Abstract: A surgical device includes a housing, a grasper assembly extending distally from the housing, a shaft extending distally from the housing, and a movable handle associated with the housing and operably coupled to the grasper assembly and the shaft. The grasper assembly includes first and second jaw members movable between an open position and a closed position. The shaft is movable relative to the grasper assembly between a retracted position and an extended position. The movable handle is associated with the housing and operably coupled to the grasper assembly and the shaft such that movement of the movable handle relative to the housing from an un-actuated position to an actuated position moves the first and second jaw members from the open position to the closed position, and moves the shaft from the retracted position to the extended position.

Abstract: Systems and methods are provided for parallel processing of datasets with dynamic skew compensation. The disclosed systems and methods may increase the efficiency of dataset processing by imposing maximum size limits on parallel processing environment tasks. The disclosed systems and methods may generate a target partition of a variable, a database storing data elements, a cluster that generates one or more output files based on the target partition and the data elements, and a display device that displays analysis results for the target partition using the one or more output files. Generation may comprise creating a calculation partition, mapping data elements according to the calculation partition, and generating the one or more output files based on the mapped data elements. The calculation partition may depend on a target partition and a uniform partition that partitions values based on one or more of statistical measures and pseudorandom functions.

Abstract: Pharmaceutical compositions comprising two or more therapeutically active agents, such as two or more anticancer agents, conjugated to one or more biocompatible polymers, wherein the molar ratio of the agents and/or schedules of delivery provide a synergistic therapeutic effect, are described. Methods of making and using the pharmaceutical compositions are further described. In one embodiment, the pharmaceutical compositions contain topoisomerase I and topoisomerase II inhibitors conjugated to the same or different biocompatible polymers. The two or more anticancer agents are covalently coupled to the polymer(s), and thereby can be delivered to a tumor at a molar ratio which provides a synergistic effect. Optionally, the agents are coupled indirectly to the polymer(s) via a linker.

Abstract: The present disclosure provides peptides and peptide compositions, optionally in the from of a vaccine, which facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (SC) and/or the cellular membranes of viable cells. Also provided are methods of employing the peptides and peptide compositions to deliver active agents; treat diseases or disorders; and inducing immune responses.

Abstract: Systems and methods are provided for parallel processing of datasets with dynamic skew compensation. The disclosed systems and methods may increase the efficiency of dataset processing by imposing maximum size limits on parallel processing environment tasks. The disclosed systems and methods may generate a target partition of a variable, a database storing data elements, a cluster that generates one or more output files based on the target partition and the data elements, and a display device that displays analysis results for the target partition using the one or more output files. Generation may comprise creating a calculation partition, mapping data elements according to the calculation partition, and generating the one or more output files based on the mapped data elements. The calculation partition may depend on a target partition and a uniform partition that partitions values based on one or more of statistical measures and pseudorandom functions.

Abstract: Methods and materials relating to a medicament preparation comprising a curcuminoid component and a euradit component provided as a curcuminoid-eudragit complex, which enhance the bioavailability of the curcumin component and are useful for the treatment of various diseases including cancer, neurodegeneration, inflammation, and immunodeficiency. In some aspects, the curcuminoid component comprises curcumin to prepare a curcumin-eudragit complex and a medicament comprising curcumin-eudragit complexes.

Abstract: A storage management system receives at a computing system one or more search results from a search operation based on a search query. The search operation had performed a first search on content in a database accessible through an application, a second search on local to the computing system content, and a third search on Web content. At least one of the search results from the first search is associated with an application identifier identifying the application. The storage management system further ranks the search results from the first search, the second search, and the third search in aggregation. A search results integrator presents the ranked search results from the first, second, and third searches in an integrated view. The search results integrator further groups a subset of the ranked search results from the first search, the second search, and the third search into a subgroup within the integrated view.

Abstract: Methods and materials relating to a medicament preparation comprising a curcuminoid component and a eudragit component provided as a curcuminoid-eudragit complex, which enhance the bioavailability of the curcumin component and are useful for the treatment of various diseases including cancer, neurodegeneration, inflammation, and immunodeficiency. In some aspects, the curcuminoid component comprises curcumin to prepare a curcumin-eudragit complex and a medicament comprising curcumin-eudragit complexes.