Abstract: Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex prepared by the present invention may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.

Abstract: A laser light source shutter system includes a light source, a variable focus optical element to transmit a beam emitted from the light source, a pinhole located on an optical path through which the beam travels from the variable focus optical element, and a controller to control a transmission and blocking of the beam by controlling a focal length of the variable focus optical element to be equal to a distance between the variable focus optical element and the pinhole or to be equal to other distances different from the distance. Therefore, a laser light source shutter free from vibration can be realized electronically with a low cost and a high light-blocking rate using a variable focus optical element such as a variable focus lens and a variable focus mirror.

Abstract: An insulin analog has a reduced insulin titer and a reduced insulin receptor binding affinity compared to the native form for the purpose of increasing the blood half-life of insulin. A conjugate is prepared by linking the insulin analog and a carrier. A long-acting formulation includes the conjugate.

Abstract: Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.

Abstract: A display device comprising a first electrode that comprises a first region, a second region, and a third region located between the first region and the second region; a first insulating film disposed on the first electrode; a second electrode that is disposed on the first insulating film and comprises a fourth region overlapping the third region; a second insulating film disposed on the second electrode; a contact hole formed through the second insulating film, the first contact hole exposing the first, second and fourth regions; and a third electrode that is disposed on the second insulating film to cover the first contact hole, and is connected to at least one of the first region and the second region exposed by the first contact hole and the fourth region exposed by the first contact hole.

Abstract: The present invention relates to a liquid formulation of highly concentrated long-acting human growth hormone conjugate, comprising a pharmaceutically effective amount of the long-acting human growth hormone conjugate in which human growth hormone (hGH) is linked to an immunoglobulin Fc region, and an albumin-free stabilizer, said stabilizer comprising a buffer, a non-ionic surfactant, a sugar alcohol, and sodium chloride as an isotonic agent, and a method for preparing the same.

Abstract: Provided is a method of preparing a physiologically active polypeptide conjugate, in which a physiologically active polypeptide and a non-peptidyl polymer are linked to each other via a covalent bond. The method is to improve an overall yield of the physiologically active polypeptide conjugate by improving a reaction of the non-peptidyl polymer and the physiologically active polypeptide, and particularly, the method is to prepare a physiologically active polypeptide conjugate in a high yield by performing a two-step reaction through selective precipitation. The preparation method of the present invention is used to produce a non-peptidyl polymer-physiologically active polypeptide conjugate and a physiologically active polypeptide-physiologically active carrier conjugate in a high yield, and therefore, the method may be used in the development of long-acting formulations of various peptide drugs which maintain in vivo activity at a relatively high level and have remarkably increased blood half-life.

Abstract: A liquid crystal display includes: a first insulation substrate; a gate line disposed on the first insulation substrate; a first data line and a second data line disposed on the first insulation substrate; a color filter disposed on the first insulation substrate and disposed between the first data line and the second data line; a first light blocking member disposed on the first data line and the second data line; and a second light blocking member disposed on the color filter and the first light blocking member, extending in the same direction as the gate line, and overlapping the first light blocking member on the first data line and the second data line.

Abstract: A display device may include a floating electrode, a common-voltage electrode, a transistor, and a pixel electrode. The floating electrode may be electrically floating. The common-voltage electrode may be electrically connected to a voltage source. The pixel electrode may be electrically connected to the transistor. A first portion of the pixel electrode may overlap neither of the floating electrode and the common-voltage electrode in a direction perpendicular to at least one of the pixel electrode and an image display side of the display device. A second portion of the pixel electrode may overlap the common-voltage electrode. A third portion of the pixel electrode may overlap the floating electrode.

Abstract: A liquid crystal display includes: a first insulation substrate; a gate line disposed on the first insulation substrate; a first data line and a second data line disposed on the first insulation substrate; a color filter disposed on the first insulation substrate and disposed between the first data line and the second data line; a first light blocking member disposed on the first data line and the second data line; and a second light blocking member disposed on the color filter and the first light blocking member, extending in the same direction as the gate line, and overlapping the first light blocking member on the first data line and the second data line.

Abstract: Provided are a liquid formulation of long-acting insulinotropic peptide conjugate, containing a pharmaceutically effective amount of long-acting insulinotropic peptide conjugate consisting of a physiologically active peptide, insulinotropic peptide, and an immunoglobulin Fc region; and an albumin-free stabilizer, wherein the stabilizer comprises a buffer, a sugar alcohol, and a non-ionic surfactant, and a method for preparing the formulation. For the purpose of preventing microbial contamination, a preservative may be added. The liquid formulation of the present invention is free of human serum albumin and other potentially hazardous factors to body, having no risk of viral contamination, and thus can provide excellent storage stability for insulinotropic peptide conjugates at high concentration.

Abstract: A curved display device including a first substrate, a thin film transistor (TFT) disposed on the first substrate, a pixel electrode connected to the TFT, a second substrate overlapping the first substrate, a liquid crystal layer disposed between the first and the second substrates, and a common electrode disposed between the second substrate and the liquid crystal layer, in which the pixel electrode includes a cross-shaped stem portion having a horizontal stem portion, a vertical stem portion, and a plurality of fine branches extending from the cross-shaped stem portion, at least one of the fine branches includes a first portion and a second portion having a width greater than that of the first portion, and an extending line from a boundary between the first portion and the second portion is sloped at an angle in a range of ?10 degrees to +10 degrees with respect to the vertical stem portion.

Abstract: A display panel includes a first substrate, a first thin film transistor disposed on the first substrate, a color filter disposed on the first thin film transistor, a passivation layer disposed on the color filter, a first opening being formed through the passivation layer and extending into the color filter, and a first pixel electrode disposed on the passivation layer, electrically connected to the first thin film transistor, and overlapping the first opening.

Abstract: The present invention relates to a liquid formulation of long-acting insulinotropic peptide conjugate, comprising a pharmaceutically effective amount of long-acting insulinotropic peptide conjugate consisting of a physiologically active peptide, insulinotropic peptide, and an immunoglobulin Fc region; and an albumin-free stabilizer, wherein the stabilizer comprises a buffer, a sugar alcohol, a non-ionic surfactant, and an isotonic agent, and a method for preparing the formulation. For the purpose of preventing microbial contamination, a preservative may be added. The liquid formulation of the present invention is free of human serum albumin and other potentially hazardous factors to body, having no risk of viral contamination, and thus can provide excellent storage stability for insulinotropic peptide conjugates at high concentration.

Abstract: A method for inserting information into a 3D structure and recognizing information in a non-destructive method is provided. A 3D printing method according to an exemplary embodiment of the present invention includes: generating a tag having specific information recorded thereon to be inserted into a 3D structure, and printing the tag on the inside of the 3D structure while printing the 3D structure. Accordingly, since the tag having information recorded thereon is printed on the inside of the 3D structure when the 3D structure is printed by a 3D printer, it is impossible to forge/falsify information.

Abstract: A display device comprising a first electrode that comprises a first region, a second region, and a third region located between the first region and the second region; a first insulating film disposed on the first electrode; a second electrode that is disposed on the first insulating film and comprises a fourth region overlapping the third region; a second insulating film disposed on the second electrode; a contact hole formed through the second insulating film, the first contact hole exposing the first, second and fourth regions; and a third electrode that is disposed on the second insulating film to cover the first contact hole, and is connected to at least one of the first region and the second region exposed by the first contact hole and the fourth region exposed by the first contact hole.

Abstract: There is provided a curved display device including a first substrate, a thin film transistor (TFT) disposed on the first substrate, a pixel electrode connected to the TFT, a second substrate facing the first substrate, a common electrode positioned on the second substrate, and a liquid crystal layer interposed between the first substrate and the second substrate, wherein the pixel electrode includes a cross-shaped stem portion including a horizontal stem portion and a vertical stem portion intersecting the horizontal stem portion and a plurality of fine branches extending from the cross-shaped stem portion, each of the fine branches includes a first portion and a second portion having a width greater than that of the first portion, and the first portion is connected to the cross-shaped stem portion.

Abstract: A plate laminated type heat exchanger includes: a plate laminated body which is formed by laminating a plurality of plates; and a heat exchanger body which includes a first header through which fluid (G) flows in from outside of the plate laminated body and a second header through which the fluid (G) flows out to the outside of the plate laminated body which are connected to the plate laminated body. Each of the plurality of plates is formed from a flat plate shape having a first surface and a second surface. The first surface is provided with a plurality of grooves defined by inner walls through which the fluid flows. The plurality of plates are connected each other so that the first surface of one of the plurality of plates is brazed to the second surface of the other one of the plurality of plates.

Abstract: A display device including a substrate, and pixels disposed on the substrate, each of the pixels including a first sub-pixel and a second sub-pixel, in which the first sub-pixel includes a first cover layer defining a first cavity on the substrate, a first liquid crystal layer disposed in the first cavity, and a first pixel electrode and a first common electrode configured to apply an electric field to the first liquid crystal layer, the second sub-pixel includes a second cover layer defining a second cavity on the substrate, a second liquid crystal layer disposed in the second cavity, and a second pixel electrode and a second common electrode configured to apply an electric field to the second liquid crystal layer, and a first distance between the first pixel electrode and the first common electrode is different from a second distance between the second pixel electrode and the second common electrode.

Abstract: The present invention relates to a rope for an elevator. The rope for the elevator comprises: a center strand formed by twisting a plurality of wires; inner layer strands formed by twisting the plurality of wires and arranged along the outer periphery of the center strand; and outer layer strands formed by twisting the plurality of wires and arranged along the outer periphery of the inner layer strands, wherein ten of each of the inner layer strands and the outer layer strands are prepared, the diameter of the center strand, the diameter of the inner layer strand and the diameter of the outer layer strand are respectively 0.33-0.35 times, 0.13-0.15 times and 0.22-0.24 times as large as the diameter of a first imaginary circle circumscribed around the outer layer strands, and a fill factor is 64-67%.