Abstract: The present disclosure relates to a method for predicting prognosis of cancer and a composition thereof. More specifically, the present disclosure relates to a composition and a method for predicting prognosis of breast cancer and predicting the treatment effect of chemotherapy. The present disclosure provides gene expression information useful for predicting whether a cancer patient is more likely to respond favorably to treatment in chemotherapy.

Abstract: A semiconductor light emitting device package includes: a ceramic substrate having first and second electrode structures; a light emitting diode chip mounted on the ceramic substrate, electrically connected to the first and second electrode structures, and configured to emit ultraviolet light; metal patterns disposed on the ceramic substrate to be spaced apart from the first and second electrode structures; an adhesive pattern disposed on the ceramic substrate between the adjacent metal patterns, the adhesive pattern having both side surfaces in contact with one side surface of the metal patterns and an upper surface positioned on a level below that of a lower surface of the light emitting diode chip; and a protector attached to the ceramic substrate by the adhesive pattern, the protector providing a cavity surrounding the light emitting diode chip.

Abstract: A passivated current collector for a battery cell is provided. A battery cell can include a first electrode that can include a first region that is coated with an active material and a second region that lacks a coating of the active material. The battery cell can include a first terminal that can be in electrical contact with the first electrode via a first current collector that can be electrically coupled to the second region of the first electrode and the first terminal. The first current collector can include a passivated portion exposed to an electrolyte in contact with the first electrode.

Abstract: An ultrasonic irradiation device includes: an ultrasonic irradiator configured to irradiate ultrasound; a detector configured to acquire cavitation information from the body; and a processor configured to control the ultrasonic irradiator, based on the acquired cavitation information, to irradiate ultrasound to a focal point for an irradiation area of a body or to not irradiate ultrasound.

Abstract: An ultrasonic irradiation device includes: an ultrasonic irradiator configured to irradiate ultrasound; a detector configured to acquire cavitation information from the body; and a processor configured to control the ultrasonic irradiator, based on the acquired cavitation information, to irradiate ultrasound to a focal point for an irradiation area of a body or to not irradiate ultrasound.

Abstract: An ultrasonic treatment and monitoring system includes: an ultrasonic treatment device configured to emit ultrasonic waves to treat a patient; an ultrasound image acquisition device configured to obtain an ultrasound image; and a control device. The control device is configured to: determine that the ultrasonic treatment device is on; based on the ultrasonic treatment device being on, control the ultrasound image acquisition device to acquire a first ultrasound image; determine that the ultrasonic treatment device is off; based on the ultrasonic treatment device being off, control the ultrasound image acquisition device to acquire a second ultrasound image; and cause the first ultrasound image and/or the second ultrasound image to be displayed on a display.

Abstract: A water supply system for an ultrasonic generator includes: an ultrasonic generator including a water membrane for transmitting ultrasonic vibration to a skin; a water supply device configured to supply water to the ultrasonic generator; and a controller configured to selectively control a flow path of the water.

Abstract: A pomalidomide derivative exhibiting effects better than those of pomalidomide, a preparation method therefor, and use thereof. The pomalidomide derivative has excellent binding force to cereblon, has low cytotoxicity, has a low potential for causing teratogenic side effects, can regulate the expression of TNF-? and proinflammatory cytokines, and has excellent in vivo pharmacokinetic stability even while inhibiting oxidative stress.

Abstract: The present invention relates to a novel thalidomide-based compound derivative having significantly improved water solubility due to the introduction of a sugar or sugar derivative into lenalidomide or pomalidomide, which are thalidomide-based compounds, wherein the lenalidomide or pomalidomide derivative according to the present invention has significantly increased water solubility compared to conventional lenalidomide or pomalidomide and can thus be formulated into an injection or eye drop formulation. Therefore, the lenalidomide or pomalidomide derivative can be administered in the form of a high concentration therapeutic agent to a local area, and can be easily administered in combination with a different therapeutic agent developed as an injection or eye drop formulation.

Abstract: The present invention relates to a method for predicting reactivity to anticancer drugs by analyzing genomic DNA methylation status and, more specifically to a method for predicting reactivity to anticancer drugs by analyzing the methylation status of adjacent CpG sites in genomic DNA. The method of the present invention can accurately predict reactivity to anticancer drugs by using the methylation disorderness of CpG sites in genomic DNA, and thus can be very useful in the selection of drugs for cancer patient treatment.

Abstract: The disclosure relates to compositions and methods of using a pomalidomide derivative that exhibits improved pharmacological effects as compared to pomalidomide for treating brain diseases. The pomalidomide derivative exhibits excellent binding to cereblon, has almost no cytotoxicity, is unlikely to cause teratogenic adverse effects, can control TNF-? expression, exhibits excellent in vivo pharmacokinetic stability while suppressing oxidative stress, ameliorates a decrease in motor function which is a symptom of Parkinson's disease, and increases tyrosine hydroxylase expression which is reduced by Parkinson's disease, and thus can be used for preventing or treating brain diseases such as Parkinson's disease.

Abstract: The present disclosure may include: a communication module configured to perform communication with an ultrasonic irradiation device, an ultrasonic imaging device, and a display device; and a processor configured to control an operation in relation to ultrasonic image processing, and the processor is configured to: receive an ultrasonic image from the ultrasonic imaging device through the communication module; extract an irradiation area image for a region of interest (ROI) in the ultrasonic image of the ultrasonic imaging device associated with an ultrasonic irradiation signal of the ultrasonic irradiation device; correct the irradiation area image based on a variation of the ultrasonic irradiation signal in the irradiation area image in a state of focused ultrasound of the ultrasonic irradiation device; and control the display device to display the corrected irradiation area image on the display device.

Abstract: An ultrasonic treatment and monitoring system includes: an ultrasonic treatment device configured to emit ultrasonic waves to treat a patient; an ultrasound image acquisition device configured to obtain an ultrasound image; and a control device. The control device is configured to: determine that the ultrasonic treatment device is on; based on the ultrasonic treatment device being on, control the ultrasound image acquisition device to acquire a first ultrasound image; determine that the ultrasonic treatment device is off; based on the ultrasonic treatment device being off, control the ultrasound image acquisition device to acquire a second ultrasound image; and cause the first ultrasound image and/or the second ultrasound image to be displayed on a display.

Abstract: A system includes: a pressure measuring device configured to measure an amount of pressure on a bed; an irradiation device configured to press on a body of a user lying on the bed and to irradiate energy towards the user; and a control device configured to control the irradiation device, wherein the control device is configured to: obtain a pressure measurement from the pressure measuring device; and control the irradiation device to stop an operation of the irradiation device based on the pressure measurement exceeding a preset level.

Abstract: A method for providing an optimal path through a computer network includes predicting a subsequent action of a target user through an optimal path prediction model that is trained in a form of a graph representing a user action trajectory of a session unit and recommending a path of the predicted action as an optimal path. The recommendation includes identifying a user intent based on a previous action trajectory of the target user in a current session, and guiding a path corresponding to the user intent as one of the optimal paths.

Abstract: A semiconductor light emitting device package includes a circuit board with an upper pad, a light emitting diode chip on the circuit board and having a first surface facing the circuit board and a second surface opposing the first surface, and the light emitting diode chip including a substrate, a semiconductor stack structure on the substrate that emits ultraviolet light, and electrodes connected to the semiconductor stack structure, connection bumps between the circuit board and the light emitting diode chip, the connection bumps connecting the upper pad and the electrodes, an underfill resin on the upper pad of the circuit board and covering at least a portion of a side surface of the light emitting diode chip, and a passivation layer on the light emitting diode chip and the underfill resin, the passivation layer covering the underfill resin and being spaced apart from the semiconductor stack structure.

Abstract: A passivated current collector for a battery cell is provided. A battery cell can include a first electrode that can include a first region that is coated with an active material and a second region that lacks a coating of the active material. The battery cell can include a first terminal that can be in electrical contact with the first electrode via a first current collector that can be electrically coupled to the second region of the first electrode and the first terminal. The first current collector can include a passivated portion exposed to an electrolyte in contact with the first electrode.

Abstract: Disclosed are systems and methods for a device. The device can include a battery housing comprising a first lateral wall and a second lateral wall. The device can include an insulator disposed within the battery housing between the battery housing and an active battery component. A portion of the insulator can be fixed to an inner surface of the first lateral wall and the portion of the insulator fixed to an inner surface of the second lateral wall.

Abstract: A method for providing an optimal path through a computer network includes predicting a subsequent action of a target user through an optimal path prediction model that is trained in a form of a graph representing a user action trajectory of a session unit and recommending a path of the predicted action as an optimal path. The recommendation includes identifying a user intent based on a previous action trajectory of the target user in a current session, and guiding a path corresponding to the user intent as one of the optimal paths.

Abstract: A method for providing an optimal path to achieve a user goal includes collecting user historical session data that includes a user action trajectory based on a session unit; and generating a model for optimal path prediction by representing the user historical session data as a path in a form of a graph and by learning the path.