Patents by Inventor Susan Grass

Susan Grass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Outer membrane protein P1 and peptides of Haemophilus influenzae type B
    Patent number: 5985288
    Abstract: The gene for outer membrane protein P1 of Haemophilus influenzae b is expressed in E. coli. Methods for expression and demonstration of the immunogenicity of recombinant P1 and portions thereof are disclosed, along with an improved method for the purification of P1. The nucleotide sequence of the P1 gene and the derived amino acid sequence of the P1 protein of Haemophilus influenzae type b are disclosed and the methods used to determine the same. Also disclosed are the methods used to clone and express the P1 gene as well as the purification protocol for the P1 gene products (recombinant P1 and P1 fusion proteins). Fourteen peptides are synthesized corresponding to specific sequences of the mature P1 protein. The use of the P1 protein as n immunogens for immunization against the disease caused by Haemophilus influenzae type b and the use of the protein as a carrier for conjugation with an oligosaccharide derived from Haemophilus to generate a potentially efficacious vaccine against the disease, are described.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 16, 1999
    Assignee: Connaught Laboratories Limited
    Inventors: Robert S. Munson, Jr., Susan Grass, Pele Chong, Yan-Ping Yang, Raafat Fahim, Dwo Yan Charles Sia, Patrick McVerry, Michel Klein
  • DNA encoding the 15kD outer membrane protein of Haemophilus influenzae
    Patent number: 5503992
    Abstract: Murine monoclonal antibodies directed against a novel outer membrane protein (OMP) of Haemophilus influenzae have been isolated and characterized. The gene encoding of the outer membrane protein has also been isolated and characterized. Portions of the DNA sequence of the 15 kD OMP gene are useful as probes to diagnose the presence of Haemophilus influenzae in samples. These DNA's also make available polypeptide sequences of immunoreactive epitopes encoded within the gene, thus permitting the production of polypeptides which are useful as standards or reagents in diagnostic tests and/or as components of vaccines. Monoclonal antibodies directed against epitopes of the 15 kD OMP are also useful for diagnostic tests and as therapeutic agents for passive immunization.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: April 2, 1996
    Assignees: Washington University, Her Majesty the Queen in right of Canada, as represented by the Minister of Health and Welfare Canada
    Inventors: Bernard R. Brodeur, Josee Hamel, Robert S. Munson, Jr., Susan Grass
  • DNA encoding the 15 kD outer membrane protein of Haemophilus influenzae
    Patent number: RE37768
    Abstract: Murine monoclonal antibodies directed against a novel outer membrane protein (OMP) of Haemophilus influenzae have been isolated and characterized. The gene encoding of the outer membrane protein has also been isolated and characterized. Portions of the DNA sequence of the 15 kD OMP gene are useful as probes to diagnose the presence of Haemophilus influenzae in samples. These DNA's also make available polypeptide sequences of immunoreactive epitopes encoded within the gene, thus permitting the production of polypeptides which are useful as standards or reagents in diagnostic tests and/or as components of vaccines. Monoclonal antibodies directed against epitopes of the 15 kD OMP are also useful for diagnostic tests and as therapeutic agents for passive immunization.
    Type: Grant
    Filed: April 2, 1998
    Date of Patent: June 25, 2002
    Inventors: Bernard R. Brodeur, Josee Hamel, Robert S. Munson, Jr., Susan Grass