Abstract: A protective film, a display device including the protective film and a method of manufacturing the protective film are provided. The protective film includes a urethane adhesive layer including a urethane adhesive resin, a base film layer on the urethane adhesive layer, and a hard coating layer on the base film layer and including a fluorine-based photocurable resin and a glycol-based photocurable resin.

Abstract: A method of operating a solid-state relay device includes receiving an input signal at an input of the solid-state relay device and coupling the input signal to transmit circuitry disposed on a transmit die. In response to receiving the input signal the transmit circuitry generates a corresponding time varying electrical voltage that is coupled from the transmit circuitry to a transmit coil and a receive coil is induced to generate an intermediate signal. A switch drive signal is generated which transitions a solid-state switch from an off state to an on state, wherein the switch drive signal corresponds to the input signal and wherein the drive signal is electrically isolated from the input signal.

Abstract: Disclosed herein are methods of manufacturing an oral appliance, the method comprising the steps of: a) importing into a computer aided design (CAD) computer program a digitized data set obtained from a three-dimensional scan of a patient's dentition; b) preparing a three-dimensional electronic model of the patient's dentition; c) subtracting the three-dimensional electronic model of the patient's dentition from an image of a solid block to obtain an appliance data set; and d) manufacturing a dental appliance in accordance with the appliance data set. Also disclosed are devices made by the above method, and methods of treating a condition, for example a sleep breathing disorder, by using a device made by the above method.

Abstract: A protective film includes a film, and a coating layer disposed on the film. The coating layer includes a binder, and beads disposed in the binder. The binder includes a protrusion portion in contact with each of the beads, and a flat portion not in contact with the beads. A tray assembly includes a tray and the coating layer disposed on the tray. A coating composition includes a binder and urethan beads disposed in the binder.

Abstract: The present invention includes methods and computer programs for use in the detection preeclampsia and/or determining an increased risk for preeclampsia in a pregnant female, the methods including identifying in a biosample obtained from the pregnant female cell-free DNA signals, including concentration, fetal fraction, and fragment size distribution. These methods provide for the identification of patients at risk of preeclampsia in the first trimester of pregnancy.

Abstract: A tray assembly includes a base tray, and an anti-slip pad disposed on the base tray, wherein the anti-slip pad has a friction coefficient in a range of about 0.5 to about 20 based on ASTM D1894, and a surface resistance in a range of about 10{circumflex over (?)}6 ?/cm2 to about 10{circumflex over (?)}9 ?/cm2 based on ASTM D257, and the anti-slip pad includes at least one of a thermoplastic olefinic elastomer (TPO), natural rubber, styrene-butadiene rubber (SBR), and polypropylene (PP).

Abstract: Disclosed herein are methods of manufacturing a dental device, the method comprising: obtaining a set of clinical options for the dental device from a health care provider; creating a first data set from the set of clinical options; communicating the data set to a computer aided design (CAD) software; preparing a digital design for the dental device using the CAD software; communicating the digital design to an automated milling apparatus; and automatedly milling a block of polymer to obtain the dental device. Also disclosed are dental devices manufactured by the above method. Further disclosed are methods of treating or ameliorating apnea jaw-related disorder in a patient, the method comprising obtaining a dental device manufactured by the above method and positioning the dental device over the dentition prior to sleep, whereby the mandible is advanced forward relative to the maxilla, thereby ameliorating the symptoms of sleep apnea or the jaw-related disorder.

Abstract: One embodiment of the present invention provides a technology that optimally designs a single-channel pump and improves performance such as high efficiency and low vibration of the single-channel pump.

Abstract: An apparatus can include a display, a facial interface, and a connection between the display and facial interface. The display can at least translate or rotate relative to the facial interface via the connection.

Abstract: Disclosed herein are mandibular advancement devices comprising an upper splint and a lower splint, where the upper splint comprises one or more upper fins, where each upper fin is located at a distance UD from back of the upper splint; the lower splints comprise one or more lower fins, where each lower fin is located at a distance LD from back of the lower splint; where the position of the upper and lower fins is unchangeable. Also disclosed are methods of reducing partial constriction of airway during sleep for a patient, the method comprising identifying a patient in need thereof; and administering to the patient the disclosed mandibular advancement device. Also disclosed are methods of manufacturing a mandibular advancement device, the method comprising obtaining measurements from a patient's dentition; digitally designing a mandibular advancement device; and milling the mandibular advancement device.

Abstract: A signal isolation device comprises a transmit die including a pair of input terminals coupled to a pair of transmitter output terminals. A receiver die includes a pair of receiver input terminals, a pair of output terminals and a coupler region, wherein the transmit die is attached to a top surface of the receiver die. The coupler region includes a transmit coil connected to the pair of transmitter output terminals, a receiver coil positioned proximate the transmit coil and connected to the pair of output terminals, receiver circuitry and a shield layer positioned between the receiver circuitry and the receiver coil.

Abstract: A method of operating a signal isolation device includes receiving an input signal at an input of a transmit die and in response, generating a corresponding time varying electrical voltage at a transmitter output of the transmit die. The time varying electrical voltage is coupled to a transmit coil disposed within a receiver die. A receive coil is induced to generate an intermediate signal in response to the coupling of the time varying electrical voltage to the transmit coil, wherein the intermediate signal corresponds to the input signal. The intermediate signal is coupled to receiver circuitry disposed within the receiver die. Electromagnetic noise generated by the receive coil is shielded from the receiver circuitry via a shield positioned between the receive coil and the receiver circuitry.

Abstract: A solid-state relay device includes a transistor die, a transmitter die including a pair of input terminals coupled to a pair of transmitter output terminals and a receiver die including a pair of receiver input terminals, a pair of output terminals and a coupler region. The transmitter die is attached to a top surface of the receiver die, wherein at least one output terminal of the pair of output terminals is attached to a gate terminal of the transistor die. The coupler region includes: a transmit coil connected to the pair of receiver input terminals; a receiver coil positioned proximate the transmit coil and connected to the pair of output terminals; receiver circuitry; and a shield layer positioned between the receiver circuitry and the receiver coil.

Abstract: A method of operating a solid-state relay device includes receiving an input signal at an input of the solid-state relay device and coupling the input signal to transmit circuitry disposed on a transmit die. In response to receiving the input signal the transmit circuitry generates a corresponding time varying electrical voltage that is coupled from the transmit circuitry to a transmit coil and a receive coil is induced to generate an intermediate signal. A switch drive signal is generated which transitions a solid-state switch from an off state to an on state, wherein the switch drive signal corresponds to the input signal and wherein the drive signal is electrically isolated from the input signal.

Abstract: An apparatus can include a display, a facial interface, and a connection between the display and facial interface. The display can at least translate or rotate relative to the facial interface via the connection.

Abstract: A resin composition according to an exemplary embodiment of the present disclosure includes a first polyol represented by Chemical Formula 1, a second polyol represented by Chemical Formula 2, and a polyisocyanate, wherein the first polyol and the second polyol have a linear structure without a side chain. each of Y1 to Y4 is H or OH—, at least one of Y1 and Y2 is OH—, at least one of Y3 and Y4 is OH—, each of X1 to X3 is independently a C1-C20 alkyl group, the alkyl group includes or does not include an unsaturated bond, —CH2— in the alkyl group may be substituted or unsubstituted with —CHOH—, and each of n and m is independently 1 to 200.

Abstract: Disclosed herein are mandibular advancement devices comprising an upper splint and a lower splint, where the upper splint comprises one or more upper fins, where each upper fin is located at a distance UD from back of the upper splint; the lower splints comprise one or more lower fins, where each lower fin is located at a distance LD from back of the lower splint; where the position of the upper and lower fins is unchangeable. Also disclosed are methods of reducing partial constriction of airway during sleep for a patient, the method comprising identifying a patient in need thereof; and administering to the patient the disclosed mandibular advancement device. Also disclosed are methods of manufacturing a mandibular advancement device, the method comprising obtaining measurements from a patient's dentition; digitally designing a mandibular advancement device; and milling the mandibular advancement device.

Abstract: Disclosed are asymmetrical splints for a mandibular advancement device (MAD) for use with a patient having an asymmetrical dentition, wherein the asymmetry of the splint complements the asymmetry of the dentition such that when the MAD is used to advance the mandible, the mandible is advanced symmetrically. Also disclosed are methods of manufacture and use of the splints.

Abstract: The technology relates in part to methods for determining copy number variations (CNVs) known or suspected to be associated with a variety of medical conditions. In some aspects, the technology relates to determining CNVs of fetuses using maternal samples comprising maternal and fetal cell free DNA. In some aspects, the technology relates to determining CNVs known or suspected to be associated with a variety of medical conditions. In some aspects, methods to improve the sensitivity and/or specificity of sequence data analysis by deriving a fragment size parameter are provided. In some aspects, information from fragments of different sizes is used to evaluate copy number variations. In some aspects, information from fragments of different sizes is used to discriminate between fetal and maternal CNVs. In some aspects, the technology relates to systems and computer program products for evaluation of CNVs of sequences of interest.

Abstract: Disclosed herein are methods of manufacturing a dental device, the method comprising: obtaining a set of clinical options for the dental device from a health care provider; creating a first data set from the set of clinical options; communicating the data set to a computer aided design (CAD) software; preparing a digital design for the dental device using the CAD software; communicating the digital design to an automated milling apparatus; and automatedly milling a block of polymer to obtain the dental device. Also disclosed are dental devices manufactured by the above method. Further disclosed are methods of treating or ameliorating apnea jaw-related disorder in a patient, the method comprising obtaining a dental device manufactured by the above method and positioning the dental device over the dentition prior to sleep, whereby the mandible is advanced forward relative to the maxilla, thereby ameliorating the symptoms of sleep apnea or the jaw-related disorder.