Patents by Inventor Suresh C. Srivastava

Suresh C. Srivastava has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10167308
    Abstract: The present invention relates to novel process of reverse 5??3? directed synthesis of RNA oligomers in the range of about 100-mer to about 200-mer has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: January 1, 2019
    Assignee: ChemGenes Corporation
    Inventors: Suresh C Srivastava, Naveen P Srivastava
  • Patent number: 9969764
    Abstract: This invention is related to nucleic acid chemistry and describes novel 1,2-dithiolane functionalized nucleoside phosphoramidites (1, Chart 1) and corresponding solid supports (2, Chart 1). In addition to these derivatives, 1,2-dithiolane moiety can also be functionalized to at the various positions of the nucleobase and sugar part as shown in Schemes 1 to 8. The nucleosides of our invention carry a primary hydroxyl for DMTr (4,4?-dimethoxytrityl) function for chain elongation. Furthermore, the phosphoramidite function is attached at the 3?-hydroxyl of the nucleoside. This allows oligonucleotide chain extension under standard DNA and RNA synthesis chemistry conditions and techniques, thus leading to high quality oligonucleotides. These derivatives are useful for introduction of reactive thiol groups either at 3?- or 5?-end of the oligonucleotides on the solid supports such as gold, silver and quantum dots.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: May 15, 2018
    Inventors: Suresh C Srivastava, Santhosh K Thatikonda, Sant K Srivastav, Praveen K. Shukla, Alok Srivastava
  • Publication number: 20180066009
    Abstract: The present invention is directed to n-alkylated synthetic nucleosides of high regiospecific purity and oligonucleotides that can be utilized for studies on reversal of cytotoxic and mutagenic DNA damage, and as diagnostic tools.
    Type: Application
    Filed: July 13, 2017
    Publication date: March 8, 2018
    Inventors: Satya P. Bajpai, Sant K. Srivastav, Suresh C. Srivastava
  • Patent number: 9884885
    Abstract: This invention relates to novel method of synthesis of RNA utilizing N-2-acetyl protected guanine as nucleoside base, nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides and RNA oligonucleotide synthesis. Our discovery using N-acetyl protected guanine as nucleoside base protecting group, which is significantly faster base labile protecting group, yet significantly more stable than commonly utilized-2-isobutyryl guanosine is a novel approach to obtain highest purity oligonucleotides. This approach is designed to lead to very high purity and very clean oligonucleotide, after efficient removal of the protecting groups, including acetyl group from guanine and to produce high purity therapeutic grade DNA oligonucleotides, RNA oligonucleotides, diagnostic DNA, diagnostic RNA for microarray platform.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: February 6, 2018
    Assignee: CHEMGENES CORPORATION
    Inventors: Suresh C. Srivastava, Naveen P. Srivastava
  • Patent number: 9788408
    Abstract: The invention relates to nuclear technology, and to irradiation targets and their preparation. One embodiment of the present invention includes a method for preparation of a target containing intermetallic composition of antimony Ti—Sb, Al—Sb, Cu—Sb, or Ni—Sb in order to produce radionuclides (e.g., tin—117m) with a beam of accelerated particles. The intermetallic compounds of antimony can be welded by means of diffusion welding to a copper backing cooled during irradiation on the beam of accelerated particles. Another target can be encapsulated into a shell made of metallic niobium, stainless steel, nickel or titanium cooled outside by water during irradiation. Titanium shell can be plated outside by nickel to avoid interaction with the cooling water.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: October 10, 2017
    Inventors: Boris L. Zhuikov, Nicolai A. Konyakhin, Vladimir M. Kokhanyuk, Suresh C. Srivastava
  • Patent number: 9718855
    Abstract: The present invention is directed to n-alkylated synthetic nucleosides of high regiospecific purity and oligonucleotides that can be utilized for studies on reversal of cytotoxic and mutagenic DNA damage, and as diagnostic tools.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: August 1, 2017
    Assignee: ChemGenes Corporation
    Inventors: Satya P. Bajpai, Sant K Srivastav, Suresh C. Srivastava
  • Patent number: 9605261
    Abstract: The present invention relates to novel phosphoramidites, A-n-bz, C-n-bz, C-n-ac, G-n-ac and U are produced with an HPLC purity of greater than 98% and 31P NMR purity greater than 99%. A novel process of reverse 5??3? directed synthesis of RNA oligomers has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: March 28, 2017
    Assignee: ChemGenes Corporation
    Inventors: Suresh C Srivastava, Divya Pandey, Satya P Bajpai, Naveen P Srivastava
  • Publication number: 20170037076
    Abstract: This invention is related to nucleic acid chemistry and describes novel 1,2-dithiolane functionalized nucleoside phosphoramidites (1, Chart 1) and corresponding solid supports (2, Chart 1). In addition to these derivatives, 1,2-dithiolane moiety can also be functionalized to at the various positions of the nucleobase and sugar part as shown in Schemes 1 to 8. The nucleosides of our invention carry a primary hydroxyl for DMTr (4,4?-dimethoxytrityl) function for chain elongation. Furthermore, the phosphoramidite function is attached at the 3?-hydroxyl of the nucleoside. This allows oligonucleotide chain extension under standard DNA and RNA synthesis chemistry conditions and techniques, thus leading to high quality oligonucleotides. These derivatives are useful for introduction of reactive thiol groups either at 3?- or 5?-end of the oligonucleotides on the solid supports such as gold, silver and quantum dots.
    Type: Application
    Filed: April 19, 2016
    Publication date: February 9, 2017
    Inventors: Suresh C SRIVASTAVA, Santhosh K THATIKONDA, Sant K SRIVASTAV, Praveen K. SHUKLA, Alok SRIVASTAVA
  • Patent number: 9512162
    Abstract: The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: December 6, 2016
    Assignee: ASED, LLC
    Inventors: Suresh C. Srivastava, Amy Yasko
  • Patent number: 9493773
    Abstract: The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: November 15, 2016
    Assignee: ASED, LLC
    Inventors: Suresh C. Srivastava, Amy Yasko
  • Patent number: 9441002
    Abstract: The thiol modified oligonucleotides have vast number of applications in the field of nucleic acid chemistry. The conjugates generated by mono thiol groups are unstable at higher temperature, in high salt concentration buffers and in presence other thiols. There is strong need to develop a novel thiol modifier probes that can generate multiple thiol groups. Described herein are efficient processes and compounds, dithiolane phosphoramidites derivative and dithiolane succinyl supports. The advantage of our cyclic disulfide thiol modifier is multifold a) each incorporation introduces two thiol groups; b) it can be introduced at any desired site of oligonucleotides; c) The symmetrical branching nature of the spacer in the linker arm of dithiolane allows for clean oligo synthesis, where cleavage of the linker arm and thereby of loss of oligo chain is prevented.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: September 13, 2016
    Assignee: ChemGenes Corporation
    Inventors: Suresh C. Srivastava, Santhosh Kumar Thatikonda, Sant K. Srivastav, Praveen K. Shukla, Alok Srivastava
  • Publication number: 20160200759
    Abstract: The present invention relates to novel process of reverse 5??3? directed synthesis of RNA oligomers in the range of about 100-mer to about 200-mer has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.
    Type: Application
    Filed: March 14, 2016
    Publication date: July 14, 2016
    Inventors: Suresh C. Srivastava, Naveen P. Srivastava
  • Patent number: 9365607
    Abstract: The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: June 14, 2016
    Assignee: ASED, LLC
    Inventors: Suresh C. Srivastava, Amy Yasko
  • Publication number: 20150252071
    Abstract: The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.
    Type: Application
    Filed: May 26, 2015
    Publication date: September 10, 2015
    Inventors: Suresh C. Srivastava, Amy Yasko
  • Publication number: 20150218557
    Abstract: The present invention relates to novel phosphoramidites, A-n-bz, C-n-bz, C-n-ac, G-n-ac and U are produced with an HPLC purity of greater than 98% and 31P NMR purity greater than 99%. A novel process of reverse 5??3? directed synthesis of RNA oligomers has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.
    Type: Application
    Filed: December 11, 2014
    Publication date: August 6, 2015
    Inventors: Suresh C Srivastava, Divya Pandey, Satya P Bajpai, Naveen P Srivastava
  • Patent number: 9045521
    Abstract: The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: June 2, 2015
    Assignee: ASED, LLC
    Inventors: Suresh C. Srivastava, Amy Yasko
  • Publication number: 20150119565
    Abstract: The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.
    Type: Application
    Filed: October 10, 2014
    Publication date: April 30, 2015
    Inventors: Suresh C. Srivastava, Amy Yasko
  • Patent number: 8981076
    Abstract: This invention relates to synthesis of novel -N-FMOC protected nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides and RNA oligonucleotide synthesis. Our discovery using N-FMOC as nucleoside base protecting group, which is highly base labile protecting group is a novel approach to obtain highest purity oligonucleotides. This approach is designed to lead to very high purity and very clean oligonucleotide, after efficient removal of the protecting groups and to produce high purity therapeutic grade DNA oligonucleotides, RNA oligonucleotides, diagnostic DNA, diagnostic RNA for microarray platform. The deprotection of FMOC protecting groups of the natural deoxy and ribonucleosides occurs under very mild deprotection conditions such as mild bases, secondary and tertiary amines for removal of such groups under such conditions would allows synthesis of various DNA and RNA of highest purity for diagnostics and therapeutic application.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: March 17, 2015
    Assignee: ChemGenes Corporation
    Inventors: Suresh C. Srivastava, Naveen P. Srivastava
  • Publication number: 20150018579
    Abstract: The 5? and 3?-thiol modified oligonucleotides are attractive tools with a vast number of potential applications in the field of nucleic acid chemistry. There is a strong interest in developing new disulfide compounds or to optimize synthesis of existing disulfide modifiers, which are efficient in generating the 3?- or 5?-end reactive thiol group. Various synthetic protocols have been employed to synthesize pure 3-((3-(bis(4-dimethoxytrityl)propyl)di-sulfanyl)propyl 2-cyanoethyl diisopropylphosphoramidite (compound 2) starting from 3-(dimethoxytrityl)propyl)disulfanyl)pro-pan-1-ol, (compound 1). Herein, we describe an efficient, reproducible synthetic and purification protocol for target compound 2 from the compound 1. It is noteworthy that our reaction conditions were reproducible even at multi-gram scale (27 g) with a purity level as achieved in a small scale.
    Type: Application
    Filed: February 22, 2012
    Publication date: January 15, 2015
    Inventors: Suresh C. Srivastava, Santhosh K. Thatikonda, Praveen Shukla, Sant Kumar Srivastav
  • Patent number: 8933214
    Abstract: The present invention relates to novel phosphoramidites, A-n-bz, C-n-bz, C-n-ac, G-n-ac and U are produced with an HPLC purity of greater than 98% and 31P NMR purity greater than 99%. A novel process of reverse 5??3? directed synthesis of RNA oligomers has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.
    Type: Grant
    Filed: October 2, 2012
    Date of Patent: January 13, 2015
    Assignee: ChemGenes Corporation
    Inventors: Suresh C Srivastava, Divya Pandey, Satya P Bajpal, Naveen P Srivastava