Abstract: The present invention features devices, systems, and methods of use thereof for delivering therapeutic or sterilizing ultraviolet (UV) radiation, such as UVC or UVA radiation.

Abstract: Vascular closure devices as well as methods for making and using vascular closure devices are disclosed. An example vascular closure device may include an intravascular sealing member configured to be disposed within a blood vessel. The vascular closure device may also include an extravascular hemostatic member configured to be disposed adjacent to an exterior of the blood vessel. The vascular closure device may also include an extravascular sealing member configured to be disposed along an outer surface of the extravascular hemostatic member. A suture may be coupled to the intravascular sealing member and the extravascular sealing member. At least one of the intravascular sealing member, the extravascular hemostatic member, the extravascular sealing member, and the suture may include a radiopaque material.

Abstract: The present invention features new lipid-polymer composite particles that are useful for the formulation of bioactive agents for administration to a subject. The nanoparticles include a block copolymer, a lipid, e.g., phospholipid, and a sterol. The formulations of a bioactive agent (e.g., a therapeutic agent, a nutraceutical agent, or a recreational agent) described herein provide for easier loading of lipid-polymer composite particles with higher drug loading capacity, increased stability of the formulations, and lower surface tension of water, which allows for lipid coating and entrapment.

Abstract: The present invention features new lipid-polymer composite particles that are useful for the formulation of bioactive agents for administration to a subject. The nanoparticles include a block copolymer, a lipid, e.g., phospholipid, and a sterol. The formulations of a bioactive agent (e.g., a therapeutic agent, a nutraceutical agent, or a recreational agent) described herein provide for easier loading of lipid-polymer composite particles with higher drug loading capacity, increased stability of the formulations, and lower surface tension of water, which allows for lipid coating and entrapment.

Abstract: The present invention features new lipid-polymer composite particles that are useful for the formulation of bioactive agents for administration to a subject. The nanoparticles include a block copolymer, a lipid, e.g., phospholipid, and a sterol. The formulations of a bioactive agent (e.g., a therapeutic agent, a nutraceutical agent, or a recreational agent) described herein provide for easier loading of lipid-polymer composite particles with higher drug loading capacity, increased stability of the formulations, and lower surface tension of water, which allows for lipid coating and entrapment.

Abstract: Arterial closure devices as well as methods for making using arterial closure devices are disclosed. An example arterial closure device may include a proximal gasket configured to be positioned on a first side of a blood vessel wall. The arterial closure device may include a distal footplate configured to be positioned on a second side of the blood vessel wall opposite the proximal gasket. The arterial closure device may include a seal configured to be positioned on the first side of the blood vessel wall between the proximal gasket and the blood vessel wall. A tether may be coupled to at least the proximal gasket and the distal footplate. A securement element may be disposed on the tether. The securement element may be configured to secure the proximal gasket and the seal against the first side of the blood vessel wall.

Abstract: The invention provides compositions containing a cannabinoid (e.g., cannabidiol) and optionally one or more bioactive agents for the treatment and/or prevention of diseases including ophthalmic diseases or conditions, dermatologic conditions, infections, inflammatory diseases, and vision disorders. The invention also provides compositions and methods of preparing the compositions containing cannabinoids for cosmetic dermatologic applications and a pharmaceutical eluting contact lens. Furthermore, the invention provides delivery vehicles including lipid-polymer particles and methods of preparing the lipid-polymer particles to deliver the compositions to a subject.

Abstract: The present invention features new lipid-polymer composite particles that are useful for the formulation of bioactive agents for administration to a subject. The nanoparticles include a block copolymer, a lipid, e.g., phospholipid, and a sterol. The formulations of a bioactive agent (e.g., a therapeutic agent, a nutraceutical agent, or a recreational agent) described herein provide for easier loading of lipid-polymer composite particles with higher drug loading capacity, increased stability of the formulations, and lower surface tension of water, which allows for lipid coating and entrapment.

Abstract: Systems and methods involving processing and/or mirroring data in real time involving one or more mobile devices and a plurality of NFC-connected interactive posters are disclosed. In one embodiment, an exemplary computer-implemented method may comprise: connecting a user mobile computing device to a server as well as coupling the device to a plurality of interactive posters via NFC; receiving user selections made on the interactive posters; processing content data related to the posters based on the user selections and/or other information; generating a GUI comprising interactive simulations corresponding to respective posters and/or statistics related to selections made on the posters; tracking, in real time, a specific experience of a user interacting with the posters; and transmitting, in real-time, data regarding the specific experience to the server.

Abstract: Systems and methods involving processing and/or mirroring data in real time between one or more mobile devices and a plurality of near field communication (NFC) connected interactive posters are disclosed. In one embodiment, an exemplary computer-implemented method may comprise: connecting a user mobile computing device to a server as well as coupling the device to a plurality of interactive posters via NFC; receiving user selections made on the interactive posters; processing content data related to the posters based on the user selections and/or other information; generating a GUI comprising interactive simulations corresponding to respective posters and/or statistics related to selections made on the posters; tracking, in real time, a specific experience of a user interacting with the posters; and transmitting, in real-time, data regarding the specific experience to the server.

Abstract: The present invention features devices, systems, and methods of use thereof for delivering therapeutic or sterilizing ultraviolet (UV) radiation, such as UVC or UVA radiation.

Abstract: The present invention features new lipid-polymer composite particles that are useful for the formulation of bioactive agents for administration to a subject. The nanoparticles include a block copolymer, a lipid, e.g., phospholipid, and a sterol. The formulations of a bioactive agent (e.g., a therapeutic agent, a nutraceutical agent, or a recreational agent) described herein provide for easier loading of lipid-polymer composite particles with higher drug loading capacity, increased stability of the formulations, and lower surface tension of water, which allows for lipid coating and entrapment.

Abstract: Systems and methods involving processing and/or mirroring data in real time involving one or more mobile devices and a plurality of NFC-connected interactive posters are disclosed. In one embodiment, an exemplary computer-implemented method may comprise: connecting a user mobile computing device to a server as well as coupling the device to a plurality of interactive posters via NFC; receiving user selections made on the interactive posters; processing content data related to the posters based on the user selections and/or other information; generating a GUI comprising interactive simulations corresponding to respective posters and/or statistics related to selections made on the posters; tracking, in real time, a specific experience of a user interacting with the posters; and transmitting, in real-time, data regarding the specific experience to the server.

Abstract: Systems and methods involving processing and/or mirroring data in real time between one or more mobile devices and a plurality of near field communication (NFC) connected interactive posters are disclosed. In one embodiment, an exemplary computer-implemented method may comprise: connecting a user mobile computing device to a server as well as coupling the device to a plurality of interactive posters via NFC; receiving user selections made on the interactive posters; processing content data related to the posters based on the user selections and/or other information; generating a GUI comprising interactive simulations corresponding to respective posters and/or statistics related to selections made on the posters; tracking, in real time, a specific experience of a user interacting with the posters; and transmitting, in real-time, data regarding the specific experience to the server.

Abstract: Systems and methods involving processing and/or mirroring data in real time between one or more mobile devices and a plurality of near field communication (NFC) connected interactive posters are disclosed. In one embodiment, an exemplary computer-implemented method may comprise: connecting a user mobile computing device to a server as well as coupling the device to a plurality of interactive posters via NFC; receiving user selections made on the interactive posters; processing content data related to the posters based on the user selections and/or other information; generating a GUI comprising interactive simulations corresponding to respective posters and/or statistics related to selections made on the posters; tracking, in real time, a specific experience of a user interacting with the posters; and transmitting, in real-time, data regarding the specific experience to the server.

Abstract: Systems and methods involving processing and/or mirroring data in real time between one or more mobile devices and a plurality of near field communication (NFC) connected interactive posters are disclosed. In one embodiment, an exemplary computer-implemented method may comprise: connecting a user mobile computing device to a server as well as coupling the device to a plurality of interactive posters via NFC; receiving user selections made on the interactive posters; processing content data related to the posters based on the user selections and/or other information; generating a GUI comprising interactive simulations corresponding to respective posters and/or statistics related to selections made on the posters; tracking, in real time, a specific experience of a user interacting with the posters; and transmitting, in real-time, data regarding the specific experience to the server.

Abstract: Techniques are described for multicast service translation. A router can provide access to a particular source for an Internet Protocol Television (IPTV) channel that is most appropriate for the subscriber despite the subscriber requesting the IPTV channel from a different source. The most appropriate source can be identified based upon a bit rate or quality of service associated with the subscriber and/or a bit rate or quality of service associated with each of one or more alternate sources of the IPTV channel. The router can receive a request to join a multicast stream from a client device of the subscriber that identifies a source associated with an IPTV channel, identify a different source of the IPTV channel for that subscriber, and transmit a different join request destined to the different source.

Abstract: Systems and methods involving processing and/or mirroring data in real time involving one or more mobile devices and a plurality of NFC-connected interactive posters are disclosed. In one embodiment, an exemplary computer-implemented method may comprise: connecting a user mobile computing device to a server as well as coupling the device to a plurality of interactive posters via NFC; receiving user selections made on the interactive posters; processing content data related to the posters based on the user selections and/or other information; generating a GUI comprising interactive simulations corresponding to respective posters and/or statistics related to selections made on the posters; tracking, in real time, a specific experience of a user interacting with the posters; and transmitting, in real-time, data regarding the specific experience to the server.

Abstract: The present invention provides high density lipoprotein (HDL) or reconstituted HDL (rHDL) particles for the delivery of non-nucleic acid therapeutic agents, therapeutic agents or nucleic acids to cells and tissues. The use of HDL or rHDL particles has advantages over other delivery systems because they are smaller in size and their contents are rapidly internalized by receptors of specific cells, including receptors on the surface of tumor tissue. The HDL or rHDL nanoparticles of the present invention may include a positively charged polyamino acid, which neutralizes the negatively charged nucleic acid, thus allowing for successful incorporation of the nucleic acid into an HDL or rHDL particle. Methods of delivering therapeutic agents to cells and target tissues using the disclosed HDL or rHDL particles are provided as are methods of treating various diseases and disorders.

Abstract: Provided is a method for making barrier tube shoulders. The method includes forming a parison from a multi-layer laminated structure having an inner layer that faces an interior of the parison, an outer layer comprising an exterior surface of the parison, and an interdisposed layer between the inner layer and the outer layer, wherein the interdisposed layer is a flavor barrier layer. The method also includes providing an extrusion blow molding (EBM) mold comprising at least one cavity shaped as a barrier tube shoulder, positioning the parison in the EBM mold, and blow molding the parison such that the parison substantially conforms to the EBM mold to form a barrier tube shoulder having the barrier layer.