Patents by Inventor Susan E. Brophy

Susan E. Brophy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES TO TROPONIN I AND METHODS OF USE THEREOF
    Publication number: 20120076803
    Abstract: The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.
    Type: Application
    Filed: February 23, 2010
    Publication date: March 29, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, Bailin Tu, Joan D. Tyner, Lowell J. Tyner, Dagang Huang, Robert N. Ziemann
  • MONOCLONAL ANTIBODIES AGAINST HEPATITIS C VIRUS CORE PROTEIN
    Publication number: 20120009196
    Abstract: The present disclosure relates to anti-HCV core protein monoclonal antibodies, methods of making them, and their uses in the prevention, diagnosis, and/or treatment of disease including HCV infections.
    Type: Application
    Filed: July 8, 2011
    Publication date: January 12, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: A Scott Muerhoff, Susan E. Brophy, Bill J. Zeck
  • Antibodies to troponin I and methods of use thereof
    Patent number: 8030026
    Abstract: The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.
    Type: Grant
    Filed: February 24, 2009
    Date of Patent: October 4, 2011
    Assignee: Abbott Laboratories
    Inventors: Susan E. Brophy, Bailin Tu, Joan D. Tyner, Lowell J. Tyner, legal representative, Dagang Huang, Robert N. Ziemann
  • Human BNP immunospecific antibodies
    Patent number: 7998480
    Abstract: The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: August 16, 2011
    Assignee: Abbott Laboratories
    Inventors: Susan E. Brophy, Joan D. Tyner, Lowell J. Tyner, legal representative, Bailin X. Tu, Mary S. Pinkus, Jessie W. Shih, Bryan C. Tieman
  • Human BNP immunospecific antibodies
    Patent number: 7939069
    Abstract: The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: May 10, 2011
    Assignee: Abbott Laboratories
    Inventors: Susan E. Brophy, Joan D. Tyner, Bryan C. Tieman
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20110091372
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: September 1, 2010
    Publication date: April 21, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Junjian Liu, Sharmila Manoj, Susan E. Brophy
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20110008766
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: April 30, 2010
    Publication date: January 13, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Junjian Liu, Susan E. Brophy, Sushil G. Devare, Frank C. Grenier, Jeffrey A. Moore, Qiaoqiao Ruan, Sergey Y. Tetin, Jennifer M. Steinhaus, Salman Ali, Hina N. Syed
  • SOLUBLE FMS-LIKE TYROSINE KINASE-1 (sFLT-1) ANTIBODY AND RELATED COMPOSITION, KIT, METHODS OF USING, AND MATERIALS AND METHOD FOR MAKING
    Publication number: 20100266575
    Abstract: An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.
    Type: Application
    Filed: December 21, 2009
    Publication date: October 21, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, Saul A. Datwyler, David J. Hawksworth, Don C. Laird, Sharmila Manoj, Dominick L. Pucci, Bryan C. Tieman, Joan Tyner, Lowell J. Tyner, Zhiguang Yu
  • ANTIBODIES TO TROPONIN I AND METHODS OF USE THEREOF
    Publication number: 20100216720
    Abstract: The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.
    Type: Application
    Filed: February 24, 2009
    Publication date: August 26, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, Bailin Tu, Joan D. Tyner, Dagang Huang, Robert N. Ziemann, Lowell J. Tyner
  • Human ring specific BNP antibodies
    Patent number: 7731965
    Abstract: The present invention relates to antibodies that specifically bind to human BNP and immunoassays using said antibodies in the quantification of human BNP or a fragment of human BNP in a test sample.
    Type: Grant
    Filed: May 23, 2005
    Date of Patent: June 8, 2010
    Inventors: Jessie W. Shih, Joan D. Tyner, Matthew S. Matias, Mary S. Pinkus, Susan E. Brophy, David J. Dagfal, David J. Hawksworth, Bryan C. Tieman
  • PIGF-1 ASSAY AND KITS AND COMPONENTS THEREOF
    Publication number: 20100015637
    Abstract: The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.
    Type: Application
    Filed: June 16, 2009
    Publication date: January 21, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, Lianli Chi, Saul A. Datwyler, David J. Hawksworth, Don M. Laird, Sharmila Manoj, Mary S. Pinkus, Dominick L. Pucci, Carol S. Ramsay, David C. Sogin, Bailin Tu, Joan D. Tyner, Lowell J Tyner, Zhiguang Yu, Robert N. Ziemann
  • Anti-T. Cruzi Antibodies and Methods of Use
    Publication number: 20090203037
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Application
    Filed: December 23, 2008
    Publication date: August 13, 2009
    Applicant: Abbott Laboratories
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Lowell J. Tyner, Robert N. Ziemann
  • Negative Mimic Antibody For Use as a Blocking Reagent In BNP Immunoassays
    Publication number: 20090203038
    Abstract: The present disclosure relates to isolated antibodies that do not bind to brain natriuretic peptide that can be used as a reagent to reduce heterophilic interference in an immunoassay.
    Type: Application
    Filed: December 23, 2008
    Publication date: August 13, 2009
    Applicant: Abbott Laboratories
    Inventors: Susan E. Brophy, William E. Brown, III, Walt J. Keirans, Joan D. Tyner
  • HUMAN BNP IMMUNOSPECIFIC ANTIBODIES
    Publication number: 20090123473
    Abstract: The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
    Type: Application
    Filed: August 11, 2008
    Publication date: May 14, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, Joan D. Tyner, Bailin X. Tu, Mary S. Pinkus, Jessie W. Shih, Bryan C. Tieman, Lowell J. Tyner
  • Human BNP Immunospecific Antibodies
    Publication number: 20080124811
    Abstract: The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
    Type: Application
    Filed: May 8, 2007
    Publication date: May 29, 2008
    Inventors: Susan E. Brophy, Joan D. Tyner, Bryan C. Tieman