Abstract: An object-based data storage service receives a request to store a data object in a first location corresponding to a first data storage tier. The request may specify a parameter to enable transitioning of the data object to another data storage tier. In response to the request, the object-based data storage service stores the data object in the first location and monitors access of the data object to determine usage data associated with the data object. The object-based data storage service processes the usage data to determine that the data object is to be transitioned to a second data storage tier. As a result of this determination, the object-based data storage service transitions the data object to a second location corresponding to the second data storage tier.

Abstract: The present subject matter relates to a new liquid and solid-state laser system comprising a laser structure and novel 7H-pyrano[2,3-b:4,5-b?]diquinoline derivative compounds as the laser active media; the novel 7H-pyrano[2,3-b:4,5-b?]diquinoline derivative compounds comprising 10-chloro-7H-pyrano[2,3-b:4,5-b?]diquinoline [(Cl-PD)] and 10-methoxy-7H-pyrano[2,3-b:4,5-b?]diquinoline [(MeO-PD)]; and a method of synthesizing the organic 7H-pyrano[2,3-b:4,5-b?]diquinoline derivative compounds used in the laser system.

Abstract: A system and method of manufacturing an aluminum fuel cell cradle are provided. The method comprises providing a negative cast mold having cavities to form the cradle, and comprises providing a feeding mechanism disposed about the mold and in fluid communication with the cavities thereof. The feeding mechanism comprises a plurality of primary risers connected to and in fluid communication with cavities. The method further comprises melting a first metallic material to define a molten metallic material, and comprises moving the mold to a vertical casting orientation about a rotational axis, while feeding molten metallic material through the runner to the cavities. The method further comprises cooling the molten metallic material to define a solidified metallic material. A second solidification time in the risers is greater than a first solidification time in the mold such that shrinkage of the solidified metallic material occurs in the risers away from the mold.

Abstract: A method includes: dequeuing a signal primitive from a signaling command queue in the set of command queues, the signal primitive pointing to a waiting command queue; in response to the signal primitive pointing to the waiting command queue, incrementing a number of pending signal primitives in the signal-wait counter matrix; dequeuing a wait primitive from the waiting command queue, the wait primitive pointing to the signaling command queue; in response to the wait primitive pointing to the signaling command queue, accessing the register to read the number of pending signal primitives; in response to the number of pending signal primitives indicating at least one pending signal primitive: decrementing the number of pending signal primitives; and dequeuing an instruction from the waiting command queue; and dispatching a control signal representing the instruction to a resource.

Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.

Abstract: A surgical stapling system includes a surgical stapling apparatus and a staple cartridge surgical buttress assembly. The surgical stapling apparatus includes a handle assembly, an elongate tubular body extending distally from the handle assembly, and an end effector extending distally from the elongate tubular body. The end effector includes an anvil assembly and a staple cartridge assembly. The staple cartridge surgical buttress assembly includes a surgical buttress and a leash. The surgical buttress includes a body having an annular configuration and legs extending from the body. The body is positioned against a tissue facing surface of the staple cartridge assembly and the legs are positioned against a housing of the staple cartridge assembly. The leash is threaded through at least one of the legs and extends proximally from the surgical buttress towards the handle assembly.

Abstract: This disclosure relates generally to a system and method for using a machine-learning system to more accurately detect fraudulent use of credit cards on an e-commerce website and block those attempts.

Abstract: An end effector for use with a surgical stapler includes a staple cartridge assembly movable relative to an anvil assembly. The staple cartridge assembly defines a plurality of retention slots and a cavity. The staple cartridge assembly includes a plurality of staples, a plurality of pushers, an actuation sled, a surgical buttress material, a suture, and an anchoring button. The actuation sled is configured for movement along a length of the staple cartridge assembly to sequentially engage the plurality of pushers to eject the plurality of staples through the respective plurality of retention slots. The anchoring button is configured to be received in the cavity of the staple cartridge assembly such that a portion of the suture is supported in the cavity to be severed by a knife blade of the actuation sled when the actuation sled is advanced distally.

Abstract: Systems and methods implementing prioritization of network resources in an aeronautical satellite network system, which determines network utilization of a beam of the aeronautical satellite system by a plurality of aircraft using network capacity of the beam, where network demand in the beam indicated by the network utilization is greater than capacity of the beam, share network bandwidth of the beam to the plurality of aircraft based on a service priority factor, where the service priority factor may depend on altitude of the plurality of aircraft in the beam.

Abstract: A document management system uses machine learning to identify legal obligations within contract documents. The document management system trains a machine-learned model using historical contract documents having historical legal obligations; the trained machine-learned model is configured to identify portions of text within a contract document that correspond to legal obligations. The machine-learned model, applied to a set of contract documents, identifies a set of legal obligations. The document management system presents, via a user interface, information about the set of identified legal obligations.

Abstract: In some implementations, a digital twin system may receive, from one or more sensors and at an interface associated with a digital twin, a first input associated with a first event. The digital twin system may determine that the first event is associated with one or more probable second events. Accordingly, the digital twin system may refrain from processing the first input for a period of time. The digital twin system may further update a prediction associated with the digital twin using the first input based on expiry of the period of time or may update a prediction associated with the digital twin using second input associated with the one or more probable second events based on receiving the second input.

Abstract: The present invention relates to discovery that TBK1 phosphorylates Syntaxin 17 and that phosphorylation of Syntaxin 17 is intimate to control autophagy initiation. The present invention is directed to this discovery and the use of TBK1 inhibitors or inhibitors of Syntaxin 17 phosphorylation alone or in combination with additional bioactive agents to inhibit autophagy in the treatment of disease, especially the treatment of cancers. Methods of treating various cancers are disclosed using TBK1 inhibitors to patients with cancer and into cancerous tissues for the treatment of cancer including the inhibition, amelioration, reduction in metastasis and in recurrence of cancer in remission. Assays and methods for identifying compounds as inhibitors of Syntaxin 17 and as potential therapeutic agents for cancer and autoimmune diseases are also diseased herein.

Abstract: A method to optimize the usage of these crypto resources for effectively sharing the resource with identical configuration crypto material and thereby reducing the operation overhead associated with cryptographic operations is disclosed.

Abstract: The present invention discloses a process for the preparation of substituted pyridine compounds of formula (I), comprises a step in which vinylogous nitriles of formula (II), are obtained from substituted ?,?-unsaturated nitrile compounds of formula (III), and a further step of converting the vinylogous nitrile compounds of formula (II) into substituted pyridines of formula (I); wherein R1, R2, R3, R4 and LG are as defined in the description.

Abstract: A network device serving as a local VXLAN) Tunnel Endpoint (VTEP) includes a communication interface, a first processor and a packet processor. The communication interface communicates between the local VTEP and remote VTEPs, each VTEP has a respective VXLAN Identifier (VNI). The first processor imports a Downstream-VNI (D-VNI) to be used in forwarding packets from the local VTEP to a remote VTEP, creates a unique egress Routing Interface (RIF) that is translatable into the imported D-VNI, and associates the unique egress RIF with one or more route entries in the local VTEP. The packet processor receives a packet destined to the remote VTEP, looks up the packet in the route entries in the local VTEP to retrieve the unique egress RIF, translates the unique egress RIF into the imported D-VNI, encapsulates the packet with the imported D-VNI, and forwards the encapsulated packet in accordance with the unique egress RIF.

Abstract: Proxy systems and methods for multiprocessing architectures are described. One method includes receiving an inference request and a statistics request from a client computing system. The method may access a load state of each processing device in a subset of processing devices preloaded with the neural network model, and select a target processing device from the subset based on the load states. One aspect includes transmitting the inference request to the target processing device, and monitoring an execution of the inference request by the target processing device based on the neural network model. The method may receive an inference result generated by the target processing device after executing the inference request, and compute an average inference time for the inference request execution based on the monitoring. The method may transmit the inference result and the average inference time to the client computing system.

Abstract: The invention provides a chemiresistive substrate for a dihydrogen-sensitive amperometric gas sensor, the chemiresistive substrate comprising: a crystalline semiconductive metal oxide layer comprising an array of spaced apart hollow metal oxide micro-shells protruding from a base plane of the metal oxide layer; and metallic nanoparticles decorating the metal oxide layer.

Abstract: A refilling device for an article of an aerosol provision system comprises refilling control circuitry configured to facilitate the transfer of aerosol-generating material from a reservoir to the article in response to detecting that the article has been received by the refilling device.

Abstract: A desktop refilling device for an article of an aerosol provision system comprises an article interface configured to receive the article, a reservoir interface configured to receive a reservoir, and refilling control circuitry configured to facilitate the transfer of aerosol-generating material from the reservoir to the article, wherein the article interface and/or the reservoir interface are configured to respectively enclose the article and the reservoir inside a housing of the desktop refilling device during the transfer of aerosol-generating material from the reservoir to the article.

Abstract: A desktop refilling device for an article of an aerosol provision system comprising the article and an aerosol provision device. The desktop refilling device comprises an article interface configured to receive the article when the article is separated from the aerosol provision device, and refilling control circuitry configured to facilitate the transfer of aerosol-generating material from a reservoir couplable to the refilling device to the article.