Abstract: This invention provides methods for identifying novel SHMT modulators. The methods comprise first screening test agents for modulators of p38 activity and then further screening the identified modulating agents for modulators of SHMT enzyme activity. The invention further provides methods and pharmaceutical compositions for modulating cellular proliferation and for treating tumors using the novel SHMT modulators.

Abstract: A method for multiplexing control signals for disk drives includes developing parallel control signals and developing serial control signals. At least one of the parallel control signals and the serial control signals are coupled to at least one of a parallel hard disk drive and a serial hard disk drive by a common control bus.

Abstract: A new scheme to transfer bidirectional data streams between a digital display and a computer is disclosed. This bidirectional data transfer can make several I/O devices attach to a display. Existing digital display interfaces are usually unidirectional from a computing to a display. Due to the nature of the existing clocking scheme, backward data transfer from the display side to the computer requires a backward clock. This invention discloses a scheme to send data bidirectionally without sending the additional backward clock. This invention also discloses a scheme to tolerate jitters from the clock source. With this approach, this new interface can make a digital display an I/O concentrator.

Abstract: A system and method for sending multiple data signals over a serial link comprises an embedding unit and a removing unit coupled by a serial line. The embedding unit preferably receives a plurality of data streams, encodes the data streams and then merges the encoded data into a serial stream that is output across a serial line to the removing unit. The removing unit receives a serial stream of data, decodes the serial stream, and then separates the decoded serial stream into separate streams thereby reconstructing the streams input to the embedding unit. The encoding and transmission by the embedding unit and the receipt and decoding by the removing unit are completely transparent, the signals output by the removing unit are identical in timing and data content to the signals input to the embedding unit. The present invention also includes a method for transmitting a plurality of data streams over a signal line, and a method for generating a plurality of data streams from a serial sequence.

Abstract: A method and apparatus for producing a transition-controlled, DC-balanced sequence of characters from an input sequence of data bytes is disclosed herein. The bits in each of the data bytes are selectively complemented in accordance with the number of logical transitions in each data byte in order to produce selectively complemented data blocks. A cumulative disparity is then determined between the logical values of different type included within ones of the selectively complemented data blocks previously encoded into characters. In addition, a current disparity in a candidate character associated with a current one of the selectively complemented data blocks being encoded is also determined. The candidate character is assigned to the current one of the selectively complemented data blocks if the current disparity is of a polarity opposite to a first polarity of the cumulative disparity.

Abstract: A new high-speed digital interface for transmitting video information over various transmission media including terminated copper wires such as twisted-pair wires and fiber optical cable is described. The significance of this new interface is that (1) it only uses a small number of data channels with all timing and control data embedded in data transmission, (2) it uses a transition controlled binary DC balanced coding for reliable, low-power and high-speed data transmission, (3) it uses low-swing differential voltage which minimizes EMI, and (4) it can be implemented in low-cost scaleable CMOS technology as a megacell or standard IC. The high-speed digital interface incorporates a method and apparatus for producing a transition-controlled, DC-balanced sequence of characters from an input sequence of data bytes. The bits in each of the data bytes are selectively complemented in accordance with the number of logical transitions in each data byte in order to produce selectively complemented data blocks.

Abstract: A system and method for sending multiple data signals over a serial link comprises an embedding unit and a removing unit coupled by a serial line. The embedding unit preferably receives a plurality of data streams, encodes the data streams and then merges the encoded data into a serial stream that is output across a serial line to the removing unit. The removing unit receives a serial stream of data, decodes the serial stream, and then separates the decoded serial stream into separate streams thereby reconstructing the streams input to the embedding unit. The encoding and transmission by the embedding unit and the receipt and decoding by the removing unit are completely transparent, the signals output by the removing unit are identical in timing and data content to the signals input to the embedding unit. The present invention also includes a method for transmitting a plurality of data streams over a signal line, and a method for generating a plurality of data streams from a serial sequence.