Patents by Inventor Sung-Ju Moon

Sung-Ju Moon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites
    Patent number: 8889835
    Abstract: The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may be conjugated to a peptide moiety that contains one or more haptens, such as HSG. The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. Methods for synthesizing and using such therapeutic-loaded polymers and their conjugates are provided.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: November 18, 2014
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg, Chien-Hsing Chang
  • Immunoconjugates with an Intracellularly-Cleavable Linkage
    Publication number: 20140328752
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Application
    Filed: June 3, 2014
    Publication date: November 6, 2014
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an Intracellularly-Cleavable Linkage
    Publication number: 20140286860
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Application
    Filed: April 22, 2014
    Publication date: September 25, 2014
    Applicant: IMMUNOMEDICS, INC.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Camptothecin-binding moiety conjugates
    Patent number: 8834886
    Abstract: The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a camptothecin as a therapeutic moiety, and further relates to processes for making and using the said conjugates.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: September 16, 2014
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, David M. Goldenberg, Sung-Ju Moon
  • Immunoconjugates with an intracellularly-cleavable linkage
    Patent number: 8759496
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: June 24, 2014
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an intracellularly-cleavable linkage
    Patent number: 8741300
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: June 3, 2014
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Camptothecin-Binding Moiety Conjugates
    Publication number: 20140099258
    Abstract: The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a camptothecin as a therapeutic moiety, and further relates to processes for making and using the said conjugates.
    Type: Application
    Filed: November 13, 2013
    Publication date: April 10, 2014
    Applicant: IMMUNOMEDICS, INC.
    Inventors: Serengulam V. Govindan, David M. Goldenberg, Sung-Ju Moon
  • Immunoconjugates with an Intracellularly-Cleavable Linkage
    Publication number: 20140058067
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Application
    Filed: October 8, 2013
    Publication date: February 27, 2014
    Applicant: IMMUNOMEDICS, INC.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Camptothecin-binding moiety conjugates
    Patent number: 8617558
    Abstract: The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a camptothecin as a therapeutic moiety, and further relates to processes for making and using the said conjugates.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: December 31, 2013
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, David M. Goldenberg, Sung-Ju Moon
  • Camptothecin-Binding Moiety Conjugates
    Publication number: 20120328564
    Abstract: The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a camptothecin as a therapeutic moiety, and further relates to processes for making and using the said conjugates.
    Type: Application
    Filed: August 15, 2012
    Publication date: December 27, 2012
    Applicant: IMMUNOMEDICS, INC.
    Inventors: Serengulam V. Govindan, David M. Goldenberg, Sung-Ju Moon
  • Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites
    Patent number: 8338140
    Abstract: The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may be conjugated to a peptide moiety that contains one or more haptens, such as HSG. The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. Methods for synthesizing and using such therapeutic-loaded polymers and their conjugates are provided.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: December 25, 2012
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg, Chien-Hsing Chang
  • Camptothecin-binding moiety conjugates
    Patent number: 8268317
    Abstract: The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a camptothecin as a therapeutic moiety, and further relates to processes for making and using the said conjugates.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: September 18, 2012
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, David M. Goldenberg, Sung-Ju Moon
  • Immunoconjugates with an Intracellularly-Cleavable Linkage
    Publication number: 20120082617
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Application
    Filed: November 8, 2011
    Publication date: April 5, 2012
    Applicant: IMMUNOMEDICS, INC.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Polymeric Carriers of Therapeutic Agents and Recognition Moieties for Antibody-Based Targeting of Disease Sites
    Publication number: 20120040431
    Abstract: The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may be conjugated to a peptide moiety that contains one or more haptens, such as HSG. The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. Methods for synthesizing and using such therapeutic-loaded polymers and their conjugates are provided.
    Type: Application
    Filed: September 27, 2011
    Publication date: February 16, 2012
    Applicant: IMMUNOMEDICS, INC.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg, Chien-Hsing Chang
  • Immunoconjugates with an intracellularly-cleavable linkage
    Patent number: 8080250
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: December 20, 2011
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Immunoconjugates with an Intracellularly-Cleavable Linkage
    Publication number: 20110293513
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Application
    Filed: June 20, 2011
    Publication date: December 1, 2011
    Applicant: IMMUNOMEDICS, INC.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites
    Patent number: 8067006
    Abstract: The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may be conjugated to a peptide moiety that contains one or more haptens, such as HSG. The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. Methods for synthesizing and using such therapeutic-loaded polymers and their conjugates are provided.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: November 29, 2011
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg, Chien-Hsing Chang
  • Immunoconjugates with an intracellularly-cleavable linkage
    Patent number: 7999083
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: August 16, 2011
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
  • Polymeric Carriers of Therapeutic Agents and Recognition Moieties for Antibody-Based Targeting of Disease Sites
    Publication number: 20100233779
    Abstract: The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may be conjugated to a peptide moiety that contains one or more haptens, such as HSG. The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. Methods for synthesizing and using such therapeutic-loaded polymers and their conjugates are provided.
    Type: Application
    Filed: April 23, 2010
    Publication date: September 16, 2010
    Applicant: IMMUNOMEDICS, INC.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg, Chien-Hsing Chang
  • Immunoconjugates with an Intracellularly-Cleavable Linkage
    Publication number: 20100104589
    Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
    Type: Application
    Filed: December 2, 2009
    Publication date: April 29, 2010
    Applicant: IMMUNOMEDICS, INC.
    Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg