Abstract: A liquid formulation of a long-acting conjugate of GLP-2 and a method for preparing the liquid formulation are disclosed. The liquid formulation contains 18 nmol/mL to 18,630 nmol/mL of a long-acting conjugate, a stabilizer, and a buffering agent in an amount for maintaining the pH of the liquid formulation in the range of 4.5 to 6.5.

Abstract: Provided is a method for inserting a copyright information indication as a means for protecting the copyright of LF content which can be played back as multi-viewpoint images, wherein the copyright information indication is only inserted in images of a specific viewpoint. A method for generating multi-viewpoint images according to an embodiment of the present invention includes the steps of: generating multi-viewpoint images; inserting a specific information indication in images of a specific viewpoint among the generated multi-viewpoint images; and storing the multi-viewpoint images in which the specific information indication has been inserted. Accordingly, the copyright of LF content, which are expensive multi-viewpoint images, can be protected by inserting the copyright information indication only in the images of the specific viewpoint.

Abstract: Provided are a method and an apparatus for printing a hologram by using a mask. The hologram printing method according to an embodiment generates a hologram fringe pattern, splits the hologram fringe pattern on a hogel basis, generates the split hogels, masks a part of the generated hogel, and prints the masked hogel on a hologram medium. Accordingly, an empty space which occurs between hogels when a hologram is printed is prevented from being generated by using a mask, so that a fill factor can be effectively enhanced, and eventually, image quality of a hologram can be enhanced.

Abstract: Provided is a method in which, when configuring an HUD that produces a holographic image at a distance using a holographic optical element (HOE), an HOE capable of correcting aberrations generated by a projection optical system is manufactured and used to improve the quality of an HUD image. A method for manufacturing an HOE for HUD according to an embodiment of the present invention comprises the steps of: measuring aberrations generated by an optical system that projects an image of a display device; recording the measured aberrations in a master HOE; reproducing an aberrated wavefront of the optical system by playing the master HOE on a display plane on which the image of the display device is expressed; and causing an interference of the reproduced aberrated wavefront and a spherical wavefront irradiated from the HUD image plane on which the image of the display device is created, and recording the interference in the HOE.

Abstract: Provided is a technology for implementing an AR optical waveguide display capable of showing a hologram image by means of a small and simple system configuration by using an HOE. A holographic display according to an embodiment of the present invention comprises: a light source module for emitting a beam; an optical waveguide through which the emitted beam is incident and propagated; a plurality of holographic optical elements (HOES) for propagating the beam incident to the optical waveguide inside the optical waveguide while totally reflecting the beam; and a modulator for reproducing a holographic image through the progressing beam and propagating the beam to the inside of the optical waveguide while totally reflecting the beam. Accordingly, it is possible to implement, as a small and simple system, an optical waveguide display showing an AR hologram by using an optical waveguide and an HOE.

Abstract: A physiologically active polypeptide-immunoglobulin Fc fragment conjugate and a method for making the conjugate are disclosed. The conjugate contains a physiologically active polypeptide linked via a non-peptidyl linker to an immunoglobulin Fc fragment having an FcRn-binding region and maintains the intrinsic binding affinity of the immunoglobulin Fc fragment. A method of maintaining the intrinsic binding affinity of the conjugate for FcRn, and a composition containing the conjugate, which maintains the intrinsic binding affinity of the immunoglobulin Fc fragment for FcRn are also disclosed.

Abstract: Provided is a hologram printing method and apparatus using a hologram medium light efficiency map. A hologram printing method according to an embodiment emits a laser to a hologram medium, acquires an image by photographing light diffracted from the hologram medium, generates a light efficiency map of the hologram medium from the acquired image, and records hogels on the hologram medium by referring to the generated light efficiency maps of the hologram medium. Accordingly, light efficiency is measured on each hogel area, and hologram printing is performed by adjusting an intensity of a laser of each wavelength according to a hogel, so that uniformity of luminance and color of a hologram printing result can be enhanced.

Abstract: Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.

Abstract: Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex prepared by the present invention may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.

Abstract: The present disclosure relates to a pharmaceutical composition containing esomeprazole or a pharmaceutically acceptable salt thereof and with a dual release profile, and particularly to a pharmaceutical composition which exhibits a dual release profile of immediate release and sustained release so that long-term efficacy can be sustained. The pharmaceutical composition containing esomeprazole or a pharmaceutically acceptable salt thereof and with a dual release profile, according to the present disclosure, can secure bioavailability equivalent to that of existing esomeprazole immediate-release/enteric-release formulations, and can maintain long-term efficacy due to the dual release profile thereof even when administered once a day, thus preventing the occurrence of nocturnal acid breakthrough, and accordingly, can be effectively used as a therapeutic agent for nocturnal acid breakthrough.

Abstract: Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.

Abstract: Provided is a method of preparing a physiologically active polypeptide conjugate, in which a physiologically active polypeptide and a non-peptidyl polymer are linked to each other via a covalent bond. The method is to improve an overall yield of the physiologically active polypeptide conjugate by improving a reaction of the non-peptidyl polymer and the physiologically active polypeptide, and particularly, the method is to prepare a physiologically active polypeptide conjugate in a high yield by performing a two-step reaction through selective precipitation. The preparation method of the present invention is used to produce a non-peptidyl polymer-physiologically active polypeptide conjugate and a physiologically active polypeptide-physiologically active carrier conjugate in a high yield, and therefore, the method may be used in the development of long-acting formulations of various peptide drugs which maintain in vivo activity at a relatively high level and have remarkably increased blood half-life.

Abstract: Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.

Abstract: The present invention relates to a liquid formulation of long-acting insulin conjugate, comprising a pharmaceutically effective amount of a long-acting insulin conjugate, wherein a physiologically active peptide, which is an insulin, is linked to an immunoglobulin Fc region; and an albumin-free stabilizer, wherein the stabilizer comprises a buffer, a sugar alcohol, a non-ionic surfactant, and an isotonic agent, and a method for preparing the formulation. For preventing microbial contamination in multiple uses, a preservative can be added to the formulation. The liquid formulation of the present invention does not comprise a human serum albumin and potentially hazardous factors to body, and thus it has excellent storage stability for insulin conjugate without a risk of viral infection.

Abstract: Provided is a Maxwellian view display which uses a space-time multiplexing scheme and widens a field of view, thereby having a degree of freedom within a set area instead of a fixed position while maintaining the advantage of the existing Maxwellian view, in which a clear image can be observed irrespective of the difference in individual ability for focal point adjustment since the focal point does not need to be adjusted. According to an embodiment of the present invention, a display includes: a light source unit for changing the position of a point light source according to time; a first lens for converting the light emitted from the light source unit to be parallel; an image generating unit for generating an image using the parallel light incident from the first lens; and a second lens for focusing the image generated by the image generating unit.

Abstract: A method for inserting information into a 3D structure and recognizing information in a non-destructive method is provided. A 3D printing method according to an exemplary embodiment of the present invention includes: generating a tag having specific information recorded thereon to be inserted into a 3D structure, and printing the tag on the inside of the 3D structure while printing the 3D structure. Accordingly, since the tag having information recorded thereon is printed on the inside of the 3D structure when the 3D structure is printed by a 3D printer, it is impossible to forge/falsify information.

Abstract: Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.

Abstract: Provided are a system and a method for displaying content in association with a position of a projector. A method for displaying an image, according to one embodiment of the present invention, comprises identifying a position of an image output device, generating a partial image from a full image on the basis of the position of the image output device, and outputting the generated partial image by means of the image output device. As a result, since the image projected from the image output device changes in association with the position of the image output device, a more realistic AR/VR may be provided.

Abstract: A liquid crystal display includes: a first insulation substrate; a gate line disposed on the first insulation substrate; a first data line and a second data line disposed on the first insulation substrate; a color filter disposed on the first insulation substrate and disposed between the first data line and the second data line; a first light blocking member disposed on the first data line and the second data line; and a second light blocking member disposed on the color filter and the first light blocking member, extending in the same direction as the gate line, and overlapping the first light blocking member on the first data line and the second data line.

Abstract: The present invention relates to a rope for an elevator. The rope for the elevator comprises: a center strand formed by twisting a plurality of wires; inner layer strands formed by twisting the plurality of wires and arranged along the outer periphery of the center strand; and outer layer strands formed by twisting the plurality of wires and arranged along the outer periphery of the inner layer strands, wherein ten of each of the inner layer strands and the outer layer strands are prepared, the diameter of the center strand, the diameter of the inner layer strand and the diameter of the outer layer strand are respectively 0.33-0.35 times, 0.13-0.15 times and 0.22-0.24 times as large as the diameter of a first imaginary circle circumscribed around the outer layer strands, and a fill factor is 64-67%.