Patents by Inventor Sung-Ju Moon

Sung-Ju Moon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoconjugates with an Intracellularly-Cleavable Linkage
    Publication number: 20170239368
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Application
    Filed: May 5, 2017
    Publication date: August 24, 2017
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites
    Patent number: 9707300
    Abstract: The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may be conjugated to a peptide moiety that contains one or more haptens, such as HSG. The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. Methods for synthesizing and using such therapeutic-loaded polymers and their conjugates are provided.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: July 18, 2017
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg, Chien-Hsing Chang
  • Immunoconjugates with an intracellularly-cleavable linkage
    Patent number: 9700634
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: July 11, 2017
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an intracellularly-cleavable linkage
    Patent number: 9675706
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: June 13, 2017
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an Intracellularly-Cleavable Linkage
    Publication number: 20170028081
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Application
    Filed: September 16, 2016
    Publication date: February 2, 2017
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an intracellularly-cleavable linkage
    Patent number: 9480756
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: November 1, 2016
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO FLT3 PROTEINS
    Publication number: 20160272716
    Abstract: Antibody drug conjugates (ADC's) that bind to FLT3 protein and variants thereof are described herein. FLT3 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
    Type: Application
    Filed: March 9, 2016
    Publication date: September 22, 2016
    Inventors: Christine Lowe, Nandini Rudra-Ganguly, Faisal Hayat Malik, Sung Ju Moon, Josh Snyder, Hector Avina, Cyrus Virata, Linnette Capo, Gao Liu
  • Immunoconjugates with an Intracellularly-Cleavable Linkage
    Publication number: 20160220695
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Application
    Filed: April 20, 2016
    Publication date: August 4, 2016
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an intracellularly-cleavable linkage
    Patent number: 9345783
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: May 24, 2016
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an Intracellularly-Cleavable Linkage
    Publication number: 20160082003
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Application
    Filed: December 2, 2015
    Publication date: March 24, 2016
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an intracellularly-cleavable linkage
    Patent number: 9233172
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: January 12, 2016
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an intracellularly-cleavable linkage
    Patent number: 9198978
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Grant
    Filed: March 2, 2015
    Date of Patent: December 1, 2015
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an intracellularly-cleavable linkage
    Patent number: 9138485
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: September 22, 2015
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an intracellularly-cleavable linkage
    Patent number: 9102735
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: August 11, 2015
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • AMATOXIN DERIVATIVES AND CELL-PERMEABLE CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE
    Publication number: 20150218220
    Abstract: The present invention relates to analogs of alpha-amanitin, methods of inhibiting RNA polymerase with such compounds, conjugates comprising such compounds, compositions comprising such compounds and conjugates, and methods of treatment using such conjugates.
    Type: Application
    Filed: September 12, 2013
    Publication date: August 6, 2015
    Inventors: Brian Alan Mendelsohn, Sung Ju Moon
  • Immunoconjugates with an Intracellularly-Cleavable Linkage
    Publication number: 20150182633
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Application
    Filed: March 17, 2015
    Publication date: July 2, 2015
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an Intracellularly-Cleavable Linkage
    Publication number: 20150174269
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Application
    Filed: March 2, 2015
    Publication date: June 25, 2015
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an Intracellularly-Cleavable Linkage
    Publication number: 20150174270
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Application
    Filed: March 3, 2015
    Publication date: June 25, 2015
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an intracellularly-cleavable linkage
    Patent number: 8999344
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: April 7, 2015
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Polymeric Carriers of Therapeutic Agents and Recognition Moieties for Antibody-Based Targeting of Disease Sites
    Publication number: 20150038686
    Abstract: The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may be conjugated to a peptide moiety that contains one or more haptens, such as HSG. The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. Methods for synthesizing and using such therapeutic-loaded polymers and their conjugates are provided.
    Type: Application
    Filed: October 9, 2014
    Publication date: February 5, 2015
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg, Chien-Hsing Chang