018
    Publication date: October 11, 2018
    Inventors: Philip S. LOW, Sumith A. KULARATNE
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20180289828
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: May 25, 2018
    Publication date: October 11, 2018
    Inventors: Philip S. LOW, Sumith A. KULARATNE
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20180271989
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: May 25, 2018
    Publication date: September 27, 2018
    Inventors: Philip S. LOW, Sumith A. KULARATNE
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20180271990
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: May 25, 2018
    Publication date: September 27, 2018
    Inventors: Philip S. LOW, Sumith A. KULARATNE
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20180271988
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: May 25, 2018
    Publication date: September 27, 2018
    Inventors: Philip S. LOW, Sumith A. KULARATNE
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20180243431
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: April 20, 2018
    Publication date: August 30, 2018
    Inventors: Philip S. Low, Sumith A. Kularatne
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 10046054
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: August 14, 2018
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A. Kularatne
  • PSMA-targeted NIR dyes and their uses
    Patent number: 9968691
    Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: May 15, 2018
    Assignee: On Target Laboratories, LLC
    Inventors: Sumith A. Kularatne, Pravin Gagare, Carrie Myers
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 9951324
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: April 24, 2018
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Venkatesh Chelvam, Youngsoon Kim, Sumith A. Kularatne
  • PSMA-TARGETED NIR DYES AND THEIR USES
    Publication number: 20180099934
    Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for a method for synthesizing a compound of the formula:
    Type: Application
    Filed: September 8, 2017
    Publication date: April 12, 2018
    Inventors: Sumith A. Kularatne, Pravin Gagare
  • CHOLECYSTOKININ 2 RECEPTOR TARGETED NIR IMAGING AND USE THEREOF
    Publication number: 20180071408
    Abstract: Compounds are described herein where CCK2R targeting ligands are attached to an imaging agent through a linker. The compounds can be used in the detection, diagnosis, imaging and treatment of cancer.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 15, 2018
    Inventors: Sumith A. Kularatne, Pravin Gagare, Mohammad Noshi
  • PSMA-TARGETED NIR DYES AND THEIR USES
    Publication number: 20170319717
    Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Application
    Filed: June 15, 2017
    Publication date: November 9, 2017
    Inventors: Sumith A. Kularatne, Pravin Gagare
  • PSMA-targeted NIR dyes and their uses
    Patent number: 9808538
    Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: November 7, 2017
    Assignee: On Target Laboratories, LLC
    Inventors: Sumith A. Kularatne, Philip S. Low, Pravin Gagare, Carrie Myers
  • PSMA-targeted NIR dyes and their uses
    Patent number: 9801956
    Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: October 31, 2017
    Assignee: On Target Laboratories, LLC
    Inventors: Sumith A. Kularatne, Philip S. Low, Pravin Gagare
  • Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
    Patent number: 9789208
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: October 17, 2017
    Assignee: Purdue Research Foundation
    Inventor: Sumith A. Kularatne
  • Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
    Patent number: 9782497
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: October 10, 2017
    Assignee: Purdue Research Foundation
    Inventor: Sumith A. Kularatne
  • SYNTHESIS AND COMPOSITION OF AMINO ACID LINKING GROUPS CONJUGATED TO COMPOUNDS USED FOR THE TARGETED IMAGING OF TUMORS
    Publication number: 20170281800
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Application
    Filed: November 30, 2015
    Publication date: October 5, 2017
    Inventor: Sumith A. Kularatne
  • PSMA-TARGETED NIR DYES AND THEIR USES
    Publication number: 20170281801
    Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Application
    Filed: June 14, 2017
    Publication date: October 5, 2017
    Inventors: Sumith A. Kularatne, Pravin Gagare
  • CA IX - NIR DYES AND THEIR USES
    Publication number: 20170285040
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Application
    Filed: March 16, 2017
    Publication date: October 5, 2017
    Inventors: Sumith A. Kularatne, Pravin Gagare, Ananda Kumar