Patents by Inventor Susan Gould-Fogerite
Susan Gould-Fogerite has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9974745Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.Type: GrantFiled: January 30, 2014Date of Patent: May 22, 2018Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
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Patent number: 9566237Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated.Type: GrantFiled: April 1, 2013Date of Patent: February 14, 2017Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu
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Patent number: 9259392Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.Type: GrantFiled: September 27, 2013Date of Patent: February 16, 2016Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Susan Gould-Fogerite, Raphael J. Mannino, Patrick Ahl, Gaofeng Shang, Zi Wei Chen, Sara L. Krause-Elsmore
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Publication number: 20140242153Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.Type: ApplicationFiled: January 30, 2014Publication date: August 28, 2014Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
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Publication number: 20140186430Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.Type: ApplicationFiled: September 27, 2013Publication date: July 3, 2014Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Susan Gould-Fogerite, Raphael J. Mannino, Patrick Ahl, Gaofeng Shang, Zi Wei Chen, Sara L. Krause-Elsmore
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Patent number: 8642073Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.Type: GrantFiled: January 11, 2007Date of Patent: February 4, 2014Assignees: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New JerseyInventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
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Patent number: 8546555Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.Type: GrantFiled: November 17, 2011Date of Patent: October 1, 2013Assignee: Biodelivery Sciences International, Inc.Inventors: Susan Gould-Fogerite, Raphael J. Mannino, Patrick Ahl, Gaofeng Shang, Zi Wei Chen, Sara L. Krause-Elsmore
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Publication number: 20130224284Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated.Type: ApplicationFiled: April 1, 2013Publication date: August 29, 2013Inventors: Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu
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Publication number: 20120282322Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.Type: ApplicationFiled: November 17, 2011Publication date: November 8, 2012Applicant: BIODELIVERY SCIENCES INTERNATIONAL, INC.Inventors: Susan Gould-Fogerite, Raphael J. Mannino, Patrick Ahl, Gaofeng Shang, Zi Wei Chen, Sara L. Krause-Elsmore
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Publication number: 20120195932Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for to later addition of cargo moieties are also contemplated.Type: ApplicationFiled: January 25, 2010Publication date: August 2, 2012Applicant: BioDelivery Sciences International, Inc.Inventors: Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu
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Publication number: 20120178793Abstract: The present invention is directed to cochleate composition that include a nucleotide. The nucleotide may generally be bound via a linker to a component of the cochleate, or to a lipophilic tail. Additionally or alternatively, the nucleotide may he associated with a transfection agent. The present invention also includes methods for making and using, the compositions provided herein.Type: ApplicationFiled: March 19, 2012Publication date: July 12, 2012Applicant: BioDelivery Sciences International, Inc.Inventors: Raphael J. Mannino, Susan Gould-Fogerite
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Publication number: 20110091523Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.Type: ApplicationFiled: February 11, 2010Publication date: April 21, 2011Applicant: BioDelivery Sciences International, Inc.Inventors: Susan Gould-Fogerite, Raphael J. Mannino, Patrick Ahl, Gaofeng Shang, Zi Wei Chen, Sara L. Krause-Elsmore
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Publication number: 20080242625Abstract: The present invention is directed to cochleate composition that include a nucleotide. The nucleotide may generally be bound via a linker to a component of the cochleate, or to a lipophilic tail. Additionally or alternatively, the nucleotide may be associated with a transfection agent. The present invention also includes methods for making and using the compositions provided herein.Type: ApplicationFiled: April 11, 2005Publication date: October 2, 2008Applicant: BioDelivery Sciences International, Inc.Inventors: Raphael J. Mannino, Susan Gould-Fogerite
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Publication number: 20080009457Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.Type: ApplicationFiled: January 11, 2007Publication date: January 10, 2008Applicant: BioDelivery Sciences International, Inc.Inventors: Susan Gould-Fogerite, Raphael Mannino, Patrick Ahl, Gaofeng Shang, Zi Chen, Sara Krause-Elsmore
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Publication number: 20070237814Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.Type: ApplicationFiled: January 11, 2007Publication date: October 11, 2007Applicants: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New JerseyInventors: Raphael Mannino, Susan Gould-Fogerite, Sara Krause-Elsmore, David Delmarre, Ruying Lu
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Publication number: 20060029656Abstract: Disclosed are cochleates and cochleate compositions that associated with an replacement enzyme component and/or a plasmid component that encodes a replacement enzyme. Also disclosed are methods of making and using the compositions of the invention, including methods of administration. Use of the invention provides safe, effective and efficient delivery of replacement enzymes and/or plasmids encoding the same in a variety of dosage forms.Type: ApplicationFiled: February 3, 2005Publication date: February 9, 2006Applicant: BioDelivery Sciences International, Inc.Inventors: Francis O'Donnell, Raphael Mannino, Susan Gould-Fogerite
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Publication number: 20060019870Abstract: Disclosed herein are cochleates and cochleate compositions associated with an apoprotein component and/or a plasmid component that encodes an apoprotein. Also disclosed are methods of making and using the compositions of the invention, including methods of administration. Use of the invention provides safe, effective and efficient delivery of apoproteins and/or plasmids encoding the same in a variety of dosage forms.Type: ApplicationFiled: January 28, 2005Publication date: January 26, 2006Inventors: Francis O'Donnell, Susan Gould-Fogerite, Raphael Mannino
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Publication number: 20050129661Abstract: An integrative DNA vector and one or more viral proteins having affinity for DNA are packaged in cochleate precipitates. The integrative DNA vector contains one or more therapeutic nucleotide sequences that are preferably positioned between DNA substrates for the proteins. Upon contact with a lipid bilayer of a target cell, the cochleate vector structure delivers one or more of the therapeutic nucleotide sequences and one or more proteins to the interior of the target cell. Upon entry into the cell, the proteins facilitate the integration of the therapeutic nucleotide sequence into the genome of the host cell.Type: ApplicationFiled: January 24, 2005Publication date: June 16, 2005Applicants: University of Medicine and Dentistry of New Jersey, University of MarylandInventors: David Margolis, Susan Gould-Fogerite, Raphael Mannino
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Publication number: 20050013855Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.Type: ApplicationFiled: April 9, 2004Publication date: January 20, 2005Applicants: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New JerseyInventors: Susan Gould-Fogerite, Raphael Mannino, Patrick Ahl, Gaofeng Shang, Zi Chen, Sara Krause-Elsmore
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Publication number: 20050013854Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.Type: ApplicationFiled: April 9, 2004Publication date: January 20, 2005Inventors: Raphael Mannino, Susan Gould-Fogerite, Sara Krause-Elsmore, David Delmarre, Ruying Lu