Abstract: Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a SO2 functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

Abstract: An electronic device may include: a first communication module; a second communication module; a display; and a processor, wherein the processor may be set so that, when an indication of a first image having metadata including shared information is selected, at least one object, information about at least one shared external electronic device related to the at least one object, and the first image including a share button for image transmission are displayed on the display, and the first image is transmitted to a first shared external electronic device selected from among the at least one shared external electronic device. Various other embodiments can be provided.

Abstract: A display apparatus includes a display; a receiver configured to receive a signal from an external input device including a control knob; at least one memory storing instructions; and at least one processor electrically connected to the display and the receiver, and which executes the stored instructions. The at least one processor displays a first content image on the display, display a rotation of the control knob of the external input device and a size of the first content image on the display based on the received signal corresponding to a user input which is input through the external input device, and change a size of the first content image and display the changed size of the first content image on the display, based on at the received signal corresponding to the rotation of the control knob of the external input device.

Abstract: The present disclosure is directed toward drugs and toxins functionalized by at least one saccharide, sulfate or sulfonate; drug conjugates comprising said drugs or toxins and a cleavable linker; and targeted conjugates comprising said drugs or toxins, cleavable linkers, and targeting moieties. The present disclosure also relates to methods of treating cancers, auto-immune diseases, and inflammatory diseases using the compounds and conjugates of the disclosure.

Abstract: This invention is directed to compositions and methods to detect and treat gastrointestinal diseases.

Abstract: A display driver circuit may include a revision controller for controlling a nonvolatile memory having instructions by which control data for controlling devices controlled by the display driver circuit are changed, and a drive controller for controlling the devices based on the instructions. The revision controller determines whether to perform a read operation to the instructions based on electrical power being applied to the display driver circuit, and transfers instruction signals, which are generated based on the determination to perform the read operation, to the driving controller.

Abstract: A bit line sense amplifier includes a plurality of semiconductor devices including sensing transistors and selection transistors disposed side by side, and configured to sense a voltage change of a bit line and a complementary bit line, and wiring patterns connected to at least one of the plurality of semiconductor devices. The sensing transistors share a source electrode. The selection transistors may be controlled to be complementarily turned on and off. The wiring patterns include a first wiring pattern electrically connecting gate electrodes of the sensing transistors and drain electrodes of the selection transistors, and a second wiring pattern electrically connecting a gate electrode of a sensing transistor and a drain electrode of another sensing transistor.

Abstract: The invention relates to activated Michael acceptor (AMA) compounds that can undergo conjugation with biomolecules containing Michael donor moieties, thereby providing plasma-stable antibody-drug conjugates (ADCs). Pharmaceutical compositions of the ADCs are disclosed as well. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.

Abstract: An electronic device is provided. The electronic device includes a housing, and a flexible connecting member disposed inside the housing, the flexible connecting member including a dielectric substrate, at least one signal wire disposed on one surface of the dielectric substrate, and at least one ground disposed on the other surface of the dielectric substrate adjacent to the signal wire. The at least one signal wire and the at least one ground may be disposed to be spaced apart from each other when viewed from above the dielectric substrate. A flexible connecting member may include a dielectric substrate, a signal wire disposed on one surface of the dielectric substrate, and a ground disposed on the other surface of the dielectric substrate adjacent to the signal wire. The signal wire and the ground may be disposed to be spaced apart from each other when viewed from above the dielectric substrate.

Abstract: This invention is directed to compositions and methods to detect and treat gastrointestinal diseases.

Abstract: This invention comprises compositions and methods to detect and treat gastrointestinal diseases.

Abstract: An electronic device having an electronic board function and an operation method thereof. The electronic device includes: a display; a touch input interface; a memory storing at least one instruction; and a processor configured to execute the at least one instruction stored in the memory to: display a writing area in a display area of the display; detect a predefined touch input in the writing area; and based on detecting the predefined touch input, reduce the writing area, display the reduced writing area in at least first part of the display area and provide an extended area in at least second part of the display area, the extended area being configured to receive a writing input continuing from the reduced writing area to the extended area.

Abstract: A display device includes a display configured to output a broadcast content or a content for an interior decoration function, a memory storing a first layout for surrounding the broadcast content and a second layout for surrounding the content for the interior decoration function, and a processor operatively connected to the display and the memory, wherein the processor removes the first layout, enlarges the broadcast content, and outputs the enlarged broadcast content through the display based on a first user input, and enlarges portions of the content for the interior decoration function and of the second layout and outputs the enlarged portions of the content for the interior decoration function and of the second layout through the display based on a second user input.

Abstract: The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

Abstract: Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a SO2 functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

Abstract: A display device includes a display configured to output a broadcast content or a content for an interior decoration function, a memory storing a first layout for surrounding the broadcast content and a second layout for surrounding the content for the interior decoration function, and a processor operatively connected to the display and the memory, wherein the processor removes the first layout, enlarges the broadcast content, and outputs the enlarged broadcast content through the display based on a first user input, and enlarges portions of the content for the interior decoration function and of the second layout and outputs the enlarged portions of the content for the interior decoration function and of the second layout through the display based on a second user input.

Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-B7-H3 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind B7-H3, as well as methods of making and using these anti-B7-H3 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.